87 results on '"Tran Thi Hong Hanh"'
Search Results
2. Cytotoxic monoterpenoid indole alkaloids from the leaves and twigs of Tabernaemontana bovina
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Ninh Thi Ngoc, Tran Hong Quang, Nguyen Huu Quan, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Van Thanh, Chu Hoang Ha, Nguyen Hoai Nam, and Chau Van Minh
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Plant Science ,Agronomy and Crop Science ,Biochemistry ,Biotechnology - Published
- 2022
3. Sulfated Naphthopyrones and Anthraquinones from the Vietnamese Crinoid Comanthus delicata
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Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Do Cong Thung, Nguyen Xuan Cuong, Nguyen Hoai Nam, Pham Van Cuong, Phan Van Kiem, and Chau Van Minh
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Drug Discovery ,General Chemistry ,General Medicine - Published
- 2022
4. Two new eudesmane sesquiterpene glucosides from the aerial parts of Artemisia vulgaris
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Tran Thi Hong Hanh, Le Ba Vinh, Nguyen Xuan Cuong, and Tran Hong Quang
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Organic Chemistry ,Plant Science ,Biochemistry ,Analytical Chemistry - Abstract
Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A (1) and B (2), and two known analogs ainsliaside E (3) and pumilaside A (4) were isolated from the aerial parts of Artemisia vulgaris. Their chemical structures were established by spectroscopic methods, including one and two-dimensional nuclear magnetic resonance (1 D and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). In addition, their cytotoxicity on five human cancer cell lines, including KB (epidermoid carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), SK-Mel-2 (melanoma), and LNCaP (prostate cancer) was also evaluated by the SRB assay. However, none of the tested eudesmane sesquiterpene glycosides showed significant cytotoxicity (IC50>100 µM).
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- 2023
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5. Cytotoxic phenolic glycosides from the seeds of Senna tora
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Tran Hong Quang, Nguyen Hoai Nam, Tran Thi Hong Hanh, Nguyen Quang Trung, Nguyen Xuan Cuong, Le Ngoc Anh, Do Hoang Anh, and Chau Van Minh
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chemistry.chemical_classification ,Senna tora ,biology ,Chemistry ,Cancer ,Glycoside ,Plant Science ,biology.organism_classification ,medicine.disease ,Biochemistry ,Phytochemical ,medicine ,Ic50 values ,Cytotoxic T cell ,Cytotoxicity ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology ,Nuclear chemistry - Abstract
Phytochemical investigations of Senna tora seeds led to the isolation of fourteen phenolic glycosides, including three new compounds, namely, sennatorosides A–C (1–3). The chemical structures of the isolated compounds were confirmed by a detailed analysis of the 1D and 2D NMR, HR-ESI-QTOF mass, and ECD spectra. Among the isolated compounds, 1-[(1-( - d -glucopyranosyl)oxy-8-hydroxy-methoxynaphthalen)-6-yl]propan-2-one (11) exhibited strong cytotoxic activity against three tested cancer cell lines, SK-LU-1 (lung cancer), HepG2 (hepatoma cancer), and MCF-7 (breast cancer), with IC50 values of 8.05 ± 0.28, 9.52 ± 1.20, and 8.54 ± 0.85 μM, respectively, whereas compounds 1–4, 6–9, 12, and 14 revealed moderated or weak cytotoxicity, with IC50 values ranging from 44.59 ± 5.03–98.24 ± 2.45 μM.
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- 2021
6. Bioactive secondary metabolites from a soybean-derived fungus Aspergillus versicolor IMBC-NMTP02
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Nguyen Thi Thanh Ngan, Nguyen Viet Phong, Dang Viet Anh, Tran Thi Hong Hanh, Nguyen Quang Trung, Tran Hong Quang, Nguyen Hoai Nam, Chau Van Minh, Nguyen Xuan Cuong, and Hyuncheol Oh
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biology ,Chemistry ,Plant Science ,Fungus ,biology.organism_classification ,Antimicrobial ,Biochemistry ,Enterococcus faecalis ,Cell culture ,LNCaP ,Aspergillus versicolor ,Fermentation ,Candida albicans ,Agronomy and Crop Science ,Biotechnology - Abstract
In the present study, 10 secondary metabolites, including three new asperversilactones A–C (2, 4, and 5) and two new natural metabolites (4Z,6S,7R)-6,7-dihydroxyocta-2,4-dien-4-lactone (1) and (4E,6S,7R)-6,7-dihydroxyocta-2,4-dien-4-lactone (3) were isolated from a culture fermentation of the soybean-derived fungus Aspergillus versicolor IMBC-NMTP02. Their structures were elucidated by comprehensive analyses of spectroscopic methods, including NMR, mass, and ECD spectra. Compounds 5, 6, and 9 were shown to have cytotoxic effects toward the HepG2, KB, HL-60, MCF-7, SK-Mel-2, and LNCaP human cancer cell lines (IC50 = 31.7–81.5 μM), whereas all of the compounds inhibited NO overproduction in LPS-stimulated BV2 cells (IC50 = 19.0–41.9 μM). Furthermore, all of the compounds showed antimicrobial effects against Enterococcus faecalis and Candida albicans, with MIC values in the range of 32–256 μM. Our investigation contributes to clarification of the chemical constituents of the soybean-derived A. versicolor and warrants further studies of some bioactive metabolites for therapeutic uses.
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- 2021
7. Chemical constituents of Blumea balsamifera
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Nguyen Xuan Cuong, Tran Thi Hong Hanh, Le Thi Thuy Hang, Tran Hong Quang, Nguyen Quang Trung, Vu Huong Giang, and Nguyen Van Thanh
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biology ,010405 organic chemistry ,Chemistry ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Phytochemical ,Chemical constituents ,Mass spectrum ,Ic50 values ,Blumea balsamifera ,Cancer cell lines ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology ,Nuclear chemistry - Abstract
Phytochemical investigations of Blumea balsamifera branches and leaves led to the isolation of ten secondary metabolites, including three new compounds, namely, balsamiferine K (1) and balsamiferosides A (2) and B (3). Structural elucidation was confirmed by detailed analysis of the 1D and 2D NMR spectra as well as HR-ESI-QTOF mass spectra. Among the isolated compounds, blumeaene J (4) exhibited moderate cytotoxicity against LNCaP (IC50 = 44.53 ± 4.95 μM) and SK-Mel2 (IC50 = 46.49 ± 3.84 μM) cell lines and weak effects on HepG2 (IC50 = 61.54 ± 2.98 μM), KB (IC50 = 65.40 ± 4.97 μM), and MCF-7 (IC50 = 70.06 ± 5.65 μM) cell lines, whereas (―)-angelicoidenol 2-O-β- d -glucopyranoside (6) revealed weak activity on all five tested cancer cell lines, with IC50 values ranging from 61.60 ± 5.64–98.73 ± 2.24 μM.
