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Aim. To assess the joint prognostic value of periprocedural dynamics of the left ventricular ejection fraction (PPD of LVEF) and subclinical pulmonary congestion during lung stress ultrasound in patients with first acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI) in relation to the development of heart failure (HF) in the postinfarction period. Materials and methods. Our prospective, single-centre, observational study included 105 patients with a first MI with no HF in the anamnesis and successful PCI. All patients underwent standard clinical and laboratory tests, NT-proBNP level assessment, echocardiography, lung stress ultrasound with a 6-minute walk test. All patients had no clinical signs of heart failure at admission and at discharge. Criteria for PPD of LV EF: improvement in LV EF50%; ∆LV EF more than 5%, but LV EF50%. According to the results of lung stress ultrasound, pulmonary congestion was diagnosed: mild (24 B-lines), moderate (59 B-lines) and severe (10 B-lines). The end point was hospitalization for HF for 2.5 years. Results. Upon admission, LV EF of 50% or more was registered in 45 patients (42.9%). Positive PPD was registered in 31 (29.5%) patients. After stress ultrasound of the lungs, 20 (19%) patients had mild subclinical pulmonary congestion, 38 (36%) moderate and 47 (45%) severe according to the criteria presented. During the observation period, patients with no PPD of LVEF were significantly more likely to be hospitalized for the development of HF (in 44.4% of cases) compared with patients with positive PPD (in 15.2% of cases) and with initial LV EF50% (in 13.4% of cases; p=0.005). When performing logistic regression analysis, the best predictive ability was found in the combination of the absence of PPD of LV EF and the sum of B-lines 10 on exercise (relative risk 7.45; 95% confidence interval 2.5521.79; p0.000). Conclusion. Evaluation of the combination of PPD of LV EF and the results of stress lung ultrasound at discharge in patients with first AMI and successful PCI with no HF in anamnesis allows us to identify a high-risk group for the development of HF in the postinfarction period.

The paper discusses the ongoing project of creating an interdisciplinary comparative dictionary of linguistic and logical terms. The dictionary includes overlapping terms used in both disciplines. The aim of the comparison consists in analyzing differences in understanding and use of the overlapping terms of linguistics and logic, and in revealing differential and integral features expressing these differences. The proposed dictionary is primarily intended for supporting interdisciplinary communication. A number of methodological issues and their solutions for this pair of scientific disciplines are discussed (defining the domains of knowledge taken into account, requirements for the metalanguage of description). As an example, the analysis of the term predicate—one of the basic terms of linguistics and logic—is presented. Six groups of differential features have been revealed and described; the tradition of the use of the term logic in linguistics and the influence of this tradition on understanding the possibilities of a predicate are considered.

In the presented observation, a female patient with diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (advanced stages) received R-ABVD regimen therapy. Return of clinical symptoms observed at the onset of the disease, as well as renewed growth of the lymph nodes after 4th therapy cycle showed refractory disease. Considering the results of earlier studies, generally showing high effectiveness of primary treatment of patients with nodular lymphocyte-predominant Hodgkin lymphoma, reevaluation of immunomorphological type of lymphoproliferative disease was performed. After change of diagnosis to grade 3A follicular lymphoma, therapy was changed to obinutuzumab in combination with bendamustine leading to fast positive antitumor effect.

During long-term autoimmune processes, most commonly in patients with Sjogren’s disease (SD), lymphoproliferative disorders (LPD) can develop. The risk of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) with involvement of parotid salivary glands is increased 1,000-fold compared to other immunomorphological variants. Some studies show that the main factors predisposing patients with SD to LPD are long-term enlargement of parotid salivary glands, generalized lymphadenopathy, cryoglobulinemic purpura. Application of an integrative approach to LDP diagnosis in patients with SD, identification of high-risk group for this malignant neoplasm promote its early detection.A clinical observation of a female patients with long-term SD which was diagnosed along with MALT lymphoma using an integrative approach to diagnosis of both diseases is presented.

Chronic pain syndrome developing in patients with oncological diseases significantly decreases their quality of life which makes effective integrative analgetic therapy a pressing issue. Currently, drugs of various pharmaceutical groups are used for pain management and administered subsequentially in accordance with the pain intensity visual analogue scale. For moderate and severe pain syndrome, opioid analgesics are used which have side effects limiting their use in some cases. Trials showed that new highly specific μ1-opioid receptor agonist tafalgin is characterized by high bioavailability, fast absorption, biotransformation, absence of accumulation which makes its safety profile favorable. Pronounced analgesic effect of tafalgin, as well as ease of administration and absence of significant adverse events, allow to significantly improve the quality of life of patients with chronic pain syndrome.

