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8. Liuwei Dihuang Decoction Drug-containing Serum Attenuates Transforming Growth Factor-β1-induced Epithelial-mesenchymal Transition in HK-2 Cells by Inhibiting NF-κB/Snail Signaling Pathway

Author

Qun Tang, Jiajun Pan, Yichen Jiang, Yuanyuan Huang, Haiying Zhang, Xi Wang, Chao Luo, Hui Wang, Miao Tang, and Gang Pei

Subjects
Pharmaceutical Science, Biotechnology
Abstract

Objectives:: The nuclear factor-κB (NF-κB) signaling pathway plays an important role in regulating tubular epithelial-mesenchymal transition (EMT), an indispensable cellular programme for driving organ fibrosis and tumor progression. Liuwei Dihuang Decoction (LWD) is an effective Chinese formula for treating chronic renal failure. Methods:: First, by using morphological examination, immunofluorescence staining assay, RTqPCR, and Western blot analysis, in vitro experiments were designed to analyze NF-κB and EMT markers (including Snail, α-SMA, and E-cadherin) in transforming growth factor-β1 (TGF-β1) induced renal tubular epithelial cells (HK-2) and to detect the expression levels of LWD-CS cotreatment. Then, the recombinant lentiviral vector was overexpressed and knocked down by NF- κB and transfected into HK-2 cells. Cells were treated with TGF-β1 (10 ng/ml) with blank serum or LWD-containing serum, respectively, and the expression of these molecules in the NF-κB/Snail signaling pathway was further evaluated. Results:: Our results confirmed that TGF-β1 could induce EMT, nuclear translocation of NF-κB p65, and activate the NF-κB/Snail signaling pathway in HK-2 cells. Furthermore, NF-κB knocked-down dramatically increases the TGF-β1-induced mRNA and protein expression level of E-cadherin and reduces the level of Snail and α-SMA; this is reversed by NF-κB overexpression. LWD can decrease the EMT levels through the NF-κB/Snail signaling activation in TGF-β1-induced EMT of HK-2 cells. Conclusion:: The present study provides evidence suggesting a novel mechanism that LWD exerts anti-fibrosis effects through inhibiting activation of the NF-κB/Snail signaling pathway and consequently downregulating the TGF-β1-induced EMT in renal tubular epithelial cells.

Published
2023

18. Prestoring lithium into SnO2 coated 3D carbon fiber cloth framework as dendrite-free lithium metal anode

Author

Tao Wei, Yanyan Zhou, Cheng Sun, Lesheng Liu, Sijia Wang, Mengting Wang, Ye Liu, Qing Huang, Quanchao Zhuang, and Yongfu Tang

Subjects
General Chemical Engineering, General Materials Science
Abstract

Three-dimensional (3D) conductive frameworks have been studied extensively in lithium (Li) metal anodes for their good electronic conductivities and superior structural integrity. In this work, we demonstrated a carbon fiber cloth (CFC) framework coated with SnO2 nanoparticles through a hydrothermal process combined with a carbonization method, which served as a reliable host for pouring molten Li to produce a CFC@SnO2@Li composite anode with dendritic suppression and long-life cycling performances. XRD, TEM, HRTEM, XPS and different electrochemical characterizations were carried out. Compared with the routine bare Li||LiFePO4 cells, the CFC@SnO2@Li||LiFePO4 cells had a strong specific ability, excellent rate performance, and stability for a long time, which confirm its great potential as lithium metal anodes in practical battery applications.

