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1. Supplementary Table 1 from AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia

Author: Bryan D. Young, Olaf Heidenreich, Hugh J.M. Brady, T. Andrew Lister, Duncan M. Gascoyne, and Jenny Dunne
Abstract: Supplementary Table 1 from AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia
Published: 2023
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2. Data from Chemosensitization of B-Cell Lymphomas by Methylseleninic Acid Involves Nuclear Factor-κB Inhibition and the Rapid Generation of Other Selenium Species

Author: Simon P. Joel, Jude Fitzgibbon, T. Andrew Lister, Heidi Goenaga-Infante, and Simone Jüliger
Abstract: Although recent reports suggest that selenium can modulate the activity of cytotoxic drugs, the mechanism underlying this activity remains unclear. This has been investigated using a panel of human B-cell lymphoma cell lines. The cytotoxic effects of chemotherapeutic agents (e.g., doxorubicin, etoposide, 4-hydroperoxycyclophosphamide, melphalan, and 1-β-d-arabinofuranosylcytosine) were increased by up to 2.5-fold when combined with minimally toxic concentrations (EC5-10) of the organic selenium compound, methylseleninic acid (MSA). DNA strand breaks were identified using comet assays, but the measured genotoxic activity of the combinations did not explain the observed synergistic effects in cell death. However, minimally toxic (EC10) concentrations of MSA induced a 50% decrease in nuclear factor-κB (NF-κB) activity after an exposure of 5 h, similar to that obtained with the specific NF-κB inhibitor, BAY 11-7082. Combinations of BAY 11-7082 with these cytotoxic drugs also resulted in synergism, suggesting that the chemosensitizing activity of MSA is mediated, at least in part, by its effects on NF-κB. Basal intracellular selenium concentration was higher in a MSA-sensitive cell line. After exposure to MSA, methylselenocysteine and selenomethionine were identified as the main intracellular species generated. Volatile selenium species, trapped using solid-phase microextraction fibers, were identified as dimethylselenide and dimethyldiselenide. These volatile species are thought to be the most biologically active forms of selenium. Taken together, these results show that the NF-κB pathway is one target for MSA underlying the interaction between MSA and chemotherapy. These data encourage the further clinical development of selenium as a potential modulator of cytotoxic drug activity in B-cell lymphomas. [Cancer Res 2007;67(22):10984–92]
Published: 2023
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3. Data from AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia

Author: Bryan D. Young, Olaf Heidenreich, Hugh J.M. Brady, T. Andrew Lister, Duncan M. Gascoyne, and Jenny Dunne
Abstract: A variety of genetic lesions, including chromosomal translocations, internal tandem duplications, and mutations, have been described in acute myeloid leukemia (AML). Expression profiling has shown that chromosomal translocations, in particular, are associated with distinctive patterns of gene expression. AML exhibiting the translocation t(8;21), which fuses the AML1 and ETO genes, has such a characteristic expression profile. One gene whose expression is highly correlated with the presence of the AML1/ETO fusion is POU4F1, which encodes the POU homeodomain transcription factor BRN3A. Here we show using specific siRNA in t(8;21) cells and overexpression studies in progenitor cells that AML1/ETO promotes expression of POU4F1/BRN3A. This effect requires DNA-binding function of AML1/ETO, and accordingly, AML1/ETO is bound to the POU4F1 locus in t(8;21) cells. Functionally, whereas overexpression of Brn3a in murine hematopoietic progenitor cells induces terminal myeloid differentiation, coexpression of AML1/ETO or AML1/ETO9a blocks this effect. Furthermore, Brn3a reduction by shRNA impairs AML1/ETO-induced immortalization of murine progenitors. In summary, we identify POU4F1/BRN3A as a novel potential upregulated AML1/ETO target gene whose dramatically high expression may cooperate with AML1/ETO in t(8;21) cells. Cancer Res; 70(10); 3985–95. ©2010 AACR.
Published: 2023
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4. Gaia Early Data Release 3 The Gaia Catalogue of Nearby Stars

Author: Zoltan Balog, G. Tauran, Vincenzo Ripepi, Gerry Gilmore, M. Barros, Łukasz Wyrzykowski, Alberto Cellino, E. Poggio, P. Gavras, Simchon Faigler, Marc Audard, C. Nicolas, M. Vaillant, A. Mora, Paolo Tanga, Silvio Leccia, Despina Hatzidimitriou, A. Dapergolas, Eva Sciacca, Alberto Krone-Martins, N. Cheek, M. Hauser, Ulrike Heiter, S. Managau, L. Rohrbasser, Mathias Schultheis, E. Utrilla, Minia Manteiga, Marcella Marconi, Xavier Luri, F. De Angeli, Shay Zucker, Paolo Giacobbe, J. Juaristi Campillo, H. I. Siddiqui, J. Torra, F. X. Pineau, Roy Gomel, Thierry Morel, T. Cornez, Eric Gosset, Mario Gai, Jose M Hernandez, G. Giuffrida, A. de Torres, Laszlo Szabados, S. Ragaini, E. van Dillen, D. Semeux, Leanne P. Guy, R. Drimmel, L. M. Sarro, S. Voutsinas, Johannes Sahlmann, Damien Ségransan, S. Liao, Derek W. Morris, Jan Rybizki, André Moitinho, T. Roegiers, Bengt Edvardsson, Tristan Cantat-Gaudin, Martin Altmann, C. Turon, Laurent Chemin, K. Janßen, D. Garabato, Alejandra Recio-Blanco, Michał Pawlak, Lorenzo Rimoldini, Sergei A. Klioner, F. Torra, Carine Babusiaux, Alfred Castro-Ginard, G. Plum, Mariateresa Crosta, Iain A. Steele, A. Yoldas, Alex Lobel, J.-L. Bassilana, Harry Enke, Rosanna Sordo, Francesca Fragkoudi, F. De Luise, M. Bernet, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, C. Diener, S. Regibo, D. Barbato, T. Pauwels, R. E. de Souza, C. Fabricius, D. Souami, L. Martin Polo, M. Ramos-Lerate, Douglas J. Marshall, A. G. Butkevich, P. Madrero Pardo, P. Re Fiorentin, J. F. Le Campion, Jérôme Berthier, N. Tonello, Ummi Abbas, Y. Lebreton, M. Biermann, D. Munoz, N. Brouillet, David Teyssier, O. Vanel, P. A. Palicio, A. Jean-Antoine Piccolo, A. F. Lanza, Jesus Salgado, E. del Pozo, Antti Penttilä, R. Geyer, Ramachrisna Teixeira, L. Chaoul, Mike Smith, Rossella Cancelliere, J. M. Martín-Fleitas, D. Baines, M. Romero-Gómez, E. Anglada Varela, E. Livanou, X. Peñalosa Esteller, S. Diakite, Alberto Vecchiato, Thomas Wevers, Daniel Hestroffer, Sebastian L. Hidalgo, M. David, Angela Bragaglia, J. De Ridder, Mark Taylor, Roberto Morbidelli, A. Sagristà Sellés, Nigel Hambly, Arnaud Siebert, R. L. Smart, P. Burgess, Y. Le Fustec, Alessandro Bressan, H. Steidelmüller, Alberto Riva, H. E. Huckle, Morgan Fouesneau, N. Bauchet, P. Osborne, S. Marinoni, Krzysztof A. Rybicki, A. Masip, Laia Casamiquela, R. Messineo, A. Garofalo, Antonella Vallenari, R. Mor, Sahar Shahaf, P. de Laverny, G. Sadowski, Peter G. Jonker, A. Kochoska, F. Taris, A. F. Mulone, M. Ajaj, C. Ducourant, T. A. Lister, F. A. Jansen, Ruth Carballo, J. M. Carrasco, Tatiana Muraveva, W. van Reeven, P. Sartoretti, Jordi Portell, Andreas Korn, E. Salguero, Ana Ulla, P. Di Matteo, Coryn A. L. Bailer-Jones, J. Bakker, F. Riclet, G. Altavilla, Ulrich Bastian, P. Esquej, R. Buzzi, M. Segol, A. C. Lanzafame, L. Balaguer-Núñez, Beatrice Bucciarelli, C. Panem, E. Balbinot, T. Carlucci, Davide Massari, P. de Teodoro, Sébastien Lambert, M. I. Carnerero, Amina Helmi, F. Solitro, C. Robin, Carlos Dafonte, Tsevi Mazeh, A. Panahi, C. Fabre, Sergi Blanco-Cuaresma, Deborah Busonero, Maroussia Roelens, O. Marchal, Tomaz Zwitter, B. Holl, G. Holland, William Thuillot, Michael Davidson, E. Licata, Michele Bellazzini, Teresa Antoja, E. Szegedi-Elek, Francesca Figueras, Eric Slezak, Sergio Messina, N. Samaras, E. Poujoulet, Mark Cropper, A. Burlacu, R. Blomme, Elmé Breedt, Annie C. Robin, H. E. Delgado, Z. Kostrzewa-Rutkowska, Georges Kordopatis, Conny Aerts, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, Grigori Fedorets, Maria Süveges, F. Crifo, J. Guiraud, D. Eappachen, K. Kruszyńska, Gisella Clementini, P. Yvard, Carme Jordi, L. Bramante, G. Busso, P. David, E. Fraile, Ugo Becciani, A. Lorca, Sanjeev Khanna, Alex Bombrun, Isabella Pagano, C. Dolding, A. M. Piersimoni, Paolo Montegriffo, A. Abreu Aramburu, Anthony G. A. Brown, Simon Hodgkin, Ennio Poretti, M. Fabrizio, I. Gonzalez-Santamaria, N. A. Walton, P. Panuzzo, Benoit Carry, Raphael Guerra, J. J. González-Vidal, T. Lebzelter, Nami Mowlavi, C. Barache, M. M. S. Marcos Santos, S. Cowell, Marco Castellani, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, N. Leclerc, S. Bartolomé, J. Álvarez Cid-Fuentes, F. van Leeuwen, S. Bouquillon, Uwe Lammers, D. W. Evans, L. Eyer, M. van Leeuwen, A. Guerrier, J. González-Núñez, H. E. P. Lindstrøm, Miguel García-Torres, Ilaria Musella, L. Palaversa, W. Roux, W. Löffler, J.-B. Delisle, Dimitri Pourbaix, Timo Prusti, J. Osinde, M. Riello, G. Orrù, C. Crowley, Alessandra Mastrobuono-Battisti, Hector Canovas, D. L. Harrison, Y. Lasne, E. F. del Peloso, Laurent Galluccio, N. Hładczuk, T. Boch, Martin A. Barstow, László Molnár, Aldo Dell'Oro, C. Pagani, Krzysztof Nienartowicz, Stefano Bertone, Patrick Charlot, Eduard Masana, Elisabetta Caffau, N. Robichon, Luciana Bianchi, Federica Spoto, Felix Franke, J. L. Halbwachs, R. Gutiérrez-Sánchez, L. Pulone, Yassine Damerdji, Frédéric Arenou, Richard I. Anderson, Elena Pancino, David Hobbs, P. Castro Sampol, Yves Fremat, Pierre Kervella, C. Zurbach, Sofia Randich, Robert G. Mann, J. C. Segovia, Diego Bossini, D. Katz, Nicholas Rowell, P. Ramos, E. Racero, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Kevin Benson, Christos Siopis, J. Souchay, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Pierre Fernique, Céline Reylé, F. Pailler, Stefan Jordan, J. H. J. de Bruijne, C. A. Stephenson, E. Gerlach, Elisa Distefano, Karri Muinonen, Y. Viala, H. Zhao, L. Siltala, C. P. Murphy, Maria-Rosa L. Cioni, Andrea Chiavassa, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, Federico Marocco, Nicoletta Sanna, Alexey Mints, Juan Zorec, Ángel Gómez, I. Bellas-Velidis, M. G. Lattanzi, C. M. Raiteri, E. Brugaletta, Mikael Granvik, O. L. Creevey, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Jon Marchant, Monica Rainer, Alessandro Spagna, Andrej Prsa, M. Sarasso, Nicolas Rambaux, Paul J. McMillan, Ludovic Delchambre, M. Garcia-Reinaldos, M. Haywood, C. Fouron, S. Girona, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, Generalitat de Catalunya, INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Astronomische Rechen-Institut [Heidelberg] (ARI), Zentrum für Astronomie der Universität Heidelberg (ZAH), Universität Heidelberg [Heidelberg]-Universität Heidelberg [Heidelberg], Systèmes de Référence Temps Espace (SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Mésocentre de calcul (MESOCENTRE), Université de Franche-Comté (UFC), Centre de Données Astronomiques de Strasbourg, Partenaires INRAE, Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), THALES, Université de Namur [Namur] (UNamur), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University-Universität Heidelberg [Heidelberg] = Heidelberg University, Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), THALES [France], Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Cantabria, Gaia Collaboration, Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Astronomy, and ITA
Subjects: trigonometric parallaxes, Solar neighborhood, Stars: luminosity function, mass function, Astronomy, Astrophysics, 01 natural sciences, luminosity function, mass function [Stars], Astronomi, astrofysik och kosmologi, luminosity: mass function [Stars], Astronomy, Astrophysics and Cosmology, MAIN-SEQUENCE, Hertzsprung-Russell-diagram, 010303 astronomy & astrophysics, Stars:low-mass brown-dwarfs, wide binaries, Physics, education.field_of_study, north galactic pole, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, BROWN DWARF, Astrophysics - Solar and Stellar Astrophysics, mass function, NORTH GALACTIC POLE, Physical Sciences, symbols, CIRCULAR-VELOCITY CURVE, Halo, astro-ph.SR, Hertzsprung–Russell diagram, stars: luminosity function, astro-ph.GA, Posterior probability, Population, main-sequence, Luminosity-Function, FOS: Physical sciences, Mass-Function, Astronomy & Astrophysics, Computer Science::Digital Libraries, Photometry (optics), DWARF LUMINOSITY-FUNCTION, dwarf luminosity-function, sky-survey, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, luminosity function [stars], low-mass [Stars], 0103 physical sciences, Stars: luminosity: mass function, Stars: low-mass, WHITE-DWARFS, education, Solar and Stellar Astrophysics (astro-ph.SR), brown dwarf, catalogs, astrometry, Hertzsprung-Russell and C-M diagrams, stars: low-mass, solar neighborhood, Astrophysics - Astrophysics of Galaxies, SKY-SURVEY, white-dwarfs, Science & Technology, 010308 nuclear & particles physics, Luminosity function, White dwarf, TRIGONOMETRIC PARALLAXES, Astronomy and Astrophysics, Low-mass, 115 Astronomy, Space science, WIDE BINARIES, Stars, Physics::History of Physics, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), solar-neighborhood, Catalogs, circular-velocity curve, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Aims. We produce a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use., Methods. Theselection of objects within 100 pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100 pc is included in the catalogue., Results. We have produced a catalogue of 331 312 objects that we estimate contains at least 92% of stars of stellar type M9 within 100 pc of the Sun. We estimate that 9% of the stars in this catalogue probably lie outside 100 pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of Gaia Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10 pc of the Sun., Conclusions. We provide the community with a large, well-characterised catalogue of objects in the solar neighbourhood. This is a primary benchmark for measuring and understanding fundamental parameters and descriptive functions in astronomy.
Published: 2021
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5. Near-Earth asteroid 2012 TC4 observing campaign: Results from a global planetary defense exercise