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- 2021
8. Secondary metabolites from the fruit peels of
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Dang Viet, Cuong, Tran Thi Hong, Hanh, Nguyen Thi, Huong, Pham Thi Mai, Huong, Le Ba, Vinh, and Tran Hong, Quang
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Three new glucosides, ziberthinosides A-C (1-3), and six known compounds, cleomiscosins A-D (4-7), sporogen AO-2 (8) and sapinofuranone A (9), were isolated from a methanol extract of
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- 2022
9. Sulfated Naphthopyrones and Anthraquinones from the Vietnamese Crinoid Comanthus delicata
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Le Thi, Vien, Tran Thi Hong, Hanh, Tran Hong, Quang, Do Cong, Thung, Nguyen Xuan, Cuong, Nguyen Hoai, Nam, Pham Van, Cuong, Phan Van, Kiem, and Chau Van, Minh
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Asian People ,Neoplasms ,Animals ,Humans ,Anthraquinones ,Antineoplastic Agents ,Echinodermata - Abstract
Three new sulfated naphthopyrone derivatives namely delicapyrons F-H (1-3) and two new sulfated anthraquinone derivatives namely delicaquinons A (4) and B (5), together with 6-methoxycomaparvin-5-methylether-8-O-sodium sulfate (6), 6-methoxycomaparvin-8-O-sodium sulfate (7), comaparvin-8-O-sodium sulfate (8), and 3-propyl-1,6,8-trihydroxy-9,10-anthraquinone-6-O-sodium sulfate (9) were isolated from the Vietnamese crinoid Comanthus delicata. Their chemical structures were elucidated by extensive analysis of the one dimensional (1D) and 2D-NMR, high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra as well as calculation of optical rotation. In addition, significant cytotoxicity was observed for 6 against LNCaP (prostate cancer) cell line with IC
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- 2022
10. Chemical Constituents from the Branches and Leaves of Alchornea trewioides
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Nguyen Thi Dieu Thuan, Nguyen Huu Huong Duyen, Nguyen Huu Toan Phan, Nguyen Xuan Cuong, Tran Thi Hong Hanh, Tran Hong Quang, and Nguyen Hoai Nam
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Circular dichroism ,biology ,Stereochemistry ,Electrospray ionization ,Euphorbiaceae ,General Chemistry ,General Medicine ,biology.organism_classification ,Nitric oxide ,chemistry.chemical_compound ,chemistry ,Cell culture ,Drug Discovery ,Mass spectrum ,Alchornea trewioides ,Cytotoxicity - Abstract
Two new megastigmane glucosides namely trewiosides A (1) and B (2), along with 20α-hydroxypregn-4-en-3-one β-D-glucopyranoside (3), sugeroside (4), and schizandriside (5) were isolated from the branches and leaves of Alchornea trewioides. The structure elucidation was confirmed by extensive analysis of the one and two dimensional (1 and 2D) NMR, electronic circular dichroism (ECD) as well as high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra. Noteworthily, the isolation of compounds 1 and 2 represents the second finding of megastigmane derivatives with a methoxycarbonyl group at C-5 to date. In addition, compound 3 showed weak cytotoxicity against three human cancer cell lines as A549 (lung carcinoma), HepG2 (hepatocarcinoma), and MCF7 (breast carcinoma). Besides, compounds 2 and 3 exhibited moderate inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Whereas, the remaining compounds 1, 4 and 5 showed weak inhibitory activity.
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- 2021
11. Secondary metabolites from a peanut-associated fungus Aspergillus niger IMBC-NMTP01 with cytotoxic, anti-inflammatory, and antimicrobial activities
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Nguyen Viet Phong, Tran Hong Quang, Nguyen Hoai Nam, Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Nguyen Quang Trung, Chau Van Minh, Le Ngoc Anh, and Tran Thi Hong Hanh
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biology ,010405 organic chemistry ,Chemistry ,medicine.drug_class ,Organic Chemistry ,Aspergillus niger ,Plant Science ,biology.organism_classification ,Antimicrobial ,01 natural sciences ,Biochemistry ,Yeast ,Enterococcus faecalis ,Anti-inflammatory ,0104 chemical sciences ,Analytical Chemistry ,Microbiology ,010404 medicinal & biomolecular chemistry ,LNCaP ,medicine ,Cytotoxicity ,Candida albicans - Abstract
Chemical investigation of a peanut-associated fungal strain Aspergillus niger IMBC-NMTP01 resulted in isolation and identification of 14 secondary metabolites, including two new, epi-aspergillusol (1) and aspernigin (3), and 12 known compounds: pyrophen (2), 2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid (4), aspergillusol A (5), rubrofusarin B (6), nigerasperone A (7), fonsecin (8), TMC-256C1 (9), pyranonigrin A (10), orlandin (11), nigerasperone C (12), asperpyrone A (13), and 5-(hydroxymethyl)-2-furancarboxylic acid (14). Compounds 9, 12-14 showed cytotoxicity toward all six human cancer cell lines, including HepG2, KB, HL-60, MCF-7, SK-Mel2, and LNCaP, with IC50 values ranging from 8.4 to 84.5 µM, compounds 3-5 were cytotoxic against five cancer cell lines except HepG2, whereas 1 exhibited cytotoxicity toward HepG2, KB, and MCF-7 cells. All of the compounds, except 2 and 13, inhibited NO overproduction in LPS-induced RAW264.7 cells. In addition, all of the compounds displayed antimicrobial effects against Enterococcus faecalis, whereas 13 compounds, except 10, significantly inhibited the growth of the yeast Candida albicans.
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- 2020
12. Oroxindols A and B, two novel secoabietane diterpenoids from Oroxylum indicum
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Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen The Cuong, Nguyen Xuan Cuong, Hyuncheol Oh, Nguyen Van Sinh, Nguyen Hoai Nam, and Chau Van Minh
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chemistry.chemical_classification ,biology ,010405 organic chemistry ,Stereochemistry ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Flavones ,Oroxylum indicum ,0104 chemical sciences ,Nitric oxide ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Hispidulin ,Oroxylin A ,Diterpene ,Agronomy and Crop Science ,IC50 ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology - Abstract
Two novel secoabietane diterpenoids, oroxindols A (1) and B (2), along with two known flavones oroxylin A (3) and hispidulin (4) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1D and 2D NMR as well as HR-ESI-QTOF mass spectra. Noteworthily, the isolation of compounds 1 and 2 represents the first case of 11β,13;12,13-diepoxy-12,13-secoabietane-type diterpene obtaining reported to date. In addition, compound 3 exhibited significant inhibitory effects on nitric oxide (NO) production in LPS-stimulated BV2 microglial cell line, with an IC50 value of 21.5 ± 1.1 μM.
