255 results on '"Tae-Oh Kim"'
Search Results
2. Outcomes according to treatment modalities as a bridge to curative surgery for malignant obstruction of the proximal colon: stent versus stoma
- Author
-
Yong Eun, Park, Seung Min, Hong, Seung Bum, Lee, Hong Sub, Lee, Dong Hoon, Baek, Rari, Cha, Jong Yoon, Lee, Tae Oh, Kim, and Jong Hoon, Lee
- Subjects
General Medicine - Abstract
Background/Aims: The optimal treatment for acute malignant obstruction of the proximal colon (MOPC, proximal to the splenic flexure) remains challenging. Emergency resection, the traditional modality for MOPC, has shown significantly high mortality and morbidity rates, according to recent studies. This study aimed to investigate the clinical outcomes of stent vs stoma as a bridge to curative surgery for MOPC.Methods: This retrospective cohort study included 72 patients who underwent endoscopic placement of a self-expanding metallic stent (SEMS) or loop ileostomy for MOPC at six referral centers between January 2011 and July 2021. Clinical and pathological characteristics, procedure-related complications, and long-term mortality rates after curative surgery were analyzed.Results: During a mean follow-up period of 32 months, 30 patients (41.7%) underwent ileostomy preferentially for more proximal cancer, complete obstruction, and advanced tumor stage compared to the SEMS group. No difference was found in procedure-related complications, but five deaths were observed after ileostomy. Survival analysis for 5-year mortality after curative surgery showed no significant difference between the bridge modalities (log-rank p = 0.253).Conclusions: In this study, SEMS as a bridge to surgery showed relatively safe results in terms of post-procedural mortality. However, these results should be considered when performing ileostomy in patients with more advanced malignant obstruction.
- Published
- 2023
3. Relationship between sexual differences and cardiovascular risk factors in the prevalence of asymptomatic coronary disease
- Author
-
Yong-Hoon, Yoon, Gyung-Min, Park, Jong-Young, Lee, Jae-Hwan, Lee, Jae-Hyung, Roh, Tae Oh, Kim, Pil Hyung, Lee, Jaewon, Choe, Young-Hak, Kim, and Seung-Whan, Lee
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
This study investigated the sexual differences of coronary artery disease (CAD) prevalence and its association with cardiovascular risk factors in the asymptomatic population.In total 6434 asymptomatic participants without known CAD (1740 women and 4694 men) underwent coronary computed tomography angiography (CCTA). The prevalence of significant CAD (diameter stenosis ≥50%) and other CCTA findings were compared by sex, and its influence on CAD was investigated in groups stratified by the number of cardiovascular risk factors, including age (55 years), hypertension, diabetes, dyslipidemia, and current smoking.The prevalence of current smokers, hypertension, and diabetes were higher in men than women. The mean coronary artery calcium score was 13.1 ± 58.4 for women and 51.1 ± 158.2 for men; the coronary atherosclerosis burden indices were significantly higher in men than women. Significant CAD was identified in 65 women (3.7%) and 429 men (9.1%), showing a significant association (adjusted odds ratio [OR] 2.38, P 0.001). The relatively higher risk for significant CAD in men was observed in patients with fewer risk factors, and the risk difference was not significant in patients with many risk factors (adjusted ORs: 7.69, 3.37, 1.71, 1.31, and 0.88 in patients with 0, 1, 2, 3, and 4-5 risk factors, respectively). The association between sex and risk factor groups was significant (P 0.001).In the asymptomatic population, a significantly higher CAD prevalence was noted in men than women. However, women with a high number of cardiovascular risk factors showed a CAD prevalence similar to that of men.
- Published
- 2023
4. 10-Year Outcomes After PCI and CABG for Nonbifurcation or Bifurcation LMCA Disease
- Author
-
Ah-Ram Kim, Do-Yoon Kang, Hwa Jung Kim, Tae Oh Kim, Pil Hyung Lee, Jung-Min Ahn, Seung-Jung Park, and Duk-Woo Park
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
5. Ticagrelor Versus Clopidogrel in East Asian Patients With Acute Coronary Syndrome and Diabetes Mellitus
- Author
-
Yeonwoo Choi, Do-Yoon Kang, JungBok Lee, Jinho Lee, Mijin Kim, Hoyun Kim, Jinsun Park, Suji Cho, Junghoon Lee, Sung Joo Cha, Tae Oh Kim, Pil Hyung Lee, Jung-Min Ahn, Seung-Jung Park, and Duk-Woo Park
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
It is still unknown whether diabetes mellitus (DM) affects the relative safety and efficacy of ticagrelor vs clopidogrel in East Asian patients with acute coronary syndrome (ACS).The authors sought to assess the safety and efficacy of ticagrelor vs clopidogrel according to the diabetic status of East Asian patients with ACS undergoing invasive management.This prespecified analysis of the TICA KOREA (Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management) trial included 800 Korean patients. The primary safety endpoint was clinically significant bleeding (PLATO [Platelet Inhibition and Clinical Outcomes] major or minor bleeding) at 12 months; the efficacy endpoint was major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke).Of 800 patients, 216 (27.0%) had DM. The incidence of clinically significant bleeding within 12 months was significantly higher with ticagrelor than clopidogrel in the nondiabetic group (10.2% vs 4.3%; HR: 2.45; 95% CI: 1.27-4.70;In Korean ACS patients undergoing early invasive management, diabetes status did not affect the relative safety and efficacy of ticagrelor and clopidogrel. (Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/Korean Patients With Acute Coronary Syndromes Intended for Invasive Management [TICA KOREA]; NCT02094963).
- Published
- 2022
6. Legal Issues in Broadcasting Regulations for Data Home Shopping - Focusing on the prohibition of live broadcasting and the regulation of aspect ratio
- Author
-
Tae OH Kim
- Subjects
General Medicine - Published
- 2022
7. Clinical outcomes and predictors of response for adalimumab in patients with moderately to severely active ulcerative colitis: a KASID prospective multicenter cohort study
- Author
-
Dennis Teng, Hyung Kil Kim, Hyo Jong Kim, Young-Ho Kim, Sang-Bum Kang, Jun Lee, Do Hyun Kim, Seung Yong Shin, Kang-Moon Lee, Jong-Hwa Kim, Eun Soo Kim, Dong Il Park, Tae Oh Kim, Soo Jung Park, Jong Pil Im, Eun Sun Kim, Sung-Ae Jung, Chang Hwan Choi, Young Goo Kim, You Sun Kim, Sung Jae Shin, Wonyong Kim, Hyun-Chul Kim, and Ji Won Kim
- Subjects
Response rate (survey) ,medicine.medical_specialty ,business.industry ,Gastroenterology ,medicine.disease ,Ulcerative colitis ,Inflammatory bowel disease ,Internal medicine ,medicine ,Adalimumab ,Observational study ,In patient ,business ,Body mass index ,Cohort study ,medicine.drug - Abstract
Background/Aims: This study assessed the efficacy and safety of adalimumab (ADA) and explored predictors of response in Korean patients with ulcerative colitis (UC).Methods: A prospective, observational, multicenter study was conducted over 56 weeks in adult patients with moderately to severely active UC who received ADA. Clinical response, remission, and mucosal healing were assessed using the Mayo score.Results: A total of 146 patients were enrolled from 17 academic hospitals. Clinical response rates were 52.1% and 37.7% and clinical remission rates were 24.0% and 22.0% at weeks 8 and 56, respectively. Mucosal healing rates were 39.0% and 30.1% at weeks 8 and 56, respectively. Prior use of anti-tumor necrosis factor-α (anti-TNF-α) did not affect clinical and endoscopic responses. The ADA drug level was significantly higher in patients with better outcomes at week 8 (P