Published
2024

27. Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis

Author

Xuefei Tian, Xi Zhang, Ting Zhou, Shunli Zhao, Sanyuan Tang, Yongli Wang, Ruoxia Wu, Xiaoyan Zeng, and Ping Yang

Subjects
General Medicine
Abstract

Background: Nasopharyngeal carcinoma (NPC) is a usual head and neck malignancy. Guggulsterone (GS) has potential in cancer chemoprophylaxis and treatment, but its therapeutic effect on NPC is unknown. We aimed to explore whether GS could promote the secretion of exosomal circFIP1L1 from NPC cells and its regulatory mechanism. Methods: NPC tissues and adjacent tissues were collected from NPC patients. Human nasopharyngeal epithelial cell lines (NP69) and NPC lines (5-8F, CNE1, and HNE1) were used for in vitro experiments. HNE1 cells were treated with GS (20, 40, 60 μmol/L). The expressions of miR-125a-5p and circFIP1L1 were evaluated by qRT-PCR. Cell proliferation and apoptosis abilities were measured by CCK-8 and flow cytometry. HNE1 cell exosomes were extracted and identified, and the levels of VEGFA and VEGFR2 were detected by ELISA. Then miR-125a-5p was knocked down and overexpressed. HUVECs angiogenesis was determined by the tube formation assay. qRT-PCR and Western blot were utilized to evaluate the expressions of VEGFA, MMP-2, MMP-9, and ICAM-1 in HUVECs. Results: miR-125a-5p was highly expressed in NPC tissues and cells. GS promoted the secretion of exosomal circFIP1L1 from HNE1 cells to affect HUVECs proliferation and angiogenesis. Overexpression of miR-125a-5p accelerated HUVECs proliferation and angiogenesis. Knocking down miR-125a- 5p inhibited VEGFA expression. In addition, exosomal circFIP1L1 sponged miR-125a-5p, inhibiting the VEGFA pathway to repress HUVECs angiogenesis. Conclusions: GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis.

Published
2023

29. Impact of Mitral Regurgitation Etiology on Mitral Surgery After Transcatheter Edge-to-Edge Repair

Author

Zaid, Syed, Avvedimento, Marisa, Vitanova, Keti, Akansel, Serdar, Bhadra, Oliver, Ascione, Guido, Saha, Shekhar, Noack, Thilo, Tagliari, Ana Paula, Pizano, Alejandro, Donatelle, Marissa, Squiers, John, Goel, Kashish, Leurent, Guillaume, Asgar, Anita, Ruaengsri, Chawannuch, Wang, Lin, Leroux, Lionel, Flagiello, Michele, Algadheeb, Muhanad, Werner, Paul, Ghattas, Angie, Bartorelli, Antonio, Dumonteil, Nicholas, Geirsson, Arnar, van Belle, Eric, Massi, Francesco, Wyler von Ballmoos, Moritz, Goel, Sachin, Reardon, Michael, Bapat, Vinayak, Nazif, Tamim, Kaneko, Tsuyoshi, Modine, Thomas, Denti, Paolo, Tang, Gilbert, Tang, Gilbert H.L., Houston Methodist Hospital [Houston, TX, USA], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], CHU Bordeaux [Bordeaux], Hospices Civils de Lyon (HCL), Clinique Pasteur, Clinique Pasteur [Toulouse], CHU Lille, Mount Sinai Health System, Dr Bhadra has received travel compensation from Edwards Lifesciences. Dr Tagliari has received research support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Dr Leurent has been a consultant and physician proctor for and has received speaker honoraria from Abbott. Dr Asgar has been a consultant for Medtronic, Abbott, Edwards Lifesciences, and W. L. Gore & Associates, and has received research grants from Abbott. Dr Leroux has been a physician proctor for Medtronic and Abbott, and a consultant for Edwards Lifesciences. Dr Dumonteil has received speaker honoraria and travel reimbursement by Edwards Lifesciences, and has been a physician proctor and consultant for Edwards Lifesciences. Dr Geirsson has been a member of the Medtronic Strategic Surgical Advisory Board. Dr Wyler von Ballmoos has served as a consultant for LivaNova, Medtronic, and Boston Scientific. Dr Reardon has been a consultant for Medtronic, Boston Scientific, Abbott, and W. L. Gore & Associates. Dr Bapat has served as a consultant for Medtronic, Edwards Lifesciences, 4C Medical, and Boston Scientific. Dr Nazif has equity in Venus Medtech, and has received consulting fees or honoraria from Keystone Heart, Edwards Lifesciences, Medtronic, and Boston Scientific. Dr Kaneko has been a speaker for Edwards Lifesciences, Medtronic, Abbott, and Baylis Medical, and has been a consultant for 4C Medical. Dr Modine has been a physician proctor and consultant for Medtronic, Edwards Lifesciences, and Abbott. Dr Denti has received speaker honoraria from Abbott and Edwards Lifesciences, and has been a consultant for InnovHeart. Dr Tang has been a physician proctor for Medtronic, a consultant for Medtronic, Abbott, and NeoChord, and a physician advisory board member for Abbott, Boston Scientific and JenaValve, and and has received speaker honoraria from Siemens Healthineers and East End Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Subjects
MESH: Aged, MESH: Mitral Valve Insufficiency, MESH: Humans, MESH: Middle Aged, MESH: Registries, transcatheter edge-to-edge repair, MESH: Retrospective Studies, MESH: Mitral Valve, mitral valve replacement, mitral valve repair, MESH: Aged, 80 and over, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cardiology and Cardiovascular Medicine, mitral valve surgery, MESH: Treatment Outcome
Abstract