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- 2020
13. Codojavanosides A-C, three new sesquiterpenoid glycosides from the roots of Codonopsis javanica
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Nguyen Huu Huong Duyen, Tran Hong Quang, Nguyen Hoai Nam, Chau Van Minh, Nguyen Huu Toan Phan, Nguyen Thi Hien, Pham Van Huyen, Nguyen Xuan Cuong, Nguyen Thi Dieu Thuan, and Tran Thi Hong Hanh
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chemistry.chemical_classification ,A549 cell ,010405 organic chemistry ,Stereochemistry ,Glycoside ,Plant Science ,Codonopsis javanica ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Phytochemical ,chemistry ,Cell culture ,Cytotoxicity ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Human cancer ,Biotechnology - Abstract
Phytochemical study of the Codonopsis javanica roots led to isolation of 12 secondary metabolites, including three new sesquiterpenoid glycosides, named codojavanosides A-C (1-3) and nine known compounds, (3R,6E,10S)-2,6,10-trimethyl-3-hydroxydodeca-6,11-diene-2,10-diol (4), (E)-2-hexenyl O-β- d -glucopyranoside (5), oct-1-en-3-ol O-α- l -arabinopyranosyl-(1′′→6′)-O-β- d -glucopyranoside (6), (Z)-3-hexenyl O-α- l -arabinopyranosyl-(1→6)-β- d -glucopyranoside (7), tangshenosides I (8) and II (9), tangshenosides V (10) and VI (11), and corchoionoside C (12). Their structures were identified by comprehensive analyses of the 1D and 2D NMR and mass spectra. Evaluation of their cytotoxic effects toward three human cancer cell lines, including lung (A549), liver (HepG2), and breast (MCF7) revealed that compounds 1, 2, 4 and 11 exhibit weak cytotoxicity toward the A549 cell line, with the induction of cell death ranging from 40.8–66.4 % at the concentration of 100 μM.
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- 2020
14. Phenolic Glycosides from the Leaves of Iodes cirrhosa Turcz. with Cytotoxic and Antimicrobial Effects
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Ninh Thi Ngoc, Tran Hong Quang, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen The Cuong, Chu Hoang Ha, Nguyen Hoai Nam, and Chau Van Minh
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Staphylococcus aureus ,Flavonols ,Molecular Structure ,Plant Extracts ,Methanol ,Bioengineering ,Antineoplastic Agents ,General Chemistry ,General Medicine ,Biochemistry ,Lignans ,Plant Leaves ,Magnoliopsida ,Anti-Infective Agents ,Phenols ,Molecular Medicine ,Glycosides ,Molecular Biology - Abstract
In the present study, 14 phenolic glycosides, including one new neolignan glycoside, iodescirrhoside A (1), three new flavonol glycosides, iodescirrhosides B-D (2-4), and 10 known metabolites were obtained from the methanol extract of Iodes cirrhosa leaves. Structural elucidation was performed by interpretating the 1D- and 2D- NMR, HR-ESI-MS, and CD spectra in comparison with literature data. All compounds were noncytotoxic to LU-1, HepG2, MCF-7, SK-Mel-2, and LNCaP cancer cell lines. Compound 11 significantly inhibited the growth of E. faecalis. In contrast, weak inhibition was observed for 1-9 and 14 against E. faecalis, for 1, 6-8, and 11 against S. aureus, for 6 and 13 against B. cereus, and 2, 4, and 6-9 against C. albicans.
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- 2022
15. Polyacetylene and phenolic constituents from the roots of Codonopsis javanica
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Tran Thi Hong Hanh, Nguyen Thi Dieu Thuan, Nguyen Xuan Cuong, Tran Hong Quang, Nguyen Hoai Nam, Chau Van Minh, Pham Van Huyen, Nguyen Huu Toan Phan, Nguyen Huu Huong Duyen, and Nguyen Thi Hien
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chemistry.chemical_classification ,Campanulaceae ,biology ,Traditional medicine ,010405 organic chemistry ,Organic Chemistry ,Glycoside ,Plant Science ,biology.organism_classification ,Codonopsis javanica ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Polyacetylene ,chemistry.chemical_compound ,chemistry ,Campanumoea javanica - Abstract
Chemical investigation of the roots of Codonopsis javanica resulted in isolation of 12 compounds, including one new polyacetylene, codojavanyol (1), one new phenolic glycoside, codobenzyloside (7), and 10 known compounds, (2E,8E)-9-(tetrahydro-2H-pyran-2-yl)nona-2,8-diene-4,6-diyl-1-ol (2), lobetyol (3), lobetyolin (4), lobetyolinin (5), cordifolioidyne B (6), benzyl-α-L-arabinopyranosyl (1-6)-β-D-glucopyranoside (8), (Z)-8-β-D-glucopyranosyloxycinnamic acid (9), syringin (10), syringaresinol (11), and tryptophan (12). Their structures were elucidated by 1 D and 2 D NMR and MS spectroscopic analyses in comparison with the data reported in the literature. The stereochemistry of the C-2′ position of 1 was identified based on time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation. Among the isolates, compounds 3-5 were shown to have weak cytotoxicity toward three human carcinoma cell lines, including lung (A549), liver (HepG2), and breast (MCF7), with the induction of 41.4 to 55.6% cell death at the concentration of 100 µM.
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- 2020
16. Iridoid glucosides and phenylethanoid glycosides from Plantago major
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Tran Thi Hong Hanh, Pham Thi Cham, Hoang Anh Do, Nguyen The Cuong, Hyuncheol Oh, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Hoai Nam, and Chau Van Minh
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chemistry.chemical_classification ,Chromatography ,biology ,010405 organic chemistry ,Glycoside ,Iridoid Glucosides ,Plant Science ,Phenylethanoid ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Ic50 values ,Plantago major ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology - Abstract
Using various chromatographic separations, five iridoid glucosides (1―5) and five phenylethanoid glycosides (6―10) were isolated from the Plantago major whole plants and included two new compounds: 10-acetylarborescoside (1) and plantainoside G (6). Their structures were elucidated by detailed analysis of 1D and 2D NMR data, HR QTOF MS data, and experimental and calculated ECD data. The isolated compounds exhibited moderate inhibitory effects on NO overproduction in LPS-stimulated BV2 microglial cells, with IC50 values ranging from 44.2–62.3 μM.
