1. Imported strongyloidiasis : Data from 1245 cases registered in the +REDIVI Spanish collaborative network (2009-2017)
- Author
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Salvador, F., Treviño, Begoña, Chamorro-Tojeiro, S., Sánchez-Montalvá, Adrián, Herrero-Martínez, J. M., Rodríguez-Guardado, A., Serre-Delcor, Núria, Torrús, D., Goikoetxea, J., Zubero, Z., Velasco, M., Sulleiro, Elena, Molina Romero, Israel, López-Vélez, R., Pérez-Molina, Jose A., Universitat Autònoma de Barcelona, Institut Català de la Salut, [Salvador F, Sánchez-Montalvá A, Sulleiro E, Molina I] Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona Barcelona, Spain. [Treviño B, Serre-Delcor N] Unitat de medicina tropical i salut internacional, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Chamorro-Tojeiro S] Ramón y Cajal University Hospital, Madrid, Spain. [Herrero-Martínez JM] Hospital Universitario 12 de Octubre, Madrid, Spain. [Rodríguez-Guardado A] Hospital Universitario Central de Asturias, Oviedo, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
0301 basic medicine ,Male ,Life Cycles ,Pediatrics ,Other subheadings::Other subheadings::/physiopathology [Other subheadings] ,Nematoda ,España ,RC955-962 ,Pathology and Laboratory Medicine ,Geographical locations ,Other subheadings::/statistics & numerical data [Other subheadings] ,Larvae ,0302 clinical medicine ,Ivermectin ,Arctic medicine. Tropical medicine ,Strongyloides ,Epidemiology ,Medicine and Health Sciences ,Eosinophilia ,Otros calificadores::/estadística & datos numéricos [Otros calificadores] ,Child ,Aged, 80 and over ,Anthelmintics ,Serodiagnosis ,Travel ,biology ,Eukaryota ,Hematology ,Strongyloides Stercoralis ,Middle Aged ,enfermedades parasitarias::helmintiasis::infecciones por nematodos::infecciones por Secernentea::infecciones por Rhabditida::estrongiloidiasis [ENFERMEDADES] ,Europe ,Serology ,Infectious Diseases ,Strongyloidiasis ,Viatgers ,Helminth Infections ,Child, Preschool ,Female ,medicine.symptom ,Public aspects of medicine ,RA1-1270 ,Research Article ,Neglected Tropical Diseases ,medicine.drug ,Adult ,medicine.medical_specialty ,Persons::Transients and Migrants [NAMED GROUPS] ,Otros calificadores::Otros calificadores::/fisiopatología [Otros calificadores] ,Adolescent ,030231 tropical medicine ,Emigrants and Immigrants ,Parasitic Diseases::Helminthiasis::Nematode Infections::Secernentea Infections::Rhabditida Infections::Strongyloidiasis [DISEASES] ,Albendazole ,Strongyloides stercoralis ,03 medical and health sciences ,Young Adult ,Diagnostic Medicine ,Parasitic Diseases ,medicine ,Animals ,Humans ,European Union ,Intestins - Infeccions ,Aged ,Retrospective Studies ,Helmints - Epidemiologia - Espanya ,business.industry ,Organisms ,Public Health, Environmental and Occupational Health ,Biology and Life Sciences ,Infant ,personas::transeúntes y migrantes [DENOMINACIONES DE GRUPOS] ,Retrospective cohort study ,South America ,Tropical Diseases ,biology.organism_classification ,medicine.disease ,Invertebrates ,030104 developmental biology ,Soil-Transmitted Helminthiases ,Spain ,Observational study ,People and places ,business ,Developmental Biology - Abstract
Background Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. Methodology This is an observational retrospective study that included all patients diagnosed of strongyloidiasis registered in the +REDIVI Collaborative Network from 2009 to 2017. Demographic, epidemiological and clinical information was collected from the +REDIVI database, and extra information regarding microbiological techniques, treatment and follow-up was requested to participant centers. Findings Overall, 1245 cases were included. Most of them were immigrants (66.9%), and South America was the most frequent area of origin. Detection of larvae in stool samples was observed in 21.9% of the patients, and serological tests allowed making the diagnosis in the rest of the cases. Eosinophilia was present in 82.2% of cases. Treatment with ivermectin (compared with albendazole) was the most strongly associated factor to achieve the cure (OR 2.34). Conclusions Given the long latency of the infection and the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions., Author summary Strongyloidiasis, the parasitic disease caused by the nematode Strongyloides stercoralis, is being increasingly diagnosed in immigrant population in Spain. In the present study we describe de clinical, epidemiological and microbiological profile of 1245 cases of imported strongyloidiasis registered in the +REDIVI Spanish Collaborative Network. Patients were mostly immigrants, and the majority of them were coming from South America. Serological tests allowed the diagnosis in most of the cases, and detection of larvae in stool samples was associated with male gender and presence of eosinophilia. Ivermectin was associated with higher probability of cure compared with albendazole. Given the risk of developing a severe presentation, screening of S. stercoralis infection should be mandatory in patients coming from or had traveling to endemic areas, especially in those with immunosuppressant conditions.
- Published
- 2019