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INTRODUCTION: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey. METHOD: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively. Data regarding efficacy and safety of the patients were transferred to the data system both before the treatment and on the 6th, 12(th) and 24(th) month following the treatment. The data were analyzed using the IBM SPSS 20.00. P value of

The liver has a very important role in thesynthesis and elimination of asymmetrical dimethylarginine (ADMA), which is amethyllated derivative of arginine. The relation of ADMA, which is a nitricoxide synthase inhibitor, with liver disease is documented; however if it isdirectly related with liver injury is unkown as of yet.Our aim in this study is to determine if ADMAhas a direct effect on liver injury, if so; to evaluate if ascorbic acid (AA)reduces the extent of damage.The study consisted of three groups comprisedof 10 rats each. 1) control group, 2) ADMA (2 mg/kg/day) recieving group, 3)ADMA+AA (50 mg/kg/day) recieving group. The rats were sacrificed on the 10thday, and AST, ALT, GGT and ALP activities were measured. The histomorphologicevaluation of the liver was done by the Ishak score system. When compared to the control group, ALT and ALPactivities were found to be higher in only the ADMA group (p=0.006 and p=0.041respectively). With AA addition, parameters were found to be lower, howeverstatistical significance was not achieved (p>0.05). when the control groupwas compared with the ADMA group; interface hepatitis, confluent necrosis,focal necrosis, histologic activity index, severity of hepatitis ve portalinflammation were all found to be higher in the ADMA group. With the additionof ADMA, although not significant, said histopathologic parameters improved (p>0.05).These results suggest that the increase inplasma ADMA levels had a detrimental effect on liver injury. The lack ofsignificant improvement with AA addition suggested that other factors besideprooxidant factors had an effect on injury.