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- 2020
17. Impacts of Culture Conditions on Ligninolytic Enzymes (LIP, MNP, and Lac) Activity of Five Bacterial Strains
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Nguyen Xuan Canh, Nguyen Thi Cam Chau, Tran Thi Hong Hanh, Nguyen Van Giang, Tran Thi Dao, Nguyen Thanh Huyen, Tran Van Mau, and Pham Hong Hien
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In this study, with the aim of determining and assessing the influence of several culture conditions on the ligninolytic enzyme (LiP, MnP, and Lac) activity of bacteria, five lignin-degrading bacteria strains were isolated from two different soil samples and cultured on minimum salt medium agar containing alkaline lignin (MSML agar). Among the five isolated strains, DL1 and X3 expressed strong and stable ligninase enzyme activity at various temperature levels (30°C, 37°C, 50°C, and 60°C) and were selected for further study. Notably, at 60°C, the ligninase activity of both strains lasted until the seventh day before decreasing. The effects of the culture medium conditions, namely, carbohydrate sources, nitrogen sources, and pH, on the ligninolytic system illustrated that both X3 and DL1 were able to generate good enzymatic activity at a pH range of 3.0 to 7.0. These strains could use various sources of carbohydrates and nitrogen, derived from glucose, lactose, peptone, meat extract, and yeast extract. In addition, the analyses of biochemical characteristics revealed that X3 was capable of hydrolyzing starch and cellulose, while DL1 was not. Therefore, the results of this study suggested the potential of applying selected lignin-degrading bacterial strains on lignin treatments of agricultural wastes.
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- 2020
18. Metabolites from Excoecaria cochinchinensis Lour
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Lai Hop Hieu, Nguyen Phuong Thao, Do Hoang Anh, Tran Thi Hong Hanh, Nguyen Duy Cong, Nguyen The Cuong, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Ngo Dai Quang, and Chau Van Minh
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biology ,Lipopolysaccharide ,010405 organic chemistry ,Stereochemistry ,Positive control ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Terpenoid ,0104 chemical sciences ,Nitric oxide ,Excoecaria cochinchinensis ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,No production ,Agronomy and Crop Science ,IC50 ,Derivative (chemistry) ,Biotechnology - Abstract
A new rhamnofolane-type diterpenoid (1) and a new phenolic derivative (2), together with eleven known compounds, were isolated from the leaves of E. cochinchinensis Lour. The chemical structures of these compounds were elucidated based on extensive spectroscopic analysis, including HR-QTOF-MS and NMR, and comparison with reported data. The inhibitory effects of compounds 1–13 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. As the obtained results, compound 9 showed a moderate inhibitory effects on NO production activity with an IC50 of 6.17 ± 0.25 µM, relative to that of the positive control cardamonin.
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- 2020
19. Diterpenoids and Flavonoids from Andrographis paniculata
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Tran Hong Quang, Nguyen Hoai Nam, Pham Thi Cham, Nguyen Xuan Cuong, Chau Van Minh, Tran Thu Huong, Nguyen Thi Thuy My, and Tran Thi Hong Hanh
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Chalcone ,biology ,010405 organic chemistry ,Stereochemistry ,Andrographolide ,General Chemistry ,General Medicine ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Terpenoid ,0104 chemical sciences ,Nitric oxide ,chemistry.chemical_compound ,chemistry ,Glucoside ,Drug Discovery ,Cytotoxicity ,IC50 ,Andrographis paniculata - Abstract
Chemical investigation of the aerial parts of Andrographis paniculata resulted in isolation of nine compounds, including a new ent-labdane diterpenoid, andrographic acid methyl ester (1), a new chalcone glucoside, pashanone glucoside (5), and seven known metabolites, andrograpanin (2), andrographolide (3), andropanolide (4), andrographidine A (6), andrographidine F (7), 6-epi-8-O-acetyl-harpagide (8), and curvifloruside F (9). Their chemical structures were elucidated based on comprehensive analyses of the spectroscopic data, including NMR and MS. Among the isolated compounds, andropanolide exerted cytotoxicity toward LNCaP, HepG2, KB, MCF7, and SK-Mel2 carcinoma cells, with IC50 values ranging from 31.8 to 45.9 µM. In addition, andropanolide significantly inhibited the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with an IC50 value of 13.4 µM.
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- 2020
20. Two new eudesmane sesquiterpene glucosides from the aerial parts of
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Tran Thi Hong, Hanh, Le Ba, Vinh, Nguyen Xuan, Cuong, and Tran Hong, Quang
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Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A (
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- 2022
21. Cytotoxic and nitric oxide inhibitory activities of triterpenoids from
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Vu Huong, Giang, Le Thi, Thuy, Tran Thi Hong, Hanh, Nguyen Xuan, Cuong, Le Ba, Vinh, Ninh Khac, Ban, Tran My, Linh, Nguyen Chi, Mai, Tran Thu, Huong, Nguyen Hai, Dang, Hyuncheol, Oh, Dong-Sung, Lee, and Tran Hong, Quang
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Inhibitory Concentration 50 ,Plants, Medicinal ,Plant Extracts ,Nitric Oxide ,Lycopodium ,Triterpenes - Abstract
Using combined chromatographic separation techniques, three new triterpenoids named lycomclavatols A-C (
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- 2022
22. Secondary metabolites from the fruit peels of Durio zibethinus L. and their cytotoxic activity
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Dang Viet Cuong, Tran Thi Hong Hanh, Nguyen Thi Huong, Pham Thi Mai Huong, Le Ba Vinh, and Tran Hong Quang
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Organic Chemistry ,Plant Science ,Biochemistry ,Analytical Chemistry - Abstract
Three new glucosides, ziberthinosides A–C (1–3), and six known compounds, cleomiscosins A–D (4–7), sporogen AO-2 (8) and sapinofuranone A (9), were isolated from a methanol extract of Durio zibethinus fruit peels. Their chemical structures were elucidated by analyses of their 1 D/2D NMR and HR-ESI-MS data as well as by comparison with the literature values. The absolute configuration of sporogen AO-2 (8) was confirmed by ECD calculation. Of the isolates, compounds 8 and 9 were cytotoxic toward all MCF7, HepG2 and SK-LU-1 cell lines, with IC50 values ranging from 10.7 to 34.9 μM. Our results contribute to better understanding of the chemical constituents of the high valued durian fruit and their pharmacological effect, such as cytotoxicity.