Currently, mining activities are mainly focused on economic efficiency and to a less extent on environmental safety. The natural environment experiences heavy impacts from mining activities. Various mining processes during the extraction of common mineral resources cause a significant increase in dust emissions. This article considers the dust fractions of granites, migmatites, marmorized limestone, ophicalcites, jades, and charoits. We determined the particle-size composition and morphology for all of the dust samples, calculated unit cell parameters and determined particle dimensions. As a result, we established that nanosize stone dust particles can enter living organisms, and their dimensions determine the impacts on the living organisms and environmental ecosystems, including the air. This research was conducted with financial support from RFBR within the scope of research project No 19-35-90096.

The adrenal gland is one of the first organs to respond to external influences. Cortisol, with its important properties affecting the immune system, proliferation and apoptosis in various tissues, is a significant indicator of such a pathological process as malignant growth. Selenium is a powerful antioxidant having an immunomodulatory action and exhibiting anticarcinogenic effects. In this paper, we investigate adrenal morphofunctional changes under experimental carcinogenesis against the background of urethane and selenium administration by determining blood cortisol concentrations and studying the aggregate morphometric index of adrenal glands. The study revealed that carcinogen introduction imitates the adaptation syndrome stages in the organism and is accompanied by changes in the cortisol level and aggregate morphometric index. Maximal values of the studied parameters were detected after 1 month of exposure to carcinogen, which indicated the development of the alarm phase. A further decrease in the indices after 2 and 3 months down to the intact level indicates the development of the resistance stage. A sharp decrease in the indices after 6 months shows the exhaustion stage. An isolated course introduction of selenium leads to a reliable decrease in the aggregate morphometric index practically in all terms that indicates the stress-relieving influence of the microelement. The combined effects of selenium and carcinogen revealed a dropout of the alarm stage, but rapid elimination of the micronutrient from the body could not prevent the development of the exhaustion phase after 6 months.

Introduction. Currently, the conservative treatment of ileocecal intussusception (ICI) has proven its effectiveness; indications for surgical treatment are increasingly narrowing and do not depend on disease duration and child’s age. And yet, there are situations when conservative treatment is ineffective, and surgical intervention is a must.Purpose. To analyze reasons leading to ineffective conservative treatment of ileocecal intussusception in children and, accordingly, to specify current indications for surgical treatment.Material and methods. 160 children with ICI, who were treated in the Clinical and Research Institute of Emergency Pediatric Surgery and Trauma (CRIEPST) in Moscow from 2011 to 2021, were taken in the trail. Boys prevailed and amounted to 67.5% (108), girls – to 32.5% (52). Average age of patients was 2.9±2.02. 81.2% (130 children ) were older than one year. If the disease was diagnosed for the first time and if there were no complications, patients with ICI had hydrocolonoscopy (HCS), regardless of child’s age and disease duration. If HCS was ineffective, laparoscopy was done. Laparoscopy was also made in case of disease recurrence. If laparoscopic disinvagination was ineffective or impossible, laparotomy was performed. In case of effective laparoscopic disinvagination but in disease relapse and in the absence of intra-abdominal anatomical problems in the postoperative period, colonoscopy was made to rule out intraluminal anatomical pathologies. In the present trial, the researchers assessed causes of ineffective HCS: anatomical problems including volumetric lymphadenopathy, invaginate necrosis and disease relapses. Types of surgical intervention and their effectiveness were also analyzed. Additionally, the authors compared studied parameters obtained in the hospital earlier when HCS protocol (n=160; 2011–2021) and laparoscopic disinvagination protocol were used (n =40, 2007–2010).Results. Surgical intervention by HCS protocol was made in 9.4% (15); HCS effectiveness was as high as 90.6%. Laparoscopy was performed in 6 children (3.75%) after ineffective HCS and in 9 children (5.6%) after disease relapse. Laparoscopic disinvagination was effective in 60.0% of cases (9) from the surgical group; laparoscopy was changed for laparotomy in 6 patients (40%). Anatomical problems accounted for 73.3% (11) in the surgical group and for 6.9% in the study group, respectively. In the rest of patients (4–26.7%), ineffectiveness of conservative disinvagination was caused by severe lymphoid hyperplasia of the ileocecal angle. In early disease relapses, 42.9% of such patients had anatomical problems. In the surgical group, invaginate necrosis was registered in 20% (3), and bowel resection with anastomosis was made in 26.7% (4); in the study group, these indexes were 1.9 and 2.5%, respectively.Conclusion. The basic reason for ICI conservative treatment failure was an anatomical problem which is a leadpoint of disease pathogenesis that causes both intussusception necrosis and intussusception relapses. Currently, the main indications for surgical ICI management are ineffectiveness of conservative treatment and ICI relapses regardless of child’s age and disease duration.

