85 results on '"Ting, J."'
Search Results
2. The potential advantages and workflow challenges of long axial field of view <scp>PET</scp> / <scp>CT</scp>
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Wei‐Ting J. Chen, William I. D. Rae, Peter L. Kench, and Steven R. Meikle
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging - Published
- 2023
3. Epidemiology of dermatologic disease in Palau: a cross‐sectional study in the national public and community health service
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Wan‐Ting J. Lee, Chien‐Chang Lee, Chung‐Kuan Wu, Ching‐Hwa Lin, Te‐Yu Lo, Chieh‐Chen Huang, Sam L. Kahler, and Haw‐Yueh Thong
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Adult ,Male ,Cross-Sectional Studies ,Palau ,Eczema ,Humans ,Female ,Community Health Services ,Health Status Disparities ,Dermatology ,Skin Diseases - Abstract
Dermatologic disease is a neglected public health challenge that disproportionately affects resource-poor settings. Globally, dermatologic disease contributes the fourth highest burden of nonfatal disability with the most acute impact in the Oceanic region, including the Republic of Palau. Efforts to address the dermatologic health inequality are hindered without the necessary epidemiologic evidence to guide health policy in the resource-poor setting of Palau.We conducted a 4-year cross-sectional study of all Dermatology Service patients in the Belau National Hospital and outreach community health centers from 2015 to 2018. No other specialized dermatology service was available. Skin disease was classified by both diagnosis and Global Burden of Disease criteria and analyzed by age, gender, region, and surrounding Oceanic nations.The study enrolled 494 patients comprising 179 males and 315 females between 2015 and 2018. The most prevalent diseases were eczema (48.8%), superficial fungal infection (24.5%), and pruritus (22.7%). The neglected tropical disease of scabies was detected in four patients. Males were significantly more likely to present with cellulitis, keratinocyte carcinoma, stasis dermatitis, wounds, marine-related dermatitis, viral skin disease, tinea faciei, verruca, and xerosis and females with melasma and hyperpigmentation.This study presents the first primary epidemiologic data describing the prevalence of dermatologic disease in the Palauan adult population. The significant burden of disease in Palau compared with other Oceanic nations validates ongoing dermatology services and informs public health implications for resource allocation and disease management to achieve health equality in the resource-poor nation.
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- 2022
4. Extra-islet expression of islet antigen boosts T-cell exhaustion to prevent autoimmune diabetes
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Claudia Selck, Gaurang Jhala, David De George, Chun-Ting J. Kwong, Marie K. Christensen, Evan Pappas, Xin Liu, Tingting Ge, Prerak Trivedi, Axel Kallies, Helen E. Thomas, Thomas W.H. Kay, and Balasubramanian Krishnamurthy
- Abstract
Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (TPEX) cells. T cell exhaustion is well studied in the context of chronic viral infections and cancer, but it is unclear if and how antigen-driven T cell exhaustion controls progression of autoimmune diabetes and whether this process can be harnessed to prevent diabetes. Using non-obese diabetic (NOD) mice, we show that some CD8+ T cells specific for the islet antigen, islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) displayed terminal exhaustion characteristics within pancreatic islets but were maintained in the TPEXcell state in peripheral lymphoid organs. To examine the impact of antigen on T cell exhaustion in diabetes, we generated transgenic NOD mice with inducible IGRP expression in peripheral antigen presenting cells. Antigen exposure in the extra-islet environment induced severely exhausted IGRP-specific T cells with reduced ability to produce IFNγ, which protected these mice from diabetes. Our data demonstrate that T cell exhaustion induced by delivery of antigen can be harnessed to prevent autoimmune diabetes.
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- 2023
5. An Atypical Presentation of Tuberculous Meningoencephalitis with Tuberculoma in a New York Taxi Driver
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Aaron C. Yee and Ting Ting J. Wong
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- 2023
6. The Most Obscured AGNs in the XMM-SERVS Fields
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Yan, Wei, Brandt, W. N., Zou, Fan, Zhu, Shifu, Chen, Chien-Ting J., Hickox, Ryan C., Luo, Bin, Ni, Qingling, Alexander, David M., Bauer, Franz E., Vignali, Cristian, and Vito, Fabio
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We perform X-ray spectral analyses to derive characteristics (e.g., column density, X-ray luminosity) of $\approx$10,200 active galactic nuclei (AGNs) in the XMM-Spitzer Extragalactic Representative Volume Survey (XMM-SERVS), which was designed to investigate the growth of supermassive black holes across a wide dynamic range of cosmic environments. Using physical torus models (e.g., Borus02) and a Bayesian approach, we uncover 22 representative Compton-thick (CT; $N_{\rm H} \;>\; 1.5\times10^{24}\; \rm cm^{-2}$) AGN candidates with good signal-to-noise ratios as well as a large sample of 136 heavily obscured AGNs. We also find an increasing CT fraction (\fct ) from low ($z0.75$) redshift. Our CT candidates tend to show hard X-ray spectral shapes and dust extinction in their SED fits, which may shed light on the connection between AGN obscuration and host-galaxy evolution., 12 pages, 9 figures, accepted for publication in ApJ
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- 2023
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7. Identification and Characterization of a Large Sample of Distant Active Dwarf Galaxies in XMM-SERVS
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Zou, Fan, Brandt, W. N., Ni, Qingling, Zhu, Shifu, Alexander, David M., Bauer, Franz E., Chen, Chien-Ting J., Luo, Bin, Sun, Mouyuan, Vignali, Cristian, Vito, Fabio, Xue, Yongquan, and Yan, Wei
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Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astrophysics - Astrophysics of Galaxies - Abstract
Active dwarf galaxies are important because they contribute to the evolution of dwarf galaxies and can reveal their hosted massive black holes. However, the sample size of such sources beyond the local universe is still highly limited. In this work, we search for active dwarf galaxies in the recently completed XMM-Spitzer Extragalactic Representative Volume Survey (XMM-SERVS). XMM-SERVS is currently the largest medium-depth X-ray survey covering 13 $\mathrm{deg}^2$ in three extragalactic fields, which all have well-characterized multi-wavelength information. After considering several factors that may lead to misidentifications, we identify 73 active dwarf galaxies at $z, 34 pages, 21 figures, 6 tables, accepted for publication in ApJ
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- 2023
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8. Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
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Seok-Ting J. Ang, Elisa M. Crombie, Han Dong, Kuan-Ting Tan, Adriel Hernando, Dejie Yu, Stuart Adamson, Seonyoung Kim, Dominic J. Withers, Hua Huang, and Shih-Yin Tsai
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Mice ,Multidisciplinary ,Muscles ,Neuromuscular Junction ,Animals ,General Physics and Astronomy ,General Chemistry ,Mechanistic Target of Rapamycin Complex 1 ,Phosphorylation ,Synaptic Transmission ,General Biochemistry, Genetics and Molecular Biology ,Adaptor Proteins, Signal Transducing - Abstract
Dysregulation of mTOR complex 1 (mTORC1) activity drives neuromuscular junction (NMJ) structural instability during aging; however, downstream targets mediating this effect have not been elucidated. Here, we investigate the roles of two mTORC1 phosphorylation targets for mRNA translation, ribosome protein S6 kinase 1 (S6K1) and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), in regulating NMJ structural instability induced by aging and sustained mTORC1 activation. While myofiber-specific deletion of S6k1 has no effect on NMJ structural integrity, 4EBP1 activation in murine muscle induces drastic morphological remodeling of the NMJ with enhancement of synaptic transmission. Mechanistically, structural modification of the NMJ is attributed to increased satellite cell activation and enhanced post-synaptic acetylcholine receptor (AChR) turnover upon 4EBP1 activation. Considering that loss of post-synaptic myonuclei and reduced NMJ turnover are features of aging, targeting 4EBP1 activation could induce NMJ renewal by expanding the pool of post-synaptic myonuclei as an alternative intervention to mitigate sarcopenia.
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- 2022
9. The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report
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Chung-ting J. Kou, Zachary S. Jarrett, WingYee Wan, and Jeffery A. Colburn
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medicine.medical_specialty ,Lipoprotein lipase ,business.industry ,digestive, oral, and skin physiology ,Hypertriglyceridemia ,nutritional and metabolic diseases ,General Medicine ,medicine.disease ,Gastroenterology ,Orlistat ,Lipoprotein lipase deficiency ,Recurrent pancreatitis ,Internal medicine ,Adjunctive treatment ,Medicine ,Pancreatitis ,lipids (amino acids, peptides, and proteins) ,Medical nutrition therapy ,business ,medicine.drug - Abstract
Background Lipoprotein Lipase (LPL) deficiency is an inherited disorder in which patients develop hypertriglyceridemia that can lead to recurrent pancreatitis. Mainstay of therapy is medical nutritional therapy. Case Report We present a case of a 35-year-old women with LPL deficiency who suffered recurrent hospitalizations for hypertriglyceridemia induced pancreatitis that was treated effectively with Orlistat. Discussion Other agents that have been studied in LPL deficiency are costly and have limiting side effects. Studies have shown Orlistat to be safe and effective for treatment of LPL deficiency in children. No studies have been performed in adults with LPL deficiency. Conclusion Orlistat may be a potential adjunctive treatment in adult LPL deficiency given its availability and favorable safety profile. Further research regarding Orlistat in the setting of LPL deficiency is needed.
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- 2022
10. Harnessing CD8 + T‐cell exhaustion to treat type 1 diabetes
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Dan V Le, Claudia Selck, Chun-Ting J. Kwong, Balasubramanian Krishnamurthy, Helen E. Thomas, Thomas W.H. Kay, Lachlan J McAnaney, and Krisna Tahija
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0301 basic medicine ,Type 1 diabetes ,endocrine system diseases ,business.industry ,medicine.medical_treatment ,Insulin ,Immunology ,nutritional and metabolic diseases ,Cell Biology ,medicine.disease ,medicine.disease_cause ,Autoimmunity ,03 medical and health sciences ,Chronic infection ,030104 developmental biology ,0302 clinical medicine ,Immune system ,Cancer immunotherapy ,medicine ,Immunology and Allergy ,Cytotoxic T cell ,business ,CD8 ,030215 immunology - Abstract
Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine clinical use or able to achieve insulin independence in patients. In addition to this, the principles of T1D treatment remain essentially unchanged since the isolation of insulin, almost a century ago. T1D is characterized by insulin deficiency as a result of destruction of insulin-producing beta cells mediated by autoreactive T cells. Therapies that target beta-cell antigen-specific T cells are needed to prevent T1D. CD8+ T-cell exhaustion is an emerging area of research in chronic infection, cancer immunotherapy, and more recently, autoimmunity. Recent data suggest that exhausted T-cell populations are associated with improved markers of T1D. T-cell exhaustion is both characterized and mediated by inhibitory receptors. This review aims to identify which inhibitory receptors may prove useful to induce T-cell exhaustion to treat T1D and identify limitations and gaps in the current literature.
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- 2021
11. Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
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Helen E. Thomas, Stacey Fynch, Balasubramanian Krishnamurthy, Tara Catterall, Satoru Akazawa, Thomas C. Brodnicki, Kate L. Graham, Claudia Selck, Thomas W.H. Kay, Chun-Ting J. Kwong, Leanne Mackin, Evan G Pappas, Andrew P. R. Sutherland, and Gaurang Jhala
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0301 basic medicine ,Adoptive cell transfer ,Endocrinology, Diabetes and Metabolism ,T cell ,030209 endocrinology & metabolism ,Nod ,Biology ,medicine.disease ,eye diseases ,03 medical and health sciences ,Sting ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Immunology ,Internal Medicine ,medicine ,Cytotoxic T cell ,Insulitis ,CD8 ,NOD mice - Abstract
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has been suggested as a driver of disease initiation both in humans and in the NOD mouse model. A possible source of type I IFN is through activation of the STING pathway. Recent studies suggest that STING also has antiproliferative and proapoptotic functions in T cells that are independent of IFN. To investigate whether STING is involved in autoimmune diabetes, we examined the impact of genetic deletion of STING in NOD mice. CRISPR/Cas9 gene editing was used to generate STING-deficient NOD mice. Quantitative real-time PCR was used to assess the level of type I IFN-regulated genes in islets from wild-type and STING-deficient NOD mice. The number of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)206-214-specific CD8+ T cells was determined by magnetic bead-based MHC tetramer enrichment and flow cytometry. The incidence of spontaneous diabetes and diabetes after adoptive transfer of T cells was determined. STING deficiency partially attenuated the type I IFN gene signature in islets but did not suppress insulitis. STING-deficient NOD mice accumulated an increased number of IGRP206-214-specific CD8+ T cells (2878 ± 642 cells in NOD.STING−/− mice and 728.8 ± 196 cells in wild-type NOD mice) in peripheral lymphoid tissue, associated with a higher incidence of spontaneous diabetes (95.5% in NOD.STING−/− mice and 86.2% in wild-type NOD mice). Splenocytes from STING-deficient mice rapidly induced diabetes after adoptive transfer into irradiated NOD recipients (median survival 75 days for NOD recipients of NOD.STING−/− mouse splenocytes and 121 days for NOD recipients of NOD mouse splenocytes). Data suggest that sensing of endogenous nucleic acids through the STING pathway may be partially responsible for the type I IFN gene signature but not autoimmunity in NOD mice. Our results show that the STING pathway may play an unexpected intrinsic role in suppressing the number of diabetogenic T cells.