Author: Richard J. Wainscoat, Rob Landis, Robert Weryk, Detlef Koschny, M. J. Brucker, Alessandra Springmann, Hong Kyu Moon, K. E. Fast, Jon D. Giorgini, Olivier Hainaut, Boris M. Shustov, Viqar Abbasi, Frank D. Ghigo, Michael S. P. Kelley, Donovan Mathias, Davide Farnocchia, Cassandra Lejoly, Lorien Wheeler, Paul W. Chodas, Theodore Kareta, Annika Gustafsson, Myung-Jin Kim, Robert S. McMillan, William Ryan, Martin A. Slade, Vishnu Reddy, James Bauer, Ravi Teja Nallapu, David Polishook, Jessie L. Dotson, James V. Scotti, John Noonan, Joseph S. Jao, Clement G. Lee, Haris Khan Niazi, Eileen V. Ryan, J. A. Larsen, Makoto Yoshikawa, T. A. Lister, Nicolas Erasmus, Michael W. Busch, Shantanu P. Naidu, Lindley S. Johnson, David G. Gilbank, Lawrence G. Snedeker, Young-Jun Choi, Rachel B. Fernandes, Walter M. Harris, Denis G. Laurin, Amber Bonsall, David Trilling, Alberto Quijano Vodniza, Benjamin N. L. Sharkey, Amanda A. Sickafoose, Lauren Schatz, Michael Mommert, Lance A. M. Benner, Marc A. Silva, Zarah Brown, Joseph R. Masiero, Marco Micheli, E. A. Kramer, Schelte J. Bus, David J. Tholen, Marina Brozovic, Cristina A. Thomas, John P. Faucher, Lindsay R. Slick, and Nicholas Moskovitz
Subjects: Rotation period, Near-Earth object, 010504 meteorology & atmospheric sciences, Astronomy and Astrophysics, Astrometry, Geodesy, Ephemeris, 01 natural sciences, law.invention, Apparent magnitude, Space and Planetary Science, law, Asteroid, Radar imaging, 0103 physical sciences, Environmental science, Radar, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: 著者人数: 69名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 吉川, 真), Number of authors: 69 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Yoshikawa, Makoto), Accepted: 2019-02-14, 資料番号: SA1190045000
Published: 2019
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6. Rapid Response and Robotic Telescopes For Understanding Small Body Transient Science

Author: T. A. Lister, Quanzhi Ye, Geza Gyuk, Jian-Yang Li, and Michael S. P. Kelley
Subjects: Physics, business.industry, Transient (oscillation), Aerospace engineering, business, Rapid response
Published: 2021
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7. The Galactic Anticentre