Mast cells play an important role in many processes occurring in the human body. These include inflammation, allergic reactions, parasitic infections, carcinogenesis and others. Therefore, the detection of mast cells plays an important role in the diagnosis of pathological conditions. The purpose of the study is to summarize data on imaging methods of mast cells. Materials and methods. Review of available literature sources published in Elibrary and PubMed. Results. There are several major groups of methods for finding mast cells: histochemical, enzyme-linked histochemical and immunohistochemical. All are based on the ability to detect specific substances contained in mast cell granules. Histochemical methods include Unno, alcian blue and safranin staining of mast cells and others. The most modern method is mast cell visualisation using immunohistochemical reactions based on antigen-antibody reactions. Conclusion. This review presents the most common methods of mast cell staining, differing in difficulty of performance, specificity in relation to mast cells and staining cost.

The article analyzes the approach to training risk managers within Industry 4.0. An analysis of the fourth stage of the industrial revolution and requirements for specialists involved in ensuring company safety at enterprises was carried out; the legislation on labor protection management was investigated. The main task is to train a risk manager able to assess and manage risks. The main educational program for training technosphere safety experts, which develops skills for assessing technogenic, natural and social risks in new conditions, is analyzed. The article shows that in order to train professionals, it is necessary to apply active learning methods and encourage research on the transition to Industry 4.0.

Use of microinfusion elastomeric pumps for extended administration of antitumor drugs improves patients’ quality of life during prolonged cyclic treatment because of the absence of venous complications and infusion allergic reactions during administration of cytostatic agents and targeted drugs.

Follicular lymphoma (FL) is the most common indolent form of lymphoma and characterized by recurrent course and heterogenous clinical signs. Selection of treatment program for patients with newly diagnosed or recurrent FL is based primarily on the size of the tumor. While use of rituximab-containing regimens led to increased progression-free survival, in some cases tumors are refractory to rituximab. Understanding of molecular mechanisms of FL pathogenesis and action of anti-CD20 monoclonal antibodies allowed to develop new drugs with several advantages compared to rituximab. According to the data of large randomized trials, use of glycoengineered monoclonal anti-CD20 type II antibody obinutuzumab in combination with chemotherapy in patients with FL has manageable toxicity profile and longer progression-free survival and event-free survival compared to use of rituximab.

This article attempts to identify eating disorders of adolescents. Theoretical and methodological analysis of the study shows that the occurrence of eating disorders is due to attempts to compensate for the lack of unmet needs. Also in this article considered the severity of loneliness manifestation does not depend on the number of interpersonal relationships, the fundamental here is a subjective perception of human interaction with others, and not an “objective” assessment of this criterion from the outside. The authors reviewed the studies of Russian and foreign scientists on the causality of eating disorders occurrence. The empirical part of the study was conducted using the questionnaire “Eating Behavior Assessment Scale” (Garner, D.M., Olmstead, M.P., Polivy, J.P.) and the methods of “Subjective feeling of loneliness” (Russell, D. and Ferguson, M.). The study involved 60 subjects, descriptive statistics were used to interpret the results. Our assumption that food can be a solution to the problems of the subjective feeling of loneliness in schoolchildren has been partially confirmed. The results on the scales with a high value of “eating disorders” and “subjective feeling of loneliness” are linked. Objective. To identify at eating disorders with subjective feelings of loneliness among adolescent. The hypothesis of the study is based on the assumption that food can become a means of solving the subjective feeling of loneliness, the higher the level of the subjective feeling of loneliness, the more often eating disorders may occur. Method and methodology. The research is based on the phenomenological method, as well as the principles of determinism and causality of mental activity. Results. We covered 60 schoolchildren living in Yakutsk city in the empirical part of the study. The hypothesis of this study that food can be a means of solving the problems for adolescents with a high level of subjective feeling of loneliness is partially confirmed as a result of the research work carried out. Based on the results of an empirical study, the conclusion was made that the occurrence of eating disorders in adolescents is associated with the level of loneliness severity. Scope of the results: the results of the study can be applied by psychologists, social workers and educators when working with adolescents with an eating disorder.