International audience; Background: Although >150,000 mitral TEER procedures have been performed worldwide, the impact of MR etiology on MV surgery after TEER remains unknown.Objectives: The authors sought to compare outcomes of mitral valve (MV) surgery after failed transcatheter edge-to-edge repair (TEER) stratified by mitral regurgitation (MR) etiology.Methods: Data from the CUTTING-EDGE registry were retrospectively analyzed. Surgeries were stratified by MR etiology: primary (PMR) and secondary (SMR). MVARC (Mitral Valve Academic Research Consortium) outcomes at 30 days and 1 year were evaluated. Median follow-up was 9.1 months (IQR: 1.1-25.8 months) after surgery.Results: From July 2009 to July 2020, 330 patients underwent MV surgery after TEER, of which 47% had PMR and 53.0% had SMR. Mean age was 73.8 ± 10.1 years, median STS risk at initial TEER was 4.0% (IQR: 2.2%-7.3%). Compared with PMR, SMR had a higher EuroSCORE, more comorbidities, lower LVEF pre-TEER and presurgery (all P < 0.05). SMR patients had more aborted TEER (25.7% vs 16.3%; P = 0.043), more surgery for mitral stenosis after TEER (19.4% vs 9.0%; P = 0.008), and fewer MV repairs (4.0% vs 11.0%; P = 0.019). Thirty-day mortality was numerically higher in SMR (20.4% vs 12.7%; P = 0.072), with an observed-to-expected ratio of 3.6 (95% CI: 1.9-5.3) overall, 2.6 (95% CI: 1.2-4.0) in PMR, and 4.6 (95% CI: 2.6-6.6) in SMR. SMR had significantly higher 1-year mortality (38.3% vs 23.2%; P = 0.019). On Kaplan-Meier analysis, the actuarial estimates of cumulative survival were significantly lower in SMR at 1 and 3 years.Conclusions: The risk of MV surgery after TEER is nontrivial, with higher mortality after surgery, especially in SMR patients. These findings provide valuable data for further research to improve these outcomes.

Published
2023

31. Revealing alkali metal ions transport mechanism in the atomic channels of Au@α-MnO2

Author

Jingzhao Chen, Yong Su, Hongjun Ye, Yushu Tang, Jitong Yan, Zhiying Gao, Dingding Zhu, Jingming Yao, Xuedong Zhang, Tingting Yang, Baiyu Guo, Hui Li, Qiushi Dai, Yali Liang, Jun Ma, Bo Wang, Haiming Sun, Qiunan Liu, Jing Wang, Congcong Du, Liqiang Zhang, Yongfu Tang, and Jianyu Huang

Subjects
Fuel Technology, Electrochemistry, Energy Engineering and Power Technology, Energy (miscellaneous)
Published
2023

33. Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats

Author

Wentao Tang, Yi Xia, Juan Deng, Haopeng Xu, Yilin Tang, Xinfang Xiao, Liu Wu, Guolin Song, Juan Qin, and Yan Wang