- Published
- 2022
8. Water splitting over an ultrasonically synthesized NiFe/MoO3@CFP electrocatalyst
- Author
-
Sung-Ho Cho, Hwang-Ju Jeon, Younggyu Son, Sung-Eun Lee, and Tae-Oh Kim
- Subjects
Fuel Technology ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,Condensed Matter Physics - Published
- 2023
9. Characteristics of the Sites-and-Services Project Combined with the Regional Development Project : Focusing on Yeosu City Case of the Secondary Cities Regional Project in Korea
- Author
-
Tae Oh Kim
- Published
- 2022
10. Quality of Life in Newly Diagnosed Moderate-to-Severe Ulcerative Colitis: Changes in the MOSAIK Cohort Over 1 Year
- Author
-
Jun Lee, Ji Won Kim, Jae Jun Park, Kang-Moon Lee, Hyun-Soo Kim, Yoon Tae Jeen, Tae Oh Kim, Joo Sung Kim, Yoo Jin Lee, Dong Il Park, Ik Hyun Jo, Dae Bum Kim, Sung Noh Hong, and Youngdoe Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Disease ,Inflammatory bowel disease ,Quality of life ,Surveys and Questionnaires ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Hepatology ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,medicine.disease ,Ulcerative colitis ,Erythrocyte sedimentation rate ,Cohort ,Quality of Life ,Colitis, Ulcerative ,Female ,business ,Cohort study - Abstract
Background/Aims Improving quality of life has been gaining importance in ulcerative colitis (UC) management. The aim of this study was to investigate changes in health-related quality of life (HRQL) and related factors in patients with moderate-to-severe UC. Methods A multicenter, hospital-based, prospective study was performed using a Moderateto- Severe Ulcerative Colitis Cohort in Korea (the MOSAIK). Changes in HRQL, evaluated using the 12-Item Short Form Health Survey (SF-12) and Inflammatory Bowel Disease Questionnaire (IBDQ), were analyzed at the time of diagnosis and 1 year later. Results In a sample of 276 patients, the mean age was 38.4 years, and the majority of patients were male (59.8%). HRQL tended to increase in both the IBDQ and SF-12 1 year after diagnosis. A higher partial Mayo score was significantly related to poorer HRQL on the IBDQ and SF-12 in a linear mixed model (p
- Published
- 2022
11. Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn’s Disease and Interact with Regulatory Variants forTAP2
- Author
-
Kwangwoo Kim, Shin Ju Oh, Junho Lee, Ayeong Kwon, Chae-Yeon Yu, Sangsoo Kim, Chang Hwan Choi, Sang-Bum Kang, Tae Oh Kim, Dong Il Park, and Chang Kyun Lee
- Abstract
Background and AimsCrohn’s disease (CD) has a complex polygenic etiology with high heritability. We keep putting an effort to identify novel variants associated with susceptibility to CD through a genome-wide association study (GWAS) in large Korean populations.MethodsGenome-wide variant data from 902 Korean patients with CD and 72,179 controls were used to assess the genetic associations in a meta-analysis with previous Korean GWAS results from 1,621 patients with CD and 4,419 controls. Epistatic interactions between CD-risk variants of interest were tested using a multivariate logistic regression model with an interaction term.ResultsWe identified two novel genetic associations with the risk of CD nearZBTB38and within the leukocyte immunoglobulin-like receptor (LILR) gene cluster (P−8), with highly consistent effect sizes between the two independent Korean cohorts. CD-risk variants in the LILR locus are known quantitative trait loci (QTL) for multiple LILR genes, of whichLILRB2directly interacts with various ligands including MHC class I molecules. The LILR lead variant exhibited a significant epistatic interaction with CD-associated regulatory variants forTAP2involved in the antigen presentation of MHC class I molecules (P=4.11×10−4), showing higher CD-risk effects of theTAP2variant in individuals carrying more risk alleles of the LILR lead variant (OR=0.941,P=0.686 in non-carriers; OR=1.45,P=2.51×10−4in single-copy carriers; OR=2.38,P=2.76×10−6in two-copy carriers).ConclusionsThis study demonstrated that genetic variants at two novel susceptibility loci and the epistatic interaction between variants in LILR andTAP2loci confer risk of CD.
- Published
- 2023
12. Valor pronóstico a 10 años de la angiografía coronaria por TAC en pacientes asintomáticos con diabetes tipo 2
- Author
-
Junho Hyun, Pil Hyung Lee, Junghoon Lee, Yujin Yang, Ju Hyeon Kim, Tae oh Kim, Soo-Jin Kang, Jun Ki Kim, Ji Sung Lee, and Seung-Whan Lee
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2023
13. Module Implementation and Simulation of Timing Constraint Check Function of I2C Protocol Using Verilog
- Author
-
Jun-Cheol Lee, Tae-Oh Kim, and Joo-Hyung Chae
- Published
- 2023
14. Validation of Academic Research Consortium for High Bleeding Risk Definition in East-Asian Patients
- Author
-
Jinho Lee, Min-Ju Kim, Mijin Kim, Jinsun Park, Hoyun Kim, Suji Cho, Yeonwoo Choi, Junghoon Lee, Ju Hyeon Kim, Sung Joo Cha, Tae Oh Kim, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Seung-Jung Park, and Duk-Woo Park
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2023
15. Ten-year prognostic value of coronary CT angiography in asymptomatic patients with type 2 diabetes
- Author
-
Junho Hyun, Pil Hyung Lee, Junghoon Lee, Yujin Yang, Ju Hyeon Kim, Tae oh Kim, Soo-Jin Kang, Jun Ki Kim, Ji Sung Lee, and Seung-Whan Lee
- Subjects
General Medicine - Published
- 2023
16. Clinical Features and Long-term Prognosis of Crohn’s Disease in Korea: Results from the Prospective CONNECT Study
- Author
-
Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Geom Seog Seo, Chang Hwan Choi, Hyun Joo Song, Gwang Ho Baik, Ji Won Kim, Sung Jae Shin, Young Sook Park, Chang Kyun Lee, Jun Lee, Sung Hee Jung, Yunho Jung, Sung Chul Park, Young-Eun Joo, Yoon Tae Jeen, Dong Soo Han, Suk-Kyun Yang, Hyo Jong Kim, Won Ho Kim, and Joo Sung Kim
- Subjects
Cohort Studies ,Crohn Disease ,Hepatology ,Gastroenterology ,Humans ,Prospective Studies ,Prognosis ,Follow-Up Studies ,Retrospective Studies - Abstract
The prospective Crohn's Disease Clinical Network and Cohort Study is a nationwide multicenter cohort study of patients with Crohn's disease (CD) in Korea, aiming to prospectively investigate the clinical features and long-term prognosis associated with CD.Patients diagnosed with CD between January 2009 and September 2019 were prospectively enrolled. They were divided into two cohorts according to the year of diagnosis: cohort 1 (diagnosed between 2009 and 2011) versus cohort 2 (between 2012 and 2019).A total of 1,175 patients were included, and the median follow-up duration was 68 months (interquartile range, 39.0 to 91.0 months). The treatment-free durations for thiopurines (p0.001) and anti-tumor necrosis factor agents (p=0.018) of cohort 2 were shorter than those of cohort 1. Among 887 patients with B1 behavior at diagnosis, 149 patients (16.8%) progressed to either B2 or B3 behavior during follow-up. Early use of thiopurine was associated with a reduced risk of behavioral progression (adjusted hazard ratio [aHR], 0.69; 95% confidence interval [CI], 0.50 to 0.90), and family history of inflammatory bowel disease was associated with an increased risk of behavioral progression (aHR, 2.29; 95% CI, 1.16 to 4.50). One hundred forty-one patients (12.0%) underwent intestinal resection, and the intestinal resection-free survival time was significantly longer in cohort 2 than in cohort 1 (p=0.003). The early use of thiopurines (aHR, 0.35; 95% CI, 0.23 to 0.51) was independently associated with a reduced risk of intestinal resection.The prognosis of CD in Korea appears to have improved over time, as evidenced by the decreasing intestinal resection rate. Early use of thiopurines was associated with an improved prognosis represented by a reduced risk of intestinal resection.