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- 2022
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23. Dammarane-type triterpenoid saponins from the flower buds of Panax pseudoginseng with cytotoxic activity
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Tran Thi Hong Hanh, Pham Thi Cham, Do Hoang Anh, Nguyen The Cuong, Nguyen Quang Trung, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Hoai Nam, and Chau Van Minh
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biology ,Traditional medicine ,Organic Chemistry ,Dammarane ,Plant Science ,biology.organism_classification ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Triterpenoid ,Panax pseudoginseng ,chemistry ,Phytochemical ,Araliaceae ,Cytotoxic T cell ,Cytotoxicity - Abstract
Phytochemical investigation of a methanol extract of Panax pseudoginseng flower buds resulted in the isolation of 22 dammarane-type triterpenoid saponins, including three new compounds, pseudoginsenosides A-C (1-3), and 19 known analogs. Their chemical structures were identified by the comprehensive spectroscopic methods, including 1 D and 2 D NMR and mass spectra. In addition, their cytotoxic effects toward three human carcinoma cell lines, including liver (HepG2), breast (MCF7), and lung (A549) were also evaluated.
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- 2022
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24. Phenolic glycosides from Oroxylum indicum
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Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen The Cuong, Nguyen Xuan Cuong, Hyuncheol Oh, Nguyen Van Sinh, Nguyen Hoai Nam, and Chau Van Minh
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chemistry.chemical_classification ,biology ,Traditional medicine ,010405 organic chemistry ,Organic Chemistry ,Glycoside ,Bignoniaceae ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Oroxylum indicum ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,chemistry ,No production - Abstract
Two new phenolic glycosides, oroxylumosides A (1) and B (2), along with four known compounds darendoside A (3), leucosceptoside A (4), acteoside (5) and decaffeoylacteoside (6) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds 1 − 4 exhibited inhibitory effects on NO production in LPS-stimulated BV2 microglial cell line with IC50 values of 58.2 ± 2.9, 70.6 ± 3.5, 56.8 ± 2.8 and 61.1 ± 3.1 µM, respectively.
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- 2022
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25. Steroids from Dendronephthya mucronata and Their Inhibitory Effects on Lipopolysaccharide-Induced No Formation in RAW264.7 Cells
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Do Cong Thung, Alla A. Kicha, Natalia V. Ivanchina, Ninh Thi Ngoc, Nguyen Xuan Cuong, Phan Van Kiem, Tran Thi Hong Hanh, Nguyen Hoai Nam, Chau Van Minh, and Nguyen Hai Dang
- Subjects
biology ,Lipopolysaccharide ,010405 organic chemistry ,Stereochemistry ,Plant Science ,General Chemistry ,Carbon-13 NMR ,biology.organism_classification ,Inhibitory postsynaptic potential ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Dendronephthya ,Spectral data ,Two-dimensional nuclear magnetic resonance spectroscopy ,No formation ,Heteronuclear single quantum coherence spectroscopy - Abstract
Four pregnane-type steroids including the new compound 5-α-pregn-20-en-3,6-dione (1) and two known cholestane-type steroids were isolated from the MeOH extract of the octocoral Dendronephthya mucronata. The structures of the compounds were elucidated using spectral data (PMR and 13C NMR, HSQC, HMBC, 1H−1H COSY, NOESY, HR-QTOF-MS) and comparisons with previously published information. The steroids exhibited moderate or weak inhibitory effects on inflammatory lipopolysaccharide-induced NO formation in RAW264.7 murine macrophage cells.
- Published
- 2019
26. Dammarane-type triterpenoid saponins from the flower buds of
- Author
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Tran Thi Hong, Hanh, Pham Thi, Cham, Do Hoang, Anh, Nguyen The, Cuong, Nguyen Quang, Trung, Tran Hong, Quang, Nguyen Xuan, Cuong, Nguyen Hoai, Nam, and Chau Van, Minh
- Subjects
Molecular Structure ,Humans ,Panax ,Antineoplastic Agents ,Flowers ,Saponins ,Triterpenes - Abstract
Phytochemical investigation of a methanol extract of
- Published
- 2021
27. Polyacetylene and phenolic constituents from the roots of
- Author
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Nguyen Huu Toan, Phan, Nguyen Thi Dieu, Thuan, Nguyen Thi Thu, Hien, Pham Van, Huyen, Nguyen Huu Huong, Duyen, Tran Thi Hong, Hanh, Nguyen Xuan, Cuong, Tran Hong, Quang, Nguyen Hoai, Nam, and Chau Van, Minh
- Subjects
Codonopsis ,Molecular Structure ,Phenols ,Humans ,Glycosides ,Plant Roots ,Polyacetylene Polymer - Abstract
Chemical investigation of the roots of
- Published
- 2021
28. Chemical constituents from the soft coralSinularia digitata
- Author
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Nguyen Thi Huong, Tran Hong Quang, Nguyen Hoai Nam, Nguyen Xuan Cuong, Ninh Thi Ngoc, Tran Thi Hong Hanh, and Chau Van Minh
- Subjects
Gerontology ,business.industry ,Chemical constituents ,Life satisfaction ,Medicine ,General Medicine ,business - Published
- 2019
29. Ursane- and oleane-type triterpene glycosides fromIlex godajam
- Author
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Pham Thi Mai Huong, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen The Cuong, Duong Thi Hoan, Tran Hong Quang, Nguyen Xuan Cuong, and Nguyen Hoai Nam
- Subjects
chemistry.chemical_classification ,Triterpene ,Chemistry ,Stereochemistry ,Glycoside ,Aquifoliaceae - Published
- 2019
30. Sesquiterpenoids from Saussurea costus
- Author
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Tran Thi Hong Hanh, Pham Thi Cham, Nguyen Thi Thuy My, Nguyen The Cuong, Nguyen Hai Dang, Tran Hong Quang, Tran Thu Huong, Nguyen Xuan Cuong, Nguyen Hoai Nam, and Chau Van Minh
- Subjects
Traditional medicine ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Plant Science ,Asteraceae ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Saussurea costus ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,No production - Abstract
Sixteen sesquiterpenoids (1 – 16), including two new compounds namely saussucostusosides A and B (1 and 2), were isolated from the roots of Saussurea costus by various chromatographic separations. Their structures were elucidated by 1 D and 2 D NMR and HR-QTOF-MS experiments. Among isolated compounds, costunlide (6), 3β-[4-hydroxymethacryloyloxy]-8α-hydroxycostunolide (10) and 11β,13-dihydrozaluzanin C (16) exhibited potent inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 7.08 ± 0.34, 2.40 ± 0.06 and 5.55 ± 0.24 µM, respectively.
