1. Higher incidence of steroid-induced ocular hypertension in keratoconus
- Author
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Emerson M. Cruz, Robert Edward T. Ang, George Asimellis, and Anastasios John Kanellopoulos
- Subjects
Keratoconus ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,Corneal collagen cross-linking ,Ocular hypertension ,010402 general chemistry ,01 natural sciences ,Topography-guided ,Steroid ,Corticosteroid induced ocular hypertension ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,Photorefractive keratectomy ,Medicine ,business.industry ,Research ,Incidence (epidemiology) ,The Athens protocol ,CXL ,Dexamethasone topical ophthalmic solution ,medicine.disease ,IOP spike ,eye diseases ,0104 chemical sciences ,Regimen ,030221 ophthalmology & optometry ,sense organs ,business - Abstract
Background To compare intraocular pressure (IOP) changes following topical dexamethasone administration for 1 month in keratoconic versus normal eyes. Methods This is a retrospective, single-center, non-randomized case series evaluation of 350 eyes. Two groups were formed: normal/control Group A (nA =73), eyes that underwent excimer laser photorefractive keratectomy; and keratoconic (KCN) Group B (nB =277), eyes that were subjected to partial laser photorefractive keratectomy combined with collagen cross-linking (The Athens Protocol). All eyes received the same post-operative regimen of topical dexamethasone 0.1 % for at least 1 month. Goldmann applanation tonometry IOP readings and central corneal thickness (CCT) measurements were monitored. Cases with induced ocular hypertension (OHT, defined as post-operative IOP higher than 21 mmHg), were identified and correlated to refractive procedure, gender, and corneal thickness. Results At 4 weeks postoperatively, OHT was noted on 27.4 % (20 /73 eyes) in Group A, and 43.7 % (121 /277 eyes) in KCN Group B, (p
- Published
- 2016