- Published
- 2022
17. Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study
- Author
-
Jin Lee, Su Bum Park, Hyung Wook Kim, Hong Sub Lee, Sam Ryong Jee, Jong Hun Lee, and Tae Oh Kim
- Subjects
Article Subject ,Hepatology ,Gastroenterology ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,behavioral disciplines and activities ,Research Article - Abstract
Background. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy of probiotic therapy for residual IBS-like symptoms in patients with UC in endoscopic remission. Methods. We conducted a multicenter, observational study between April 2018 and December 2020 across two university hospitals in Korea. Patients with UC whose IBS-like symptoms persisted during endoscopic remission were included in this study. Endoscopic remission was defined as a Mayo endoscopic score ≤ 1 , and IBS-like symptoms were defined as those meeting the ROME-IV diagnostic criteria. A Biotop capsule® (Lactobacillus acidophilus, 75 mg; Clostridium butyricum TO-A, 25 mg; Bacillus mesentericus TO-A, 25 mg; and Streptococcus faecalis T-110, 5 mg) was administered three times daily for one month. All patients completed bowel-related symptom questionnaires and short inflammatory bowel disease questionnaires (SIBDQs) at the start and end of the 4-week treatment period. Results. A total of 43 patients were enrolled and analyzed. Statistically significant improvements from baseline were observed at the end of the 4-week treatment. The total SIBDQ score improved from 50.6 to 53.6 ( P = 0.005 ). SIBDQ scores of bowel function ( P = 0.018 ), systemic function ( P = 0.040 ), and social function ( P = 0.005 ) improved. Stool frequency and Bristol stool scale scores improved after probiotic therapy ( P < 0.05 ). Conclusion. This study showed that probiotic administration improved bowel-related symptoms and quality of life in patients with UC whose IBS-like symptoms persisted during endoscopic remission. As this is an observational study and has no placebo-controlled arm, further prospective randomized controlled trials are needed to confirm these results.
- Published
- 2022
18. How Korea Has Accepted Apartment Housing in Urban Planning?: Focusing on the Impact of Urban Growth Management Policies in the 1970s
- Author
-
Seung Jung Kim and Tae Oh Kim
- Published
- 2021
19. Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study
- Author
-
Jongwook Yu, Soo Jung Park, Hyung Wook Kim, Yun Jeong Lim, Jihye Park, Jae Myung Cha, Byong Duk Ye, Tae Oh Kim, Hyun-Soo Kim, Hyun Seok Lee, Su Young Jung, Youngdoe Kim, and Chang Hwan Choi
- Subjects
Adult ,Treatment Outcome ,Drug-Related Side Effects and Adverse Reactions ,Hepatology ,Remission Induction ,Gastroenterology ,Antibodies, Monoclonal ,Humans ,Colitis, Ulcerative ,Prospective Studies ,Middle Aged ,Severity of Illness Index - Abstract
Golimumab has been used for patients with ulcerative colitis (UC) since 2013. However, there is limited data on the effectiveness and safety of the real-world use of golimumab in Asian patients.This was a multicenter, prospective, observational study. We enrolled patients with moderate-to-severe UC who were administered subcutaneous golimumab at 46 medical centers between May 2014 and November 2019. The primary outcome was the effectiveness and safety of golimumab at week 22. Clinical outcomes and adverse events were assessed according to partial Mayo score at weeks 0, 2, 6, 14, and 22.A total of 130 patients were included (mean age: 45.7±16.0 years). The clinical response/ remission rates at weeks 2, 6, 14, and 22 were 40.4%/22.9%, 56.0%/35.8%, 70.6%/49.5%, and 67.9%/48.6%, respectively. Based on full Mayo score at week 14, clinical response and remission rates were 84.2% and 39.5%, respectively. Mucosal healing rate was 65.8%. In multivariate analysis with logistic regression, longer disease duration was significantly associated with a higher clinical response rate (adjusted odds ratio [aOR], 1.136; 95% confidence interval [CI], 1.006 to 1.282; p=0.040 at week 6; aOR, 1.256; 95% CI, 1.049 to 1.503; p=0.013 at week 22). A higher baseline Mayo endoscopic subscore was significantly associated with a lower clinical response rate at week 6 (aOR, 0.248; 95% CI, 0.089 to 0.692; p=0.008). The incidence of adverse drug reactions was 4.6% (6/130, nine events). No serious unexpected adverse drug reactions or deaths were reported.Golimumab was effective and safe as an induction and maintenance treatment for Korean patients with moderate-to-severe UC.
- Published
- 2021
20. Clinical Features and Prognosis of Patients with Primary Intestinal B-cell Lymphoma Treated with Chemotherapy with or without Surgery
- Author
-
Ra Ri, Cha, Dong Hoon, Baek, Gyeong Won, Lee, Seun Ja, Park, Jong Hoon, Lee, Jong Ha, Park, Tae Oh, Kim, Sang Heon, Lee, Hyung Wook, Kim, and Hyun Jin, Kim
- Subjects
Male ,Survival Rate ,Antineoplastic Combined Chemotherapy Protocols ,Intestine, Small ,Humans ,Female ,Lymphoma, Large B-Cell, Diffuse ,General Medicine ,Middle Aged ,Prognosis ,Neoplasm Staging ,Retrospective Studies - Abstract
This multicenter study reviewed the clinical features and prognosis according to the primary site of involvement and the treatment modality in patients with B-cell primary intestinal lymphoma (PIL).Among 125 consecutive patients diagnosed with PIL, 100 patients were analyzed.The median age was 59 years, and the male to female ratio was 1.86:1. Diffuse large B-cell lymphoma (66/100, 66.0%) was the most common histological subtype. The estimated 5-year survival rate (5-YSR) was 48.5%. The 5-YSR was similar regardless of the type of primary treatment (chemotherapy alone vs. surgery/chemotherapy, 50.7 vs. 45.3%, p=0.582). A comparison of the survival according to the primary site of involvement revealed a 5-YSR of 32.5% (p=0.027), 64.3% (reference), 46.5% (p=0.113), and 49.8% (p=0.024) for the small intestine, ileocecal region, large intestine, and multiple sites, respectively. Multivariate analysis, however, revealed a low hemoglobin level, advanced Ann Arbor stage, and aggressive histological type to be independent prognostic factors for shorter survival but not ileocecal region involvement.The Ann Arbor stage, hemoglobin level, and histological type were independent prognostic factors for survival, while the primary site of involvement and treatment modality did not affect the prognosis in patients with B-cell PIL.