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- 2021
12. Use of a Chemotherapy Toxicity Prediction Tool to Decrease Risks for Hospitalization in Older Patients
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Mintcho E Mintchev, Arjun G Kalra, Chung-Ting J Kou, James K Aden, Matthew L Bezzant, Wilfred P dela Cruz, and Adrian R Bersabe
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General Engineering - Abstract
Objectives Performance status (PS) scales such as the Eastern Cooperative Oncology Group (ECOG) PS and the Karnofsky Performance Index have limited utility in selecting therapies and predicting related adverse events in older patients with cancer. In July 2016, medical oncologists at our institution adopted the Cancer and Aging Research Group toxicity prediction score (CARG), a toxicity prediction tool, to identify patients who are "fit" for chemotherapy versus those who are "frail" and may experience severe complications. Methods Our retrospective review included referrals of beneficiaries 75 years of age and older who received standard systemic therapy and patients of the same age whose treatment was modified due to CARG. We compared the score's utilization six months before and after its incorporation and then assessed how its application impacted admissions, emergency department (ED) visits, and medical management. Results Thirty-eight patients with a mean age of 81 years met the inclusion criteria. Their diagnoses included gastrointestinal (37%), lung (21%), hematologic (18%), breast (10.5%), genitourinary (3%), and other (10.5%) malignancies. CARG was documented for 12.5% of systemic therapy recipients before its adoption and 41% of recipients after adoption. Its use was limited by the reliance on physicians to perform scoring during time-constrained patient encounters. Patients had fewer mean inpatient admissions (0.7 versus 2.3), admission days (4.3 versus 8), and ED visits (1.1 versus 2.5) when management was modified based on the score. Conclusion CARG assessment may facilitate a safer and more tailored approach to cancer care in older patients than conventional PS scales alone. Its integration into patient screening would increase its application and better define its potential predictive capacity to decrease risks for hospitalization.
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- 2022
13. Familial Essential Thrombocythemia With Novel MPL L502G and G208K Mutations
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Matthew Rendo, Christian Cavacece, Chung-ting J Kou, Bradley W Beeler, and Joshua Fenderson
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General Engineering - Published
- 2022
14. X-ray properties of dust-obscured galaxies with broad optical/UV emission lines
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W. N. Brandt, Chien-Ting J. Chen, Ashraf Ayubinia, Fan Zou, Daniel Stern, Gordon P. Garmire, and F. Vito
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Physics ,Supermassive black hole ,010308 nuclear & particles physics ,Infrared ,Astrophysics::High Energy Astrophysical Phenomena ,X-ray ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Lambda ,Astrophysics - Astrophysics of Galaxies ,01 natural sciences ,Galaxy ,Virial theorem ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,0103 physical sciences ,Emission spectrum ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
Dust-obscured galaxies (DOGs) with extreme infrared luminosities may represent a key phase in the co-evolution of galaxies and supermassive black holes. We select 12 DOGs at $0.3\lesssim z\lesssim1.0$ with broad Mg II or H$\beta$ emission lines and investigate their X-ray properties utilizing snapshot observations ($\sim3~\mathrm{ks}$ per source) with Chandra. By assuming that the broad lines are broadened due to virial motions of broad-line regions, we find that our sources generally have high Eddington ratios ($\lambda_\mathrm{Edd}$). Our sources generally have moderate intrinsic X-ray luminosities ($L_\mathrm{X}\lesssim10^{45}~\mathrm{erg~s^{-1}}$), which are similar to those of other DOGs, but are more obscured. They also present moderate outflows and intense starbursts. Based on these findings, we conclude that high-$\lambda_\mathrm{Edd}$ DOGs are closer to the peaks of both host-galaxy and black-hole growth compared to other DOGs, and that AGN feedback has not swept away their reservoirs of gas. However, we cannot fully rule out the possibility that the broad lines are broadened by outflows, at least for some sources. We investigate the relations among $L_\mathrm{X}$, AGN rest-frame $6~\mathrm{\mu m}$ monochromatic luminosity, and AGN bolometric luminosity, and find the relations are consistent with the expected ones., Comment: 19 pages, 14 figures, accepted for publication in MNRAS
- Published
- 2020
15. Variation in lung function and nutritional decline in cystic fibrosis by genotype: An analysis of the Canadian cystic fibrosis registry
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Dhenuka Radhakrishnan, Garvin J. Leung, Thomas Kovesi, Ting J. Cho, and Jemila S. Hamid
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Adult ,Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Canada ,medicine.medical_specialty ,Cystic Fibrosis ,Population ,Cystic Fibrosis Transmembrane Conductance Regulator ,Nutritional Status ,Severity of Illness Index ,Cystic fibrosis ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Epidemiology ,Genotype ,medicine ,Humans ,Registries ,Child ,Chloride Channel Agonists ,education ,ΔF508 ,Genetic Association Studies ,Lung function ,education.field_of_study ,business.industry ,Homozygote ,Patient Acuity ,medicine.disease ,Respiratory Function Tests ,Natural history ,Treatment Outcome ,030104 developmental biology ,030228 respiratory system ,Mutation ,Pediatrics, Perinatology and Child Health ,Female ,business ,Body mass index - Abstract
Background This study aimed to improve our understanding of the natural history of cystic fibrosis (CF) by comparing lung function and body mass index z-score (zBMI) between patients with different genotypes and identify a genotype with outcomes most comparable to homozygous ΔF508 patients. Methods Data was obtained from the Canadian CF Registry between January 1st 2007-January 1st 2016. Patients were categorized into one of five groups based on their genotype. A mixed-effects model was conducted with adjustments for age, sex, age of diagnosis, and baseline clinical measures. Results Among 2612 patients, those with non-mild forms of CF, and particularly adult patients with the same functional allele classification were found to have a lung function trajectory comparable to individuals with the homozygous ∆F508 genotype (annual change in percent predicted forced expiratory volume in 1 s of −0.83, 95% CI: −0.93, −0.73). The rates of zBMI change over the study period were not significantly different between the genotype groups. Conclusion This population-based study of Canadian CF patients provides adjusted rates of lung function decline and zBMI over ten years. The finding that there are different genotypes with comparable rates of lung function decline to patients of the homozygous ∆F508 group supports the use of multiple comparison groups to assess the long-term efficacy of emerging CF therapies.
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- 2020
16. An atypical presentation of CNS tuberculosis manifesting with meningoencephalitis and tuberculoma in a New York taxi driver
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Aaron C. Yee and Ting Ting J. Wong
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Infectious Diseases - Published
- 2023
17. NuSTAR Observations of a Heavily X-Ray-obscured AGN in the Dwarf Galaxy J144013+024744
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Shrey Ansh, Chien-Ting J. Chen, W. N. Brandt, Carol E. Hood, E. S. Kammoun, G. Lansbury, Stéphane Paltani, Amy E. Reines, C. Ricci, Douglas A. Swartz, Jonathan R. Trump, F. Vito, and Ryan C. Hickox
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a multi-wavelength analysis of the dwarf Seyfert-2 galaxy J$144013+024744$, a candidate obscured active galactic nucleus (AGN) thought to be powered by an intermediate-mass black hole (IMBH, $M_\bullet \approx 10^{4-6} M_\odot$) of mass $M_{\bullet} \sim 10^{5.2}M_\odot$. To study its X-ray properties, we targeted J$144013+024744$ with NuSTAR for $\approx 100$ ks. The X-ray spectrum was fitted with absorbed power law, Pexmon and a physical model (RXTorus). A Bayesian X-ray analysis was performed to estimate the posteriors. The phenomenological and the physical models suggest the AGN to be heavily obscured by a column density of $N_{\rm H} = (3.4-7.0)\times10^{23}$ cm$^{-2}$. In particular, the RXTorus model with a sub-solar metallicity suggests the obscuring column to be almost Compton-thick. We compared the $2-10$ keV intrinsic X-ray luminosity with the inferred X-ray luminosities based on empirical scaling relations for unobscured AGNs using $L_{\rm [OIV](25.89\mu {\rm m})}$, $L_{[{\rm OIII}](5007 {\rm angstrom})}$, and $L_{6\rm \mu m}$ and found that the high-excitation $[{\rm OIV}]$ line provides a better estimate of the intrinsic $2-10$ keV X-ray luminosity ($L_{2-10}^{\rm int} \sim 10^{41.41}{\rm erg s}^{-1}$). Our results suggest that J$144013+024744$ is the first type-2 dwarf galaxy that shows X-ray spectroscopic evidence for obscuration. The column density that we estimated is among the highest measured to date for IMBH-powered AGNs, implying that a typical AGN torus geometry might extend to the low-mass end. This work has implications for constraining the black hole occupation fraction in dwarf galaxies using X-ray observations., Comment: Accepted for Publication in ApJ
- Published
- 2023
18. Aero to the heart: A case of aortic valve endocarditis caused by Aerococcus Urinae in an elderly woman
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Aaron C. Yee and Ting Ting J. Wong
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Infectious Diseases - Published
- 2023
19. Evolutionary tracking of cancer haplotypes at single-cell resolution
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Nicholas Ceglia, Diljot Grewal, Justina Biele, Weiner Ac, Brimhall J, Peter Eirew, Samuel Aparicio, Ciara H. O'Flanagan, Havasov E, Masud T, Hakwoo Lee, Beatty S, Samantha Leung, Florian Uhlitz, Abrams D, Ignacio Vázquez-García, Marc J Williams, Damian Yap, Daniel Lai, Salehi S, Sohrab P. Shah, Ting J, Wang B, Farhia Kabeer, Nicole Rusk, Bojilova, Tyler Funnell, Jenifer Pham, and Andrew McPherson
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Loss of heterozygosity ,Genetics ,Structural variation ,medicine.anatomical_structure ,Haplotype ,Cell ,medicine ,Cancer ,Biology ,Allele ,medicine.disease ,Phenotype ,Genome - Abstract
Cancer genomes exhibit extensive chromosomal copy number changes and structural variation, yet how allele specific alterations drive cancer genome evolution remains unclear. Here, through application of a new computational approach we report allele specific copy number alterations in 11,097 single cell whole genomes from genetically engineered mammary epithelial cells and 21,852 cells from high grade serous ovarian and triple negative breast cancers. Resolving single cell copy number profiles to individual alleles uncovered genomic background distributions of gains, losses and loss of heterozygosity, yielding evidence of positive selection of specific chromosomal alterations. In addition specific genomic loci in maternal and paternal alleles were commonly found to be altered in parallel with convergent phenotypic transcriptional effects. Finally we show that haplotype specific alterations trace the cyclical etiology of high level amplifications and reveal clonal haplotype decomposition of complex structures. Together, our results illuminate how allele and haplotype specific alterations, here determined across thousands of single cell cancer genomes, impact the etiology and evolution of structural variations in human tumours.
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- 2021
20. Chandra Observations of Excess Fe Kα Line Emission in Galaxies with High Star Formation Rates: X-Ray Reflection on Galaxy Scales?
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Ryan C. Hickox, Chien-Ting J. Chen, Alberto Masini, Franz E. Bauer, David M. Alexander, Claudio Ricci, and Wei Yan
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Physics ,Supermassive black hole ,Active galactic nucleus ,Stellar mass ,010308 nuclear & particles physics ,Star formation ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,01 natural sciences ,Galaxy ,Luminosity ,Space and Planetary Science ,0103 physical sciences ,Chandra Deep Field South ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics ,Equivalent width ,Astrophysics::Galaxy Astrophysics - Abstract
In active galactic nuclei (AGN), fluorescent Fe K$\alpha$ (iron) line emission is generally interpreted as originating from obscuring material around a supermassive black hole (SMBH) on the scale of a few parsecs (pc). However, recent Chandra studies indicate the existence of iron line emission extending to kpc scales in the host galaxy. The connection between iron line emission and large-scale material can be spatially resolved directly only in nearby galaxies, but could be inferred in more distant AGNs by a connection between line emission and star-forming gas and dust that is more extended than the pc-scale torus. Here we present the results from a stacking analysis and X-ray spectral fitting performed on sources in the Chandra Deep Field South (CDFS) 7 Ms observations. From the deep stacked spectra, we select sources with stellar mass $\log(M_*/M_\odot)>10$ at $0.5, Comment: 8 pages, 5 figures, accepted by ApJ
- Published
- 2021
21. Lenalidomide-Associated Hemophagocytic Lymphohistiocytosis With Plasma Cell Phagocytosis
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Joshua L. Fenderson, Chung-ting J Kou, Matthew J. Rendo, David Lynch, and Elliot Runge
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Phagocytosis ,lenalidomide ,Adult population ,030204 cardiovascular system & hematology ,Plasma cell ,medicine.disease_cause ,diagnosis of multiple myeloma ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,medicine ,secondary hlh ,Multiple myeloma ,Lenalidomide ,Hemophagocytic lymphohistiocytosis ,business.industry ,General Engineering ,Hematology ,Immune dysregulation ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Immunology ,hemophagocytic lymphohistiocytosis (hlh) ,Hemophagocytosis ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic inflammatory syndrome that is often fatal. In the adult population, it is believed to develop secondary to immune dysregulation due to rheumatologic, infectious, malignant, and recently, immunomodulatory drugs. It’s co-occurrence with phagocytosis by non-macrophage cells has not been previously well defined. We present a case of lenalidomide-associated HLH with concurrent plasma cell hemophagocytosis in a patient with controlled multiple myeloma (MM).