Author: Vincenzo Ripepi, A. de Torres, Annie C. Robin, Mariateresa Crosta, C. Diener, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, K. Kruszyńska, E. Fraile, André Moitinho, Michał Pawlak, P. Panuzzo, M. Riello, Benoit Carry, A. Yoldas, Harry Enke, N. Tonello, P. Gavras, M. Vaillant, Rosanna Sordo, E. del Pozo, Lorenzo Rimoldini, M. Bernet, G. Orrù, W. van Reeven, J. M. Martín-Fleitas, S. Diakite, P. Burgess, P. Osborne, Derek W. Morris, M. I. Carnerero, Amina Helmi, Mike Smith, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, A. Sagristà Sellés, Roberto Molinaro, B. Holl, D. Baines, D. Molina, J. Fernández-Hernández, S. Marinoni, Michele Bellazzini, Maria Süveges, Teresa Antoja, D. Barbato, Uwe Lammers, Isabella Pagano, Davide Massari, G. Plum, P. Ramos, G. Jevardat de Fombelle, M. Biermann, C. Crowley, Mathias Schultheis, D. W. Evans, P. A. Palicio, Paolo Montegriffo, Ramachrisna Teixeira, R. Blomme, Elmé Breedt, T. A. Lister, F. A. Jansen, Ruth Carballo, Marcella Marconi, A. Abreu Aramburu, J. M. Carrasco, F. Royer, S. Accart, A. Burlacu, S. Regibo, Andrej Prsa, M. Sarasso, Nicolas Rambaux, A. F. Mulone, Ana Ulla, Eric Gosset, Alessandra Mastrobuono-Battisti, George M. Seabroke, H. E. Delgado, Federico Marocco, C. Nicolas, T. Lebzelter, Nami Mowlavi, C. Barache, Nicoletta Sanna, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Silvio Leccia, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, F. Figueras, G. Busso, C. Fabre, P. Di Matteo, F. Riclet, F. Solitro, Eric Slezak, N. Samaras, João Alves, Emese Plachy, Timo Prusti, F. van Leeuwen, J. Osinde, O. Marchal, M. Ajaj, C. Ducourant, Tatiana Muraveva, Shay Zucker, H. Steidelmüller, Alberto Riva, D. Semeux, N. Cheek, Laurent Galluccio, Martin A. Barstow, Alex Bombrun, S. Liao, M. van Leeuwen, R. E. de Souza, P. de Laverny, T. Roegiers, Paul J. McMillan, G. Holland, Alexey Mints, G. Giuffrida, L. M. Sarro, Juan Zorec, G. Sadowski, P. Yvard, Carme Jordi, J. L. Halbwachs, Laurent Chemin, Ludovic Delchambre, M. Garcia-Reinaldos, Ugo Becciani, Diego Bossini, Ángel Gómez, Sergi Blanco-Cuaresma, Rossella Cancelliere, C. Fabricius, J. De Ridder, L. Eyer, L. Pulone, Simon Hodgkin, Ennio Poretti, F. De Angeli, M. Haywood, E. Anglada Varela, Antonella Vallenari, F. X. Pineau, D. Garabato, A. Guerrier, H. E. P. Lindstrøm, Thomas Hilger, I. Bellas-Velidis, Frédéric Arenou, Paolo Giacobbe, Ilaria Musella, Tristan Cantat-Gaudin, L. Palaversa, Pedro García-Lario, David Hobbs, C. Turon, E. Balbinot, P. de Teodoro, Sébastien Lambert, D. Katz, Angela Bragaglia, Anthony G. A. Brown, Paolo Tanga, P. Castro Sampol, J. C. Segovia, Alejandra Recio-Blanco, Yves Fremat, Jon Marchant, Jose M Hernandez, S. Ragaini, Sofia Randich, P. Re Fiorentin, J. F. Le Campion, Gisella Clementini, M. Segol, P. David, R. Drimmel, F. Crifo, J. Guiraud, M. David, R. L. Smart, M. Fabrizio, I. Gonzalez-Santamaria, D. Eappachen, M. G. Lattanzi, Miguel García-Torres, Andreas Korn, S. Voutsinas, László Molnár, Simchon Faigler, A. Mora, Nicholas Rowell, Antti Penttilä, R. Geyer, Sanjeev Khanna, Aldo Dell'Oro, H. E. Huckle, C. Dolding, N. Leclerc, Monica Rainer, R. Mor, J. Bakker, Maroussia Roelens, Douglas J. Marshall, A. G. Butkevich, Nigel Hambly, A. Masip, Laia Casamiquela, R. Messineo, Martin Altmann, A. M. Piersimoni, Alessandro Spagna, Gerry Gilmore, Stefano Bertone, Patrick Charlot, O. Vanel, Daniel Hestroffer, Marco Castellani, Sebastian L. Hidalgo, W. Roux, Łukasz Wyrzykowski, Krzysztof A. Rybicki, M. M. S. Marcos Santos, Raphael Guerra, Alberto Cellino, E. Poggio, Gérard Jasniewicz, J. J. González-Vidal, S. Cowell, Peter G. Jonker, C. M. Raiteri, S. Bartolomé, J. Álvarez Cid-Fuentes, Elisabetta Caffau, J. J. Aguado, N. R. Millar, Ulrike Heiter, Federica Spoto, Felix Franke, A. Baudesson-Stella, M. Barros, Tsevi Mazeh, A. Panahi, E. Brugaletta, R. Buzzi, Elena Pancino, G. Altavilla, E. Racero, Enrique Solano, Mikael Granvik, Minia Manteiga, C. Robin, Tomaz Zwitter, Deborah Busonero, Alberto Krone-Martins, Marc Audard, Kevin Benson, Christos Siopis, L. Balaguer-Núñez, C. A. L. Bailer-Jones, E. Poujoulet, O. L. Creevey, E. Szegedi-Elek, C. Fouron, Michael Davidson, E. Licata, Despina Hatzidimitriou, Mark Cropper, Z. Kostrzewa-Rutkowska, S. Managau, A. Dapergolas, Sergio Messina, Laszlo Szabados, H. I. Siddiqui, W. Löffler, Mario Gai, J.-B. Delisle, Leanne P. Guy, S. G. Baker, W. J. Cooper, Alfred Castro-Ginard, Conny Aerts, A. Lorca, Xavier Luri, Damien Ségransan, Grigori Fedorets, A. Garofalo, J. Juaristi Campillo, F. De Luise, F. Pailler, F. Taris, L. Bramante, Thierry Morel, T. Cornez, L. Martin Polo, M. Ramos-Lerate, Jordi Portell, E. Salguero, Sergei A. Klioner, K. Janßen, Ulrich Bastian, Stefan Jordan, P. Esquej, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Y. Lebreton, Carlos Dafonte, S. Girona, D. Munoz, Dimitri Pourbaix, William Thuillot, J. H. J. de Bruijne, N. Brouillet, L. Chaoul, F. Torra, Alex Lobel, J.-L. Bassilana, Francesca Fragkoudi, M. Romero-Gómez, C. A. Stephenson, T. Pauwels, Eva Sciacca, Alessandro Bressan, Morgan Fouesneau, E. Livanou, E. Gerlach, X. Peñalosa Esteller, Roberto Morbidelli, L. Rohrbasser, Johannes Sahlmann, Elisa Distefano, P. Sartoretti, Karri Muinonen, Zoltan Balog, Y. Viala, J. Torra, H. Zhao, L. Siltala, G. Tauran, D. Souami, P. Madrero Pardo, David Teyssier, Jesus Salgado, J. Souchay, C. P. Murphy, Maria-Rosa L. Cioni, N. A. Walton, S. Bouquillon, Andrea Chiavassa, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Yassine Damerdji, Richard I. Anderson, Pierre Fernique, Céline Reylé, M. Hauser, E. Utrilla, Pierre Kervella, C. Zurbach, Robert G. Mann, Ummi Abbas, Hector Canovas, D. L. Harrison, Y. Lasne, Mark Taylor, Y. Le Fustec, E. F. del Peloso, N. Bauchet, E. van Dillen, Jan Rybizki, N. Hładczuk, T. Boch, J. González-Núñez, Carine Babusiaux, C. Pagani, Krzysztof Nienartowicz, Eduard Masana, G. Kordopatis, N. Robichon, Luciana Bianchi, R. Gutiérrez-Sánchez, Arnaud Siebert, A. Kochoska, T. Carlucci, Jérôme Berthier, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, European Commission, Centros de Excelencia Severo Ochoa, BARCELONA SUPERCOMPUTING CENTER (BSC), SEV2015-0493, Krone Martins, A. [0000-0002-2308-6623], McMillan, P. [0000-0002-8861-2620], Carrasco Martínez, J. P. [0000-0002-3029-5853], Sozzetti, A. [0000-0002-7504-365X], Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MINECO/ICTI2013-2016/MDM-2014-0369, Centrode Excelencia Científica Instituto de Ciencias del Cosmos Universidad de Barcelona, MINECO/ICTI2013-2016/SEV2015-0493, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), National Natural Science Foundation of China (NSFC), Estonian Ministry of Education and Research, Centre National D'Etudes Spatiales (CNES), Agence Nationale de la Recherche (ANR), Centre National de la Recherche Scientifique (CNRS), European Commission (EC), European Research Council (ERC), Institut des Sciences de l'Univers (INSU), Institut National Polytechnique (INP), Institut National de Physique nucleaire et de Physique des Particules (IN2P3), Deutsches Zentrum für Luft- und Raumfahrt (DLR), Hungarian Academy of Sciences, Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Italian Istituto Nazionale di Astrofisica (INAF), Netherlands Organisation for Scientific Research (NWO), Polish National Science Centre, Ministry of Science and Higher Education (MNiSW), Fundacao para a Ciencia e a Tecnologia (FCT), Slovenian Research Agency, Agencia Estatal de Investigación (AEI), Generalitat de Catalunya, United Kingdom Science and Technology Facilities Council (STFC), United Kingdom Space Agency (UKSA), Gaia Collaboration, Universidad de Cantabria, Astronomy, Kapteyn Astronomical Institute, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), M2A 2021, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), and Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: trigonometric parallaxes, SOLAR NEIGHBORHOOD, Astronomy, SAGITTARIUS DWARF GALAXY, Astrophysics, 01 natural sciences, sagittarius dwarf galaxy, 010303 astronomy & astrophysics, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], solar neighborhood, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, Gelexy: kinematics and dynamics, Kinematics and Dynamics, Open clusters and asssociations: individual: Berkeley 29, sky survey, Disk, Physical Sciences, kinematics and dynamics [Gelexy], old open clusters, MILKY-WAY, Astrophysics::Earth and Planetary Astrophysics, open clusters and associations: individual: Berkeley 29, Galaxy: kinematics and dynamics, disk [Galaxy], individual: Berkeley 29 [open clusters and associations], Astrometria, Berkeley 29, EXPLORING HALO SUBSTRUCTURE, LOCAL KINEMATICS, Milky Way, FOS: Physical sciences, Open Clusters and Associations, Individual, exploring halo substructure, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, Computer Science::Digital Libraries, stellar structure, Galaxy: disk, Open clusters and associations: individual: Saurer 1, Galactic halo, Halo, Settore FIS/05 - Astronomia e Astrofisica, individual: Berkeley 29 [Open clusters and asssociations], 0103 physical sciences, distances [stars], halo [Galaxy], Disc, Stars: distances, milky-way, Saurer 1, Astrophysics::Galaxy Astrophysics, canis-major, Science & Technology, 010308 nuclear & particles physics, TRIGONOMETRIC PARALLAXES, Galaxy: halo, stars: distances, open clusters and associations: individual: Saurer 1, Astrophysics - Astrophysics of Galaxies, Astronomy and Astrophysics, Galactic plane, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, CANIS-MAJOR, Stars, Galaxy, Physics::History of Physics, Estels, individual: Saurer 1 [open clusters and associations], Distances, local kinematics, OLD OPEN CLUSTERS, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), SKY SURVEY, Open cluster, STELLAR STRUCTURE
Abstract: Aims. We aim to demonstrate the scientific potential of the Gaia Early Data Release 3 (EDR3) for the study of different aspects of the Milky Way structure and evolution and we provide, at the same time, a description of several practical aspects of the data and examples of their usage., Methods. We used astrometric positions, proper motions, parallaxes, and photometry from EDR3 to select different populations and components and to calculate the distances and velocities in the direction of the anticentre. In this direction, the Gaia astrometric data alone enable the calculation of the vertical and azimuthal velocities; also, the extinction is relatively low compared to other directions in the Galactic plane. We then explore the disturbances of the current disc, the spatial and kinematical distributions of early accreted versus in situ stars, the structures in the outer parts of the disc, and the orbits of open clusters Berkeley 29 and Saurer 1., Results. With the improved astrometry and photometry of EDR3, we find that: (i) the dynamics of the Galactic disc are very complex with oscillations in the median rotation and vertical velocities as a function of radius, vertical asymmetries, and new correlations, including a bimodality with disc stars with large angular momentum moving vertically upwards from below the plane, and disc stars with slightly lower angular momentum moving preferentially downwards; (ii) we resolve the kinematic substructure (diagonal ridges) in the outer parts of the disc for the first time; (iii) the red sequence that has been associated with the proto-Galactic disc that was present at the time of the merger with Gaia-Enceladus-Sausage is currently radially concentrated up to around 14 kpc, while the blue sequence that has been associated with debris of the satellite extends beyond that; (iv) there are density structures in the outer disc, both above and below the plane, most probably related to Monoceros, the Anticentre Stream, and TriAnd, for which the Gaia data allow an exhaustive selection of candidate member stars and dynamical study; and (v) the open clusters Berkeley 29 and Saurer 1, despite being located at large distances from the Galactic centre, are on nearly circular disc-like orbits., Conclusions. Even with our simple preliminary exploration of the Gaia EDR3, we demonstrate how, once again, these data from the European Space Agency are crucial for our understanding of the different pieces of our Galaxy and their connection to its global structure and history.
Published: 2021
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8. Improving the focus of Las Cumbres Observatory’s 1-meter telescopes