- Published
- 2019
31. Scutebarbatolides A-C, new neo-clerodane diterpenoids from Scutellaria barbata D. Don with cytotoxic activity
- Author
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Tran Thi Hong Hanh, Do Hoang Anh, Tran Hong Quang, Nguyen Quang Trung, Do Thi Thao, Nguyen The Cuong, Nguyen Thai An, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, and Chau Van Minh
- Subjects
biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Cancer ,Plant Science ,medicine.disease ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Phytochemical ,Cell culture ,LNCaP ,medicine ,Cytotoxic T cell ,Cytotoxicity ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Scutellaria barbata ,Biotechnology - Abstract
Phytochemical investigation of the whole plant of Scutellaria barbata resulted in the isolation of three new neo-clerodane diterpenoids, named scutebarbatolides A-C (1–3), along with six known analogues as 14-deoxy-11,12-didehydroandrographolide (4), scutehenanine H (5), 14β-hydroxyscutolide K (6), scutebata O (7), scutebartines H (8) and I (9). Their structures were elucidated by spectroscopic analyses, including 1D and 2D NMR and mass spectra in comparison with the data reported in the literature. Cytotoxicity of the isolates was evaluated toward five human cancer cell lines, including LNCaP, HepG2, KB, MCF7, and SK-Mel2 cells. Of the isolates, compounds 1 and 6 were shown to have moderate cytotoxicity toward all the cancer cell lines, with IC50 values ranging from 30.8 to 51.1 μM. Our results contribute to more insightful clarification of the use of S. barbata in the prevention and treatment of cancer.
- Published
- 2019
32. Triterpenoid derivatives from Barringtonia racemosa
- Author
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Nguyen Xuan Cuong, Nguyen Van Thanh, Chau Van Minh, Quach Thi Thanh Van, Phan Thi Thanh Huong, Le Thi Vien, Tran Thi Hong Hanh, and Nguyen Hoai Nam
- Subjects
Barringtonia racemosa ,Triterpenoid ,Traditional medicine ,biology ,Chemistry ,Lecythidaceae ,biology.organism_classification - Published
- 2019
33. Triterpene Tetraglycosides From Stichopus Herrmanni Semper, 1868
- Author
-
Le Thi Vien, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Van Thanh, Do Thi Thao, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, and Phan Van Kiem
- Subjects
Pharmacology ,Complementary and alternative medicine ,Drug Discovery ,Plant Science ,General Medicine - Abstract
Using various column chromatographic methods, 5 triterpene tetraglycosides (1−5), including one new compound, namely holothurin A6 (1), were obtained from the water soluble part of the methanol extract of the sea cucumber Stichopus herrmanni. Their structures were confirmed by careful analysis of the 1D and 2D NMR, and HR ESI QTOF mass spectra. Noteworthily, 24-dehydroechinoside A (3) showed potent cytotoxicity to 5 human cancer cell lines {HepG2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma)} with IC50 values ranging from 0.19 ± 0.03 to 1.17 ± 0.18 µM.
- Published
- 2022
34. Sesquiterpenoids from the rhizomes of Curcuma aeruginosa
- Author
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Nguyen Xuan Cuong, Pham Thi Cham, Le Quynh Lien, Souksakhone Sengchanh, Phoutthalack Boutsada, Tran Thi Hong Hanh, Ninh Khac Ban, Nguyen Chi Mai, Vu Huong Giang, Tran My Linh, and Kompheng Phonenavong
- Subjects
010404 medicinal & biomolecular chemistry ,Traditional medicine ,010405 organic chemistry ,Zingiberaceae ,Biology ,biology.organism_classification ,01 natural sciences ,Curcuma aeruginosa ,0104 chemical sciences ,Rhizome - Published
- 2018
35. Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus
- Author
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Le Thi Vien, Chau Van Minh, Phan Thi Thanh Huong, Nguyen Hai Dang, Phan Van Kiem, Tran Thi Hong Hanh, Nguyen Hoai Nam, Nguyen Van Thanh, Do Cong Thung, and Nguyen Xuan Cuong
- Subjects
Lipopolysaccharide ,biology ,010405 organic chemistry ,Stereochemistry ,General Chemistry ,General Medicine ,01 natural sciences ,Anthraquinone ,0104 chemical sciences ,Nitric oxide ,Nitric oxide synthase ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Anthraquinones ,biology.protein ,Cyclooxygenase ,IC50 ,Butenolide - Abstract
Seven anthraquinones including two new compounds namely capillasterquinones A and B (1 and 2) and one new butenolide namely capillasterolide (8) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus. The inhibitory effect of compounds 1-8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A (1) showed strong NO production inhibitory activity with an IC50 of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.
- Published
- 2018
36. Named entity recognition architecture combining contextual and global features
- Author
-
Tran Thi Hong Hanh, Antoine Doucet, Jose G. Moreno, Nicolas Sidere, Senja Pollak, Laboratoire Informatique, Image et Interaction - EA 2118 (L3I), Université de La Rochelle (ULR), Jozef Stefan Institute [Ljubljana] (IJS), Recherche d’Information et Synthèse d’Information (IRIT-IRIS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Hao-Ren Ke, Chei Sian Lee, and Kazunari Sugiyama
- Subjects
FOS: Computer and information sciences ,Computer science ,XLNet ,02 engineering and technology ,computer.software_genre ,[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL] ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG] ,Named-entity recognition ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,[INFO.INFO-DL]Computer Science [cs]/Digital Libraries [cs.DL] ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Architecture ,Computer Science - Computation and Language ,contextual embeddings ,business.industry ,GCN ,[INFO.INFO-TT]Computer Science [cs]/Document and Text Processing ,global embeddings ,[INFO.INFO-IR]Computer Science [cs]/Information Retrieval [cs.IR] ,NER ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer ,Computation and Language (cs.CL) ,Natural language processing - Abstract
International audience; Named entity recognition (NER) is an information extraction technique that aims to locate and classify named entities (e.g., organizations, locations,...) within a document into predefined categories. Correctly identifying these phrases plays a significant role in simplifying information access. However, it remains a difficult task because named entities (NEs) have multiple forms and they are context dependent. While the context can be represented by contextual features, the global relations are often misrepresented by those models. In this paper, we propose the combination of contextual features from XLNet and global features from Graph Convolution Network (GCN) to enhance NER performance. Experiments over a widely-used dataset, CoNLL 2003, show the benefits of our strategy, with results competitive with the state of the art (SOTA).