Subjects
Acoustics and Ultrasonics, Radiological and Ultrasound Technology, Biophysics, Radiology, Nuclear Medicine and imaging
Published
2023

35. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

Author

Wenjie Zi, Jiaxing Song, Weilin Kong, Jiacheng Huang, Changwei Guo, Wencheng He, Yinquan Yu, Bo Zhang, Wanjie Geng, Xiaolin Tan, Yaoyu Tian, Zongtao Liu, Minghua Cao, Daoyou Cheng, Bo Li, Wenguo Huang, Junsheng Liu, Pengfei Wang, Zhou Yu, Hao Liang, Shuang Yang, Mingshan Tang, Wenhua Liu, Xianjun Huang, Shugai Liu, Yufeng Tang, Youlin Wu, Li Yao, Zhu Shi, Pengcheng He, Haojin Zhao, Zhuo Chen, Jun Luo, Yue Wan, Qiang Shi, Maorong Wang, De Yang, Xianglin Chen, Fang Huang, Jinlin Mu, Hao Li, Zhimin Li, Jingbang Zheng, Shunli Xie, Tieying Cai, Yuqi Peng, Weihua Xie, Zhongming Qiu, Chang Liu, Chengsong Yue, Linyu Li, Yan Tian, Dahong Yang, Jian Miao, Jie Yang, Jinrong Hu, Raul G. Nogueira, Duolao Wang, Jeffrey L. Saver, Fengli Li, and Qingwu Yang

Subjects
General Medicine
Published
2023

40. Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial

Author

Yuesong Pan, Xia Meng, Baoshi Yuan, S Claiborne Johnston, Hao Li, Philip M Bath, Qiang Dong, Anding Xu, Jing Jing, Jinxi Lin, Yong Jiang, Xuewei Xie, Aoming Jin, Yue Suo, Hongqin Yang, Yefang Feng, Yanhua Zhou, Qing Liu, Xueli Li, Bin Liu, Hui Zhu, Jinguo Zhao, Xuerong Huang, Haitao Li, Yunyun Xiong, Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang, Yanxia Wang, Cunrui Wang, Yazhou Han, Ming Yu, Guoping Zou, Aisheng Wu, Guiru Zhang, Ping Zhang, Mingzong Yan, Jia Zhang, Jingyan Zhao, Huitian Zhang, Qinde Qi, Jianling Zhang, Zhishan Zhu, Wenfeng Fan, Liguo Chang, Lan Tan, Liang Zhao, Yanzhong Xue, Peiru Liu, Xiaohua Ju, Zuowen Zhang, Linwen Li, Feng Wei, Lixia Yang, Xuemei Li, Zhixiong Zheng, Hui Liang, Yan Wei, Ming Zhang, Ting Wang, Jianbo Yang, Panbing Huang, Guojun Tan, Yongming Chen, Jin Zhou, Zhongping An, Chunlei Li, Guohua Chen, Runxiu Zhu, Xin Sun, Yong Liu, Mei Zhang, Yanguang Zhuo, Fanwen Meng, Kebo Li, Wei Zhang, Xiangting Chai, Ke Deng, Jianhua Li, Zhiyou Cai, Hailian Jin, Bo Li, Xiaomei Zhang, Beihai Ge, Wei Hu, Zhen Jiao, Lianmei Zhong, Lijie Ren, Xinyi Li, Songdi Wu, Yinguo Wan, Jinghua Zhang, Xiaoyan Ma, Jizheng Hu, Ge Zhang, Chunling Zheng, Jun Xu, YuAn Zou, Zhihui Duan, Changxin Li, Qingxiu Zhang, Xiaoming Song, Zhengchang Jia, Chun Wang, Peining Shao, Jijun Teng, Hua Bao, Yangkun Chen, Yunfei Wei, Xu Zhang, Xisi Meng, Guangning Li, Pengke Pan, Aixia Zhuang, Xiaofei Chen, Jun Tang, Hongwei An, Shihao You, Yanyan Tang, Guilian Zhang, Hongyan Li, Miao Guo, Chunlei Yu, Ying Li, Haichao Liu, Pengfei Liang, Guangming Kang, Huijie Sun, Yu Che, Juan Tang, Dandan Li, Xiaopeng Feng, Yu Geng, Huibing Wang, Ping Shen, Huaiping Zhu, Farong Li, Lifang Zhang, Minghua Cao, Yong You, Guiyun Cui, Jun Gu, Xiangfeng Zhang, Xiaojun Liu, Houqin Chen, Yuehua Zhang, Hongnian Zhao, Ke Liang, Rui Zhi, Ling Ma, Yuanhua Wu, Yalan Geng, Ping Sun, Bing Zhong, Dongxue Li, Jingya Jiao, Yanlei Hao, Guozhong Li, Shaohua Su, Weiping Ju, Lianqiu Min, Liyan Guo, Yafei Shangguan, Yingdong Tai, Ying Xing, Hongshan Chang, Wenya Chen, Hongtao Tang, Shuchun Huang, Jingxian Fang, Donghui Yu, Hailong Zhao, Lei Xu, Aimei Wu, Hebin Wan, Hongliang Wang, Zhihui Shen, Qing Zhang, and Qian Wang