Author: T. A. Lister, N. H. Volgenau, Patrick Conway, Lindy Lindstrom, and Daniel Harbeck
Subjects: Telescope, Focus (computing), Observatory, Computer science, law, Metre, Remote sensing, Time domain astronomy, law.invention
Abstract: In Las Cumbres Observatory’s global network, the 1-meter telescopes are in greatest demand. Beginning in 2019, we undertook an investigation into the focus stability of these telescopes. We also refined the procedures for setting and maintaining optimal focus. The investigation showed the sensitivity of the telescopes’ optical components to temperature variations. The temperatures within the domes, as well as along the telescopes, are rarely stable for the first 80-120 minutes of science observations. A consequence is that start-of-night focus corrections must later be countered by additional corrections after thermalization. We report the various improvements to telescope focus that our investigation has spawned. The start-of-night focus corrections are now made immediately before science observations begin. Focus checks are now monitored during the night and trigger actionable alerts if they fail. Finally, we report on our effort to use the guide cameras as real-time focus sensors.
Published: 2020
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9. Gaia Early Data Release 3: Acceleration of the solar system from Gaia astrometry

Author: Vincenzo Ripepi, P. Gavras, M. Vaillant, Mathias Schultheis, László Molnár, E. Poujoulet, Mark Cropper, C. Babusiaux, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, A. de Torres, Aldo Dell'Oro, J. Castañeda, Z. Kostrzewa-Rutkowska, A. Bombrun, André Moitinho, Marcella Marconi, Rossella Cancelliere, M. Hauser, M. Ajaj, C. M. Raiteri, L. Eyer, Michał Pawlak, H. I. Siddiqui, C. Ducourant, Tatiana Muraveva, Tsevi Mazeh, A. Panahi, Federico Marocco, Stefano Bertone, D. Vicente, Patrick Charlot, A. Guerrier, R. De March, Mario Gai, J. Souchay, H. E. P. Lindstrøm, Nicoletta Sanna, Agnes Fienga, Giovanni Comoretto, Jon Marchant, A. Lorca, E. Utrilla, A. Garcia-Gutierrez, Ilaria Musella, L. Balaguer-Núñez, Leanne P. Guy, N. Leclerc, E. Brugaletta, A. Yoldas, Harry Enke, Rosanna Sordo, Zoltan Balog, H. E. Huckle, L. Palaversa, Monica Rainer, T. A. Lister, F. A. Jansen, Ruth Carballo, Alessandro Spagna, J. M. Carrasco, Mikael Granvik, Derek W. Morris, F. Julbe, A. Hutton, J. Osinde, D. W. Evans, M. van Leeuwen, M. Weiler, F. Thévenin, F. Torra, Iain A. Steele, Lorenzo Rimoldini, Alessandro Sozzetti, Francesca Fragkoudi, K. Janßen, O. L. Creevey, J. González-Núñez, T. Pauwels, R. Buzzi, Miguel García-Torres, S. Liao, G. Tauran, Lennart Lindegren, C. Fouron, Pierre Fernique, Céline Reylé, P. Di Matteo, E. Szegedi-Elek, F. Pailler, Stefan Jordan, Roberto Molinaro, Elisabetta Caffau, Federica Spoto, Felix Franke, D. Barbato, Isabelle Lecoeur-Taïbi, Tristan Cantat-Gaudin, Alejandra Recio-Blanco, E. Livanou, W. Roux, X. Peñalosa Esteller, P. A. Palicio, J. H. J. de Bruijne, Sergi Blanco-Cuaresma, Deborah Busonero, F. Riclet, Conny Aerts, Georges Kordopatis, Guy Rixon, F. Solitro, Davide Massari, Mike Smith, D. Baines, Roberto Morbidelli, Gerry Gilmore, G. Plum, Alexey Mints, O. Marchal, Juan Zorec, Ángel Gómez, C. A. Stephenson, Michael Davidson, C. Fabricius, E. Licata, Sergio Messina, Laszlo Szabados, M. Biermann, A. Garofalo, G. Holland, F. De Angeli, Andreas Korn, E. Anglada Varela, Grigori Fedorets, S. Girona, E. Gerlach, Antonella Vallenari, M. Riello, Łukasz Wyrzykowski, Damien Ségransan, F. Taris, L. Bramante, Alberto Cellino, S. Regibo, Andrej Prsa, M. Sarasso, E. Poggio, W. Löffler, Paolo Giacobbe, Jordi Portell, Elisa Distefano, Eric Slezak, I. Bellas-Velidis, Nicolas Rambaux, E. Balbinot, J.-B. Delisle, Maroussia Roelens, E. Salguero, P. de Teodoro, E. van Dillen, Y. Lebreton, Francois Mignard, Sergei A. Klioner, Ulrich Bastian, N. Samaras, G. Orrù, R. E. de Souza, P. Esquej, Paul J. McMillan, A. C. Lanzafame, Sébastien Lambert, Beatrice Bucciarelli, Jose M Hernandez, M. Bernet, S. Ragaini, Gisella Clementini, A. F. Mulone, Ludovic Delchambre, C. Panem, Eric Gosset, P. David, M. Garcia-Reinaldos, Ana Ulla, F. Crifo, J. Guiraud, Mariateresa Crosta, L. Chaoul, C. Diener, Carlos Dafonte, Karri Muinonen, Alex Lobel, J.-L. Bassilana, Maria Süveges, Isabella Pagano, Dimitri Pourbaix, D. Eappachen, M. Haywood, R. Drimmel, Y. Viala, S. Voutsinas, D. Semeux, William Thuillot, N. A. Walton, Paolo Montegriffo, A. Abreu Aramburu, C. Fabre, H. Zhao, Alessandro Bressan, S. Bouquillon, Sanjeev Khanna, T. Lebzelter, N. Tonello, L. Siltala, M. G. Lattanzi, C. Crowley, P. Yvard, Carme Jordi, Elena Pancino, E. del Pozo, Jan Rybizki, Nami Mowlavi, C. Barache, Morgan Fouesneau, J. De Ridder, Ugo Becciani, Martin Altmann, F. van Leeuwen, P. M. Marrese, M. A. Álvarez, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, Caroline Soubiran, C. P. Murphy, A. M. Piersimoni, Alessandra Mastrobuono-Battisti, Peter G. Jonker, A. Sagristà Sellés, T. Roegiers, S. Marinoni, Johannes Sahlmann, Rene Andrae, P. Sartoretti, G. Altavilla, Raphael Guerra, F. X. Pineau, M. Segol, T. Prusti, J. J. González-Vidal, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, Andrea Chiavassa, Laurent Chemin, C. Turon, H. Steidelmüller, Douglas J. Marshall, A. G. Butkevich, Alberto Riva, P. de Laverny, Simchon Faigler, Laurent Galluccio, A. Mora, P. Re Fiorentin, C. Ordénovic, J. F. Le Campion, A. Delgado, V. Sanchez Gimenez, M. David, G. Sadowski, R. L. Smart, A. Masip, Laia Casamiquela, R. Messineo, R. Mor, J. Bakker, C. Dolding, J. M. Martín-Fleitas, S. Diakite, Coryn A. L. Bailer-Jones, D. Souami, P. Madrero Pardo, Martin A. Barstow, David Teyssier, Ummi Abbas, Jesus Salgado, Paolo Tanga, A. Burlacu, O. Vanel, Ulrike Heiter, Daniel Hestroffer, Sebastian L. Hidalgo, H. E. Delgado, Alberto Krone-Martins, C. Robin, Kevin Benson, Christos Siopis, S. Managau, P. Burgess, Tomaz Zwitter, M. M. S. Marcos Santos, S. Cowell, J. L. Halbwachs, Xavier Luri, Antti Penttilä, R. Geyer, Minia Manteiga, Yassine Damerdji, Nigel Hambly, S. Bartolomé, J. Álvarez Cid-Fuentes, P. Osborne, J. Juaristi Campillo, Mark Taylor, Richard I. Anderson, Y. Le Fustec, Thierry Morel, T. Cornez, Krzysztof A. Rybicki, L. Pulone, N. Bauchet, Pierre Kervella, C. Zurbach, Alfred Castro-Ginard, Frédéric Arenou, P. Ramos, Robert G. Mann, Annie C. Robin, J. C. Segovia, M. Barros, Hector Canovas, D. L. Harrison, Y. Lasne, L. Noval, David Hobbs, E. F. del Peloso, P. Castro Sampol, Yves Fremat, F. De Luise, Daniel Michalik, P. J. Richards, L. Karbevska, N. Hładczuk, K. Kruszyńska, T. Boch, Sofia Randich, A. G. A. Brown, C. Pagani, L. Martin Polo, M. Ramos-Lerate, Krzysztof Nienartowicz, Eduard Masana, E. Racero, E. Fraile, Marc Audard, N. Robichon, Luciana Bianchi, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Jérôme Berthier, Despina Hatzidimitriou, R. Gutiérrez-Sánchez, M. Fabrizio, I. Gonzalez-Santamaria, A. Dapergolas, P. Panuzzo, Benoit Carry, Francesca Figueras, R. Blomme, Elmé Breedt, D. Munoz, Diego Bossini, G. Busso, D. Katz, Simon Hodgkin, Ennio Poretti, N. Brouillet, Marco Castellani, Nicholas Rowell, Arnaud Siebert, M. Romero-Gómez, Shay Zucker, W. van Reeven, A. Kochoska, G. Giuffrida, Eva Sciacca, T. Carlucci, L. M. Sarro, M. I. Carnerero, Amina Helmi, D. Garabato, B. Holl, Michele Bellazzini, L. Rohrbasser, Teresa Antoja, J. Torra, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, C. Nicolas, Silvio Leccia, N. Cheek, Uwe Lammers, Ramachrisna Teixeira, Techniche Universtât Desden, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lund Observatory, Lund University [Lund], Zentrum für astronomie, Universität Heidelberg [Heidelberg], Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Merck Serono S.A [Geneva Research Center], Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Gaia Collaboration, Unidad de Excelencia Científica María de Maeztu Instituto de Ciencias del Cosmos Universidad de Barcelona, MDM-2014-0369, Centro de Excelencia Científica Severo Ochoa, Instituto de Ciencias del Cosmos de la Universidad de Barcelona, SEV2015-0493, Deliste, J. B. [0000-0001-5844-9888], Sozzeti, A. [0000-0002-7504-365X], Forderung der wissenschaftlichen Forschung (FWF), Belgian federal Science Policy Office (BELSPO), Hertha Firnberg Programme, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (COFECUB), National Natural Science Foundation of China (NSFC), China Scholarship Council (CSC), European Commission (EC), European Research Council (ERC), Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Istituto Nazionale di Astrofisica (INAF), Netherlands Research School for Astronomy (NOVA), Fundacao para a Ciencia e a Tecnologia (FCT), Agencia Estatal de Investigación (AEI), European Space Agency (ESA), Centre National D'Etudes Spatiales (CNES), Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR), Narodowe Centrum Nauki (NCN), Slovenian Research Agency, Swedish National Space Agency (SNSA), United Kingdom Science and Technology Facilities Council (STFC), Universitat de Barcelona (UB), Generalitat de Catalunya, Xunta de Galicia, Universidad de Cantabria, ITA, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Astronomy, and Kapteyn Astronomical Institute
Subjects: Data Analysis, Solar System, Astronomy, kinematics and dynamics, virgo cluster, Astrophysics, 01 natural sciences, bar, Astronomi, astrofysik och kosmologi, large-magellanic-cloud, Methods, Astronomy, Astrophysics and Cosmology, 010303 astronomy & astrophysics, Physics, Astrophysics of Galaxies, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, VIRGO CLUSTER, Kinematics and Dynamics, Amplitude, kinematics, Physical Sciences, MILKY-WAY, astrometry, Galaxy: kinematics and dynamics, PROPER MOTION, Proper motion, perturbation, proper motions, reference systems, methods: data analysis, Astrophysics - Astrophysics of Galaxies, FOS: Physical sciences, Context (language use), proper motion, Astronomy & Astrophysics, MASS, Computer Science::Digital Libraries, Gravitational potential, Acceleration, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, data analysis [methods], Vector spherical harmonics, KINEMATICS, distance, milky-way, Science & Technology, PERTURBATION, 010308 nuclear & particles physics, Astronomy and Astrophysics, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, Physics::History of Physics, BAR, Galaxy, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), DISTANCE, mass, LARGE-MAGELLANIC-CLOUD
Abstract: Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions., Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Universe. Apart from being an important scientific result by itself, the acceleration measured in this way is a good quality indicator of the Gaia astrometric solution., Methods. Theeffect of the acceleration was obtained as a part of the general expansion of the vector field of proper motions in vector spherical harmonics (VSH). Various versions of the VSH fit and various subsets of the sources were tried and compared to get the most consistent result and a realistic estimate of its uncertainty. Additional tests with the Gaia astrometric solution were used to get a better idea of the possible systematic errors in the estimate., Results. Our best estimate of the acceleration based on Gaia EDR3 is (2.32 +/- 0.16) x 10(-10) m s(-2) (or 7.33 +/- 0.51 km s(-1) Myr-1) towards alpha = 269.1 degrees +/- 5.4 degrees, delta = -31.6 degrees +/- 4.1 degrees, corresponding to a proper motion amplitude of 5.05 +/- 0.35 mu as yr(-1). This is in good agreement with the acceleration expected from current models of the Galactic gravitational potential. We expect that future Gaia data releases will provide estimates of the acceleration with uncertainties substantially below 0.1 mu as yr(-1).
Published: 2020
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10. Gemini and Lowell observations of 67P/Churyumov−Gerasimenko during the Rosetta mission