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- 2021
22. Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice
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Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Thomas W.H. Kay, and Balasubramanian Krishnamurthy
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lcsh:Immunologic diseases. Allergy ,0301 basic medicine ,immune tolerance ,endocrine system ,endocrine system diseases ,type 1 diabetes ,Immunology ,Nod ,Biology ,digestive system ,proinsulin-1 ,Immune tolerance ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Antigen ,Mice, Inbred NOD ,medicine ,Animals ,Insulin ,Immunology and Allergy ,Antigen-presenting cell ,Original Research ,Autoantibodies ,Proinsulin ,NOD mice ,Type 1 diabetes ,nutritional and metabolic diseases ,medicine.disease ,CD4+ T cells ,Diabetes Mellitus, Type 1 ,030104 developmental biology ,Glucose-6-Phosphatase ,lcsh:RC581-607 ,Insulitis ,hormones, hormone substitutes, and hormone antagonists ,030215 immunology - Abstract
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differentially expressed, with predominant proinsulin-2 expression in the thymus and proinsulin-1 in islet beta-cells. In contrast to proinsulin-2, proinsulin-1 knockout NOD mice are protected from autoimmune diabetes. This indicates that proinsulin-1 epitopes in beta-cells maybe preferentially targeted by autoreactive T cells. To study the contribution of proinsulin-1 reactive T cells in autoimmune diabetes, we generated transgenic NOD mice with tetracycline-regulated expression of proinsulin-1 in antigen presenting cells (TIP-1 mice) with an aim to induce immune tolerance. TIP-1 mice displayed a significantly reduced incidence of spontaneous diabetes, which was associated with reduced severity of insulitis and insulin autoantibody development. Antigen experienced proinsulin specific T cells were significantly reduced in in TIP-1 mice indicating immune tolerance. Moreover, T cells from TIP-1 mice expressing proinsulin-1 transferred diabetes at a significantly reduced frequency. However, proinsulin-1 expression in APCs had minimal impact on the immune responses to the downstream antigen islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) and did not prevent diabetes in NOD 8.3 mice with a pre-existing repertoire of IGRP reactive T cells. Thus, boosting immune tolerance to proinsulin-1 partially prevents islet-autoimmunity. This study further extends the previously established role of proinsulin-1 epitopes in autoimmune diabetes in NOD mice.
- Published
- 2021
23. Harnessing CD8
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Chun-Ting J, Kwong, Claudia, Selck, Krisna, Tahija, Lachlan J, McAnaney, Dan V, Le, Thomas Wh, Kay, Helen E, Thomas, and Balasubramanian, Krishnamurthy
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Diabetes Mellitus, Type 1 ,Insulin-Secreting Cells ,Humans ,Insulin ,Autoimmunity ,CD8-Positive T-Lymphocytes - Abstract
Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine clinical use or able to achieve insulin independence in patients. In addition to this, the principles of T1D treatment remain essentially unchanged since the isolation of insulin, almost a century ago. T1D is characterized by insulin deficiency as a result of destruction of insulin-producing beta cells mediated by autoreactive T cells. Therapies that target beta-cell antigen-specific T cells are needed to prevent T1D. CD8
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- 2021
24. Chandra Observations of Excess Fe K$��$ Line Emission in Galaxies with High Star Formation Rates: X-ray Reflection on Galaxy Scales?
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Yan, Wei, Hickox, Ryan C., Chen, Chien-Ting J., Ricci, Claudio, Masini, Alberto, Bauer, Franz E., and Alexander, David M.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
In active galactic nuclei (AGN), fluorescent Fe K$��$ (iron) line emission is generally interpreted as originating from obscuring material around a supermassive black hole (SMBH) on the scale of a few parsecs (pc). However, recent Chandra studies indicate the existence of iron line emission extending to kpc scales in the host galaxy. The connection between iron line emission and large-scale material can be spatially resolved directly only in nearby galaxies, but could be inferred in more distant AGNs by a connection between line emission and star-forming gas and dust that is more extended than the pc-scale torus. Here we present the results from a stacking analysis and X-ray spectral fitting performed on sources in the Chandra Deep Field South (CDFS) 7 Ms observations. From the deep stacked spectra, we select sources with stellar mass $\log(M_*/M_\odot)>10$ at $0.5, 8 pages, 5 figures, accepted by ApJ
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- 2021
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25. Colorectal Cancer in a Patient With Multiple Myeloma: A Treatment Dilemma
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Devin R Broadwater, Joshua Romain, Chung-ting J Kou, and Taylor Barnett
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Oncology ,bisphosphonate ,medicine.medical_specialty ,Palliative treatment ,Colorectal cancer ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,fluoropyrimidines ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Medicine ,secondary primary malignancy ,Multiple myeloma ,business.industry ,General Engineering ,Monoclonal immunoglobulin ,Treatment options ,Hematology ,Bisphosphonate ,medicine.disease ,multiple myeloma ,Increased risk ,colon adenocarcinoma ,business ,030217 neurology & neurosurgery - Abstract
Multiple myeloma (MM) is a malignancy of plasma cells characterized by the clonal proliferation of plasma cells that produce monoclonal immunoglobulins. While typically considered to be incurable, advances in treatment options have led to remarkable improvements in survival for these patients. Accumulating evidence suggests an increased risk for the development of a secondary primary malignancy (SPM) in these patients, perhaps as a result of myeloma directed therapy or as an effect of their underlying disease process. Here we present a case of a patient who was diagnosed with an SPM while undergoing palliative treatment for multiple myeloma and a treatment approach.
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- 2020
26. Malignant Peripheral Nerve Sheath Tumor in an Army Reservist With Neurofibromatosis Type 1
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Bradley W. Beeler, Devin R. Broadwater, Chung-ting J Kou, and Matthew Rendo
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Adult ,congenital, hereditary, and neonatal diseases and abnormalities ,Pathology ,medicine.medical_specialty ,Neurofibromatosis 1 ,Malignant peripheral nerve sheath tumor ,Gene mutation ,03 medical and health sciences ,0302 clinical medicine ,Neurofibrosarcoma ,Café au lait spot ,medicine ,Neurofibroma ,Humans ,Neurofibromatosis ,030304 developmental biology ,0303 health sciences ,Neurofibromin 1 ,biology ,business.industry ,Cafe-au-Lait Spots ,Public Health, Environmental and Occupational Health ,Axillary freckling ,General Medicine ,medicine.disease ,nervous system diseases ,Black or African American ,Military Personnel ,030220 oncology & carcinogenesis ,biology.protein ,medicine.symptom ,business - Abstract
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting 1 in 3,500 people resulting from an NF1 gene mutation that encodes the nonfunctional protein neurofibromin mutant. Neurofibromin is a negative regulator of RAS signaling involved in cell survival and proliferation. NF1 typically presents at birth or in early childhood with multiple light brown (café au lait) spots and axillary freckling. With age, patients may develop scattered neurofibromas as well as additional neurological and malignant abnormalities. Additionally, the nonfunctional protein neurofibromin mutant may be involved in the pathogenesis of peripheral malignant nerve sheath tumors, which is a rare and life-threatening complication of NF1. While a disqualifying condition for military duty, it may not initially be clinically apparent until complications develop. Here, we present a case of malignant peripheral sheath in an U.S. Army African American reservist with NF1 in whom cutaneous manifestations of NF1 such as café au lait spots and axillary freckling were not identified on the initial military entrance processing examination.
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- 2020
27. Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
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Satoru, Akazawa, Leanne, Mackin, Gaurang, Jhala, Stacey, Fynch, Tara, Catterall, Claudia, Selck, Kate L, Graham, Balasubramanian, Krishnamurthy, Evan G, Pappas, Chun-Ting J, Kwong, Andrew P R, Sutherland, Thomas W H, Kay, Thomas C, Brodnicki, and Helen E, Thomas
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Male ,Mice, Knockout ,Membrane Proteins ,Autoimmunity ,CD8-Positive T-Lymphocytes ,Lymphocyte Activation ,Adoptive Transfer ,Disease Models, Animal ,Islets of Langerhans ,Diabetes Mellitus, Type 1 ,Gene Expression Regulation ,Mice, Inbred NOD ,Animals ,Female ,Cell Proliferation ,Signal Transduction - Abstract
Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells. A type I IFN gene signature seen before the onset of type 1 diabetes has been suggested as a driver of disease initiation both in humans and in the NOD mouse model. A possible source of type I IFN is through activation of the STING pathway. Recent studies suggest that STING also has antiproliferative and proapoptotic functions in T cells that are independent of IFN. To investigate whether STING is involved in autoimmune diabetes, we examined the impact of genetic deletion of STING in NOD mice.CRISPR/Cas9 gene editing was used to generate STING-deficient NOD mice. Quantitative real-time PCR was used to assess the level of type I IFN-regulated genes in islets from wild-type and STING-deficient NOD mice. The number of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)STING deficiency partially attenuated the type I IFN gene signature in islets but did not suppress insulitis. STING-deficient NOD mice accumulated an increased number of IGRPData suggest that sensing of endogenous nucleic acids through the STING pathway may be partially responsible for the type I IFN gene signature but not autoimmunity in NOD mice. Our results show that the STING pathway may play an unexpected intrinsic role in suppressing the number of diabetogenic T cells.
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- 2020
28. Phlegmasia Cerulea Dolens: A Life-Threatening Manifestation of Deep Vein Thrombosis
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Chung-Ting J Kou, Caitlin Batzlaff, Tyson Sjulin, and Matthew L Bezzant
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medicine.medical_specialty ,phlegmasia cerulea dolens ,Deep vein ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Thrombolytic drug ,Internal Medicine ,medicine ,gangrene ,deep venous thrombosis ,Phlegmasia cerulea dolens ,Gangrene ,business.industry ,General Engineering ,medicine.disease ,Thrombosis ,Surgery ,Catheter ,Venous thrombosis ,medicine.anatomical_structure ,Amputation ,endovascular catheter-directed thrombolysis ,thrombectomy ,venous thrombosis ,business ,030217 neurology & neurosurgery - Abstract
Deep vein thrombosis is a common condition encounter by hospitalists and managed by either oral or intravenous anti-coagulation. Although uncommon, phlegmasia cerulea dolens (PCD) is a life-threatening manifestation of acute deep vein thrombosis requiring early recognition and aggressive intervention to preserve life and limb. PCD is characterized by marked swelling of the lower extremities with pain and cyanosis, which often leads to gangrene and amputation. We present the case of a patient who developed PCD of her left lower extremity who was successfully treated with an EkoSonic™ endovascular catheter (Boston Scientific, Marlborough, MA, USA), which accelerates lytic dispersion of the thrombolytic drug through ultrasound technology.