Background. Currently, about 80 % of men with low-grade prostate cancer (per ISUP 1 (International Society of Urological Pathology)) have indications for radical treatment. Overdiagnosis of low-grade cancer is associated with the use of systematic biopsy methods (standard transrectal, saturation) under ultrasound control for diagnosis verification. To improve prostate cancer diagnosis, the European Association of Urology (2019) recommended multiparametric magnetic resonance imaging before biopsy, and in case of detection of a suspicious lesion magnetic resonance imaging (MRI)-targeted biopsy. In clinical practice, the most common method of MRI-targeted biopsy is multiparametric MRI ultrasound-guided (mpMRI/US) fusion biopsy. However, some studies show contradictory results in detection of prostate cancer using systematic and MRI-targeted biopsy techniques.Aim. To compare detection of clinically significant prostate cancer (ISUP ≥2) using mpMRI/US fusion, standard, and saturation biopsy.Materials and methods. The study included 96 patients. The following inclusion criteria were applied: prostate-specific antigen >2 ng/mL and/or detection of a suspicious lesion during digital rectal and/or transrectal ultrasound examination, and PI-RADS (Prostate Imaging Reporting and Data System) v.2.1 score ≥3. At the first stage, “unblinded” urologist performed a transperineal mpMRI/US fusion and saturation biopsies. At the second stage, “blinded” urologist performed standard transrectal biopsy. Clinically significant cancer was defined as ISUP ≥2.Results. Median age was 63 years, prostate volume – 47 cm3, prostate-specific antigen – 6.82 ng/mL. MpMRI/US fusion, standard, and saturation biopsies were comparable in regard to the rate of detection of clinically significant (29, 24, 28 %; p = 0.81) and clinically insignificant (25, 26, 35 %; p = 0.43) cancer. Overall prostate cancer detection rates were also similar: 54, 50, 63 %, respectively (p = 0.59). The percentages of positive cores in mpMRI/US fusion, standard, and saturation biopsies were 33, 10 and 13 %, respectively (p p = 0.7).Conclusion. Detection rates of clinically significant, clinically insignificant prostate cancer and overall detection rate are comparable between systematic biopsy techniques and mpMRI/US fusion biopsy.

Background and Aim: Histophilus somni is a Gram-negative bacterium belonging to the Pasteurellaceae family that can cause bovine histophilosis. Histophilus may act as a commensal or opportunistic bacterial cattle pathogen. Comparing genomes of the pathogenic strain 2336 with the non-pathogenic preputial 129Pt isolate revealed some putative virulence factors. The study of the complete genomes of H. somni strains circulating in Russia has never been conducted before. This study aimed to identify genetic features of the H. somni strains isolated in Russia and evaluate the possibility of using strains for vaccine development. Materials and Methods: Three strains of H. somni were isolated from different sources. Strain 188-VIEV was isolated from a vaginal swab sample of cattle with endometritis. 532-VIEV and 551-VIEV were cultured from the cryopreserved bull semen samples imported from Canada. Histophilus somni strain ATCC 700025 provided by ATCC (American Type Culture Collection) was also used in the study. DNA extraction was performed using QIAamp DNA Mini Kit (QIAGEN, USA). The whole-genome sequencing of the four strains was performed using Illumina Miseq. The comparison of the resulting sequences with the complete genomes of H. somni 2336 and 129Pt, and detection of the resistance genes and virulence factors, was performed using the ResFinder and Virulence Factor Database web services. Results: The genome size of the samples varied from 1.9 to 2.3 Mb. The number of coding sequences varied from 1795 to 2256. The average sequence density was 90%. The total guanine-cytosine (GC) content was 36.8%–37.2%, which coincided with data previously obtained for H. somni. Three out of four studied strains encoded putative virulence factors such as filamentous hemagglutinin homologs, lipooligosaccharide biosynthesis proteins, and proteins involved in iron transport and utilization. The Ser83Ile substitution was identified in the DNA topoisomerase II (gyrA) in H. somni strains 532-VIEV and 551-VIEV cultured from bull semen which led to resistance to fluoroquinolones. The gene (AAC-6-Ia + APH-2”) encoding a bifunctional aminoglycoside modification enzyme was detected in strain 551-VIEV. Conclusion: Strains with virulence genes identified could be candidates for designing vaccines and potentially represent antigen sources. The results show that antibiotic-resistant H. somni can be spread with semen used for artificial insemination.