- Published
- 2021
21. Natural Killer-cell Enteropathy of the Stomach in an Elderly Woman: A Case Report
- Author
-
Ye young Koo, Jin Lee, Bomi Kim, Su Jin Jeong, Eun Hye Oh, Yong Eun Park, Jongha Park, and Tae Oh Kim
- Subjects
General Medicine - Published
- 2021
22. A Study on the Status of Firefighters Wearing Seat-Belts
- Author
-
Tae-Oh Kim and Sin-Woong Choi
- Published
- 2021
23. Machine Learning-Based Prediction of Post-Treatment Ambulatory Blood Pressure in Patients with Hypertension (Preprint)
- Author
-
Hyeonyong Hae, Soo-Jin Kang, Tae Oh Kim, Pil Hyung Lee, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, and Seong-Wook Park
- Abstract
BACKGROUND Pre-treatment prediction of individual blood pressure (BP) response to anti-hypertensive drugs is important to select and optimize medication for promptly and safely achieving a target BP. However, it is challenging to predict individually variable BP responses to a specific regimen. OBJECTIVE This study aimed to develop supervised machine learning (ML) models for predicting patient-specific treatment effects using 24-hour ambulatory BP monitoring (ABPM) data. METHODS A total of 1,129 patients who had both baseline and follow-up ABPM data were randomly assigned into training, validation and test sets in a 3:1:1 ratio. Utilizing the features including clinical and laboratory findings, initial ABPM data, and anti-hypertensive medication at baseline and at follow-up, ML models were developed to predict post-treatment individual BP response. Each case was labeled by the mean 24-hour and daytime BPs derived from the follow-up ABPM. RESULTS At baseline, 616 (55%) patients had been treated using mono or combination therapy with 45 anti-hypertensive drugs. By using CatBoost, the difference between predicted vs. measured mean 24-hour systolic BP at follow-up was 8.4 ± 7.0 mm Hg (% difference of 6.6% ± 5.7%). The difference between predicted vs. measured mean 24-hour diastolic BP was 5.3 ± 4.3 mm Hg (% difference of 6.8% ± 5.5%). There were significant correlations between the CatBoost-predicted vs. the ABPM-measured changes in the mean 24-hour Systolic (r=0.74) and diastolic (r=0.68) BPs from baseline to follow-up. Even in the patients with renal insufficiency or diabetes, the correlations between CatBoost-predicted vs. ABPM-measured BP changes were significant. CONCLUSIONS ML algorithms accurately predict the post-treatment ambulatory BP levels, which may assist clinicians in personalizing anti-hypertensive treatment. CLINICALTRIAL not-applicable
- Published
- 2022
24. Multi-center study of residual gastric volume and bowel preparation after the usage of 1L and 2L polyethylene glycol in Korea
- Author
-
Yong Eun Park, Su Jin Jeong, Jin Lee, Jongha Park, Seung Jung Yu, Sam Ryong Jee, and Tae Oh Kim
- Subjects
Cathartics ,Republic of Korea ,Humans ,Water ,General Medicine ,Colonoscopy ,Polyethylene Glycols - Abstract
In colonoscopy, good bowel preparation is an important factor in determining the quality of colonoscopy. However, an increase in residual gastric volume (RGV) can lead to a higher risk of aspiration pneumonia. Therefore, the purpose of this study was to investigate the factors related to an increase in RGV with the usage of 1L polyethylene glycol (PEG).We prospectively analyzed 268 patients who underwent both gastroscopy and colonoscopy at 2 hospitals from May to October 2021. Bowel preparation was performed using 1L in 127 patients (47.4%) and 2L PEG in 141 patients (52.6%). We investigated the time taken for bowel preparation solutions, the last water intake, total water intake, and RGV, and conducted a survey on taking compliance and satisfaction.The level of RGV was significantly increased in the 1L PEG group when compared to the 2L PEG group (1L, 52.26 ± 65.33 vs 2L, 23.55 ± 22.99; P .001). There was no difference between the 2 groups in the degree of bowel preparation, but there were more bubbles formed in the 1L group (1L, 1.91 ± 2.74 vs 2L, 1.10 ± 2.02; P = .007). In the case of RGV ≥ 50 mL, in multivariate analysis, the risk was higher in water intake within 5 hours and the patients who think the dose is too high (all P .05).Therefore, since RGV is higher in 1L PEG than in 2L PEG, it is necessary to be careful not to take water for at least 5 hours before the test.
- Published
- 2022
25. Comparison of Long-Term Outcomes Following Coronary Revascularization in Men-vs-Women with Unprotected Left Main Disease
- Author
-
Duk-Woo Park, Ah-Ram Kim, Jeen Hwa Lee, Do-Yoon Kang, Junghoon Lee, Hanbit Park, Ju Hyeon Kim, Hyeon Jeong Oh, Yeong Jin Jeong, Sangwoo Park, Junho Hyun, Pil Hyung Lee, Mihee Jang, Yeon Jeong Lee, Tae Oh Kim, Seung-Jung Park, Taesun Kim, Jung-Min Ahn, and Yujin Yang
- Subjects
Lung Diseases ,Acute coronary syndrome ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Comorbidity ,Coronary Artery Disease ,Coronary Angiography ,Revascularization ,Severity of Illness Index ,Coronary artery disease ,Peripheral Arterial Disease ,Age Distribution ,Percutaneous Coronary Intervention ,Sex Factors ,Internal medicine ,Diabetes Mellitus ,Myocardial Revascularization ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Angina, Stable ,Angina, Unstable ,cardiovascular diseases ,Myocardial infarction ,Acute Coronary Syndrome ,Coronary Artery Bypass ,Mammary Arteries ,Non-ST Elevated Myocardial Infarction ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Middle Aged ,medicine.disease ,Hypertension ,Radial Artery ,Conventional PCI ,Cardiology ,ST Elevation Myocardial Infarction ,Cardiology and Cardiovascular Medicine ,business - Abstract
Gender differences have been recognized in several aspects of coronary artery disease (CAD). However, evidence for gender differences in long-term outcomes after left main coronary artery (LMCA) revascularization is limited. We sought to evaluate the impact of gender on outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for unprotected LMCA disease. We evaluated 4,320 patients with LMCA disease who underwent CABG (n = 1,456) or PCI (n = 2,864) from the Interventional Research Incorporation Society-Left MAIN Revascularization registry. The primary outcome was a composite of death, myocardial infarction (MI), or stroke. Among 4,320 patients, 968 (22.4%) were females and 3,352 (77.6%) were males. Compared to males, females were older, had a higher prevalence of hypertension and insulin-requiring diabetes, more frequently presented with acute coronary syndrome, but had less extensive CAD and less frequent left main bifurcation involvement. The adjusted risk for the primary outcome was not different after PCI or CABG in females and males (hazard ratio [HR] 1.09; 95% confidence interval [CI]: 0.73-1.63 and HR 0.97; 95% CI: 0.80-1.19, respectively); there was no significant interaction between gender and the revascularization strategy (P for interaction = 0.775). In multivariable analysis, gender did not appear to be an independent predictor for the primary outcome. In revascularization for LMCA disease, females and males had a comparable primary composite outcome of death, MI, or stroke with either CABG or PCI without a significant interaction of gender with the revascularization strategy.
- Published
- 2021
26. Randomised clinical trial: comparison of tegoprazan and lansoprazole as maintenance therapy for healed mild erosive oesophagitis
- Author
-
Yu Kyung Cho, Jae Hak Kim, Hyun‐Soo Kim, Tae‐Oh Kim, Jung‐Hwan Oh, Suck Chei Choi, Jeong Seop Moon, Sang Kil Lee, Sung Woo Jung, Sung Soo Kim, Hye‐Kyung Jung, Sang Pyo Lee, Gab‐Jin Cheon, Moo In Park, Hwoon‐Yong Jung, Kwang Hyun Ko, In Kyung Sung, Si Hyung Lee, Ju Yup Lee, Soo Teik Lee, Poong‐Lyul Rhee, Nayoung Kim, Su Jin Hong, Hyun Jin Kim, Gwang Ha Kim, Kwang Jae Lee, Sung Kook Kim, Woon Geon Shin, and Oh Young Lee
- Subjects
Hepatology ,Gastroenterology ,Pharmacology (medical) - Abstract
Tegoprazan is a novel potassium-competitive acid blocker used to treat acid-related disorders.To compare tegoprazan 25 mg with lansoprazole 15 mg as maintenance therapy in healed erosive oesophagitis (EE) METHODS: In this phase 3, double-blind, multi-centre study, patients with endoscopically confirmed healed EE were randomised 1:1 to receive tegoprazan 25 mg or lansoprazole 15 mg once daily for up to 24 weeks. The primary efficacy endpoint was the endoscopic remission rate after 24 weeks. The secondary efficacy endpoint was the endoscopic remission rate after 12 weeks. Safety endpoints included adverse events, clinical laboratory results and serum gastrin and pepsinogen I/II levels.We randomised patients to tegoprazan 25 mg (n = 174) or lansoprazole 15 mg (n = 177). Most had mild EE (Los Angeles (LA) grade A: 57.3%, LA grade B: 37.3%). The endoscopic remission rate after 24 weeks was 90.6% with tegoprazan and 89.5% with lansoprazole. Tegoprazan was not inferior to lansoprazole for maintaining endoscopic remission at 24 weeks and 12 weeks. In subgroup analysis, tegoprazan 25 mg showed no significant difference in maintenance rate according to LA grade (p = 0.47). The maintenance effect of tegoprazan was consistent in CYP2C19 extensive metabolisers (p = 0.76). Increases in serum gastrin were not higher in tegoprazan-treated than lansoprazole-treated patients.Tegoprazan 25 mg was non-inferior to lansoprazole 15 mg in maintenance of healing of mild EE. In this study, tegoprazan had a similar safety profile to lansoprazole.