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- 2020
29. Observational Evidence for Enhanced Black Hole Accretion in Giant Elliptical Galaxies
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Michael S. Calzadilla, Chien-Ting J. Chen, Erin Kara, Michael McDonald, Brian R. McNamara, Massimo Gaspari, Ryan C. Hickox, and Ilia Korchagin
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Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Supermassive black hole ,Active galactic nucleus ,Radio galaxy ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Galaxy groups and clusters ,Space and Planetary Science ,Galaxy group ,Astrophysics of Galaxies (astro-ph.GA) ,Elliptical galaxy ,Bhar ,Astrophysics - High Energy Astrophysical Phenomena ,Galaxy cluster ,Astrophysics::Galaxy Astrophysics - Abstract
We present a study of the relationship between black hole accretion rate (BHAR) and star formation rate (SFR) in a sample of giant elliptical galaxies. These galaxies, which live at the centers of galaxy groups and clusters, have star formation and black hole activity that is primarily fueled by gas condensing out of the hot intracluster medium. For a sample of 46 galaxies spanning 5 orders of magnitude in BHAR and SFR, we find a mean ratio of log(BHAR/SFR) = -1.45 +/- 0.2, independent of the methodology used to constrain both SFR and BHAR. This ratio is significantly higher than most previously-published values for field galaxies. We investigate whether these high BHAR/SFR ratios are driven by high BHAR, low SFR, or a different accretion efficiency in radio galaxies. The data suggest that the high BHAR/SFR ratios are primarily driven by boosted black hole accretion in spheroidal galaxies compared to their disk counterparts. We propose that angular momentum of the cool gas is the primary driver in suppressing BHAR in lower mass galaxies, with massive galaxies accreting gas that has condensed out of the hot phase on nearly radial trajectories. Additionally, we demonstrate that the relationship between specific BHAR and SFR has much less scatter over 6 orders of magnitude in both parameters, due to competing dependence on morphology between the M_BH--M_* and BHAR--SFR relations. In general, active galaxies selected by typical techniques have sBHAR/sSFR ~ 10, while galactic nuclei with no clear AGN signatures have sBHAR/sSFR ~ 1, consistent with a universal M_BH--M_spheroid relation., Comment: 15 pages, 12 figure. Accepted for publication in ApJ
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- 2020
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30. Effect of hydraulic retention time on electricity generation using a solid plain-graphite plate microbial fuel cell anoxic/oxic process for treating pharmaceutical sewage
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Wei-L Chao, Wann-N Jane, Ting-J Chang, Yun-H Chang, and Yi-T. Chang
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0106 biological sciences ,Environmental Engineering ,Microbial fuel cell ,Drug Industry ,Hydraulic retention time ,Bioelectric Energy Sources ,Nitrogen ,Industrial Waste ,Sewage ,010501 environmental sciences ,01 natural sciences ,Comamonadaceae ,Bioreactors ,Electricity ,Bacterial nanowires ,010608 biotechnology ,Leptothrix ,Graphite ,0105 earth and related environmental sciences ,Power density ,Nanowires ,business.industry ,General Medicine ,equipment and supplies ,Pulp and paper industry ,Anoxic waters ,Carbon ,Biodegradation, Environmental ,Electricity generation ,Biofilms ,Environmental science ,business - Abstract
Treatment efficiency and electricity generation were evaluated using a solid plain-graphite plate microbial fuel cell (MFC) anoxic/oxic (A/O) process that treated pharmaceutical sewage using different hydraulic retention times (HRT). Short HRTs increased the volumetric organic loading rate, thereby reducing the MFC performance due to rapid depletion of the substrate (carbon/nitrogen source). The COD removal efficiency decreased from 96.28% at a HRT of 8 h to 90.67% at a HRT of 5 h. The removal efficiency of total nitrogen was reduced from 74.16% at a HRT of 8 h to 53.42% at a HRT of 5 h. A shorter HRT decreased the efficiency in treatment of the pharmaceutical products (PPs), which included acetaminophen, ibuprofen and sulfamethoxazole in an aerobic reactor because these antibiotic compounds inhibited the microbial activity of the aerobic activated sludge in the MFC A/O system. The average power density and coulombic efficiency values were 162.74 mW m
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- 2018
31. Hip arthroscopy utilization and associated complications: a population-based analysis
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Ting J. Pan, Anil S. Ranawat, Johnathan A. Bernard, Stephen Lyman, Bryan T. Kelly, Danyal H. Nawabi, and Ryan M. Degen
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030222 orthopedics ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,MEDLINE ,Retrospective cohort study ,030229 sport sciences ,Population based ,Evidence-based medicine ,Readmission rate ,Arthroplasty ,3. Good health ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Hip arthroscopy ,business ,Complication ,Research Articles - Abstract
The purpose of this study is to review the trends in hip arthroscopy using data from a statewide database, focusing on utilization rates, patient demographics and complication rates. The Statewide Planning and Research Cooperative System (SPARCS) database for New York State was queried for cases of hip arthroscopy from 1998 to 2012. Patient demographics and procedural details were collected. Patients were subsequently reviewed for complications and readmissions within 30 and 90 days. In total, 12 194 hip arthroscopy procedures were performed by 295 surgeons in 137 centers between 1998 and 2012. There was a 95-fold increase in the annual frequency of hip arthroscopy procedures between 1998 (n = 24) and 2012 (n = 2296). Thirty-day complication rates were 0.2% (n = 19), whereas the 90-day complication rate was 0.3% (n = 30). The all-cause 30-day readmission rate was 0.5% (n = 66), whereas the 90-day rate was 1.6% (n = 200). The number of surgeons performing hip arthroscopy increased 7-fold over the observation period. However, only 14.9% (n = 44) of surgeons performed more than 30 procedures annually. Lower volume surgeons (163 cases/year, P
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- 2017
32. Evident black hole-bulge coevolution in the distant universe
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Guang Yang, W. N. Brandt, David M. Alexander, F. Vito, Fei-Fan Zhu, Q. Ni, and Chien-Ting J. Chen
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Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,education.field_of_study ,Supermassive black hole ,Stellar mass ,010308 nuclear & particles physics ,Population ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,01 natural sciences ,Galaxy ,Redshift ,Black hole ,Space and Planetary Science ,Bulge ,Astrophysics of Galaxies (astro-ph.GA) ,0103 physical sciences ,Bhar ,Astrophysics - High Energy Astrophysical Phenomena ,education ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
Observations in the local universe show a tight correlation between the masses of supermassive black holes (SMBHs; $M_{\rm BH}$) and host-galaxy bulges ($M_{\rm bulge}$), suggesting a strong connection between SMBH and bulge growth. However, direct evidence for such a connection in the distant universe remains elusive. We have studied sample-averaged SMBH accretion rate ($\overline{\rm BHAR}$) for bulge-dominated galaxies at $z=0.5-3$. While previous observations found $\overline{\rm BHAR}$ is strongly related to host-galaxy stellar mass ($M_\star$) for the overall galaxy population, our analyses show that, for the bulge-dominated population, $\overline{\rm BHAR}$ is mainly related to SFR rather than $M_\star$. This ${\overline{\rm BHAR}}$-SFR relation is highly significant, e.g. $9.0\sigma$ (Pearson statistic) at $z=0.5-1.5$. Such a $\overline{\rm BHAR}$-SFR connection does not exist among our comparison sample of galaxies that are not bulge-dominated, for which $M_\star$ appears to be the main determinant of SMBH accretion. This difference between the bulge-dominated and comparison samples indicates that SMBHs only coevolve with bulges rather than the entire galaxies, explaining the tightness of the local $M_{\rm BH}$-$M_{\rm bulge}$ correlation. Our best-fit $\overline{\rm BHAR}$-SFR relation for the bulge-dominated sample is $\log\overline{\rm BHAR} = \log\mathrm{SFR} - (2.48\pm0.05)$ (solar units). The best-fit $\overline{\rm BHAR}/\mathrm{SFR}$ ratio ($10^{-2.48}$) for bulge-dominated galaxies is similar to the observed $M_{\rm BH}/M_{\rm bulge}$ values in the local universe. Our results reveal that SMBH and bulge growth are in lockstep, and thus non-causal scenarios of merger averaging are unlikely the origin of the $M_{\rm BH}$-$M_{\rm bulge}$ correlation. This lockstep growth also predicts that the $M_{\rm BH}$-$M_{\rm bulge}$ relation should not have strong redshift dependence., Comment: 18 Pages, 11 figures, 4 tables; MNRAS accepted
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- 2019
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33. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities
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Shah P, Lui K, Reichman B, Norman M, Kusuda S, Lehtonen L, Adams M, Vento M, Darlow B, Modi N, Rusconi F, Hakansson S, San Feliciano L, Helenius K, Bassler D, Hirano S, Lee S, Marshall P, Schmidt P, Dhawan A, Craven P, de Waal K, Simmer K, Gill A, Pillow J, Stack J, Birch P, Cooke L, Casalaz D, Holberton J, Stewart A, Downe L, Stewart M, Bajuk B, Berry A, Hunt R, Kilburn C, De Paoli T, Bolisetty S, Paradisis M, Rieger I, Koorts P, Kuschel C, Numa A, Carlisle H, Badawi N, Loughran-Fowlds A, Koh G, Davis J, Luig M, Andersen C, Chambers G, Austin N, Lynn A, Edmonds L, Mildenhall L, Buksh M, Battin M, van den Boom J, Bourchier D, Richardson V, Dineen F, Rajadurai V, Fung G, Harrison A, Synnes A, Ting J, Cieslak Z, Sherlock R, Yee W, Aziz K, Toye J, Fajardo C, Kalapesi Z, Sankaran K, Daspal S, Seshia M, Alvaro R, Mukerji A, Da Silva O, Nwaesei C, Lee K, Dunn M, Lemyre B, Dow K, Pelausa E, Barrington K, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Mabry H, Ojah C, Monterrosa L, Deshpandey A, Afifi J, Kajetanowicz A, Andersson S, Tammela O, Sankilampi U, Saarela T, Prazad P, Noguchi A, McWan K, Button B, Stratton W, Hamvus A, Raghaven A, Derrick M, Hadley R, Covert R, Lablanc O, Weiss M, Bell A, Shareef M, Silvestri J, Heymann E, Zangen S, Smolkin T, Mimouni F, Bader D, Rothschild A, Strauss Z, Felszer C, Oman H, Toy-Friedman S, Bar-Oz B, Feldman M, Saad N, Flidel-Rimon O, Weisbrod M, Lubin D, Litmanovitz I, Kngelman A, Shinwell E, Klinger G, Nijim Y, Bin-Nun A, Golan A, Mandel D, Fleisher-Sheffer V, Kohelet D, Bakhrakh L, Hattori S, Shirai M, Ishioka T, Mori T, Amiznka T, Huchimukai T, Yoshida H, Sasaki A, Shimizu J, Nakamura T, Maruyama M, Matsumoto H, Hosokawa S, Taki A, Nakagawa M, Ko K, Uozumi A, Nakata S, Shimazaki A, Yoda T, Numata O, Imamura H, Kobayashi A, Tokuriki S, Uchida Y, Arai T, Ito M, Ieda K, Ono T, Hayashi M, Maki K, Yamakawa M, Kawai M, Fujii N, Shiomi K, Nozaki K, Wada H, Kim T, Tokunaga Y, Takatera A, Oshima T, Sumida H, Michinomae Y, Knsumoto Y, Yoshimoto S, Morisawa T, Ohashi T, Takahashi Y, Sugimoto M, Ono N, Miyagawa S, Saijo T, Yamagami T, Koyano K, Kobayashi S, Kanda T, Sakemi Y, Aoki M, Iida K, Goshi M, Maruyama Y, Avila-Alvarez A, Fernandez-Trisac J, Pico M, Seara M, Gutierrez A, Vizcaino C, Iglesias M, Zaplana H, Colomer B, Lopez J, Mozo R, Martinez M, Sebastian M, Carbonell M, Bamnsell J, Puiggros M, Aloy J, Mussons F, Sanz I, Galiana G, Coroleu W, Iriondo M, Vilella L, Porta R, Demestre X, Nadal S, Martinez C, Cuesta M, Mora D, Tardio J, Benavente I, Alonso A, Olmos R, Cabezas M, Jimenez M, Caballero M, Diaz M, Fagundo A, Canals L, Rodrigo F, Marti L, Galdo M, Suazo J, Lopez E, Fernandez J, Altana M, Navarro D, Dominguez M, del Prado M, Diez I, Benavides M, Lapena S, Prada T, Mir E, Sanchez A, Vega E, del Prado N, Fernandez C, Vilaplana L, Perez I, Gomez L, Comeche L, Martin I, Armengod C, Labian C, Munoz M, Bravo D, Perez V, Fernandez M, Gonzalez C, Segura S, Azorin M, Jimenez A, Sanchez-Tamayo T, Moreno E, Gonzalez M, Martinez J, Garcia J, Orayen C, Gonzalez J, Albo M, Colmenero E, Gonzalez E, del Arco B, Gordillo L, Asensio M, Diaz C, Albujar M, Jorge P, Romero S, Falero M, Izquierdo A, Capell J, Macian M, Vicente M, Caballero R, Euba A, Serna A, Goya J, Legorburu A, Amoros A, Isabel V, Gonzalez N, Gracia S, Faci M, Villagrasa M, Kofron J, Brodd K, Odlind A, Alberg L, Arwehed S, Hafstrom O, Kasemo A, Nederman K, Ahman L, Ingemarsson F, Petersson H, Thum P, Albinsson E, Selander B, Abrahamsson T, Heimdahl I, Sveinsdottir K, Wejryd E, Hedlund A, Soderberg M, Hallberg B, Brune T, Backstrom J, Robinson J, Farooqi A, Normann E, Fredriksson M, Palm A, Rosenqvist U, Hagman C, Ohlin A, Floral R, Smedsaas-Lofvenberg A, Meyer P, Anderegg C, Schulzke S, Nelle M, Wagner B, Riedel T, Kaczala G, Walde B, Pfister R, Tolsa J, Roth M, Stocker M, Laubscher B, Malzacher A, Micallef J, Hegi L, Arlettaz R, Bernet V, Dani C, Fiorini P, Boldrini A, Tomasini B, Mittal A, Kefas J, Kamalanathan A, Jayachandran, Yoxall B, McBride T, Webb D, Garr R, Hassan A, Ambadkar P, Dyke M, McDevitt K, Rewitzky G, D'Amore A, Panasa N, Settle P, Maddock N, Edi-Osagie N, Zipitis C, Heal C, Birch J, Hasib A, Soe A, Kumar N, Kisat H, Vasu V, Lama M, Gupta R, Rawlingson C, Wickham T, Theron M, Kendall G, Gupta A, Aladangady N, Ali I, Alsford L, Lopez W, Murthy V, Sullivan C, Thomas M, Bate T, Godambe S, Watts T, Kuna J, Chang J, Pai V, Huddy C, Yasin S, Nicholl R, Pandey P, Kairamkonda V, Muogbo D, Harry L, Simmons P, Nycyk J, Gallagher A, Pillay T, Deshpande S, Mahadevan, Moore A, Clark S, Garbash M, Lal M, Abu-Harb M, Allwood A, Selter M, Munyard P, Bartle D, Paul S, Whincup G, Mallik A, Amess P, Godden C, Reynolds P, Misra I, De Halpert P, Salgia S, Sanghavi R, Wigfield R, Deketelaere A, Khashu M, Hall M, Groves C, Brown N, Brennan N, Vamvakiti K, McIntyre J, Pirie S, Jones S, Mannix P, Cairns P, Eaton M, Schwarz K, Gibson D, Miall L, Krishnamurthy, and Int Network Evaluating Outcomes iN
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outcomes research ,neonatal intensive care ,Preterm infants - Abstract
Neonates born very preterm (before 32 weeks' gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.