Author: Jean-Baptiste Vincent, T. A. Lister, David G. Schleicher, Brian Skiff, Blair C. Conn, Matthew M. Knight, and Colin Snodgrass
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Physics, 010504 meteorology & atmospheric sciences, Comet, FOS: Physical sciences, Astronomy, Astronomy and Astrophysics, Coma (optics), Astrophysics, 01 natural sciences, Space and Planetary Science, Observatory, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics - Earth and Planetary Astrophysics, 0105 earth and related environmental sciences
Abstract: We present observations of comet 67P/Churyumov-Gerasimenko acquired in support of the $Rosetta$ mission. We obtained usable data on 68 nights from 2014 September until 2016 May, with data acquired regularly whenever the comet was observable. We collected an extensive set of near-IR $J$, $H$, and $Ks$ data throughout the apparition plus visible-light images in $g'$, $r'$, $i'$, and $z'$ when the comet was fainter. We also obtained broadband $R$ and narrowband $CN$ filter observations when the comet was brightest using telescopes at Lowell Observatory. The appearance was dominated by a central condensation and the tail until 2015 June. From 2015 August onwards there were clear asymmetries in the coma, which enhancements revealed to be due to the presence of up to three features (i.e., jets). The features were similar in all broadband filters; $CN$ images did not show these features but were instead broadly enhanced in the southeastern hemisphere. Modeling using the parameters from Vincent et al. (2013) replicated the dust morphology reasonably well, indicating that the pole orientation and locations of active areas have been relatively unchanged over at least the last three apparitions. The dust production, as measured by $A(0^{\circ})f{\rho}$ peaked $\sim$30 days after perihelion and was consistent with predictions from previous apparitions. $A(0^{\circ})f{\rho}$ as a function of heliocentric distance was well fit by a power-law with slope $-$4.2 from 35-120 days post-perihelion. We detected photometric evidence of apparent outbursts on 2015 August 22 and 2015 September 19, although neither was discernible morphologically in this dataset., Comment: Accepted by MNRAS; 15 pages, 6 figures, 2 tables
Published: 2017
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11. Edward Shelton Henderson MD Chemotherapy Pioneer July 19, 1932 to June 24, 2020

Author: T. Andrew Lister, Jerome W. Yates, and Robert Peter Gale
Subjects: Cancer Research, Chemotherapy, Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, General surgery, MEDLINE, Cancer, Hematology, medicine.disease, Oncology, Medicine, business
Published: 2020
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12. Gaia Data Release 2