- Published
- 2022
27. Risks of colorectal cancer and biliary cancer according to accompanied primary sclerosing cholangitis in Korean patients with ulcerative colitis: a nationwide population-based study
- Author
-
Eun Hye Oh, Ye-Jee Kim, Minju Kim, Seung Ha Park, Tae Oh Kim, and Sang Hyoung Park
- Subjects
Gastroenterology - Abstract
Background/Aims: We conducted a nationwide population-based study to investigate incidence rates of colorectal and biliary cancers according to accompanying primary sclerosing cholangitis in Korean ulcerative colitis patients. Methods: We used the Health Insurance Review and Assessment claim database from January 2007 to April 2020. Standardized incidence ratios of colorectal and biliary cancers in ulcerative colitis patients were calculated. Results: Among 35,189 newly diagnosed ulcerative colitis patients, 1,224 patients were diagnosed with primary sclerosing cholangitis. During the study period, 122 and 52 patients were diagnosed with colorectal and biliary cancers, respectively. Incidences of colorectal cancer were not higher in ulcerative colitis patients than those in the general population (standardized incidence ratios, 0.83; 95% confidence interval, 0.69–0.99), regardless of accompanied primary sclerosing cholangitis (standardized incidence ratio, 0.73; 95% confidence interval, 0.24–1.71). While incidences of biliary cancer were not higher in ulcerative colitis patients than those in the general population (standardized incidence ratio, 1.14; 95% confidence interval, 0.80–1.58), these were much higher with accompanied primary sclerosing cholangitis (standardized incidence ratio, 10.07; 95% confidence interval, 5.75–16.36). Cumulative incidences of colorectal and biliary cancers increased in patients who were diagnosed with ulcerative colitis at an older age. Conclusions: In Korean ulcerative colitis patients, colorectal cancer incidences were not higher than those in the general population regardless of accompanied primary sclerosing cholangitis. However, biliary cancer incidences were much higher in ulcerative colitis patients with primary sclerosing cholangitis than in those without, or in the general population.
- Published
- 2022
28. 10-Year Outcomes After PCI and CABG for Nonbifurcation or Bifurcation LMCA Disease: A Prespecified Analysis of Extended PRECOMBAT Trial
- Author
-
Ah-Ram, Kim, Do-Yoon, Kang, Hwa Jung, Kim, Tae Oh, Kim, Pil Hyung, Lee, Jung-Min, Ahn, Seung-Jung, Park, and Duk-Woo, Park
- Subjects
Percutaneous Coronary Intervention ,Treatment Outcome ,Humans ,Drug-Eluting Stents ,Coronary Artery Disease ,Coronary Artery Bypass - Published
- 2022
29. Efficiency improvement of dye-sensitized solar cells using Cu,Co/TiO2 photoelectrodes doped by applying ultrasonic treatment
- Author
-
Jae-hun Bae, Hwang-Ju Jeon, Sung-Ho Cho, Yong-beom Cho, Sung-Eun Lee, and Tae-Oh Kim
- Subjects
General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
30. COVID-19에 따른 영업제한과 손실보상의무 ― 독일의 논의와 그 시사점 ―
- Author
-
Tae-oh Kim
- Subjects
General Earth and Planetary Sciences ,Theology ,General Environmental Science ,Mathematics - Published
- 2021
31. Characteristics of Air Pollutant Emissions and Distribution for Particulate Matter Concentration of Air Pollution Networks in Gyeongsangbuk-do
- Author
-
Tae-Oh Kim, InJo Hwang, Tae-Jung Lee, and Gwi-Nam Bae
- Subjects
Environmental Engineering ,business.industry ,Pollutant emissions ,Environmental engineering ,Air pollution ,Distribution (economics) ,Environmental Science (miscellaneous) ,Particulates ,medicine.disease_cause ,Pollution ,medicine ,Environmental Chemistry ,Environmental science ,business - Published
- 2021
32. Comparison of treatment modalities as a bridge to curative surgery for malignant right-sided colonic obstruction: stent versus stoma
- Author
-
Yong Eun Park, Seung Min Hong, Seung Bum Lee, Hong Sub Lee, Dong Hoon Baek, Rari Cha, Jong Yoon Lee, Tae Oh Kim, and Jong Hoon Lee
- Abstract
Background: The optimal treatment for acute malignant right-sided colonic obstruction (RSCO) remains challenging. Emergency resection, the traditional modality for RSCO, has shown significantly high mortality and morbidity rates according to recent studies. Initial bowel decompression by stent placement or stoma creation has been established for distal colonic obstruction. This study aimed to compare the clinical outcomes of these two procedures as a bridge to curative surgery for RSCO.Methods: This retrospective cohort study included 85 patients (46 men, mean age: 73 ± 16 years) who underwent loop ileostomy or endoscopic placement of a self-expanding metallic stent (SEMS) for RSCO at six referral centers between January, 2011 and July, 2021. Clinicopathologic characteristics, procedure-related complications, surgical outcomes, and risk factors for short-term mortality were analyzed.Results: During a median follow-up period of 26 months (range: 0.5–60 months), 40 patients (47.1%) underwent ileostomy preferentially in clinical situations with tumor in ascending colon/hepatic flexure, complete obstruction, and more advanced tumor stage compared to SEMS group. No significant differences were found in procedure-related complications. Multivariate Cox regression analysis revealed that ileostomy as a bridge treatment was associated with increased likelihood of 1-year mortality (hazard ratio, 17.805; 95% confidence interval, 1.924–164.788; P = 0.011).Conclusions: In this study, ileostomy as a bridge to surgery showed a significantly higher mortality rate than stent placement. However, these results should be considered when performing ileostomy in patients with more advanced malignant obstruction of the right colon.
- Published
- 2022
33. Clinical Course of Terminal Ileal Ulcers Observed Incidentally During Colonoscopy
- Author
-
Jae Hyun Kim, Jong Hoon Lee, Won Moon, Jong Yoon Lee, Jongha Park, Yong Eun Park, Seun Ja Park, and Tae Oh Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Remission, Spontaneous ,Colonoscopy ,Gastroenterology ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Ileal Ulcer ,Ileum ,Interquartile range ,Internal medicine ,Biopsy ,medicine ,Humans ,Ileitis ,Ulcer ,Aged ,Retrospective Studies ,Incidental Findings ,medicine.diagnostic_test ,Ileal Diseases ,business.industry ,Middle Aged ,Hepatology ,medicine.disease ,Endoscopy ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Cecal intubation is essential during colonoscopy, and observation of the terminal ileum is performed in most clinical practices. However, data on terminal ileal (TI) ulcers observed incidentally during colonoscopy are rare. We aimed to identify the characteristics and clinical course of TI ulcers observed incidentally during colonoscopy. Between January 2008 and December 2018, medical records from multi-centers reporting asymptomatic subjects who underwent biopsy on TI ulcers during colonoscopy were retrospectively reviewed. The characteristics of endoscopic findings and clinical course of TI ulcers were analyzed, and the factors affecting the clinical course of TI ulcers were evaluated. The median follow-up durations from first to second colonoscopy and from second to third colonoscopy were 20 months (interquartile range, 12–36) and 24 months (interquartile range, 12–34), respectively. A total of 134 subjects were included in the analysis. The histopathologic findings of TI ulcers were mostly chronic or active ileitis/inflammation (92.7%). On the second colonoscopy, 59 (44.0%) patients had no ulcers, 38 (28.4%) showed a decrease in size or number, and 37 (27.6%) patients showed no change in ulcers. Among 62 subjects who underwent a third colonoscopy, 14 (10.4%) had decreased size or number, 10 (7.5%) had no ulcer change, and two (1.5%) had increased ulcer size or number. In multivariate logistic regression analysis, a star shape was the only factor affecting continuation without improvement of incidental TI ulcers. Most TI ulcers observed incidentally showed no unusual findings on biopsy and improved on follow-up colonoscopy without treatment.