Aim. To assess periprocedural dynamics of left ventricular ejection fraction (LVEF) in patients with first acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI) without heart failure (HF) in the medical history, as well as its prognostic value in the development of cardiovascular complications in the postinfarction period.Materials and methods. A prospective, single-center observational study included 131 patients with first AMI without HF in the past medical history and successful PCI. LVEF was assessed before PCI at admission and before discharge. In patients with reduced baseline LVEF of less than 50%, the criteria for its periprocedural improvement were chosen: 1) LVEF ≥ 50%; 2) ΔLVEF of more than 5%, but EF < 50%. The endpoints were hospitalization for the development of HF and death from cardiovascular disease in combination with the development of HF. The average follow-up period was 2.5 years.Results. At admission, LVEF was < 50% in 74 (56.5%) patients. At discharge, according to the criteria for LVEF improvement, the proportion of patients in this group was 40.5 and 14.9%, respectively. In 44.6% of cases, no increase in LVEF was noted. The predictors of the absence of periprocedural dynamics in LFEF included impaired regional contractility index > 1.94, left ventricular end-systolic volume > 57 ml, left ventricular end-diastolic diameter > 5.1 cm, pulmonary artery systolic pressure >27 mm Hg, NT-proBNP > 530 pg / ml, and E / A ratio > 1.06. During the follow-up period, 28 (21.4%) patients were hospitalized for the development of HF, 33 (25.2%) patients had a combined endpoint. The absence of periprocedural improvement in left ventricular contractility was independently associated with higher odds of hospitalization for HF (relative risk (RR) 3.5; 95% confidence interval (CI) 1.63–7.55; p = 0.001) and the combined endpoint (RR 2.6; 95% CI 1.28–5.48; p = 0.009) in the postinfarction period.Conclusion. In patients with first AMI and left ventricular systolic dysfunction, periprocedural evaluation of LVEF is reasonable to stratify the risk of adverse cardiovascular outcomes.

Breast cancer is a widespread oncological disorder, which is considered one of the leading causes of mortality among women. DNA repair processes a well as its methylation involving genes of folate cycle play a crucial role in cancerogenesis. The aim of the study is to generalize the current data about association between polymorphic variants of folate cycle genes MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) with risk of breast cancer development. The search of scientific papers has been conducted using PubMed and elibrary.ru sources. Original and randomized surveys published from 2008 till 2022 have been included in this review. The study has accumulated sufficient data on MTHFR С677Т polymorphic variant in breast cancer patients, having significant influence on disease development. However, the data about MTR A2756G and MTRR A66G variants is quite limited. According to the findigs of many scientific papers, there is no link between polymorphic variants of these genes and breast cancerogenesis manifestation. Such factors like ethniсity and sufficient consumption of folates with nutrition can have significant impact on results and conclusions of studies about role of folate cycle genes in breast cancer patients. Further investigation of MTHFR С677Т (rs1801133), MTR A2756G (rs1805087) and MTRR А66G (rs1801394) genetic polymorphic variants with consideration of gene-environment and gene-gene interactions could explain the presence of individual differences of breast cancer risk.

Background. Appropriate prescribing of complementary food allows to optimize the intake of macro- and micronutrients, provides adequate indicators of growth and development of the child, reduces the risk of non-infectious pathology. Taking into account the significance of this problem, World Health Organization (WHO) experts, together with The European Society for Paediatric Gastroenterology Hepatology and Nutrition, carried out a research where they studied issues related to the appointment of complementary food for children in the European Region and their compliance with existing recommendations. Aim. To study the features of the introduction of complementary food in the Russian Federation on the basis of an assessment of the implementation of the recommendations of the "National program for optimizing the feeding of children in the first year of life in the Russian Federation", 2009 and to conduct a comparative analysis of the results obtained and the data presented in the study carried out by WHO experts. Materials and methods. A multicenter retrospective, uncontrolled, non-randomized study was conducted in 7 cities of the Russian Federation. Results. The median age at which complementary foods were introduced was 5 [46] months; vegetables (51.0%) and cereals (31.2%) were the first complementary food products; children began to receive fruit mainly (77.3%) in the second half of life; the age of introduction of meat puree was 7 [68] months, while every 4th child by 9 months did not receive meat; juices were introduced at 7 [69] months, but in 8.8% of children juices became the first product of complementary foods; median age for yolk administration was 8 [710] months, fish 9 [810] months. Only 14.0% of mothers used products of exclusively industrial production in the nutrition of their children, 33.9% prepared it themselves. Correlation analysis did not revealed any relationship between the body weight of a child at the age of 12 months and the time of introduction of the first complementary food product, as well as with the age of introduction of each of the introduced products. A connection was established between the body weight of a child at the age of 12 months and the volume of individual products that children receive between the age of 6 and 12 months. The recommendations of the National program for optimizing the feeding of children in the first year of life in the Russian Federation were generally implemented. Our analyses revealed the most frequent violations during the introduction and use of complementary food products: late start of their introduction (after the age of 6 months) in 41.3% of children, delayed prescription of meat, frequent use of home-made cereals not enriched with micronutrients, dilution of dairy-free porridge with water, irregular inclusion in the diet of egg yolk. Conclusion. The results obtained confirm the importance of implementation of the Program for Optimizing Feeding of Children in the First Year of Life in the Russian Federation updated in 2019 and approved by the Ministry of Health of Russia and indicate the need for further work on its improvement.