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- 2019
34. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries
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Lui K, Lee S, Kusuda S, Adams M, Vento M, Reichman B, Darlow B, Lehtonen L, Modi N, Norman M, Hakansson S, Bassler D, Rusconi F, Lodha A, Yang J, Shah P, Marshall P, Schmidt P, Dhawan A, Craven P, de Waal K, Simmer K, Gill A, Pillow J, Stack J, Birch P, Cooke L, Casalaz D, Holberton J, Stewart A, Downe L, Stewart M, Bajuk B, Berry A, Hunt R, Kilburn C, De Paoli T, Bolisetty S, Paradisis M, Rieger I, Koorts P, Kuschel C, Doyle L, Numa A, Carlisle H, Badawi N, Loughran-Fowlds A, Koh G, Davis J, Luig M, Andersen C, Chambers G, Austin N, Lynn A, Edmonds L, Mildenhall L, Buksh M, Battin M, van den Boom J, Bourchier D, Richardson V, Dineen F, Rajadurai V, Lam S, Fung G, Harrison A, Synnes A, Cieslak Z, Sherlock R, Yee W, Aziz K, Fajardo C, Kalapesi Z, Sankaran K, Daspal S, Seshia M, Alvaro R, Mukerji A, Da Silva O, Nwaesei C, Lee K, Dunn M, Lemyre B, Dow K, Pelausa E, Barrington K, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Makary H, Ojah C, Monterrosa L, Deshpandey A, Afifi J, Kajetanowicz A, Andersson S, Tammela O, Sankilampi U, Saarela T, Prazad P, Noguchi A, McWan K, Button B, Stratton W, Hamvus A, Raghaven A, Derrick M, Hadley R, Covert R, Lablanc O, Weiss M, Bell A, Shareef M, Silvestri J, Heymann E, Zangen S, Smolkin T, Mimouni F, Bader D, Rothschild A, Strauss Z, Felszer C, Omari H, Tov-Friedman S, Bar-Oz B, Feldman M, Saad N, Flidel-Rimon O, Weisbrod M, Lubin D, Litmanovitz I, Kugelman A, Shinwell E, Klinger G, Nijim Y, Bin-Nun A, Golan A, Mandel D, Fleisher-Sheffer V, Kohelet D, Bakhrakh L, Hattori S, Shirai M, Ishioka T, Mori T, Amizuka T, Huchimukai T, Yoshida H, Sasaki A, Shimizu J, Nakamura T, Maruyama M, Matsumoto H, Hosokawa S, Taki A, Nakagawa M, Ko K, Uozumi A, Nakata S, Shimazaki A, Yoda T, Numata O, Imamura H, Kobayashi A, Tokuriki S, Uchida Y, Arai T, Ito M, Ieda K, Ono T, Hayashi M, Maki K, Yamakawa M, Kawai M, Fujii N, Shiomi K, Nozaki K, Wada H, Kim T, Tokunaga Y, Takatera A, Oshima T, Sumida H, Michinomae Y, Kusumoto Y, Yoshimoto S, Morisawa T, Ohashi T, Takahashi Y, Sugimoto M, Ono N, Miyagawa S, Saijo T, Yamagami T, Koyano K, Kobayashi S, Kanda T, Sakemi Y, Aoki M, Iida K, Goshi M, Maruyama Y, Avila-Alvarez A, Ting J, Toye J, Fernandez-Trisac J, Pico M, Seara M, Gutierrez A, Vizcaino C, Iglesias M, Zaplana H, Colomer B, Lopez J, Mozo R, Martinez M, Sebastian M, Carbonell M, Barnusell J, Puiggros M, Aloy J, Mussons F, Sanz I, Galiana G, Coroleu W, Iriondo M, Vilella L, Porta R, Demestre X, Nadal S, Martinez C, Cuesta M, Mora D, Tardio J, Benavente I, Alonso A, Olmos R, Cabezas M, Jimenez M, Caballero P, Diaz M, Fagundo A, Canals L, Rodrigo F, Marti L, Galdo M, Suazo J, Lopez E, Fernandez J, Altuna M, Muga O, Navarro D, Dominguez M, del Prado M, Diez I, Benavides M, Lapena S, Prada T, Mir E, Sanchez A, Vega E, del Prado N, Fernandez C, Vilaplana L, Perez I, Gomez L, Comeche L, Martin I, Armengod C, Labian C, Munoz M, Bravo D, Perez V, Fernandez M, Gonzalez C, Segura S, Azorin M, Jimenez A, Sanchez-Tamayo T, Moreno E, Gonzalez M, Martinez J, Garcia J, Orayen C, Gonzalez J, Albo M, Colmenero E, Gonzalez E, del Arco B, Gordillo L, Asensio M, Diaz C, Albujar R, Jorge P, Romero S, Falero M, Izquierdo A, Capell J, Vicente M, Caballero R, Euba A, Serna A, Goya J, Legorburu A, Amoros A, Isabel V, Gonzalez N, Gracia S, Faci P, Villagrasa M, Macian M, Kofron J, Brodd K, Odlind A, Alberg L, Arwehed S, Hafstrom O, Kasemo A, Nederman K, Ahman L, Ingemarsson F, Petersson H, Thurn P, Albinsson E, Selander B, Abrahamsson T, Heimdahl I, Sveinsdottir K, Wejryd E, Hedlund A, Soderberg M, Hallberg B, Brune T, Backstrom J, Robinson J, Farooqi A, Normann E, Fredriksson M, Palm A, Rosenqvist U, Walde B, Hagman C, Ohlin A, Florell R, Smedsaas-Lofvenberg A, Meyer P, Anderegg C, Schulzke S, Nelle M, Wagner B, Riedel T, Kaczala G, Pfister R, Tolsa J, Roth M, Stocker M, Laubscher B, Malzacher A, Micallef J, Hegi L, Arlettaz R, Bernet V, Fiorini P, Boldrini A, Tomasini B, Kefas J, Kamalanathan A, Jayachandran, Yoxall B, McBride T, Webb D, Garr R, Hassan A, Ambadkar P, Dyke M, McDevitt K, Rewitzky G, D'Amore A, Panasa N, Settle P, Maddock N, Edi-Osagie N, Zipitis C, Heal C, Birch J, Hasib A, Soe A, Kumar N, Kisat H, Vasu V, Lama M, Gupta R, Rawlingson C, Wickham T, Theron M, Kendall G, Gupta A, Aladangady N, Ali I, Alsford L, Lopez W, Murthy V, Sullivan C, Thomas M, Bate T, Godambe S, Watts T, Kuna J, Chang J, Pai V, Huddy C, Yasin S, Nicholl R, Pandey P, Cusack J, Kairamkonda V, Muogbo D, Harry L, Simmons P, Nycyk J, Gallagher A, Pillay T, Deshpande S, Mahadevan, Moore A, Clark S, Garbash M, Lal M, Abu-Harb M, Dani C, Mittal A, Allwood A, Selter M, Munyard P, Bartle D, Paul S, Whincup G, Mallik A, Amess P, Godden C, Reynolds P, Misra I, De Halpert P, Salgia S, Sanghavi R, Wigfield R, Deketelaere A, Khashu M, Hall M, Groves C, Brown N, Brennan N, Vamvakiti K, McIntyre J, Pirie S, Jones S, Mannix P, Cairns P, Eaton M, Schwarz K, Gibson D, Miall L, Krishnamurthy, and Int Network Evaluation Outcomes iN
- Abstract
Objective To evaluate outcome trends of neonates born very preterm in 11 high-income countries participating in the International Network for Evaluating Outcomes of neonates. Study design In a retrospective cohort study, we included 154 233 neonates admitted to 529 neonatal units between January 1, 2007, and December 31, 2015, at 24(0/7) to 31(6/7) weeks of gestational age and birth weight
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- 2019
35. Does black-hole growth depend fundamentally on host-galaxy compactness?
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W. N. Brandt, Q. Ni, Birong Luo, Yongquan Xue, Guang Yang, Chien-Ting J. Chen, F. Vito, and David M. Alexander
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Physics ,Stellar mass ,010308 nuclear & particles physics ,Star formation ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,01 natural sciences ,Galaxy ,Accretion (astrophysics) ,Black hole ,Accretion rate ,Compact space ,Space and Planetary Science ,Primary (astronomy) ,Astrophysics of Galaxies (astro-ph.GA) ,0103 physical sciences ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
Possible connections between central black-hole (BH) growth and host-galaxy compactness have been found observationally, which may provide insight into BH-galaxy coevolution: compact galaxies might have large amounts of gas in their centers due to their high mass-to-size ratios, and simulations predict that high central gas density can boost BH accretion. However, it is not yet clear if BH growth is fundamentally related to the compactness of the host galaxy, due to observational degeneracies between compactness, stellar mass ($M_\bigstar$), and star formation rate (SFR). To break these degeneracies, we carry out systematic partial-correlation studies to investigate the dependence of sample-averaged BH accretion rate ($\rm \overline{BHAR}$) on the compactness of host galaxies, represented by the surface-mass density, $\Sigma_\rm e$, or the projected central surface-mass density within 1 kpc, $\Sigma_1$. We utilize 8842 galaxies with H < 24.5 in the five CANDELS fields at z = 0.5-3. We find that $\rm \overline{BHAR}$ does not significantly depend on compactness when controlling for SFR or $M_\bigstar$ among bulge-dominated galaxies and galaxies that are not dominated by bulges, respectively. However, when testing is confined to star-forming galaxies at z = 0.5-1.5, we find that the $\rm \overline{BHAR}$-$\Sigma_1$ relation is not simply a secondary manifestation of a primary $\rm \overline{BHAR}$-$M_\bigstar$ relation, which may indicate a link between BH growth and the gas density within the central 1 kpc of galaxies., Comment: 21 pages, 20 figures. Accepted for publication in MNRAS
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- 2019
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36. The Chandra Deep Wide-field Survey: A New Chandra Legacy Survey in the Boötes Field. I. X-Ray Point Source Catalog, Number Counts, and Multiwavelength Counterparts
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Stephen S. Murray, Christine Jones, Alexey Vikhlinin, Anthony H. Gonzalez, Kevin N. Hainline, M. A. DiPompeo, Ryan C. Hickox, Richard G. Bower, Daniel Stern, Kenneth Duncan, Michael J. I. Brown, Eric D. Miller, Alberto Masini, Peter Eisenhardt, Andrew Ptak, James Aird, William R. Forman, David M. Alexander, Chien-Ting J. Chen, Mark Brodwin, Christopher S. Kochanek, David A. Wake, A. Stanford, Ralph P. Kraft, James Mullaney, Buell T. Jannuzi, Christopher M. Carroll, Andy D. Goulding, Roberto J. Assef, Adam D. Myers, Arjun Dey, Suchetana Chatterjee, and Kyoung-Soo Lee
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Physics ,X-ray astronomy ,Active galactic nucleus ,COSMIC cancer database ,010504 meteorology & atmospheric sciences ,Point source ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy and Astrophysics ,BOOTES ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,01 natural sciences ,Redshift ,Space and Planetary Science ,Observatory ,0103 physical sciences ,Catalog Number ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences - Abstract
We present a new, ambitious survey performed with the Chandra X-ray Observatory of the 9.3 deg$^2$ Bo\"otes field of the NOAO Deep Wide-Field Survey. The wide field probes a statistically representative volume of the Universe at high redshift. The Chandra Deep Wide-Field Survey exploits the excellent sensitivity and angular resolution of Chandra over a wide area, combining 281 observations spanning 15 years, for a total exposure time of 3.4 Ms, and detects 6891 X-ray point sources down to limiting fluxes of $4.7\times10^{-16}$, $1.5\times10^{-16}$, and $9\times10^{-16}$ erg cm$^{-2}$ s$^{-1}$, in the $0.5-7$ keV, $0.5-2$ keV, and $2-7$ keV bands, respectively. The robustness and reliability of the detection strategy is validated through extensive, state-of-the-art simulations of the whole field. Accurate number counts, in good agreement with previous X-ray surveys, are derived thanks to the uniquely large number of point sources detected, which resolve $65.0 \pm 12.8\%$ of the cosmic X-ray background between $0.5-2$ keV and $81.0 \pm 11.5\%$ between $2-7$ keV. Exploiting the wealth of multi-wavelength data available on the field, we assign redshifts to $\sim 94\%$ of the X-ray sources, estimate their obscuration and derive absorption-corrected luminosities. We provide an electronic catalog containing all the relevant quantities needed for future investigations., Comment: Accepted for publication in ApJS. The catalogs associated to this paper can be accessed at http://www.dartmouth.edu/~hickox/cdwfs.php
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- 2020
37. The XMM-SERVS survey: new XMM–Newton point-source catalogue for the XMM-LSS field
