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Additional file 1.

Table S1. The relationship between TRIS and clinicopathological variables. Table S2. Comparison of prognostic performance among postoperative variables and ICPI. Table S3. Comparison of prognostic performance among HCC staging systems and ICPI. Table S4. Components of 7 staging systems for hepatocellular carcinoma. Table S5. Antibody sources and staining conditions. (DOCX 28 kb)

Figure S1. Study flowchart. Figure S2. Digital image analyzed using the image software (Image-pro plus 6.0), with tissue represented in yellow and stained cells represented in red. Figure S3. Immunohistochemistry expression pattern of 14 immune infiltrations in tumor and adjacent liver tissues, including CD3, CD4, CD8, CD14, CD20, CD27, CD45RA, CD45RO, CD57, CD66b, CD68, CD103, CXCR5, and PD1. Figure S4. X-tile plots of ICPI in the training cohort automatically selecting the optimum cut point according to the highest Ď 2 value defined by the Kaplan-Meier survival analysis and log-rank test. Figure S5. Kaplan-Meier survival curves of the training cohort categorized by different staging systems. Figure S6. (A) Nomogram for predicting the survival probability in HCC patients. (B) Calibration of the predictive models at 1, 3, and 5â years in the derivation and validation cohorts. Figure S7. The correlation between TRIS and the density of intratumoral immune features, including CD4+, CD20+, CD45RO+, and CD45RA+ cells. (DOCX 5565 kb)

Supplementary methods. (DOCX 40 kb)