Author: H. E. Huckle, F. Riclet, R. Buzzi, D. J. Marshall, Deborah Busonero, Michael Davidson, C Boeche, Sergio Messina, F. X. Pineau, G. Jasniewicz, L. Balaguer-Núñez, C. A. L. Bailer-Jones, L. Chaoul, J. L. Halbwachs, D. Teyssier, A. F. Lanza, Alberto Vecchiato, Shay Zucker, Francois Taris, Conny Aerts, L. Pulone, Mario Gai, L. M. Sarro, Frédéric Arenou, Á. L. Juhász, Alessandro Bressan, Joao Alves, Morgan Fouesneau, David Hobbs, Yves Fremat, L. Ruiz-Dern, A. Hutton, Sofia Randich, Gerry Gilmore, D. Garabato, Leanne P. Guy, J. González-Núñez, M. Weiler, H. Steidelmüller, D. de Martino, M. A. Álvarez, Vincenzo Ripepi, G. Gracia-Abril, Uwe Lammers, P. de Laverny, G. Sadowski, Nicolas Mary, Bengt Edvardsson, Laszlo Szabados, Łukasz Wyrzykowski, David Barrado, Alberto Cellino, Damien Ségransan, T Roegiers, Olivier Wertz, A. Recio-Blanco, Sergei A. Klioner, J. Durán, A. Panahi, A. Karampelas, Alex Lobel, J.-L. Bassilana, H. Voss, Sven Zschocke, A. Bombrun, F. De Angeli, Toni Santana-Ros, J. C. Segovia, D. Vicente, S. Blanco-Cuaresma, A. G. Butkevich, M. Riello, Amina Helmi, J. Bakker, J. Souchay, A. Kewley, R Alvarez, Daniel Hestroffer, Sergey E. Koposov, Tsevi Mazeh, Maria Süveges, F. F. Suess, P. Drazinos, B. Holl, H. Ziaeepour, T. Wevems, Eva Sciacca, P. Esquej, A. Gueguen, J. Heu, R. Geyer, J. Fernández-Hernández, E. Licata, Laurent Galluccio, J. Cuypers, Peter G. Jonker, Ummi Abbas, Elena Pancino, Jean Surdej, E. Anglada Varela, Michele Bellazzini, Teresa Antoja, Martin A. Barstow, László Molnár, Isabella Pagano, E. Solano, E. Brugaletta, P. Koubsky, Paolo Tanga, Alberto Krone-Martins, M. Clotet, Nigel Hambly, R. L. Smart, Paolo Giacobbe, Simchon Faigler, G. Giuffrida, Aldo Dell'Oro, Yveline Lebreton, Stefano Bertone, Mario G. Lattanzi, Paul S. Barklem, D. Tapiador, Patrick Charlot, A. H. Andrei, Luciano Nicastro, S. Managau, Lorenzo Rimoldini, Mario Di Martino, Paolo Montegriffo, A. Abreu Aramburu, O. Marchal, Marcella Marconi, K. Janßen, K. Findeisen, Xavier Luri, A. Berihuete, M. Schultheis, P. Di Matteo, R. Mor, C. Barata, A. Mora, W. van Reeven, Mikael Granvik, M. Barros, Carine Babusiaux, A. G. A. Brown, Mark Taylor, Y. Le Fustec, T. Lebzelter, Nami Mowlavi, O. L. Creevey, F. Barblan, Thierry Morel, Timo Prusti, A. Riva, S. Girona, S. Liao, Viktor Votruba, Frédéric Royer, Laurent Chemin, G. Altavilla, A. M. Piersimoni, Davide Massari, Marco Delbo, S. Diakite, V. Valette, N. Bach, H. Lenhardt, André Moitinho, Christophe Barache, S. Galleti, Michał Pawlak, A. Yoldas, Harry Enke, Rosanna Sordo, A. Jean-Antoine-Piccolo, Patrice David, Giacomo Cannizzaro, W. Löffler, J. Torra, Tristan Cantat-Gaudin, Marc Audard, D. Katz, Jose M Hernandez, Gijs Nelemans, S. Ragaini, P. Osborne, D. Terrett, A. J. Falcão, D. L. Harrison, G. Plum, R. G. Mann, Ulrike Heiter, Carla Cacciari, Gal Matijevic, J. M. Petit, A. Titarenko, Despina Hatzidimitriou, Juan Zorec, Angela Bragaglia, Nicholas Rowell, Annie C. Robin, Mario David, Tri L. Astraatmadja, Giovanni Comoretto, F. Julbe, Derek W. Morris, R. Drimmel, F. García-Sedano, A. Dapergolas, L. Noval, Mike Smith, Grigori Fedorets, H. Palacin, L. Bramante, D. Molina, Jesus Salgado, C. Dolding, M. Vaillant, Daniel Michalik, H. I. Siddiqui, Minia Manteiga, P. J. Richards, D. Barbato, A. Fonti, Raphael Guerra, J. J. González-Vidal, E. del Pozo, Mariateresa Crosta, M. Žerjal, F. Torra Clotet, C. Diener, M. Hauser, G. Walmsley, Sonia Nieto, I. Bellas-Velidis, T. Boch, Antonella Vallenari, M. Segol, S. Voutsinas, F. Leroux, A. F. Mulone, Pierre Fernique, Céline Reylé, P. Panuzzo, W. Hofmann, S. Bouquillon, F. Crifo, S. Cowell, Ana Ulla, Benoit Carry, C. Ordenovic, F. Pailler, E. Utrilla, Dimitri Pourbaix, A. Hypki, Stefan Jordan, T. Carlucci, Gráinne Costigan, Alfred Castro-Ginard, C. Fabre, C. Crowley, R. Borrachero, Sébastien Lambert, J. H. J. de Bruijne, D. W. Evans, C. Turon, T. Brüsemeister, F. De Luise, R. Haigron, Carme Jordi, G. Marschalkó, C. von Essen, C. Pagani, Katrien Kolenberg, M. van Leeuwen, N. R. Millar, Gisella Clementini, A. de Torres, Ugo Becciani, S. Marinoni, Geraldine Bourda, A. F. Silva, L. Eyer, Misha Haywood, C. Fabricius, Krzysztof Nienartowicz, Miguel García-Torres, S. Regibo, P. Gavras, Gábor Marton, Elisa Distefano, A. Guerrier, H. E. P. Lindstrøm, N. A. Walton, N. Brouillet, G. Eynard Bontemps, T. A. Lister, F. A. Jansen, Ruth Carballo, Steve Vogt, J. M. Carrasco, G. Mantelet, M. Romero-Gómez, Ramachrisna Teixeira, Kjell Eriksson, A. Kochoska, Johannes Sahlmann, Joakim Klar, R. Gutiérrez-Sánchez, Ilaria Musella, L. Palaversa, Karri Muinonen, J. M. Martín-Fleitas, T. Sagristà Sellés, Marco Castellani, Y. Viala, Laia Casamiquela, R. Messineo, Eduard Masana, R. de Souza, H. Stoev, L. Siltala, B. Frezouls, E. Szegedi-Elek, Tomaz Zwitter, G. Kordopatis, C. Ducourant, Tatiana Muraveva, P. Burgess, J. De Ridder, E. Salguero, A. Burlacu, I-C. Shih, U. Stampa, V. Icardi, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, F. Solitro, H. E. Delgado, G. Holland, J.-B. Lavigne, Andreas Korn, M. Biermann, E. Fraile, M. Fabrizio, Francesca Figueras, R. Blomme, P. Teyssandier, Elisabetta Caffau, G. Busso, Maroussia Roelens, Maarten A. Breddels, Simon Hodgkin, Luciana Bianchi, Olivier Bienaymé, Silvio Leccia, C. Le Poncin-Lafitte, Morgan Fraser, M. Ramos-Lerate, M. Gomes, N. Cheek, J. Osinde, Jérôme Berthier, Kevin Benson, Christos Siopis, P. Balm, E. Gosset, Yassine Damerdji, Richard I. Anderson, C. Zurbach, Jonas Debosscher, G. Cocozza, William O'Mullane, Andrea Chiavassa, F.E. van Leeuwen, Diego Bossini, Federica Spoto, G. Jevardat de Fombelle, Nicoletta Sanna, J. Guiraud, G. Tauran, K. W. Smith, E. Poujoulet, Mark Cropper, Z. Kostrzewa-Rutkowska, F. Glass, J. Gerssen, Thomas Hilger, C.A. Stephenson, D. Ordóñez-Blanco, Andrej Prsa, M. Sarasso, E. Kontizas, Luciana Federici, Paul J. McMillan, Nicolas Rambaux, Ludovic Delchambre, M. Garcia-Reinaldos, T. Pauwels, M. Farràs Casas, S. Bartholomé Muñoz, E. Livanou, E. Van Hemelryck, Roberto Morbidelli, R. Kohley, A. Garofalo, Jovan Veljanoski, Jon Marchant, Jordi Portell, Ulrich Bastian, M. Lopez, Bernardino Arcay, H. Savietto, Alessandro Spagna, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Carlos Dafonte, Y. Lasne, P. Sartoretti, E. Racero, William Thuillot, A. Gavel, J. Castañeda, Gaetano Valentini, A. Rivard, E. Poggio, N. Garralda, R. De March, S. G. Baker, S. Accart, M. Altmann, F. Filippi, George M. Seabroke, F. Thévenin, A. van Elteren, Emese Plachy, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, S Uzzi, M Vaschetto, Francois Mignard, E. Antiche, P. M. Marrese, N. Leclerc, Caroline Soubiran, Rene Andrae, A. Delgado, and Rossella Cancelliere
Subjects: Physics, 010504 meteorology & atmospheric sciences, Astronomy, Astronomy and Astrophysics, galaxies: dwarf, Astrophysics, Astrometry, globular clusters: general, 01 natural sciences, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, 0103 physical sciences, Local Group, astrometry, High Energy Physics, Galaxy: kinematics and dynamics, astrometry, globular clusters: general, galaxies: dwarf, Local Group, errata, addenda, Galaxy: kinematics and dynamics, addenda, 010303 astronomy & astrophysics, Data release, Astrophysique, errata, 0105 earth and related environmental sciences
Abstract: 0, info:eu-repo/semantics/published
Published: 2020
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13. Observational investigation of the 2013 near-Earth encounter by asteroid (367943) Duende

Author: Takahiro Nagayama, Nicholas Moskovitz, Thomas Endicott, A. C. Gilmore, Daniel J. Scheeres, T. A. Lister, Conor J. Benson, Mark Willman, Scott S. Sheppard, Richard P. Binzel, Peter Birtwhistle, P. M. Kilmartin, Olesja Smirnova, Amanda A. Sickafoose, Carl Hergenrother, Susan D. Benecchi, Francesca E. DeMeo, William Ryan, Thomas Augusteijn, Franck Marchis, Eileen V. Ryan, David Polishook, and Arie Verveer
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Physics, Rotation period, Near-Earth object, Short axis, 010504 meteorology & atmospheric sciences, FOS: Physical sciences, Astronomy, Astronomy and Astrophysics, 01 natural sciences, Earth radius, Photometry (optics), Gravitation, 13. Climate action, Space and Planetary Science, Asteroid, Radar imaging, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics - Earth and Planetary Astrophysics, 0105 earth and related environmental sciences
Abstract: On 15 February 2013, the asteroid 367943 Duende (2012 DA14) experienced a near-Earth encounter at an altitude of 27,700 km or 4.2 Earth radii. We present here the results of an extensive, multi-observatory campaign designed to probe for spectral and/or rotational changes to Duende due to gravitational interactions with the Earth during the flyby. Our spectral data reveal no changes within the systematic uncertainties of the data. Post-flyby lightcurve photometry places strong constraints on the rotation state of Duende, showing that it is in non-principal axis rotation with fundamental periods of P_1 = 8.71 +/- 0.03 and P_2 = 23.7 +/- 0.2 hours. Multiple lightcurve analysis techniques, coupled with theoretical considerations and delay-doppler radar imaging, allows us to assign these periods to specific rotational axes of the body. In particular we suggest that Duende is now in a non-principal, short axis mode rotation state with a precessional period equal to P_1 and oscillation about the symmetry axis at a rate equal to P_2. Temporal and signal-to-noise limitations inherent to the pre-flyby photometric dataset make it difficult to definitively diagnose whether these periods represent a change imparted due to gravitational torques during the flyby. However, based on multiple analysis techniques and a number of plausibility arguments, we suggest that Duende experienced a rotational change during the planetary encounter with an increase in its precessional rotation period. Our preferred interpretation of the available data is that the precession rate increased from 8.4 hours prior to the flyby to 8.7 hours afterwards. A companion paper by Benson et al. (2019) provides a more detailed dynamical analysis of this event and compares the data to synthetic lightcurves computed from a simple shape model of Duende. (abbreviated abstract), Comment: 50 pages (double spaced), 12 figures, 5 tables, accepted to Icarus
Published: 2020
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14. Real-time processing of the imaging data from the network of Las Cumbres Observatory Telescopes using BANZAI

Author: Curtis McCully, T. A. Lister, N. H. Volgenau, Mark Bowman, Daniel-Rolf Harbeck, Robert J. Siiverd, Monica L. Turner, and Eric S. Saunders
Subjects: Data stream, Data processing, 010308 nuclear & particles physics, business.industry, Computer science, Automated data processing, Real-time computing, FOS: Physical sciences, Image processing, 01 natural sciences, Pipeline (software), law.invention, Telescope, Software, Observatory, law, 0103 physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, business, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics
Abstract: Work in time-domain astronomy necessitates robust, automated data processing pipelines that operate in real time. We present the BANZAI pipeline which processes the thousands of science images produced across the Las Cumbres Observatory Global Telescope (LCOGT) network of robotic telescopes each night. BANZAI is designed to perform near real-time preview and end-of-night final processing for four types of optical CCD imagers on the three LCOGT telescope classes. It performs instrumental signature removal (bad pixel masking, bias and dark removal, flat-field correction), astrometric fitting and source catalog extraction. We discuss the design considerations for BANZAI, including testing, performance, and extensibility. BANZAI is integrated into the observatory infrastructure and fulfills two critical functions: (1) real-time data processing that delivers data to users quickly and (2) derive metrics from those data products to monitor the health of the telescope network. In the era of time-domain astronomy, to get from these observations to scientific results, we must be able to automatically reduce data with minimal human interaction, but still have insight into the data stream for quality control., 9 Pages, 6 figures
Published: 2018
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15. A stellar occultation by Vanth, a satellite of (90482) Orcus