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Jonathan R. Trump, Ian Smail, Ray P. Norris, Chien-Ting J. Chen, David M. Alexander, Franz E. Bauer, Paolo Tozzi, Kristina Nyland, B. Häußler, Ohad Shemmer, D. D. Kelson, Mouyuan Sun, Matt J. Jarvis, Piero Ranalli, Michele Cirasuolo, John D. Silverman, Maurizio Paolillo, Mark Lacy, W. N. Brandt, Fabio Vito, M. Banerji, Roberto Gilli, Guang Yang, Bret D. Lehmer, Donald P. Schneider, Kate Chow, Yongquan Xue, Mattia Vaccari, Masayuki Tanaka, B. Luo, Cristian Vignali, Chen, C.-T.J., Brandt, W.N., Luo, B., Ranalli, P., Yang, G., Alexander, D.M., Bauer, F.E., Kelson, D.D., Lacy, M., Nyland, K., Tozzi, P., Vito, F., Cirasuolo, M., Gilli, R., Jarvis, M.J., Lehmer, B.D., Paolillo, M., Schneider, D.P., Shemmer, O., Smail, I., Sun, M., Tanaka, M., Vaccari, M., Vignali, C., Xue, Y.Q., Banerji, M., Chow, K.E., Häußler, B., Norris, R.P., Silverman, J.D., Trump, J.R., Chen, C. -T. J., Brandt, W. N., Alexander, D. M., Bauer, F. E., Kelson, D. D., Jarvis, M. J., Lehmer, B. D., Schneider, D. P., Xue, Y. Q., Chow, K. E., Norris, R. P., Silverman, J. D., Trump, J. R., ITA, USA, GBR, DEU, JPN, and CHN
- Subjects
Field (physics) ,Point source ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,FOS: Physical sciences ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Photometry (optics) ,0103 physical sciences ,Scale structure ,Survey ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics ,Physics ,010308 nuclear & particles physics ,Astronomy and Astrophysics ,Galaxies: active ,Astronomy and Astrophysic ,Astrophysics - Astrophysics of Galaxies ,Redshift ,Quasars: general ,X-rays: galaxies ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,catalogue ,X-rays: galaxie - Abstract
We present an X-ray point-source catalog from the XMM-Large Scale Structure survey region (XMM-LSS), one of the XMM-Spitzer Extragalactic Representative Volume Survey (XMM-SERVS) fields. We target the XMM-LSS region with $1.3$ Ms of new XMM-Newton AO-15 observations, transforming the archival X-ray coverage in this region into a 5.3 deg$^2$ contiguous field with uniform X-ray coverage totaling $2.7$ Ms of flare-filtered exposure, with a $46$ ks median PN exposure time. We provide an X-ray catalog of 5242 sources detected in the soft (0.5-2 keV), hard (2-10 keV), and/or full (0.5-10 keV) bands with a 1% expected spurious fraction determined from simulations. A total of 2381 new X-ray sources are detected compared to previous source catalogs in the same area. Our survey has flux limits of $1.7\times10^{-15}$, $1.3\times10^{-14}$, and $6.5\times10^{-15}$ erg cm$^{-2}$ s$^{-1}$ over 90% of its area in the soft, hard, and full bands, respectively, which is comparable to those of the XMM-COSMOS survey. We identify multiwavelength counterpart candidates for 99.9% of the X-ray sources, of which 93% are considered as reliable based on their matching likelihood ratios. The reliabilities of these high-likelihood-ratio counterparts are further confirmed to be $\approx 97$% reliable based on deep Chandra coverage over $\approx 5$% of the XMM-LSS region. Results of multiwavelength identifications are also included in the source catalog, along with basic optical-to-infrared photometry and spectroscopic redshifts from publicly available surveys. We compute photometric redshifts for X-ray sources in 4.5 deg$^2$ of our field where forced-aperture multi-band photometry is available; $>70$% of the X-ray sources in this subfield have either spectroscopic or high-quality photometric redshifts., MNRAS, accepted. 34 pages, 25 figures, and 8 tables. The data products are available at this http url: http://personal.psu.edu/wnb3/xmmservs/xmmservs.html
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- 2018
38. Flexible Blade-Coated Multicolor Polymer Light-Emitting Diodes for Optoelectronic Sensors
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Han, D, Khan, Y, Ting, J, King, SM, Yaacobi-Gross, N, Humphries, MJ, Newsome, CJ, and Arias, AC
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Engineering ,blade coating ,wearable sensors ,printed sensors ,Physical Sciences ,Chemical Sciences ,polymer light-emitting diodes ,organic light-emitting diodes ,Nanoscience & Nanotechnology ,flexible electronics ,pulse oximetry - Abstract
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A method to print two materials of different functionality during the same printing step is presented. In printed electronics, devices are built layer by layer and conventionally only one type of material is deposited in one pass. Here, the challenges involving printing of two emissive materials to form polymer light-emitting diodes (PLEDs) that emit light of different wavelengths without any significant changes in the device characteristics are described. The surface-energy-patterning technique is utilized to print materials in regions of interest. This technique proves beneficial in reducing the amount of ink used during blade coating and improving the reproducibility of printed films. A variety of colors (green, red, and near-infrared) are demonstrated and characterized. This is the first known attempt to print multiple materials by blade coating. These devices are further used in conjunction with a commercially available photodiode to perform blood oxygenation measurements on the wrist, where common accessories are worn. Prior to actual application, the threshold conditions for each color are discussed, in order to acquire a stable and reproducible photoplethysmogram (PPG) signal. Finally, based on the conditions, PPG and oxygenation measurements are successfully performed on the wrist with green and red PLEDs.
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- 2017
39. Risk of failure of primary hip arthroscopy-a population-based study
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Brenda Chang, Peter Chamberlin, Danyal H. Nawabi, Nabil Mehta, Ryan M. Degen, Ting J. Pan, Anil S. Ranawat, Bryan T. Kelly, and Stephen Lyman
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030222 orthopedics ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Arthroscopy ,030229 sport sciences ,Lower risk ,Arthroplasty ,Confidence interval ,3. Good health ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Hip arthroscopy ,business ,Survival rate ,Survival analysis ,Research Articles - Abstract
The aims of this study are (i) to report on the rates of subsequent surgery following hip arthroscopy and (ii) to identify prognostic variables associated with revision surgery, survival rates and complication rates. The Statewide Planning and Research Cooperative System database, a census of hospital admissions and ambulatory surgery in New York State, was used to identify cases of primary hip arthroscopy. Demographic information and rates of subsequent revision hip arthroscopy or arthroplasty were collected. The risks were modeled with use of age, sex, procedure and surgeon volume as risk factors. Survival analyses were also performed, and 30-day complication was recorded. We identified 8267 procedures in 7836 patients from 1998 to 2012. Revision surgery occurred in 1087 cases (13.2%) at a mean of 1.7 ± 1.6 (mean ± SD) years. Revision arthroscopy accounted for 311 cases (3.8%), and arthroplasty for 796 (9.7%) cases. Survival analysis showed a 2-year survival rate of 88.1%, 5-year of 80.7% and 10-year of 74.9%. Regression analysis revealed that age >50 years [hazard ratio (HR) 2.09; confidence interval (CI) 1.82–2.39, P 164 cases/year) resulted in a lower risk of re-operation versus lower volume (
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- 2017
40. Hard X-ray selected AGNs in low-mass galaxies from the NuSTAR serendipitous survey
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David M. Alexander, Daniel Stern, Claudio Ricci, Chien-Ting J. Chen, Poshak Gandhi, Bin Luo, Fiona A. Harrison, Lauranne Lanz, George B. Lansbury, Michael Koss, James Mullaney, Amy E. Reines, W. N. Brandt, Franz E. Bauer, Ryan C. Hickox, A. Del Moro, and Jonathan R. Trump
- Subjects
Physics ,Active galactic nucleus ,Demographics ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,X-ray ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Sample (graphics) ,Astrophysics - Astrophysics of Galaxies ,Galaxy ,Redshift ,Space and Planetary Science ,Sample size determination ,Astrophysics of Galaxies (astro-ph.GA) ,0103 physical sciences ,Low Mass ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
We present a sample of 10 low-mass active galactic nuclei (AGNs) selected from the 40-month NuSTAR serendipitous survey. The sample is selected to have robust NuSTAR detections at $3 - 24$~keV, to be at $z < 0.3$, and to have optical r-band magnitudes at least 0.5~mag fainter than an $L_\star$ galaxy at its redshift. The median values of absolute magnitude, stellar mass and 2--10 X-ray luminosity of our sample are $\langle M_r\rangle = -20.03$, $\langle M_\star\rangle = 4.6\times10^{9}M_\odot$, and $\langle L_{2-10\mathrm{keV}}\rangle = 3.1\times10^{42}$ erg s$^{-1}$, respectively. Five objects have detectable broad H$��$ emission in their optical spectra, indicating black-hole masses of $(1.1-10.4)\times 10^6 M_\odot$. We find that $30^{+17}_{-10}\%$ of the galaxies in our sample do not show AGN-like optical narrow emission lines, and one of the ten galaxies in our sample, J115851+4243.2, shows evidence for heavy X-ray absorption. This result implies that a non-negligible fraction of low-mass galaxies might harbor accreting massive black holes that are missed by optical spectroscopic surveys and $10$ keV) X-ray selected low-mass AGN sample size is still limited, our results show that sensitive NuSTAR observations are capable of probing faint hard X-ray emission originating from the nuclei of low-mass galaxies out to moderate redshift ($z, Accepted for publication in ApJ. 27 pages, 6 tables, 10 figures, including one online figure set available at https://ctjchen.github.io/ctc_nustardwarf_figset.pdf (v2: updated acknowledgement.)
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- 2017
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41. A correlation between star formation rate and average black hole accretion rate in star forming galaxies
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Ryan C. Hickox and Chien-Ting J. Chen
- Subjects
Physics ,Star formation ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,Astronomy and Astrophysics ,Quasar ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Galaxy merger ,Dwarf spheroidal galaxy ,Black hole ,Space and Planetary Science ,Elliptical galaxy ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Disc ,Lenticular galaxy ,Astrophysics::Galaxy Astrophysics - Abstract
We present the results of recent studies on the co-evolution of galaxies and the supermassive black holes (SMBHs) using Herschel far-infrared and Chandra X-ray observations in the Boötes survey region. For a sample of star-forming (SF) galaxies, we find a strong correlation between galactic star formation rate and the average SMBH accretion rate in SF galaxies. Recent studies have shown that star formation and AGN accretion are only weakly correlated for individual AGN, but this may be due to the short variability timescale of AGN relative to star formation. Averaging over the full AGN population yields a strong linear correlation between accretion and star formation, consistent with a simple picture in which the growth of SMBHs and their host galaxies are closely linked over galaxy evolution time scales.