Modern digital technologies based on artificial intelligence and big data have a significant impact on many areas of the socioeconomic life of society. At present, digitalization has not affected the public financial management system to a small extent. However, this particular area has a high potential for the use of big data and artificial intelligence, as it is based on significant amounts of information, including unstructured information. At the same time, the process, mechanism and forms of the digital technologies impact on public finance management have been little studied in the scientific literature. The paper forecasts changing in the public financial management system that may occur under the influence of digital technologies in the medium and long term. The authors used a methodical approach based on extrapolation for forecasting. Nowadays, digital technologies have significantly influenced some sectors of the socio-economic people’s activity. The forms and mechanisms of such influence had been extrapolated to the public financial management system and, primarily, to various stages of the budget process.

The study of the photorearrangement of diarylethene showed that the predominant step is deprotonation after 6π-electrocyclization, which is confirmed by the introduction of an electronegative group into the ethene bridge and the solvent polarity.

The article focuses on methodological tendences in urban language research. Authors, meanwhile, substantiate rationality of its spoken and written varieties as separate fields of study. These studies are marked with a high rate of activity and they highlight a new concept of the «regiolect» — a regional variety of the national language. The analysis of the scientific results of linguo-urbanistics reveals the dominance of the onomastic vector and obvious lack of research into urban speech. The authors specify discrepancies in the function of written and spoken language in linguistic, semiotic and psychological aspects. They also state destructive results of simple mechanical transfer of oral speech techniques to urban epigraphy, the differences between word-formation processes in written and oral speech are described. The visuality of a written sign, the possibility of hybrid word formation with the help of other symbolic and graphic systems, as well as the activity of language norms are listed as features of written communication. A distinctive feature of the oral form is the possibility of meaning explication through non-verbal signs. According to the authors, greater reliability of scientific results in the field of modern urban studies can be achieved through compliance with the principle of unmixed study of living speech and urban writing.

The ever-increasing volumes of gold mining in the Republic of Uzbekistan requires an increase in the cost of water resources. However, the subdivisions of the Navoi MMC are located in the arid, lowwater areas with high (40–80 %) and extreme (more than 80 %) water shortages. Therefore, the problem of water supply, water disposal and improvement of the closed water circulation system with the use of innovative biotechnological solutions is acute for the enterprise. The purpose of this work is to summarize current data on the use of wastewater bioremediation technologies at mining enterprises and to assess the prospects for using this technology by Navoi Mining and Metallurgical Company. The article summarizes the data on the use of bioremediation at mining enterprises in Russia and other countries and data obtained from our own experimental studies of the cleansing functions of plants in Uzbekistan. These studies were carried out under the laboratory modeling conditions using wastewater from tailing ponds GMZ-2 and GMZ-3 NMMC. The cleansing functions of the plants of the Zarafshan river valley were studied: eichornia, pistia, azoles and duckweed. It was found that eichornia has the highest cleansing potential: due to the high activity of the cyanidutilizing enzyme beta-cyanoalanine synthase, it accumulates metals and metabolizes cyanides. Pistia and azola have proven to be tolerant to high salinity levels and need to be adapted by adding organic matter, including sheep manure. The next stage is semi-industrial testing in a tailing dump and development of technical regulations.

The relevance of reading is determined by its great role in the life of individual and society, due to its multifunctionality and priority position among other means of education and upbringing. Therefore, its study, including in historical retrospective, is an important area of the modern scientific research. Due to the lack of comprehensive studies of library reading in pre-revolutionary Siberia, this article for the first time examines the fiction books lending in the Tomsk City Public Library in the late 19th — early 20th centuries. The purpose of the article is to analyse the demand for fiction by users of the Tomsk City Public Library during the specified period. The tasks are to determine the share of fiction in the total amount of book lending; to make ratings of the most popular domestic and foreign authors of fiction works.The authors use methods of comparative analysis, statistical and source studies. Data were collected from ten reports of the Tomsk City Public Library, as well as from its catalogue, that allowed us to recognize the source base of the article as representative. For the first time, the relative and average number of fiction lending was calculated. The obtained results demonstrate that in the late 19th — early 20th centuries the fiction book lending compounds at least two-thirds of all books lending in the Tomsk City Public Library.The number of fiction lending exceeded the number of lending from other departments by dozens of times. The authors compiled and presented joint and separate ratings of popularity of Russian and foreign authors among users of the library, among whom there were almost only prose writers. It is proven that the works of domestic writers were more in demand among library users, and the percentage of female authors in the top 10 and top 30 was minimal. This study expanded the idea of reading fiction in pre-revolutionary Tomsk, its place in the reading circle and popular authors.