Author: Anja Genade, Amanda S. Bosh, Carlos A. Zuluaga, Stephen E. Levine, Karsten Schindler, T. A. Lister, and Amanda A. Sickafoose
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), 010504 meteorology & atmospheric sciences, Infrared telescope, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, 01 natural sciences, Occultation, law.invention, Telescope, Stars, Photometry (astronomy), Space and Planetary Science, law, Observatory, 0103 physical sciences, Trans-Neptunian object, 010303 astronomy & astrophysics, Geology, Optical depth, Astrophysics - Earth and Planetary Astrophysics, 0105 earth and related environmental sciences
Abstract: A stellar occultation by the large trans-Neptunian object (90482) Orcus was predicted to occur on 2017 March 07. Observations were made at five sites in North and South America. High-speed, visible-wavelength images were taken at all sites, in addition to simultaneous K-band images at one location. Solid-body occultations were observed from two sites. Post-event reconstruction suggested an occultation of two different stars observed from two different sites. Follow-up, speckle imaging at Gemini Observatory revealed a second star, which verified that the occulting body in both cases was Orcus` satellite, Vanth. The two single-chord detections, with an anomalously large timing delay in one chord, have lengths of 291+/-125 km and 434.4+/-2.4 km. The observations, combined with a non-detection at a nearby site, allow a tight constraint of 443+/-10 km to be placed on Vanth`s size (assuming it is spherical). A 3-{\sigma} upper limit of 1-4 {\mu}bar (depending on constituent) is found for a global Vanth atmosphere. The immersion and emersion profiles are slightly different, with atmospheric constraints 40 percent higher on immersion than on emersion. No rings or other material were detected within ten thousand kms of Vanth, and beyond 8010 km from Orcus, to the tightest optical depth limit of approximately 0.1 at 5 km scale. The occultation probed as close as 5040 km from Orcus, placing an optical depth limit of approximately 0.3 at 5 km scale on any encircling material at that distance., Comment: 37 Pages; 12 Figures; 3 Tables
Published: 2018
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16. London Region Atlas of Topsoil Geochemistry

Author: Ferreira, Antonio, C C Johnson, J D Appleton, D M A Flight, T R Lister, K V Knights, L Ander, C Scheib, A Scheib, M Cave, J Wragg, F Fordyce, and R Lawley
Published: 2017
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17. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification

Author: T. Andrew Lister, Lawrence H. Schwartz, Sally F. Barrington, Bruce D. Cheson, Franco Cavalli, Richard I. Fisher, and Emanuele Zucca
Subjects: Cancer Research, medicine.medical_specialty, International Cooperation, Fluorodeoxyglucose F18, Predictive Value of Tests, hemic and lymphatic diseases, Refractory Hodgkin Lymphoma, medicine, Humans, Refractory Diffuse Large B-Cell Lymphoma, Medical physics, Neoplasm Staging, Fluorodeoxyglucose, medicine.diagnostic_test, business.industry, Lymphoma, Non-Hodgkin, Liver Neoplasms, Cancer, Prognosis, medicine.disease, Hodgkin Disease, Lymphoma, Clinical trial, Treatment Outcome, Oncology, Positron emission tomography, Positron-Emission Tomography, Radiology, Primary mediastinal B-cell lymphoma, Radiopharmaceuticals, Bone Marrow Neoplasms, Tomography, X-Ray Computed, business, medicine.drug
Abstract: The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers. Clinical and imaging subcommittees presented their conclusions at a subsequent workshop at the 12th International Conference on Malignant Lymphoma, leading to revised criteria for staging and of the International Working Group Guidelines of 2007 for response. As a result, fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) was formally incorporated into standard staging for FDG-avid lymphomas. A modification of the Ann Arbor descriptive terminology will be used for anatomic distribution of disease extent, but the suffixes A or B for symptoms will only be included for HL. A bone marrow biopsy is no longer indicated for the routine staging of HL and most diffuse large B-cell lymphomas. However, regardless of stage, general practice is to treat patients based on limited (stages I and II, nonbulky) or advanced (stage III or IV) disease, with stage II bulky disease considered as limited or advanced disease based on histology and a number of prognostic factors. PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale. The product of the perpendicular diameters of a single node can be used to identify progressive disease. Routine surveillance scans are discouraged. These recommendations should improve evaluation of patients with lymphoma and enhance the ability to compare outcomes of clinical trials.
Published: 2014
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18. The LCOGT NEO Follow-up Network

Author: E. Christensen, T. A. Lister, Edward Gomez, Sarah Greenstreet, and S. M. Larson
Subjects: Space and Planetary Science, Asteroid, Astronomy, Astronomy and Astrophysics, Astrometry, Geology
Abstract: Las Cumbres Observatory Global Telescope Network (LCOGT) has deployed a homogeneous telescope network of nine 1-meter telescopes to four locations in the northern and southern hemispheres, with a planned network size of twelve 1-meter telescopes at 6 locations. This network is very versatile and is designed to respond rapidly to target of opportunity events and also to perform long term monitoring of slowly changing astronomical phenomena. The global coverage of the network and the apertures of telescope available make LCOGT ideal for follow-up and characterization of Solar System objects (e.g. asteroids, Kuiper Belt Objects, comets, Near-Earth Objects (NEOs)) and additionally for the discovery of new objects.We are using the LCOGT network to confirm newly detected NEO candidates produced by the major sky surveys such as Catalina Sky Survey (CSS) and PanSTARRS (PS1&2) and several hundred targets are now being followed per year. An increasing amount of time is being spent to obtain follow-up astrometry and photometry for radar-targeted objects and those on the Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) or Asteroid Retrieval Mission (ARM) lists in order to improve the orbits, determine the light curves and rotation periods and improve the characterization. This will be extended to obtain more light curves of other NEOs which could be targets. Recent results have included the first period determinations for several of the Goldstone-targeted NEOs. We are in the process of building a NEO follow-up portal which will allow professionals, amateurs and Citizen Scientists to plan, schedule and analyze NEO imaging and spectroscopy observations and data using the LCOGT Network and to act as a co-ordination hub for the NEO follow-up efforts.
Published: 2015
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19. EZH2 mutations are frequent and represent an early event in follicular lymphoma

Author: Andreas Rosenwald, Erlend B. Smeland, T. Andrew Lister, Sameena Iqbal, Vera Grossmann, John G. Gribben, Alexander Kohlmann, George E. Wright, Lisa M. Rimsza, Claude Chelala, Nikolay Popov, German Ott, Robert Kerrin Hills, Randy D. Gascoyne, Andrew Clear, King Tan, Abigail M. Lee, Hajnalka Rajnai, Olivier Elemento, Wing C. Chan, Louis M. Staudt, Shamzah Araf, Ciaran O'Riain, Jessica Okosun, Rita M. Braziel, Janet Matthews, Torsten Haferlach, Jun Wang, Jacek Marzec, Elias Campo, András Matolcsy, Jude Fitzgibbon, Silvia Montoto, and Csaba Bödör
Subjects: endocrine system, Time Factors, Methyltransferase, medicine.medical_treatment, DNA Mutational Analysis, Immunology, Follicular lymphoma, Kaplan-Meier Estimate, macromolecular substances, Biology, medicine.disease_cause, Biochemistry, Targeted therapy, Cohort Studies, Gene Frequency, hemic and lymphatic diseases, Biomarkers, Tumor, medicine, Humans, Enhancer of Zeste Homolog 2 Protein, Lymphoma, Follicular, Allele frequency, Mutation, Lymphoid Neoplasia, MEF2 Transcription Factors, Gene Expression Profiling, EZH2, Polycomb Repressive Complex 2, Germinal center, Cell Biology, Hematology, medicine.disease, CREB-Binding Protein, Lymphoma, Disease Progression, Cancer research, Receptors, Tumor Necrosis Factor, Member 14
Abstract: Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations were detected at 3 recurrent mutation hot spots (Y646, A682, and A692) in 27% of FL cases with variant allele frequencies (VAF) ranging from 2% to 61%. By comparing VAF of EZH2 with other mutation targets (CREBBP, MLL2, TNFRSF14, and MEF2B), we were able to distinguish patients harboring clonal EZH2 mutation from rarer cases with subclonal mutations. Overall, the high incidence of EZH2 mutations in FL and their stability during disease progression makes FL an appropriate disease to evaluate EZH2 targeted therapy.
Published: 2013
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20. Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors

Author: Isabel Syndikus, Andrea M. Stevens, T. A. Lister, H Lucraft, David Cunningham, John Radford, Dianne Gilson, Alan Horwich, Rosie Cooke, Michael Jones, S J Harris, S Falk, Peter Hoskin, Timothy M Illidge, Barry W. Hancock, David C. Linch, M. V. Williams, and Anthony J. Swerdlow
Subjects: Adult, Cancer Research, medicine.medical_specialty, Neoplasms, Radiation-Induced, Epidemiology, supradiaphragmatic radiotherapy, Breast Neoplasms, Cohort Studies, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Pregnancy, medicine, Humans, 030212 general & internal medicine, Reproductive History, Menarche, Gynecology, Wales, Obstetrics, business.industry, Age Factors, Case-control study, Odds ratio, Middle Aged, medicine.disease, Hodgkin Disease, 3. Good health, Menopause, England, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Cohort, Female, business, Hodgkin lymphoma, Cohort study
Abstract: Background: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk. Methods: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case–control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages
Published: 2013
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21. WASP-10b: a 3M , gas-giant planet transiting a late-type K star

Author: François Bouchy, Andrew Norton, D. M. Wilson, David R. Anderson, B. Enoch, N. R. Parley, T. A. Lister, D. L. Pollacco, Damian J. Christian, I. Skillen, Barry Smalley, A. Collier Cameron, R. A. Street, Will Clarkson, Yogesh C. Joshi, P. Maxted, D. Queloz, S. J. Bentley, Stéphane Udry, B. Loeillet, Francis P. Keenan, G. Hebrard, Neale P. Gibson, M. Mayor, Carole A. Haswell, H. C. Stempels, Keith Horne, Robert Ryans, E. K. Simpson, Richard G. West, C. Hellier, Peter J. Wheatley, C. Moutou, S. R. Kane, Iain McDonald, I. Todd, Frederic Pont, Andra M. Smith, J. M. Irwin, Leslie Hebb, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Dwarf star, Gas giant, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Current sample, techniques: photometric, Planet, techniques: radial velocities, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Galaxy Astrophysics, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Late type, Astrophysics (astro-ph), Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, methods: data analysis, Exoplanet, Radial velocity, Stars, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics::Earth and Planetary Astrophysics, stars: planetary systems
Abstract: We report the discovery of WASP-10b, a new transiting extrasolar planet (ESP) discovered by the WASP Consortium and confirmed using NOT FIES and SOPHIE radial velocity data. A 3.09 day period, 29 mmag transit depth, and 2.36 hour duration are derived for WASP-10b using WASP and high precision photometric observations. Simultaneous fitting to the photometric and radial velocity data using a Markov-chain Monte Carlo procedure leads to a planet radius of 1.28R_J, a mass of 2.96M_J and eccentricity of ~0.06. WASP-10b is one of the more massive transiting ESPs, and we compare its characteristics to the current sample of transiting ESP, where there is currently little information for masses greater than ~2M_J and non-zero eccentricities. WASP-10's host star, GSC 2752-00114 (USNO-B1.0 1214-0586164) is among the fainter stars in the WASP sample, with V=12.7 and a spectral type of K5. This result shows promise for future late-type dwarf star surveys., Comment: 6 Pages, 3 Figures, 3 Tables, accepted in MNRAS
Published: 2016
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22. Acute Myelogenous Leukaemia in Patients 60 Years and Older: A Retrospective Analysis from St Bartholomew's Hospital 1969-1999