- Published
- 2021
- Full Text
- View/download PDF
37. Secondary metabolites from a peanut-associated fungus
- Author
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Tran Hong, Quang, Nguyen Viet, Phong, Le Ngoc, Anh, Tran Thi Hong, Hanh, Nguyen Xuan, Cuong, Nguyen Thi Thanh, Ngan, Nguyen Quang, Trung, Nguyen Hoai, Nam, and Chau Van, Minh
- Subjects
Anti-Infective Agents ,Arachis ,Molecular Structure ,Cell Line, Tumor ,Anti-Inflammatory Agents ,MCF-7 Cells ,Humans ,Aspergillus niger - Abstract
Chemical investigation of a peanut-associated fungal strain
- Published
- 2020
38. Chemical Constituents from the Branches and Leaves of Alchornea trewioides
- Author
-
Nguyen Huu Toan, Phan, Nguyen Thi Dieu, Thuan, Nguyen Huu Huong, Duyen, Tran Thi Hong, Hanh, Tran Hong, Quang, Nguyen Xuan, Cuong, and Nguyen Hoai, Nam
- Subjects
Lipopolysaccharides ,Plant Extracts ,Euphorbiaceae ,Nitric Oxide ,Antineoplastic Agents, Phytogenic ,Plant Leaves ,Mice ,RAW 264.7 Cells ,Cell Line, Tumor ,Animals ,Humans ,Drug Screening Assays, Antitumor ,Density Functional Theory ,Cell Proliferation - Abstract
Two new megastigmane glucosides namely trewiosides A (1) and B (2), along with 20α-hydroxypregn-4-en-3-one β-D-glucopyranoside (3), sugeroside (4), and schizandriside (5) were isolated from the branches and leaves of Alchornea trewioides. The structure elucidation was confirmed by extensive analysis of the one and two dimensional (1 and 2D) NMR, electronic circular dichroism (ECD) as well as high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra. Noteworthily, the isolation of compounds 1 and 2 represents the second finding of megastigmane derivatives with a methoxycarbonyl group at C-5 to date. In addition, compound 3 showed weak cytotoxicity against three human cancer cell lines as A549 (lung carcinoma), HepG2 (hepatocarcinoma), and MCF7 (breast carcinoma). Besides, compounds 2 and 3 exhibited moderate inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Whereas, the remaining compounds 1, 4 and 5 showed weak inhibitory activity.
- Published
- 2020
39. Chemical constituents from the branches and leaves of
- Author
-
Nguyen Huu Toan, Phan, Nguyen Thi Dieu, Thuan, Nguyen Thi Thu, Hien, Pham Van, Huyen, Tran Thi Hong, Hanh, Tran Hong, Quang, Nguyen Xuan, Cuong, and Nguyen Hoai, Nam
- Subjects
Plant Leaves ,Mice ,RAW 264.7 Cells ,Plant Extracts ,Phytochemicals ,Euphorbiaceae ,Animals - Abstract
Phytochemical investigation of the branches and leaves of
- Published
- 2020
40. Phenolic glycosides from
- Author
-
Le, Thi Vien, Tran, Thi Hong Hanh, Tran Hong, Quang, Nguyen The, Cuong, Nguyen Xuan, Cuong, Hyuncheol, Oh, Nguyen Van, Sinh, Nguyen Hoai, Nam, and Chau, Van Minh
- Subjects
Plant Extracts ,Bignoniaceae ,Glycosides - Abstract
Two new phenolic glycosides, oroxylumosides A (
- Published
- 2020
41. Polyhydroxylated steroid derivatives from the starfish
- Author
-
Le Thi, Vien, Tran Thi Hong, Hanh, Tran Hong, Quang, Nguyen Xuan, Cuong, Do Thi, Thao, Nguyen Hoai, Nam, Do Cong, Thung, Phan Van, Kiem, and Chau Van, Minh
- Subjects
Mice ,Starfish ,Magnetic Resonance Spectroscopy ,RAW 264.7 Cells ,Animals ,Steroids ,Glycosides - Abstract
A new polyhydroxysteroid glycoside, regulusoside D (
- Published
- 2020
42. Cytotoxic and immunomodulatory phenol derivatives from a marine sponge-derived fungus
- Author
-
Tran Hong, Quang, Nguyen Viet, Phong, Tran Thi Hong, Hanh, Nguyen Xuan, Cuong, Nguyen Thi Thanh, Ngan, Hyuncheol, Oh, Nguyen Hoai, Nam, and Chau, Van Minh
- Subjects
Ascomycota ,Molecular Structure ,Phenol ,Cyclooxygenase 2 ,Animals ,Antineoplastic Agents ,Porifera - Abstract
Chemical investigation of the marine-derived endophytic fungus
- Published
- 2020
43. Diterpenoids and Flavonoids from Andrographis paniculata
- Author
-
Tran Thi Hong, Hanh, Nguyen Thi Thuy, My, Pham Thi, Cham, Tran Hong, Quang, Nguyen Xuan, Cuong, Tran Thu, Huong, Nguyen Hoai, Nam, and Chau Van, Minh
- Subjects
Flavonoids ,Lipopolysaccharides ,Magnetic Resonance Spectroscopy ,Cell Survival ,Macrophages ,Molecular Conformation ,Plant Components, Aerial ,Nitric Oxide ,Mice ,RAW 264.7 Cells ,Cell Line, Tumor ,Animals ,Humans ,Andrographis ,Diterpenes - Abstract
Chemical investigation of the aerial parts of Andrographis paniculata resulted in isolation of nine compounds, including a new ent-labdane diterpenoid, andrographic acid methyl ester (1), a new chalcone glucoside, pashanone glucoside (5), and seven known metabolites, andrograpanin (2), andrographolide (3), andropanolide (4), andrographidine A (6), andrographidine F (7), 6-epi-8-O-acetyl-harpagide (8), and curvifloruside F (9). Their chemical structures were elucidated based on comprehensive analyses of the spectroscopic data, including NMR and MS. Among the isolated compounds, andropanolide exerted cytotoxicity toward LNCaP, HepG2, KB, MCF7, and SK-Mel2 carcinoma cells, with IC
- Published
- 2020
44. Acylated flavonoid glycosides from Barringtonia racemosa
- Author
-
Quach Thi Thanh Van, Le Thi Vien, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen The Cuong, Nguyen Phuong Thao, Nguyen Huy Thuan, Nguyen Hai Dang, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, and Chau Van Minh
- Subjects
Barringtonia racemosa ,biology ,Traditional medicine ,Flavonoid glycosides ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Lecythidaceae ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,No production - Abstract
Using various chromatographic separations, three new acylated flavonoid glycosides, namely barringosides G–I (1–3), were isolated from the water-soluble extract of Barringtonia racemosa branches and leaves. The structure elucidation was performed by extensive analysis of the 1D and 2D NMR and HR-QTOF-MS data. Of the isolated compounds, barringoside I (3) showed moderate inhibitory effects on LPS-induced NO production in RAW264.7 cells with an IC50 of 52.48 ± 1.04 µM.