- Published
- 2013
42. Search for displaced muonic lepton jets from light Higgs boson decay in proton–proton collisions at s=7 TeV with the ATLAS detector
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Xuai Zhuang, Samira Hassani, C. Da Via, J. Boek, Gregor Kasieczka, G. Bruni, Stefanie Adomeit, D. Liu, J. Keung, F. Etienne, Bellisario Esposito, G. Usai, B. Zabinski, Alexandra Tudorache, B. Butler, J. Hoffman, Frank Siegert, M. C. Tamsett, P. P. Allport, F. Koetsveld, T. Perez Cavalcanti, G. Zevi della Porta, K. Korcyl, Michele Pinamonti, Volker Büscher, J. L. Holzbauer, M. Hauschild, W. Wiedenmann, A. Wilson, Tancredi Carli, Roberto Cardarelli, C. García, Bruno Galhardo, E. S. Kuwertz, Remi Lafaye, C. Mattravers, S. Cole, E. Devetak, Elliot Hughes, K. Whalen, F. Garberson, V. Perez Reale, P. Weigell, U. K. Yang, C. Cuenca Almenar, D. Paredes Hernandez, Peter Jenni, I. Chalupkova, G. Lenzen, C. Conta, A. Krasznahorkay, Gideon Bella, M. Strang, B. A. Schumm, L. Liu, D. Fassouliotis, Rohin Narayan, E. Perez Codina, S. Mahmoud, S. J. Wollstadt, Jean-Francois Grivaz, M. C. Hodgkinson, Lucio Cerrito, J. Colas, E. Paganis, Julien Maurer, H. J. Burckhart, R. D. Harrington, Si Xie, M. Lokajicek, Manuela Venturi, W. Lampl, E. B. Klinkby, I. Turk Cakir, Tomoe Kishimoto, T. Nattermann, R. Piegaia, D. Caforio, C. L. Lampen, Armin Michael Nairz, E. Benhar Noccioli, E. Williams, F. Crescioli, V. Vacek, James Shank, Christian Weiser, Paolo Laurelli, Barbara Liberti, Philippe Mermod, N. Benekos, L. E. Price, Jan Andre Stillings, M. Villa, J. T. Childers, J. Dodd, Veronique Boisvert, G. Darbo, W. Ji, K. Cranmer, L. Mendoza Navas, Maurice Garcia-Sciveres, S. Bahinipati, A. DʼOrazio, M. Atkinson, B. Gibbard, E. W. Varnes, P. de Jong, T. Kanno, P. Radloff, Vincent Hedberg, D. O. Savu, L. Serkin, Yasuyuki Okumura, M. Mechtel, Kunihiro Nagano, T. Yamazaki, Yury Smirnov, N. Massol, G. V. Ybeles Smit, M. Teinturier, C. T. Potter, Ludovico Pontecorvo, N. Amram, A. Borisov, Robert Clarke, K. Benslama, M. T. Dova, P. S. Wells, M. A. Pleier, P. S. Mangeard, F. M. Brochu, Flera Rizatdinova, W. Kozanecki, T. Loddenkoetter, O. Rosenthal, Imma Riu, J. Mechnich, C. H. Wang, Valerio Ippolito, E. A. Ouellette, R. Simoniello, S. Nemecek, Gabriella Gaudio, P. Nemethy, C. Del Papa, S. Eckweiler, A. Napier, B. Caron, J. Idarraga, D. Roda Dos Santos, C. Zeitnitz, A. Palma, M. A. Dufour, A. T. Watson, J. Grosse-Knetter, G. Jones, Yoichi Ikegami, S. Kortner, C. Suhr, J. Odier, J. A. Gray, S. White, M. Schernau, V. Kus, Thomas Müller, Xiaohu Sun, Vadim Bednyakov, M. R. Sutton, M. Yamada, R. Spiwoks, Rainer Bartoldus, P. Hansson, Daniel Muenstermann, S. Patricelli, F. Vives Vaque, O. Simard, F. Pastore, M. Keil, Timothy Knight Nelson, Marianna Testa, Mauro Citterio, C. Topfel, Alexander Cheplakov, S. P. Baranov, S. R. Hou, S. Errede, Mossadek Talby, Evgenia Panagiotopoulou, B. Demirkoz, L. N. Smirnova, Andrzej Olszewski, V. Bartsch, A. Barbaro Galtieri, R. St. Denis, W. Bhimji, S. Bethke, M. Lungwitz, Graeme Stewart, M. He, M. Vanadia, Mattias Ellert, H. Wellenstein, W. J. Murray, A. Beddall, C. Lapoire, D. M. Rebuzzi, Diane Cinca, T. J. 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Taylor, Alexander Undrus, Konstantinos Karakostas, Lorenzo Feligioni, V. A. Giakoumopoulou, Irinel Caprini, Z. Kohout, Tatsuya Masubuchi, Oliver Keith Baker, W. S. Lockman, Daniel Whiteson, H. Kurashige, S. Laplace, C. Dallapiccola, M. Vlasak, Dmitri Tsybychev, R. L. McCarthy, O. Røhne, E. Torrence, Bradley Cox, Vladimir Peshekhonov, S. Johnert, C. Schiavi, S. Aefsky, John Alison, D. della Volpe, M. Moreno Llácer, M. Kurata, C. Pahl, M. C. N. Fiolhais, Frank Winklmeier, F. Bucci, Z. Zinonos, M. Lehmacher, R. Caloi, Umar Gul, M. A. Alam, J. A. Klinger, A. M. Rahimi, M. Ibbotson, Christine Kourkoumelis, M. Rybar, D. Barberis, Pedro Jorge, Sarah Heim, Mauro Iodice, S. V. Mouraviev, C. Bohm, V. Grassi, Monica Dunford, Ch Geich-Gimbel, S. Bedikian, Andreas Salzburger, J. Maneira, P. Loscutoff, J. Virzi, Ruggero Turra, F. Corriveau, B. Martin dit Latour, D. Boscherini, Woiciech Fedorko, Dorothee Schaile, Claudia Bertella, Michael Boehler, Metin Arik, F. Safai Tehrani, S. Pospisil, V. O. Tikhomirov, M. Davies, Alexey Anisenkov, T. Nunnemann, K. Edmonds, G. Duckeck, B. Aubert, A. Mengarelli, Ian Brock, R. Di Nardo, P. Hodgson, E. V. Bouhova-Thacker, V. Andrei, Federica Legger, Clara Troncon, R. Kowalewski, F. Wicek, Lukasz Zwalinski, I. Stumer, T. Hrynʼova, G. W. Brandenburg, Masaharu Nomachi, Christoph Rembser, J. Mc Donald, L. Chikovani, A. A. Minaenko, Agnieszka Leyko, E. Badescu, F. Friedrich, A. Rimoldi, Bartosz Mindur, Antonio Baroncelli, Ulrich Landgraf, L. de Mora, H. Yamaguchi, F. Cerutti, D. Errede, M. Franchini, G. Nunes Hanninger, M. J. Costa, A. Tykhonov, J. Petersen, N. Vranjes, K. M. Mercurio, S. Nektarijevic, M. Morii, Ryo Nagai, F. Ould-Saada, B. Guo, Valerio Dao, B. G. Fulsom, Holger Schulz, M. Medinnis, T. Kubota, C. Pizio, Yang Gao, A. Ruiz-Martinez, M. Uhlenbrock, Y. V. Grishkevich, Andrea Favareto, Enrico Tassi, F. Salvatore, H. Liao, Scarlet Norberg, J. G. Rocha de Lima, V. A. Schegelsky, R. Di Sipio, D. H. Saxon, J. R. Goddard, J. Kvita, I. M. Trigger, N. I. Zimin, M. Hohlfeld, X. Portell Bueso, L. De Nooij, A. S. Kozhin, A. J. Lowe, T. G. McCarthy, Ralf Hertenberger, D. Côté, Irakli Minashvili, A. A. Abdelalim, V. Giangiobbe, M. L. Gonzalez Silva, D. Gillberg, X. Ju, M. Kuze, Y. Azuma, Frank Paige, Else Lytken, S. Goldfarb, F. Broggi, T. Mclaughlan, D. Xu, Amanda R. Vest, Speranza Falciano, G. D. Carrillo-Montoya, P. Bernat, E. van der Poel, E. Gorini, Uladzimir Kruchonak, Gideon Alexander, Cristian Stanescu, P. J. Bell, P. Branchini, Sw. Banerjee, Mikhail Mineev, Ovsat Abdinov, C. Fukunaga, V. Kaushik, M. Ishitsuka, A. Manousakis-Katsikakis, A. Staude, Danuta Kisielewska, Allan G Clark, Roger Moore, N. Zhou, S. González de la Hoz, B. Yabsley, K. Hanawa, Kirika Uchida, Tatsumi Koi, S. Yamamoto, Sabine Crépé-Renaudin, P. Waller, L. Živković, Emmanuel Busato, T. Buanes, P. Klimek, C. Roda, J. Valenta, A. Bogouch, S. Mättig, Valerie Susanne Lang, T. Varol, Fred Hartjes, J. Wotschack, B. Fatholahzadeh, Hans Krüger, U. Soldevila, Howard Gordon, K. E. Selbach, Yosuke Takubo, David Berge, J. A. Aguilar-Saavedra, M. Cirilli, Z. L. Ren, C. A. Jung, Michela Biglietti, Miroslav Havranek, Fabienne Ledroit-Guillon, Vadim Kantserov, C. Cowden, V. Zutshi, L. S. Gomez Fajardo, H. Czirr, J. F. Marchand, M. Mazur, D. Wendland, Massimiliano Bellomo, S. De Castro, Y. Rozen, H-C. Schultz-Coulon, Nicola Venturi, Sergey Burdin, Dmitry Emeliyanov, J. C. Clemens, Yasuhiro Makida, V. Radescu, Steve McMahon, Robert Gardner, Stefan Schlenker, C. Isaksson, R. Ueno, T. Naumann, Margret Fincke-Keeler, R. P. Thun, S. P. Denisov, S. Oda, C. P. Ward, M. A. Thomson, M. Henke, A. Brandt, M. Giunta, M. C. Vetterli, Martin Spousta, I. J. Watson, B. Resende, S. P. Bieniek, Iftach Sadeh, Giacomo Polesello, D. Tsionou, M. Y. Kazarinov, P. A. Gorbounov, M. Livan, T. Kluge, A. L. Read, F. Grancagnolo, Christoph Falk Anders, M. S. Alam, Martin Kocian, M. Nash, Giuseppe Francesco Tartarelli, J. Llorente Merino, S. P. Amor Dos Santos, M. Karnevskiy, V. Consorti, Cedric Serfon, Florencia Canelli, Dirk Zerwas, S. Pashapour, Aleandro Nisati, Beate Heinemann, I. Dawson, B. Lund-Jensen, K. Stoerig, E. K. U. Gross, U. De Sanctis, T. Slavicek, Göran Jarlskog, M. Fehling-Kaschek, L. A. Kogan, S. Xella, J. Griffiths, Valentina Tudorache, S. F. Brazzale, F. Barreiro, A. Gomes, Kirsten Tollefson, M. Mikuž, K. E. Johansson, R. E. Blair, A. Dos Anjos, J. Ernwein, M. Battistin, Yousuke Kataoka, O. E. Vickey Boeriu, L. M. Mir, D. Goujdami, M. D. M. Capeans Garrido, P. Koevesarki, T. Beau, S. Pedraza Lopez, Marc Escalier, F. Podlyski, P. Schacht, G. E. Pospelov, W. Fernando, S. Franz, H. Duran Yildiz, Z. V. Krumshteyn, Kohei Yorita, P. Ruzicka, A. Bertin, Andree Robichaud-Veronneau, T. Sarangi, V. V. Zmouchko, Alfred Goshaw, Francesco Michelangelo Giorgi, L. Rinaldi, K. Tackmann, E. Sarkisyan-Grinbaum, E. Reinherz-Aronis, Federico Meloni, G. Colon, Andrea Catinaccio, W. Buttinger, A. G. Myagkov, B. H. Samset, J. A. Bogaerts, Timothy Barklow, J. Salt, N. Krieger, E. Oliver Garcia, Renat Sadykov, Rudiger Voss, Louise Skinnari, J. Love, S. Chen, K. Grybel, Akira Yamamoto, S. Thoma, I. Reisinger, H. Ten Kate, J. Ye, Simona Serena Bocchetta, J. E.M. Robinson, T. Ženiš, J. Rothberg, F. M. Newcomer, G. Chiefari, V. Castillo Gimenez, David Salek, Francesco Spanò, D. Robinson, S. Kreiss, U. Bratzler, O. M. Kind, A. Poblaguev, Giuseppe Salamanna, K. J. Anderson, L. Hooft van Huysduynen, Zuzana Rurikova, Alexander Bogdanchikov, T. Abajyan, M. Sandhoff, Anne Kathrin Becker, J. Solc, Takuya Nobe, S. Strandberg, R. Mameghani, O. Le Dortz, L. L. Ma, W. Mohr, J. B. De Vivie De Regie, Jan Kretzschmar, D. S. Damiani, K. Prokofiev, D. Wicke, A. Warburton, Eleni Mountricha, T. Barillari, Grigori Rybkin, B. Gaur, V. Nguyen Thi Hong, Carolina Gabaldon, O. M. Harris, R. Mackeprang, A. Harvey, V. Bansal, M. Johansen, S. W. Snow, E. Davies, J. de Graat, G. Mirabelli, Henso Abreu, A. S. Cerqueira, R. E. Long, S. Horner, M. Bianco, N. Soni, R. J. Hawkings, A. Hoummada, Lj. Simic, A. Hamilton, A. Shibata, T. Kittelmann, William Trischuk, A. Passeri, T. Djobava, Oxana Smirnova, T. Todorov, A. Renaud, Konstantinos Bachas, P. Giusti, R. D. Schamberger, Malte Backhaus, Pascal Pralavorio, Lamberto Luminari, Dong Su, I. Vichou, S. Rolli, R. Zaidan, M. Fiascaris, J. A. Frost, Kristian Peters, K. Lie, Gabriella Sciolla, Y. Munwes, G. Fischer, Louis Fayard, K. Perez, G. Zobernig, L. A. Thomsen, G. Unel, P. Lichard, C. P. Marino, F. Marchese, Valery Pozdnyakov, V. Gratchev, Jean-Francois Laporte, J. Lundberg, E. Carquin, C. Schroeder, Fabrice Hubaut, P. Pais, C. G. Lester, S. Kuleshov, Kazunori Hanagaki, G. Nanava, K. Kiuchi, L. Fabbri, C. A. Solans, Marcello Borri, Charles Leggett, Fabian Huegging, A. M. Zaitsev, M. Mazzanti, A. A. Carter, M. Miñano Moya, Giacomo Artoni, R. C.W. Henderson, V. I. Rud, James Howarth, S. Sultansoy, V. Zhuravlov, Stephen Haywood, Sotirios Vlachos, A. Redelbach, David Miller, A. Ochi, Vladimir Vinogradov, W. Iwanski, Gabriel Stoicea, R. Staszewski, Marcella Capua, Alessandra Doria, and E. Chareyre
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Physics ,Nuclear and High Energy Physics ,Particle physics ,Muon ,Large Hadron Collider ,010308 nuclear & particles physics ,Atlas detector ,Astrophysics::High Energy Astrophysical Phenomena ,01 natural sciences ,Collimated light ,Nuclear physics ,Massless particle ,Hidden sector ,0103 physical sciences ,Higgs boson ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,Nuclear Experiment ,010306 general physics ,Lepton - Abstract
A search is performed for collimated muon pairs displaced from the primary vertex produced in the decay of long-lived neutral particles in proton-proton collisions at root s = 7 TeV centre-of-mass ...