The aim of the study was to determine the opportunities of multiparametric ultrasound in the early detection of papillary thyroid cancer. Examination results of 258 patients with papillary thyroid cancer at the stage of preoperative preparation were analyzed. All patients underwent multiparametric ultrasound examination in grey-scale mode, in color Doppler mapping mode, in compression elastography mode and shear wave elastography, ultrasound with contrast enhancement. In papillary thyroid cancer, "cold" tones prevailed. the velocity of the shear wave was 4.61±1.33 m/s (95% CI), Young's modulus was 63.3±14.7 kPa (95% CI), the elasticity index (strain ratio) was 4.89±1.65 (95% CI) c.u. When assessing the qualitative parameters of ultrasound with contrast enhancement, it was noted that in papillary thyroid cancer, heterogeneous accumulation of ultrasound contrast agent prevailed (54.5%), there was a more pronounced intensive accumulation of ultrasound contrast agent (63.6%). when measuring TPI, the EC indicator was 20.64±4.37 s, PI – 31.08±1.65 dB, PI (DT/2) – 64.00±10.27 s. Thus, the study showed that the complex use of multiparametric ultrasound examination techniques (B-mode, color Doppler mapping, compression elastography, shear wave elastography, ultrasound with contrast enhancement) is highly informative and should be used in the differential diagnosis of papillary thyroid cancer in the preoperative assessment.

The most accessible method for diagnosing various pathological processes is a complete blood cell count. It can reveal, in particular, such changes in the white hematopoietic lineage as leukocytosis and leukopenia. the causes of leukocytosis are very diverse. the most dangerous among them are leukemias and leukemoid reactions. in doubtful cases, additional methods of clinical examination are counting the differential white blood cell count and determining inflammation markers. Leukemoid reactions can develop against the background of sepsis, peritonitis, oncological diseases and severe infectious processes. This article presents a clinical case of leukemoid reaction in acute surgical pathology. the high point of the event was intestinal necrosis, which was manifested by corresponding symptoms and signs and a change in the complete blood cell count. the correctness of the diagnosis was proved by rapid normalization of the patient's white blood parameters after the surgical intervention.

This article considers issues of language contacts between Yakut, Even, and Evenk people through an analysis of plant vocabulary. We define etymological characteristics of fixed lexical units that denote plant names and present results of a comparative analysis of plant naming in these three languages, with emphasis on lexical parallels and structural types in designating plant names. To our knowledge, this is the first research to undertake a comparative study of plant naming in the Yakut and Tungusic languages (Even and Evenk) with consideration of the methods of their formation. The study is highly relevant because of the unique contribution of plant-world vocabulary in helping to clarify peculiarities of native speakers’ natural environments. Our results show that, based on lexical units with stable semantic meaning, the Evenk language is in the closest position vis-à-vis Yakut. There are 16 names in Yakut of plants and four of common names of herbs that grow on the territory of the Republic of Sakha (Yakutia) and have borrowed names in Evenk and Even. Twenty-eight names have lexical parallels in Evenk (including variations) and two in Even.

Osteosarcomas are rare tumors with aggressive biology. It is important to refer such patients to a high-volume center, where an accurate diagnosis and optimal treatment are more likely to be performed. In contrast to Ewing's sarcoma, conventional osteosarcomas are believed to be generally resistant to radiation therapy, and the main treatment modalities are surgery and chemotherapy. In this clinical case, we demonstrate the efficacy of combined treatment of osteosarcoma of the femur.Preoperative chemotherapy allowed to evaluate tumor sensitivity to systemic treatment in vivo and optimize adjuvant treatment after R0 resection which allowed to achieve complete clinical response to treatment.

Supporting therapy is a necessary component of successful antitumor treatment in patients with both solid tumors and malignant blood disorders. Adherence to administration protocol for antiemetic drugs aimed at prevention of induced gastrointestinal complications (nausea and vomiting), allows to improve patients' quality of life and treatment compliance. Development of a combination antiemetic drug (netupitant/palonosetron) simultaneously affecting 2 main mechanisms of nausea and vomiting as well as its easy administration allowed to significantly improve control of these complications in patients with solid tumors and patients with malignant blood disorders.We present a literature review on the effectiveness of netupitant/palonosetron and describe our own experience of using this antiemetic drug for prevention of chemotherapy-induced nausea and vomiting.