Subjects
Neurology (clinical)
Published
2023

44. Systematic analysis of distinct flow characteristics and underlying microstructural evolution mechanisms of a novel fine-grained P/M nickel-based superalloy during isothermal compression

Author

Hongning Wen, Junsong Jin, Xuefeng Tang, Xinyun Wang, Heyang Yang, Yiding Zhang, Lei Deng, Pan Gong, Qingsong Wei, Yingjie He, and Jianzheng Guo

Subjects
Polymers and Plastics, Mechanics of Materials, Mechanical Engineering, Materials Chemistry, Metals and Alloys, Ceramics and Composites
Published
2023

49. Gene Expression Network and Circ_0008012 Promote Progression in MLL/AF4 Positive Acute Lymphoblastic Leukemia

Author

Yan-Lai, Tang, Jia-Yin, Su, Jie-Si, Luo, Li-Dan, Zhang, Li-Min, Zheng, Cong, Liang, Li-Na, Wang, Yu, Li, Zhong, Fan, Dan-Ping, Huang, Panpan, Sun, Zhenhua, Luo, Ning Hao, Qi, Jing-Jing, Lan, Xiao-Li, Zhang, Li-Bin, Huang, and Xue-Qun, Luo

Subjects
Cancer Research, Oncology, Drug Discovery, Pharmacology (medical), General Medicine
Abstract

Background: Acute lymphoblastic leukemia with MLL/AF4 rearrangement remains a major hurdle to improving outcomes. Gene network and circRNAs have been found to participate in tumorigenesis, while their roles in leukemia still need to be explored. Recent patents have shown that circRNAs exhibit the markers for the children ALL, although the target and related mechanism remain to be elucidated. Objective: This study aims to explore the possible targets and mechanisms of ALL with MLLAF4 rearrangement. Methods: We first generated a gene network focusing on MLL-AF4 rearrangement. Cell viability was determined with Cell Counting Kit-8 assay. The cell apoptosis was tested by the Annexin V/PI assay. The RNA-protein complexes were analyzed by qRT-PCR, and the pathway proteins were analyzed by western blot. Results: This gene network was associated with biological processes, such as nucleic acid metabolism and immunity, indicating its key role in inflammation. We found that circ_0008012 was upregulated in MLL/AF4 ALL cells and regulated cell proliferation and apoptosis. Further computed simulation and RIP showed that IKKβ was the strongest protein in the NF-κB pathway binding with circ_0008012. As a result, possible regulation of circ_0008012 is suggested by binding IKKβ in the IKKα:IKKβ:IKKγ compound, which then phosphorylates IκB and activates NF- κB:p65:p300 compound in cell nucleus, thereby leading to leukemia. Conclusion: We identified a gene network for MLL/AF4 ALL. Moreover, circ_0008012 may be a therapeutic target for this subtype of ALL.

Published
2023

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