- Published
- 2020
- Full Text
- View/download PDF
45. Chemical constituents from the branches and leaves of Alchornea annamica
- Author
-
Nguyen Thi Hien, Tran Thi Hong Hanh, Pham Van Huyen, Tran Hong Quang, Nguyen Hoai Nam, Nguyen Thi Dieu Thuan, Nguyen Huu Toan Phan, and Nguyen Xuan Cuong
- Subjects
biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Euphorbiaceae ,Biological activity ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Phytochemical ,Alchornea ,Chemical constituents ,Ic50 values ,No production - Abstract
Phytochemical investigation of the branches and leaves of Alchornea annamica led to isolation of ten secondary metabolites, including two new megastigmane glucosides alnamicosides A (1) and B (2). The structure elucidation was confirmed by 1 D and 2 D NMR, ECD as well as HR-QTOF-MS experiments. The megastigmane derivatives 1 − 3 exhibited inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 78.72 ± 1.90, 77.40 ± 9.40 and 82.16 ± 4.56 µM, respectively. This is the first report on chemical constituents and biological activity of the plant A. annamica.
- Published
- 2020
- Full Text
- View/download PDF
46. Cytotoxic and immunomodulatory phenol derivatives from a marine sponge-derived fungus Ascomycota sp. VK12
- Author
-
Hyuncheol Oh, Nguyen Viet Phong, Tran Thi Hong Hanh, Nguyen Thi Thanh Ngan, Chau Van Minh, Tran Hong Quang, Nguyen Hoai Nam, and Nguyen Xuan Cuong
- Subjects
biology ,Ascomycota ,010405 organic chemistry ,medicine.drug_class ,Ascomycota sp ,Chemistry ,Organic Chemistry ,Plant Science ,Fungus ,Endophytic fungus ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Anti-inflammatory ,0104 chemical sciences ,Analytical Chemistry ,Microbiology ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Sponge ,medicine ,Cytotoxic T cell ,Phenol - Abstract
Chemical investigation of the marine-derived endophytic fungus Ascomycota sp. VK12 resulted in isolation and identification of a new compound, (3R)-(3′,5′-dihydroxyphenyl)butan-2-one (1) and five known ones: AGI-7 (2), sescandelin (3), sescandelin-B (4), 4-hydroxybenzaldehyde (5), and hydroxysydonic acid (6). The absolute configuration of 1 was determined by time-dependent density functional theory electronic circular dichroism, specific optical rotation, and NMR calculations. Compounds 1 and 2 showed cytotoxicity towards HepG2, MCF-7, and SK-Mel2 carcinoma cells, with IC50 values ranging from 48.6 to 96.5 µM. Compounds 1, 2, 4–6 displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC50 values in a range from 24.2 to 76.5 µM. Compound 2 further inhibited PGE2 overproduction, with an IC50 value of 25.3 µM. The inhibitory effects of 2 towards NO and PGE2 overproduction were found to have a close relationship with its suppression of iNOS and COX-2 protein expression, respectively.
- Published
- 2020
- Full Text
- View/download PDF
47. Triterpene tetraglycosides from the Vietnamese sea cucumber Holothuria impatiens
- Author
-
Nguyen Hoai Nam, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Xuan Cuong, Do Cong Thung, Tran Thi Hong Hanh, and Le Thi Vien
- Subjects
chemistry.chemical_classification ,biology ,010405 organic chemistry ,Vietnamese ,Saponin ,Holothurin ,Holothuria impatiens ,biology.organism_classification ,01 natural sciences ,language.human_language ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Sea cucumber ,chemistry ,Triterpene ,Botany ,language - Published
- 2018
48. Release of chondroitin sulfate form the chicken keel cartilage by protamex hydrolysis
- Author
-
Dong Thi Anh Dao, Tran Thi Hong Hanh, Luu Van Thien Phu, Nguyen Thi Le Vien, and Nguyen Thi Thanh Phuong
- Subjects
0301 basic medicine ,Glycosaminoglycan ,03 medical and health sciences ,chemistry.chemical_compound ,Hydrolysis ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Cartilage ,medicine ,Chondroitin sulfate ,Keel (bird anatomy) - Published
- 2018
49. Cytotoxic steroids from the Vietnamese gorgonian Verrucella corona
- Author
-
Chau Van Minh, Nguyen Hoai Nam, Do Cong Thung, Nguyen Xuan Cuong, Ninh Thi Ngoc, Do Thi Thao, Nguyen Van Thanh, Tran Thi Hong Hanh, and Phan Van Kiem
- Subjects
Cell Survival ,Clinical Biochemistry ,Antineoplastic Agents ,HL-60 Cells ,01 natural sciences ,Biochemistry ,Prostate cancer ,Endocrinology ,Breast cancer ,Cell Line, Tumor ,LNCaP ,medicine ,Animals ,Humans ,Lung cancer ,Cytotoxicity ,Molecular Biology ,Pharmacology ,Acute leukemia ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Cancer ,Anthozoa ,medicine.disease ,Molecular biology ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Epidermoid carcinoma ,Steroids ,Drug Screening Assays, Antitumor - Abstract
Using various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A–F (1–6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8,22-dien-7-one (14), and 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-8(14),22-dien-7-one (15) showed significant cytotoxicity (IC50 values ranging from 12.32 ± 1.47 to 33.77 ± 1.28 μM) against eight human cancer cell lines as LNCaP (prostate cancer), HepG2 (hepatoma cancer), KB (epidermoid carcinoma), MCF-7 (breast cancer), SK-Mel2 (melanoma), HL-60 (acute leukemia), LU-1 (lung cancer), and SW480 (colon adenocarcinoma).
- Published
- 2018
50. Sulphated flavones and pregnane-type steroids from
- Author
-
Luu Hong, Truong, Nguyen Hieu, Cuong, Tran Huu, Dang, Trinh Thi My, Dung, Pham Thi, Cham, Tran Thi Hong, Hanh, Tran Hong, Quang, Nguyen Hai, Dang, Nguyen Xuan, Cuong, Nguyen Hoai, Nam, and Chau Van, Minh
- Subjects
Molecular Structure ,Sulfates ,Phytochemicals ,Flavones ,Pregnanes ,Malvaceae - Abstract
In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of
- Published
- 2019
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