Primary cutaneous diffuse large B-cell lymphoma, leg type, is diagnosed in 20-25 % cases of all primary cutaneous B-cell lymphomas, primarily in elderly women (older than 70 years). The disease has aggressive recurrent progression and worse prognosis than other variants. The standard antitumor drug therapy are such regimens as R-CHOP and CHOP-like programs including anthracycline antibiotics. Use of these programs can be limited by the presence of cardiovascular and other concomitant disorders.Due to the limited variety of combinations of antitumor agents, low frequency of diagnosis of this immunomorphological variant of lymphoproliferative disease and absence of a single algorithm of drug therapy, every clinical case is interesting and informative.In the presented clinical case, an 80-year-old female patient with primary cutaneous diffuse large B-cell lymphoma, leg type, and concomitant pathology of the cardiovascular system underwent 2 courses of R-CVP regimen drug therapy without anthracyclines. A significant antitumor clinical effect was achieved in the form of complete tumor regression. Treatment was not accompanied by significant toxicity which allowed to complete therapy.

The modern Russian education system is on the path of digital modernization, which is accompanied by a paradigm shift in the choice of models of educational institutions, approaches to the management of the educational process, modification of learning conditions, innovations within the methodological arsenal of teachers, modern digital technologies are being introduced. Digital transformation or digitalization of education, along with computerization, individualization, etc., is one of the key trends in the development of the education sector. Undoubtedly, for the successful digital transformation of the educational system Russia needs to solve many tasks, both global (logistics, upgrading professional competencies, stimulating the development of educational IT technologies, etc.) and local. Among the local, but no less significant, tasks is the search for digital learning tools that can improve the effectiveness of the educational environment. It is necessary to answer the question: how is it possible to train qualified specialists basing on digital educational tools? In this article, the authors consider the use of machine learning technology in successful educational practices, as well as highlight “digital products” tested by teachers of the Department of History of Astrakhan State University. Digital transformation of education is considered by the authors of the article in relation to the economic development of the country, The Caspian region and the Astrakhan region, which characterizes the features of the “state order” in the educational sphere.

Introduction. The article is devoted to the problems of ecological consequences of forest fires in protected areas. It is proposed to assess atmospheric air pollution during forest fires and their impact on public health by the calculated method of specific emissions and hazard coefficients. The aim of the work is to perform a comparative analysis of environmental risks for the populations of three subjects of the Russian Federation in the Baikal region, and ranking of territories by the level of atmospheric air pollution during forest fires.Materials and Methods. The initial data were statistical information on forest fires in the Irkutsk region, the Republic of Buryatia, the Trans-Baikal Territory in the period from 2013 to 2020, procedural documents of forest fires, including schemes and types of fires, areas and coordinates of fires, protocols of inspection of the fire site, acts of official investigation and other materials.Results. The paper analyzes forest fires in the protected Baikal natural area of the Baikal region and their environmental consequences. The emphasis is placed on establishing the average annual characteristics of forest fires (number, area, economic damage, specific emissions of combustion product into the atmosphere, risks to public health). It is proved that bulk emissions from forest fires bring additional atmospheric pollution; it is 20 % of stationary sources of emissions. The Republic of Buryatia and the Irkutsk region contribute the most to the pollution of the atmosphere of the Baikal region.Discussion and Conclusion. The methodology proposed by the authors for ranking territories by environmental risks can be used for predictive assessment of the consequences of fires for public health. The forecast results serve to support organizational and administrative measures, including decisions to attract additional forces and equipment, and to evacuate the population. According to the results of the forecast of the consequences of fires for the health of the population, a fire-fighting plan is being developed, which determines the methods and tactics of fire extinguishing, the distribution of forces and means, the decisive direction of actions, etc. According to the greatest contribution to the deterioration of living conditions and the risk of poisoning by combustion products, the studied territories are ranked in the following order: Irkutsk region – Republic of Buryatia – Trans-Baikal Territory.

Under conditions of intensive development in the northern and Arctic territories, the issue of preserving the linguistic and cultural diversity of the Peoples of the North and the Arctic of Russia is becoming increasingly relevant. Within this context, this article studies linguistic ecology in light of sustainable development and wellbeing in communities of Dolgan and Evenki—small-numbered indigenous peoples living in the Arctic zone of the Republic of Sakha (Yakutia), Russia. Linguistic ecology is associated with the study of factors affecting the functioning and development of language, as well as with the search for ways and means of preserving and enriching language. Monitoring the processes taking place in the speech practices of society makes it possible to judge some negative phenomena and trends in the language.