- Published
- 2021
34. Cap-assisted Endoscopic Mucosal Resection of Rectal Perineurioma Mimicking a Neuroendocrine Tumor
- Author
-
Eun Hye Oh, Bo Mi Kim, Jongha Park, Dong Geon Lee, Su Jin Jeong, Tae Oh Kim, Yong Eun Park, and Jin Lee
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Mesenchymal stem cell ,CD34 ,Colonoscopy ,Endoscopic mucosal resection ,General Medicine ,Neuroendocrine tumors ,medicine.disease ,rectal neoplasms ,Epithelium ,medicine.anatomical_structure ,Perineurioma ,endoscopic mucosal resection ,medicine ,Medicine ,neuroendocrine tumors ,business ,Hyperplastic crypts - Abstract
Colorectal perineuriomas are benign mucosal-based mesenchymal tumors composed of perineurial cells and show serrated or hyperplastic crypts in epithelium on histopathological evaluation. Most perineuriomas are usually presented as sessile polyps and often as subepithelial tumors. In this case, colonoscopy revealed a rectal subepithelial tumor (measuring approximately 7 mm) with yellowish- colored normal mucosa. A rectal neuroendocrine tumor was suspected, and cap-assisted endoscopic mucosal resection was performed. Histopathological examination of the resected specimen revealed bland spindle cells showing immunopositivity for CD34. The patient was finally diagnosed with rectal perineurioma.
- Published
- 2021
35. Hydrogen production by electrochemical reaction using ethylene glycol with terephthalic acid
- Author
-
Tae-Oh Kim, Se-Hyun Kim, Chan-Soo Kim, Sung-Eun Lee, and Sang-Won Woo
- Subjects
Terephthalic acid ,Reaction mechanism ,Aqueous solution ,Hydrogen ,General Chemical Engineering ,Inorganic chemistry ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Decomposition ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,0210 nano-technology ,Ethylene glycol ,Hydrogen production - Abstract
In this study, ethylene glycol (EG) and terephthalic acid (TPA) were used to generate hydrogen using copper electrodes in an alkaline aqueous solution and the corresponding reaction mechanism was experimentally investigated. Both EG and TPA produced hydrogen; however, TPA consumed OH−, inhibiting the production of intermediary compounds of EG and causing EG to actively react with H2O, ultimately leading to enhanced hydrogen production. In addition, the initiation potential of water decomposition of the EG and TPA alkaline aqueous solution was 1.0 V; when 1.8 V (vs. RHE) was applied, the hydrogen production reached 440 mmol L−1, which was substantially greater than the hydrogen production rate of 150 mmol L−1 during water decomposition.
- Published
- 2021
36. Changes in fecal metabolic and lipidomic features by anti-TNF treatment and prediction of clinical remission in patients with ulcerative colitis
- Author
-
Seok-Young Kim, Seung Yong Shin, Soo Jung Park, Jong Pil Im, Hyo Jong Kim, Kang-Moon Lee, Ji Won Kim, Sung-Ae Jung, Jun Lee, Sang-Bum Kang, Sung Jae Shin, Eun Sun Kim, You Sun Kim, Tae Oh Kim, Hyun-Soo Kim, Dong Il Park, Hyung Kil Kim, Eun Soo Kim, Young-Ho Kim, Dennis Teng, Jong-Hwa Kim, Wonyong Kim, Maham Saeed, Jung Min Moon, Kisung Kim, Chang Hwan Choi, and Hyung-Kyoon Choi
- Subjects
Gastroenterology - Abstract
Background: Therapeutic targets for ulcerative colitis (UC) and prediction models of antitumor necrosis factor (TNF) therapy outcomes have not been fully reported. Objective: Investigate the characteristic metabolite and lipid profiles of fecal samples of UC patients before and after adalimumab treatment and develop a prediction model of clinical remission following adalimumab treatment. Design: Prospective, observational, multicenter study was conducted on moderate-to-severe UC patients ( n = 116). Methods: Fecal samples were collected from UC patients at 8 and 56 weeks of adalimumab treatment and from healthy controls (HC, n = 37). Clinical remission was assessed using the Mayo score. Metabolomic and lipidomic analyses were performed using gas chromatography mass spectrometry and nano electrospray ionization mass spectrometry, respectively. Orthogonal partial least squares discriminant analysis was performed to establish a remission prediction model. Results: Fecal metabolites in UC patients markedly differed from those in HC at baseline and were changed similarly to those in HC during treatment; however, lipid profiles did not show these patterns. After treatment, the fecal characteristics of remitters (RM) were closer to those of HC than to those of non-remitters (NRM). At 8 and 56 weeks, amino acid levels in RM were lower than those in NRM and similar to those in HC. After 56 weeks, levels of 3-hydroxybutyrate, lysine, and phenethylamine decreased, and dodecanoate level increased in RM similarly to those in HC. The prediction model of long-term remission in male patients based on lipid biomarkers showed a higher performance than clinical markers. Conclusion: Fecal metabolites in UC patients markedly differ from those in HC, and the levels in RM are changed similarly to those in HC after anti-TNF therapy. Moreover, 3-hydroxybutyrate, lysine, phenethylamine, and dodecanoate are suggested as potential therapeutic targets for UC. A prediction model of long-term remission based on lipid biomarkers may help implement personalized treatment.
- Published
- 2023
37. How Korea Has Transformed Self-help Housing into Completed Housing?
- Author
-
Tae Oh Kim
- Subjects
Self-help ,business.industry ,Public relations ,Psychology ,business - Published
- 2020
38. A Statistical Analysis on Burn Accidents Sustained by Firefighters
- Author
-
Tae-Oh Kim
- Published
- 2020
39. Dehydrogenation of pure methanol in an alkaline solution using copper electrodes
- Author
-
Chan-Soo Kim, Tae-Oh Kim, Sang-Won Woo, and Sung-Eun Lee
- Subjects
Electrolysis ,Materials science ,Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Electrochemistry ,01 natural sciences ,Copper ,0104 chemical sciences ,Ruthenium ,law.invention ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,law ,Dehydrogenation ,Formate ,Methanol ,0210 nano-technology ,Platinum - Abstract
Herein, we focused on electrolysis to produce hydrogen-based energy to reduce pollution and cost of energy generation by replacing platinum (Pt) and ruthenium (Ru) anodes with copper (Cu) anodes, while demonstrating that H2 and CO can be obtained by dehydrogenating pure methanol in a non-compartment cell. Also this is a new study that is completely different from DMFC. Redox products of methanol and electrochemical efficiency were determined using various techniques. 1 V (vs Ag/AgCl [KCl sat’]) was applied to quantitatively evaluate H2 generation; on average, 801.17 mmol g−1 L−1 h−1 of H2 was generated. The Cu electrode was electrochemically stable under the stirring at 150 rpm, indicating reduced toxicity by CO adsorption. Gas-phase CO and H2, along with liquid-phase formate, carbonate, and paraformaldehyde, were obtained; the main product was H2. However, details of the dehydrogenation mechanism remain unclear, and merit further investigations.