- Published
- 2013
43. Intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: a systematic review and meta-analysis
- Author
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Yu C, Huang, Yu N, Chien, Yu T, Chen, Yu C, Li, and Ting J, Chen
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Adult ,Dose-Response Relationship, Drug ,Stevens-Johnson Syndrome ,Humans ,Immunoglobulins, Intravenous ,Immunologic Factors ,Randomized Controlled Trials as Topic - Abstract
The efficacy of intravenous immunoglobulin (IVIg) for toxic epidermal necrolysis (TEN) remains controversial, particularly for high-dose IVIg. In the present study, we conducted a SCORTEN (SCORe of Toxic Epidermal Necrosis)-based standardized mortality ratio (SMR) meta-analysis, with a focus on the efficacy of high-dose IVIg.A systematic review and meta-analysis of the literature published between January 01, 2000 and April 30, 2016 was conducted. Studies with9 TEN patients receiving IVIg treatment with SCORTEN scores were included.Mortality rate and pooled SMR were calculated for all TEN patients and adult TEN patients receiving IVIg. Eleven studies met the inclusion criteria. The overall mortality rate of TEN patients treated with IVIg was 24.2%, with a pooled SMR of 1.00 (95% CI, 0.76-1.32; I2=0%, P=0.67). The mortality rate among adult patients treated with high-dose IVIg was 11.7%. Sub-analysis of adult patients treated with high-dose IVIg showed a pooled SMR of 0.99 (95% CI, 0.60-1.63; I2=0%, P=0.78).The findings of the present meta-analysis do not support the clinical benefits of IVIg for TEN, even at high-doses. Additional randomized controlled trials are required to validate this result.
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- 2016
44. Effect of inclined roof on the airflow associated with a wind driven turbine ventilator
- Author
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Shao Ting J. Lien and Noor A. Ahmed
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Engineering ,business.industry ,Mechanical Engineering ,Airflow ,Natural ventilation ,Building and Construction ,Aerodynamics ,Static pressure ,Structural engineering ,Turbine ,Wind speed ,law.invention ,law ,Ventilation (architecture) ,Electrical and Electronic Engineering ,business ,Roof ,Civil and Structural Engineering ,Marine engineering - Abstract
Rotating wind driven turbine ventilator has been used as cost-effective environmental friendly natural ventilation device. Rotating wind driven turbine ventilator type of device is usually installed on the rooftop to extract air extract air flow from a building to improve air quality and comfort. Performance investigations carried thus far on turbine ventilator have ignored the effect of the inclination on rooftop. An experimental program was, therefore, formulated at the aerodynamic laboratory of the University of New South Wales to study such effect on a simulated rooftop. The results obtained from the measured forces and rotational speeds on different configurations indicate that the effect is minimal in extracting air from a building at low wind speed. The static pressure and skin friction distributions on the simulated roof further supports this finding. Two important conclusions can be drawn from the present investigation: firstly, the presence of the inclined roof may extend the safety margin in the operation of a turbine ventilator at high wind speed by reducing the magnitude of the total force that acts on the ventilator; secondly the dependency of the total fore on low Reynolds number suggests that the efficiency and reliability of operation of such ventilator should be boosted through the provision of other power source such as solar power at low wind speed.
- Published
- 2011
45. Enrollment in Clinical Trials Correlates with Improved Survival in Metastatic Melanoma
- Author
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Russell S. Berman, Nagashree Seetharamu, Paul J. Christos, Richard L. Shapiro, Patrick A. Ott, Ting J. Tu, Iman Osman, and Anna C. Pavlick
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Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Multivariate statistics ,Skin Neoplasms ,Multivariate analysis ,Survival ,Metastasis ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Melanoma ,Survival analysis ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Clinical Trials as Topic ,Proportional hazards model ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Surgery ,Clinical trial ,Multivariate Analysis ,Female ,business ,Follow-Up Studies - Abstract
Background: Although the current median survival time of stage-IV melanoma patients is less than 12 months, there is a subset of patients who experience long-term survival. Due to poor response rates to standard cytotoxic agents in metastatic melanoma, patients are encouraged to participate in clinical trials, the overall impact of which has not been studied, however. The aim of our study was to identify the factors associated with long-term survival and to determine the impact of clinical trial enrollment on patient outcome. Methods: We studied stage-IV melanoma patients prospectively enrolled at New York University Medical Center from 2002–2008. Associations between clinicopathologic variables and overall post-stage-IV survival were examined. Kaplan-Meier survival analysis was used to identify univariate predictors of post-stage-IV survival and the independent effect of these variables was assessed in a multivariate Cox proportional hazards regression model. The associations between clinicopathologic variables and long-term survival status (≧2 vs. 2 analysis and the independent effect of these variables on the latter was assessed in a multivariate logistic regression model. Results: Site of metastasis, treatment (systemic vs. localized) and pretreatment lactate dehydrogenase (LDH) level independently correlated with post-stage-IV survival. Participation in clinical trials and normal LDH levels were associated with a long-term survival of ≧2 years. Conclusion: Our data suggest that enrollment in clinical trials independently correlates with prolonged survival after a diagnosis of stage IV melanoma.
- Published
- 2011
46. On Improving Replenishment Lot Size of an Integrated Manufacturing System with Discontinuous Issuing Policy and Imperfect Rework
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Singa W. Chiu, Huei H. Chang, and Ting J. Lee
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Integrated manufacturing ,business.industry ,Holding cost ,Rework ,General Medicine ,Manufacturing systems ,Industrial engineering ,Cost reduction ,Economics ,Operations management ,Imperfect ,Research result ,business ,Quality assurance - Abstract
This paper proposes a cost reduction distribution policy for an integrated manufacturing system operating under quality assurance practice. We reexamine the problem studied by Chiu et al. [Numerical method for determination of the optimal lot size for a manufacturing system with discontinuous issuing policy and rework. International Journal for Numerical Methods in Biomedical Engineering, doi:10.1002/cnm.1369] and improve its replenishment lot-size solution in terms of lowering producer’s stock holding cost. Mathematical modeling and analysis is employed in this study and optimal replenishment lot size is derived. A numerical example is provided to show the practical usage of research result as well as to demonstrate significant savings in producer’s holding cost as compared to that in Chiu et al.
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- 2011
47. A High Proliferative Index of Recurrent Melanoma Is Associated with Worse Survival
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Madhu Mazumdar, Ting J. Tu, Stefano Monni, Michelle W. Ma, David Polsky, Russell S. Berman, Iman Osman, Herman Yee, Amy E. Rose, Richard L. Shapiro, Anna C. Pavlick, and Farbod Darvishian
- Subjects
Male ,Oncology ,Cancer Research ,Prognostic variable ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Proliferative index ,Kaplan-Meier Estimate ,Disease-Free Survival ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Neoplasm Metastasis ,Stage (cooking) ,Prospective cohort study ,Melanoma ,Proportional Hazards Models ,Univariate analysis ,L-Lactate Dehydrogenase ,business.industry ,Proportional hazards model ,General Medicine ,Clinical Translational Research ,Middle Aged ,Prognosis ,medicine.disease ,Primary tumor ,Ki-67 Antigen ,Female ,business - Abstract
Objective: Previous melanoma studies evaluating prognostic factors of survival at recurrence have focused on primary tumor characteristics and clinical variables at first recurrence. We examined the prognostic relevance of recurrent tumor proliferation. Methods: 114 melanoma patients with available recurrent tissues who were prospectively enrolled at New York University Medical Center were studied. Standard of care prognostic variables (e.g. stage at initial diagnosis and lactate dehydrogenase level) and recurrent tissue expression of proliferative marker Ki-67 were evaluated for their association with overall survival. Results: High Ki-67 expression was observed in 57 (50%) of the 114 recurrent melanomas. On univariate analysis, the median overall survival of patients whose recurrent tumors overexpressed Ki-67 was significantly shorter than that of patients whose recurrent tumors had low Ki-67 expression (3.6 vs. 9.5 years, p = 0.03). On multivariate analysis, a high proliferative index of the recurrent melanoma remained an independent predictor of worse overall survival, controlling for stage at initial diagnosis, disease-free survival, and stage at first recurrence [HR = 2.09 (95% CI 1.24–3.54), p = 0.006]. Conclusions: Our results demonstrate the prognostic relevance of tumor proliferation in recurrent melanoma patients. Data also support restratification of risk assessment upon recurrence that considers tumor biology in addition to clinical variables evaluated as part of the standard of care.
- Published
- 2011
48. Numerical simulation of rooftop ventilator flow
- Author
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Noor A. Ahmed and Shao-Ting J. Lien
- Subjects
Environmental Engineering ,business.industry ,Geography, Planning and Development ,Airflow ,Natural ventilation ,Building and Construction ,Aerodynamics ,Computational fluid dynamics ,Turbine ,Wind speed ,law.invention ,law ,Ventilation (architecture) ,business ,Simulation ,Civil and Structural Engineering ,Wind tunnel ,Mathematics ,Marine engineering - Abstract
Rotating rooftop turbine ventilators are cost effective environmental friendly natural ventilation devices, which are used to extract airflow from a building to improve air quality and comfort. A CFD study using the standard k-ɛ turbulence model with multiple reference frame (MRF) meshing technique was employed to explore the suitability of numerical approach in modelling various features of a ventilator flow. The initial CFD results were validated against wind tunnel data obtained for a commercial ventilator on a simulated inclined rooftop configuration conducted at the aerodynamic laboratory of University of New South Wales. The numerical studies were then extended to examine both the internal and the external flows associated with the ventilator at different wind speeds and to quantify the performance of a rotating ventilator in terms of air extraction rate. The trend observed appeared to be in good agreement with published data suggesting that application of numerical simulation is feasible as a cost effective tool in the future design, development and performance analysis of rotating wind driven ventilation device.
- Published
- 2010
49. Optimizing stochastic circuits for accuracy-energy tradeoffs
- Author
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Armin Alaghi, Wei-Ting J. Chan, John P. Hayes, Andrew B. Kahng, and Jiajia Li
- Published
- 2015
50. A Connection between Obscuration and Star Formation in Luminous Quasars
- Author
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Christine Jones, Varoujan Gorjian, Mark Brodwin, Kevin N. Hainline, Roberto J. Assef, Michael J. I. Brown, William R. Forman, Daniel Stern, Chien-Ting J. Chen, Ryan C. Hickox, Andy D. Goulding, Stacey Alberts, Agnese Del Moro, Christopher Harrison, Alexandra Pope, Emmanouel Rovilos, Christopher S. Kochanek, David M. Alexander, and Stephen S. Murray
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Physics ,Luminous infrared galaxy ,Active galactic nucleus ,active [Galaxies] ,Infrared ,Star formation ,Astrophysics::High Energy Astrophysical Phenomena ,galaxies. [X-rays] ,FOS: Physical sciences ,general [Quasars] ,Astronomy and Astrophysics ,Quasar ,Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Galaxy ,starburst [Galaxies] ,galaxies [Infrared] ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,Galaxy formation and evolution ,Spectral energy distribution ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
We present a measurement of the star formation properties of a uniform sample of mid-IR selected, unobscured and obscured quasars (QSO1s and QSO2s) in the Bo\"otes survey region. We use an spectral energy distribution (SED) analysis for photometric data spanning optical to far-IR wavelengths to decompose AGN and host galaxy components. We find that when compared to a matched sample of QSO1s, the QSO2s have higher far-IR detection fractions, far-IR fluxes and infrared star formation luminosities ($L_{\rm IR}^{\rm SF}$) by a factor of $\sim2$. Correspondingly, we show that the AGN obscured fraction rises from 0.3 to 0.7 between $4-40\times10^{11}L_\odot$. We also find evidence associating the absorption in the X-ray emission with the presence of far-IR emitting dust. Overall, these results are consistent with galaxy evolution models in which quasar obscurations can be associated with a dust-enshrouded starburst galaxies., Comment: 15 pages, 8 figures, accepted for publication in ApJ
- Published
- 2015
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