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3. Leucine-Rich Alpha-2 Glycoprotein in Monitoring Disease Activity and Intestinal Stenosis in Inflammatory Bowel Disease

Author

Tatsuki, Yoshida, Yosuke, Shimodaira, Sho, Fukuda, Noboru, Watanabe, Shigeto, Koizumi, Tamotsu, Matsuhashi, Kengo, Onochi, and Katsunori, Iijima

Subjects
Inflammation, Constriction, Pathologic, General Medicine, Inflammatory Bowel Diseases, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, C-Reactive Protein, Crohn Disease, Leucine, Humans, Colitis, Ulcerative, Biomarkers, Glycoproteins, Retrospective Studies
Abstract

Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in inflammatory bowel disease (IBD). The aim of this study was to evaluate its utility in monitoring disease activity. In this retrospective study based on case records between August 2020 and July 2021 at our two centers, we examined the correlation between serum levels of LRG and C-reactive protein (CRP) with disease activity in IBD patients. Background factors related to serum LRG levels were also analyzed. Overall, 47 Crohn's disease (CD) and 123 ulcerative colitis (UC) patients were evaluated. In patients with CD, LRG and CRP levels correlated with Harvey-Bradshaw Index (HBI) and Simple Endoscopic Score for CD (SES-CD) (LRG and HBI, r = 0.397; LRG and SES-CD, r = 0.637; CRP and HBI, r = 0.253; CRP and SES-CD, r = 0.332). In patients with UC, LRG and CRP significantly correlated with the partial Mayo score (PMS) and Mayo endoscopic subscore (MES) (LRG and PMS, r = 0.3; CRP and PMS, r = 0.282; LRG and MES, r = 0.424; CRP and MES, r = 0.459). In CD patients with normal CRP, serum LRG level was significantly higher in those with mucosal inflammation than in those with mucosal healing (16.4 vs. 10.7 μg/ mL). Stenosis was associated with serum LRG levels in CD group using multiple regression analysis. Therefore, LRG is a useful biomarker for monitoring disease activity and mucosal inflammation, and indicates the status of intestinal stenosis in IBD patients.

Published
2022

5. Low risk of esophageal adenocarcinoma among patients with ultrashort‐segment Barrett's esophagus in Japan

Author

Sho Fukuda, Katsunori Iijima, Shusei Fujimori, Taiga Komatsu, Kenta Watanabe, Tatsuki Yoshida, Yosuke Shimodaira, So Takahashi, Tamotsu Matsuhashi, Kenji Shirane, and Yohei Horikawa

Subjects
medicine.medical_specialty, Esophageal Neoplasms, Population, Esophageal adenocarcinoma, Adenocarcinoma, Gastroenterology, Barrett Esophagus, Japan, Stomach Neoplasms, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Esophagus, education, Retrospective Studies, education.field_of_study, medicine.diagnostic_test, business.industry, Incidence (epidemiology), Cancer, medicine.disease, digestive system diseases, Endoscopy, medicine.anatomical_structure, Barrett's esophagus, Atrophy, business, Follow-Up Studies, Endoscopic image
Abstract

OBJECTS Ultrashort-segment Barrett's esophagus (USSBE; length of

Published
2021

6. Transition-Metal-Free O-Arylation of Alcohols and Phenols with

Author

Tatsuki, Yoshida, Yuki, Honda, Tatsuya, Morofuji, and Naokazu, Kano

Subjects
Phenols, Alcohols, Transition Elements, Catalysis, Copper, Ethers
Abstract

Herein, we report the transition-metal-free O-arylation of alcohols and phenols with

Published
2022

7. Arylation of aryllithiums with S-arylphenothiazinium ions for biaryl synthesis

Author

Naokazu Kano, Masahiro Yamanaka, Tatsuki Yoshida, Tatsuya Morofuji, and Ryosuke Tsutsumi

Subjects
Chemistry, Aryl, Metals and Alloys, General Chemistry, Combinatorial chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Ion, chemistry.chemical_compound, Nucleophile, Ligand coupling, Materials Chemistry, Ceramics and Composites
Abstract

Aryllithiums are one of the most common and important aryl nucleophiles; nevertheless, methods for arylation of aryllithums to produce biaryls have been limited. Herein, we report arylation of aryllithiums with S-arylphenothiazinium ions through selective ligand coupling of intermediary sulfuranes. Various unsymmetrical biaryls could be obtained without transition-metal catalysis.

Published
2020

8. Arylation of aryllithiums with

Author

Tatsuya, Morofuji, Tatsuki, Yoshida, Ryosuke, Tsutsumi, Masahiro, Yamanaka, and Naokazu, Kano

Abstract

Aryllithiums are one of the most common and important aryl nucleophiles; nevertheless, methods for arylation of aryllithums to produce biaryls have been limited. Herein, we report arylation of aryllithiums with S-arylphenothiazinium ions through selective ligand coupling of intermediary sulfuranes. Various unsymmetrical biaryls could be obtained without transition-metal catalysis.

Published
2020

9. Successful treatment of hepatocellular carcinoma with lung metastasis using hepatic and bronchial artery infusion chemotherapy

Author

Kentaro Kamada, Ryo Kanata, Itsuki Hasegawa, Manabu Hashimoto, Hirohide Ohnishi, Yuko Sugimoto, Takashi Goto, Kouichi Miura, Toshitaka Sakai, Akashi Fujita, Tatsuki Yoshida, Junichi Fujiwara, Kenichi Takahashi, Takahiro Dohmen, Wataru Sato, Mitsuaki Ishioka, Shinichiro Minami, Shigetoshi Ohshima, Tomomi Shibuya, and Mitsuru Chiba

Subjects
Sorafenib, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Lung Neoplasms, medicine.medical_treatment, Antineoplastic Agents, Bronchial Arteries, Gastroenterology, Hepatic Artery, Internal medicine, medicine.artery, Internal Medicine, medicine, Carcinoma, Humans, Infusions, Intra-Arterial, Cisplatin, Chemotherapy, Lung, business.industry, Liver Neoplasms, General Medicine, respiratory system, Middle Aged, medicine.disease, Thrombosis, digestive system diseases, respiratory tract diseases, medicine.anatomical_structure, Hepatocellular carcinoma, Radiology, business, Bronchial artery, medicine.drug
Abstract

We herein report a case of hepatocellular carcinoma (HCC) with lung metastasis that was successfully treated with transcatheter arterial infusion chemotherapy via the hepatic and bronchial arteries. A 64-year-old man diagnosed with HCC in 2003 was treated with locoregional therapy followed by sorafenib for recurrent HCC. Tumor thrombosis and lung metastasis were noted in April 2012. We administered IA-call(®), a fine-powder formulation of cisplatin, via the hepatic and bronchial arteries. This therapy resulted in the disappearance of the lung metastases and a partial response to tumor thrombosis. The patient remained alive for 23 months after developing lung metastasis.

Published
2014

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