- Published
- 2020
40. Incidence and Impact of Thrombocytopenia in Patients Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents
- Author
-
Seung-Jung Park, Sang-Cheol Cho, Duk-Woo Park, Pil Hyung Lee, Hanbit Park, Jung-Min Ahn, Sangwoo Park, Tae Oh Kim, and Do-Yoon Kang
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Comorbidity ,Coronary Artery Disease ,Postoperative Hemorrhage ,Severity of Illness Index ,Coronary artery disease ,Percutaneous Coronary Intervention ,Postoperative Complications ,Risk Factors ,Cause of Death ,Internal medicine ,Antithrombotic ,Severity of illness ,medicine ,Humans ,cardiovascular diseases ,Mortality ,Aged ,Proportional Hazards Models ,Cause of death ,Duration of Therapy ,business.industry ,Dual Anti-Platelet Therapy ,Incidence ,Incidence (epidemiology) ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Middle Aged ,Prognosis ,medicine.disease ,Thrombocytopenia ,Surgery ,Stroke ,surgical procedures, operative ,Multivariate Analysis ,Conventional PCI ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors - Abstract
Platelets are crucial in the pathophysiology of coronary artery disease and are a major target of antithrombotic agents in patients receiving percutaneous coronary intervention (PCI). We sought to evaluate the incidence and prognostic impact of thrombocytopenia on clinical outcomes in patients undergoing PCI with drug-eluting stents (DES). We evaluated consecutive patients who received PCI with DES in the IRIS-DES registry between April 2008 and December 2017. Patients were divided into 2 groups based on the presence of thrombocytopenia (platelet count150 × 10
- Published
- 2020
41. Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room
- Author
-
Hyun Ae Lee, Hye-Kyung Jung, Tae Oh Kim, Ju-Ran Byeon, Eui-Sun Jeong, Hyun-Ji Cho, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, and Sung-Ae Jung
- Subjects
ROC Curve ,Risk Factors ,Acute Disease ,Humans ,Gastrointestinal Hemorrhage ,Emergency Service, Hospital ,Prognosis ,Tomography, X-Ray Computed ,Risk Assessment ,Severity of Illness Index ,Tomography ,Retrospective Studies - Abstract
Background/Aims: Acute upper gastrointestinal (UGI) bleeding is a significant emergency situation with a mortality rate of 2% to 10%. Therefore, initial risk stratification is important for proper management. We aimed to evaluate the role of contrast-enhanced multidetector computed tomography (MDCT) for risk stratification in patients with acute UGI bleeding in the emergency room (ER).Methods: This retrospective study included patients with UGI bleeding in the ER. Glasgow-Blatchford risk score-computed tomography (GBS-CT) was assessed using a combination of GBS and the MDCT scan scoring system.Results: Of the 297 patients with UGI bleeding, 124 (41.8%) underwent abdominal MDCT. Among them, 90.3% were classified as high-risk by GBS, and five patients died (4.0%). Rebleeding occurred in nine patients (7.3%). The high-risk GBS-CT group had significantly higher in-hospital mortality (10.5% in high-risk vs. 1.4% in moderate risk vs. 0% in low-risk, p = 0.049), transfusion amount (p < 0.001), and endoscopic hemostasis (p < 0.001) compared to the moderate- and low-risk groups.Conclusions: Adding MDCT scans to the existing validated prognosis model when predicting the risk of UGI bleeding in patients in the ER plays a significant role in determining in-hospital mortality, transfusions, and the need for endoscopic hemostasis.
- Published
- 2022
42. Implication of Different ECG Left Ventricular Hypertrophy in Patients Undergoing Transcatheter Aortic Valve Replacement
- Author
-
Yujin Yang, Jung‐Min Ahn, Do‐Yoon Kang, Euihong Ko, Seonok Kim, Tae Oh Kim, Ju Hyeon Kim, Junghoon Lee, Seung‐Ah Lee, Dae‐Hee Kim, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Seung‐Jung Park, and Duk‐Woo Park
- Subjects
Electrocardiography ,Risk Factors ,RC666-701 ,Humans ,transcatheter aortic valve replacement ,Diseases of the circulatory (Cardiovascular) system ,Hypertrophy, Left Ventricular ,aortic valve stenosis ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,left ventricular hypertrophy - Abstract
Background Various ECG criteria for left ventricular hypertrophy (LVH) have been proposed, but their association with clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement is unknown. We investigated the prevalence of ECG LVH according to different criteria and its prognostic impact on clinical outcomes after transcatheter aortic valve replacement. Methods and Results In this prospective observational cohort, we evaluated 700 patients who underwent transcatheter aortic valve replacement between March 2010 and December 2019. Baseline preprocedural LVH was defined by 3 ECG criteria—Sokolow‐Lyon, Romhilt‐Estes, and Cornell voltage criteria. The primary outcome was major adverse cardiac or cerebrovascular event (MACCE; composite of death, myocardial infarction, stroke, or rehospitalization from cardiovascular cause); the key secondary outcome was all‐cause and cardiovascular mortality. Among 596 eligible patients, the prevalence of LVH was determined as 56.3% by Sokolow‐Lyon, 31.1% by Romhilt‐Estes, and 48.1% by Cornell criteria. Regardless of the criteria, patients with ECG LVH had more severe aortic stenosis hemodynamics and higher left ventricular mass index. After multivariate adjustment, the presence of LVH by the Cornell criteria was significantly associated with lower risks of MACCE (adjusted hazard ratio [HR], 0.68; 95% CI, 0.51–0.91; P =0.009), all‐cause mortality (adjusted HR, 0.55; 95% CI, 0.34–0.90 [ P =0.017]), and cardiovascular mortality (adjusted HR, 0.40; 95% CI, 0.20–0.79 [ P =0.008]). However, this association was absent with the Sokolow‐Lyon and Romhilt‐Estes criteria. Conclusions ECG LVH by Cornell criteria only was significantly associated with lower risks of MACCE and all‐cause or cardiovascular mortality. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03298178.
- Published
- 2022
43. A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease
- Author
-
Su Hyun Park, Kang Nyeong Lee, Oh Young Lee, Myung Gyu Choi, Jie-Hyun Kim, In-Kyung Sung, Jae Young Jang, Kyung Sik Park, Hoon Jai Chun, Eun Young Kim, Jun Kyu Lee, Jin Seok Jang, Gwang Ha Kim, Su Jin Hong, Yong Chan Lee, Suck-Chei Choi, Hyun Soo Kim, Tae Oh Kim, Gwang Ho Baik, and Yong Cheol Jeon
- Subjects
Hepatology ,Gastroenterology - Abstract
Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). The aim of this study was to comparatively evaluate the efficacy and safety of esomeprazole with sodium bicarbonate and esomeprazole alone.This was a multicenter, randomized, double-blind, active-controlled, noninferiority comparative study. A total of 379 patients with NERD were randomly allocated to receive either EsoduoA total of 355 patients completed the study (180 in the EsoduoEsoduo
- Published
- 2022
44. Oxidative Decomposition with Peg-Mno2 Catalyst for Removal of Formaldehyde: Chemical Aspects on Hcho Oxidation Mechanism
- Author
-
Seong-Bin Do, Sung-Eun Lee, and Tae-Oh Kim
- Subjects
History ,Polymers and Plastics ,General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Business and International Management ,Condensed Matter Physics ,Industrial and Manufacturing Engineering ,Surfaces, Coatings and Films - Published
- 2022
45. Water Splitting Over an Ultrasonically Synthesized NiFe/MoO3@CFP Electrocatalyst
- Author
-
Sung-ho Cho, Hwang-Ju Jeon, Younggyu Son, Muthupandian Ashokkumar, Sung-Eun Lee, and Tae-oh Kim
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
46. Sexual Difference and Relationship with Cardiovascular Risk Factors in Asymptomatic Coronary Disease
- Author
-
Yong-Hoon Yoon, Gyung-Min Park, Jong-Young Lee, Jae-Hwan Lee, Jae-Hyung Roh, Tae oh Kim, Pil Hyung Lee, Jaewon Choe, Young-Hak Kim, and Seung-Whan Lee
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
47. Revascularization in Patients With Left Main Coronary Artery Disease and Left Ventricular Dysfunction
- Author
-
Iris-Main Registry Investigators, Do-Yoon Kang, Pil Hyung Lee, Sangwoo Park, Tae Oh Kim, Ju Hyeon Kim, Yujin Yang, Kyungjin Choe, Duk-Woo Park, Junho Hyun, Yeong Jin Jeong, Hanbit Park, Jung-Min Ahn, Junghoon Lee, and Seung-Jung Park
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Revascularization ,Cohort Studies ,Ventricular Dysfunction, Left ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,Republic of Korea ,Humans ,Medicine ,Registries ,cardiovascular diseases ,030212 general & internal medicine ,Coronary Artery Bypass ,Stroke ,Aged ,Ejection fraction ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Confidence interval ,medicine.anatomical_structure ,Conventional PCI ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Left main coronary artery (LMCA) disease is associated with high mortality and morbidity due to a large area of jeopardized myocardium. However, the optimal revascularization strategy for patients with LMCA disease and left ventricular dysfunction is still unclear.This study sought to examine long-term comparative outcomes after percutaneous coronary intervention (PCI) or a coronary artery bypass grafting (CABG) according to the severity of left ventricular dysfunction.The authors evaluated a total of 3,488 patients with LMCA disease who underwent CABG (n = 1,355) or PCI (n = 2,133) from the IRIS-MAIN (Interventional Research Incorporation Society-Left MAIN Revascularization) registry. Left ventricular function was categorized according to left ventricular ejection fraction (LVEF) as normal function (LVEF ≥55%), mild dysfunction (LVEF ≥45% to 55%), moderate dysfunction (LVEF ≥35% to 45%), or severe dysfunction (LVEF 35%). The primary outcome was a composite of death, myocardial infarction, or stroke.Among the overall patient population, 2,641 (75.7%) patients had normal LVEF and 403 (11.6%), 260 (7.5%), and 184 (5.3%) had mild, moderate, and severe left ventricular dysfunction at baseline, respectively. Compared with CABG, PCI was associated with a higher adjusted risk of primary outcomes in patients with moderate (hazard ratio [HR]: 2.23; 95% confidence interval [CI]: 1.17 to 4.28) or severe (HR: 2.45; 95% CI: 1.27 to 4.73) dysfunction. In contrast, PCI and CABG had similar risks of the primary outcomes in patients with normal (HR: 0.80; 95% CI: 0.59 to 1.07) or mild (HR: 1.17; 95% CI: 0.63 to 2.17) dysfunction (p for interaction = 0.004).In the revascularization of LMCA disease, PCI was associated with an inferior primary composite outcome of death, MI, or stroke compared with CABG in patients with moderate or severe left ventricular dysfunction. However, the risk for the primary outcome was comparable between PCI and CABG in those with normal or mild left ventricular dysfunction. (Observational Study for Left Main Disease Treatment; NCT01341327).
