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7 results on '"Topinka, J."'

4. Mutagenesis by asbestos in the lung of lambda-lacI transgenic rats

Author

Topinka, J., Loli, P., Georgiadis, Panagiotis, Dusinska, M., Hurbankova, M., Kovacikova, Z., Volkovova, K., Kazimirova, A., Barancokova, M., Tatrai, E., Oesterle, D., Wolff, I., and Kyrtopoulos, S. A.

Abstract

Journal URL: http://www.sciencedirect.com/science/journal/00275107

Published
2008

5. Monitoring genotoxic exposure in uranium miners

Author

L. Dobiáš, Topinka J, V Rericha, Bavorová H, P Rössner, D. Veselý, R.J. Šrám, J Stejskalová, D Veselá, and B. Binková

Subjects
Adult, Male, Aflatoxin, Lung Neoplasms, Health, Toxicology and Mutagenesis, Biology, Mining, Microbiology, Uranium mine, Lipid peroxidation, Toxicology, chemistry.chemical_compound, Occupational Exposure, Biomonitoring, Humans, Mycotoxin, Chromosome Aberrations, Public Health, Environmental and Occupational Health, technology, industry, and agriculture, DNA, Mycotoxins, Citrinin, Czechoslovakia, Occupational Diseases, chemistry, Mutation, Uranium, Lipid Peroxidation, Secalonic acid, Sterigmatocystin, Environmental Monitoring, Research Article
Abstract

Recent data from deep uranium mines in Czechoslovakia indicated that in addition to radon daughter products, miners are also exposed to chemical mutagens. Mycotoxins were identified as a possible source of mutagenicity present in the mines. Various methods of biomonitoring were used to examine three groups of miners from different uranium mines. Cytogenetic analysis of peripheral lymphocytes, unscheduled DNA synthesis (UDS) in lymphocytes, and lipid peroxidation (LPO) in both plasma and lymphocytes were studied on 66 exposed miners and 56 controls. Throat swabs were taken from 116 miners and 78 controls. Significantly increased numbers of aberrant cells were found in all groups of miners, as well as decreased UDS values in lymphocytes and increased LPO plasma levels in comparison to controls. Molds were detected in throat swabs from 27% of miners, and 58% of these molds were embryotoxic. Only 5% of the control samples contained molds and none of them was embryotoxic. The following mycotoxins were isolated from miners' throat swab samples: rugulosin, sterigmatocystin, mycophenolic acid, brevianamid A, citreoviridin, citrinin, penicilic acid, and secalonic acid. These data suggest that mycotoxins are a genotoxic factor affecting uranium miners.

Published
1993

6. Effect of Antioxidant Supplementation in an Elderly Population

Author

Topinka J, R.J. Šrám, F. Kotěšovec, Jan Klaschka, M. Prošek, J. Kočišová, I. Fojtíková, J. Machálek, I. Hanel, and B. Binková

Subjects
chemistry.chemical_classification, Senescence, Antioxidant, medicine.medical_treatment, Cell, RNA, Physiology, Biology, Ascorbic acid, chemistry.chemical_compound, Enzyme, medicine.anatomical_structure, chemistry, Elderly population, medicine, sense organs, skin and connective tissue diseases, DNA
Abstract

According to some contemporary theories, the aging process in humans may be the result of the accumulation of unsuccessfully repaired genetic damage. The critical changes determining cell senescence are most probably the changes that take place in macromolecules such as DNA and RNA, enzymes, and structural parts of biomembranes--lipids and proteins.

Published
1993
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