- Published
- 2020
48. Current Status of Amebic Liver Abscess in Korea Comparing with Pyogenic Liver Abscess
- Author
-
Jongha Park, Joon Hyuk Choi, Eunju Kim, Dong-Hee Park, Nae-Yun Heo, Jun Seong Hwang, Eun Hye Oh, Tae Oh Kim, Kyung-Joong Kim, Seung Ha Park, Yong Eun Park, and Jin Lee
- Subjects
Male ,medicine.medical_specialty ,lcsh:Medicine ,Gastroenterology ,Procalcitonin ,Serology ,Hospitals, University ,Entamoeba histolytica ,Klebsiella ,Internal medicine ,Republic of Korea ,Leukocytes ,medicine ,Humans ,Aged ,Retrospective Studies ,amebic ,Pyogenic liver abscess ,biology ,business.industry ,Incidence (epidemiology) ,lcsh:R ,General Medicine ,Middle Aged ,bacterial infections and mycoses ,University hospital ,biology.organism_classification ,medicine.disease ,liver abscess ,C-Reactive Protein ,Liver Abscess, Pyogenic ,Immunoglobulin G ,Liver Abscess, Amebic ,Female ,Tomography, X-Ray Computed ,Amebic liver abscess ,business ,Liver abscess - Abstract
Backgrounds/aims With the improvement of hygiene, the incidence of amebic liver abscess is decreasing in South Korea. On the other hand, there is little data on the status of amebic liver abscess compared to pyogenic liver abscess. Methods Patients with an amebic liver abscess, in whom Entamoeba histolytica (E. histolytica) IgG was positive, were identified retrospectively in a university hospital. The clinical, laboratory, and radiological characteristics of amebic liver abscess were compared with those of pyogenic liver abscess in the same period. Results Between March 2010 and October 2016, 413 patients with a liver abscess were identified. Among them, the serologic test for E. histolytica was performed in 209 patients. Fifteen (7.2%) were classified as an amebic liver abscess, and the remainder were diagnosed with a pyogenic liver abscess. The age, gender, white blood cell, and CRP was comparable between the two groups. Procalcitonin was lower in amebic liver abscess than the pyogenic one. On CT, peripheral rim enhancement was more frequent, but cluster signs were not observed in amebic liver abscess compared to pyogenic liver abscess. None of the patients with amebic liver abscess died. In contrast, the mortality of pyogenic liver abscess was 4.7%. Conclusions Amebic liver abscess should still be considered as one of the causes of liver abscess in Korea. It is difficult to discriminate an amebic liver abscess from a pyogenic liver abscess only according to the clinical, laboratory, and radiologic findings. Therefore, it is necessary to perform a serologic test for E. histolytica for a precise evaluation of liver abscess in a high-risk group.
- Published
- 2020
49. Issues of Telcos’ Cable Network M&A from the Perspective of Regulatory Administrative Law
- Author
-
Tae Oh Kim
- Subjects
Judicial review ,media_common.quotation_subject ,Administrative law ,Perspective (graphical) ,Cable network ,Business ,Discretion ,media_common ,Market definition ,Law and economics - Published
- 2020
50. Trends in the prevalence of chronic liver disease in the Korean adult population, 1998–2017
- Author
-
Hang Jea Jang, Joon Hyuk Choi, Nae-Yun Heo, Ki Tae Suk, Young Soo Moon, Dong Joon Kim, Jongha Park, Ha Young Park, Seung Ha Park, Hyun Kuk Kim, Yong Eun Park, Jin Lee, Tae Oh Kim, and Lindsay D. Plank
- Subjects
Adult ,Male ,medicine.medical_specialty ,Alcohol Drinking ,hepatitis b, chronic ,National Health and Nutrition Examination Survey ,prevalence ,Hyperlipidemias ,Chronic liver disease ,Gastroenterology ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Republic of Korea ,medicine ,Humans ,Obesity ,hepatitis c, chronic ,lcsh:RC799-869 ,Molecular Biology ,alcoholic-related liver disease ,Hepatology ,business.industry ,Liver Diseases ,Fatty liver ,non-alcoholic fatty liver disease ,Hepatitis C ,Middle Aged ,Hepatitis B ,Nutrition Surveys ,medicine.disease ,030220 oncology & carcinogenesis ,Chronic Disease ,Original Article ,Female ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,business - Abstract
Background and Aim Data on the trends in the prevalence of chronic liver disease (CLD) in Korea are scarce. This study aimed to evaluate whether the CLD prevalence changed between 1998–2001 and 2016–2017. Methods Data were extracted from the Korea National Health and Nutrition Examination Survey (1998–2001 to 2016–2017; n=25,893). Non-alcoholic fatty liver disease (NAFLD) was defined as a hepatic steatosis index >36 in the absence of any other evidence of CLD. The definition of alcohol-related liver disease (ALD) was excessive alcohol consumption (≥210 g/week for men and ≥140 g/week for women) and an ALD/NAFLD index >0. Results The prevalence of NAFLD increased from 18.6% (95% confidence interval [CI], 17.8–19.5%) in 1998–2001 to 21.5% (95% CI, 20.6–22.6%) in 2016–2017. During the same time period, increases were observed in the prevalence of obesity (27.0 vs. 35.1%), central obesity (29.4 vs. 36.0%), diabetes (7.5 vs. 10.6%), and excessive drinking (7.3 vs. 10.5%). ALD prevalence also increased from 3.8% (95% CI, 3.4–4.2%) to 7.0% (95% CI, 6.4–7.6%). In contrast, chronic hepatitis B decreased from 5.1% (95% CI, 4.6–5.5%) to 3.4% (95% CI, 3.0–3.8%). The prevalence of chronic hepatitis C was approximately 0.3% in 2016–2017. Conclusions The prevalence of NAFLD and ALD increase among Korean adults. Our results suggest potential targets for interventions to reduce the future burden of CLD.
- Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.