Author: T. A. Lister, Peter MacCallum, J. A. L. Amess, Christopher D Dalley, Sarah Slater, Mike Bradburn, A. Z. S. Rohatiner, M. Carter, and Debra M. Lillington
Subjects: Pediatrics, medicine.medical_specialty, Chemotherapy, Multivariate analysis, business.industry, medicine.medical_treatment, Hepatosplenomegaly, Complete remission, Hematology, Acute myelogenous leukaemia, 03 medical and health sciences, 0302 clinical medicine, Median follow-up, 030220 oncology & carcinogenesis, Cohort, medicine, In patient, medicine.symptom, business, 030215 immunology
Abstract: Between 1969 and 1999, 420 patients (age > 60 years) with newly diagnosed AML were managed at St Bartholomew's Hospital (SBH), London, UK. Sixty-nine percent of patients received therapy with curative intent Eighty-eight patients (31%) of the latter achieved complete remission (CR), representing an overall CR rate of 21%. Treatment failure due to early death (ED) and resistant disease (RD) occurred in 50 and 19%, respectively. With median follow up of 11 years, actuarial survivals at 1,3 and 5 years were 20, 7 and 4%, respectively, the median survival of the entire cohort was 2 months. For patients who achieved CR, median survival was significantly better than that of patients in whom treatment failed (14 vs. 6 months). Over the 30 years, CR rate and the relative incidence of RD both increased from 13 to 45%, and 3 to 27%, respectively, whilst ED rate reduced from 84 to 27%. Multivariate analysis showed that treatment era, hepatosplenomegaly and increasing age predicted for reduced CR rate and OS. Although elderly patients with AML are characterised by a poor response to intensive chemotherapy, significant improvements in supportive care and the delivery of intensive treatment have led to improved CR rates and OS. New therapeutic strategies and a greater awareness of prognostic factors may further improve clinical outcome in this important group of patients.
Published: 2016

23. The perihelion activity of comet 67P/Churyumov-Gerasimenko as seen by robotic telescopes

Author: Cyrielle Opitom, Robert J. Smith, Jean Manfroid, Helen Jermak, Philippe Rousselot, Anny Chantal Levasseur-Regourd, Miguel de Val-Borro, T. Granzer, Alan Fitzsimmons, Emmanuel Jehin, Colin Snodgrass, Jon Marchant, Iain A. Steele, Karen J. Meech, T. A. Lister, Geraint H. Jones, School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Department of Astrophysical Sciences [Princeton], Princeton University, Astrochemistry Laboratory [Greenbelt], NASA Goddard Space Flight Center (GSFC), Las Cumbres Observatory (LCO), Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Centre for Planetary Sciences [UCL/Birkbeck] (CPS), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Department of Physics [Lancaster], Lancaster University, Leibniz-Institut für Astrophysik Potsdam (AIP), Institute for Astronomy [Honolulu], University of Hawai‘i [Mānoa] (UHM), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)
Subjects: 67P/Churyumov-Gerasimenko, Physics, Earth and Planetary Astrophysics (astro-ph.EP), Brightness, 010504 meteorology & atmospheric sciences, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Photometry (optics), 13. Climate action, Space and Planetary Science, astro-ph.EP, 0103 physical sciences, Comets, Snodgrass, 010303 astronomy & astrophysics, QC, QB, Astrophysics - Earth and Planetary Astrophysics, 0105 earth and related environmental sciences, Production rate
Abstract: Around the time of its perihelion passage the observability of 67P/Churyumov-Gerasimenko from Earth was limited to very short windows each morning from any given site, due to the low solar elongation of the comet. The peak in the comet's activity was therefore difficult to observe with conventionally scheduled telescopes, but was possible where service/queue scheduled mode was possible, and with robotic telescopes. We describe the robotic observations that allowed us to measure the total activity of the comet around perihelion, via photometry (dust) and spectroscopy (gas), and compare these results with the measurements at this time by Rosetta's instruments. The peak of activity occurred approximately two weeks after perihelion. The total brightness (dust) largely followed the predictions from Snodgrass et al. 2013, with no significant change in total activity levels from previous apparitions. The CN gas production rate matched previous orbits near perihelion, but appeared to be relatively low later in the year., Comment: To appear in special issue of MNRAS "The ESLAB 50 Symposium - spacecraft at comets from 1P/Halley to 67P/Churyumov-Gerasimenko"
Published: 2016
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24. Breast Cancer Risk After Supradiaphragmatic Radiotherapy for Hodgkin's Lymphoma in England and Wales: A National Cohort Study

Author: Isabel Syndikus, Barry W. Hancock, John Radford, H Lucraft, Andrew Bates, David Cunningham, Andrea M. Stevens, M. V. Williams, Alan Horwich, Dianne Gilson, Peter Hoskin, T. Andrew Lister, Anthony J. Swerdlow, Rosie Cooke, Stephen Falk, David C. Linch, and Sarah J. Harris
Subjects: Adult, Risk, Cancer Research, medicine.medical_specialty, Neoplasms, Radiation-Induced, Adolescent, medicine.medical_treatment, Diaphragm, Breast Neoplasms, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Humans, 030304 developmental biology, Gynecology, 0303 health sciences, Wales, business.industry, Age Factors, Absolute risk reduction, Radiotherapy Dosage, Ductal carcinoma, Hodgkin's lymphoma, medicine.disease, Hodgkin Disease, 3. Good health, Radiation therapy, Standardized mortality ratio, England, Oncology, 030220 oncology & carcinogenesis, Cohort, business, Cohort study
Abstract: Purpose To investigate breast cancer risk after supradiaphragmatic radiotherapy administered to young women with Hodgkin's lymphoma (HL) in a much larger cohort than previously to provide data for patient follow-up and screening individualized according to treatment type, age, and time point during follow-up. Patients and Methods Breast cancer risk was assessed in 5,002 women in England and Wales treated for HL with supradiaphragmatic radiotherapy at age < 36 years from 1956 to 2003, who underwent follow-up with 97% completeness until December 31, 2008. Results Breast cancer or ductal carcinoma in situ developed in 373 patients, with a standardized incidence ratio (SIR) of 5.0 (95% CI, 4.5 to 5.5). SIRs were greatest for those treated at age 14 years (47.2; 95% CI, 28.0 to 79.8) and continued to remain high for at least 40 years. The maximum absolute excess risk was at attained ages 50 to 59 years. Alkylating chemotherapy or pelvic radiotherapy diminished the risk, but only for women treated at age ≥ 20 years, not for those treated when younger. Cumulative risks were tabulated in detail; for 40-year follow-up, the risk for patients receiving ≥ 40 Gy mantle radiotherapy at young ages was 48%. Conclusion This article provides individualized risk estimates based on large numbers for patients with HL undergoing follow-up after radiotherapy at young ages. Follow-up of such women needs to continue for 40 years or longer and may require more-intensive screening regimens than those in national general population programs. Special consideration is needed of potential measures to reduce breast cancer risk for girls treated with supradiaphragmatic radiotherapy at pubertal ages.
Published: 2012
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25. T-cell replete fludarabine/cyclophosphamide reduced intensity allogeneic stem cell transplantation for lymphoid malignancies

Author: T. Andrew Lister, Heather Oakervee, Samir G. Agrawal, Jamie Cavenagh, Denise Syndercombe-Court, Finlay MacDougall, David Taussig, Rebecca Auer, John G. Gribben, and Jeff K. Davies
Subjects: Adult, Oncology, medicine.medical_specialty, Transplantation Conditioning, Cyclophosphamide, T-Lymphocytes, Follicular lymphoma, Graft vs Host Disease, Autologous stem-cell transplantation, Recurrence, Internal medicine, medicine, Humans, Transplantation, Homologous, Multiple myeloma, Aged, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, medicine.disease, Survival Analysis, Lymphoproliferative Disorders, Fludarabine, Surgery, Transplantation, Regimen, Hematologic Neoplasms, business, Vidarabine, medicine.drug
Abstract: The relative merits of reduced-intensity allogeneic stem cell transplantation (RISCT) for high-risk indolent lymphoid malignancies are emerging, although the preferred conditioning regimen to manage the risks of graft-versus-host disease (GVHD) is not clearly defined. Here we report the outcome of 73 patients with lymphoid malignancies who received RISCT with a fludarabine/cyclophosphosphamide conditioning regimen and a median follow-up of 3 years. Median age was 54 years. Forty-eight per cent of patients had previously undergone autologous stem cell transplantation with a median of three prior therapies. Non-relapse mortality at 3 years was 19% but only 5% for patients with multiple myeloma (MM). Three-year overall survival and current progression-free survival was 67% and 63% respectively. Grade 2-4 acute GVHD occurred in 14% of patients while 49% had chronic GVHD requiring systemic immunosuppression. The preparatory regimen in this study has the advantage of reduced acute GVHD and low mortality, notably in patients with MM. In addition, this strategy provides long-term disease control in a significant proportion of patients with particular benefit in those with high-risk follicular lymphoma.
Published: 2012
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26. SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma

Author: Sameena Iqbal, Lucia Conde, David Wrench, Csaba Bödör, T. Andrew Lister, Jean-Baptiste Cazier, Janet Matthews, Christine F. Skibola, Maria Calaminici, John G. Gribben, Emanuela Carlotti, Jude Fitzgibbon, Silvia Montoto, and Pamela Leighton
Subjects: medicine.medical_specialty, Time Factors, Immunology, Follicular lymphoma, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Biochemistry, Germline, International Prognostic Index, HLA Antigens, Risk Factors, Internal medicine, medicine, Humans, SNP, Lymphoma, Follicular, Lymphoid Neoplasia, Hematology, Cancer, Cell Biology, Middle Aged, medicine.disease, United Kingdom, Cell Transformation, Neoplastic, Chromosomes, Human, Pair 6
Abstract: Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10−9) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
Published: 2011
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27. Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment

Author: Kelly J. Morris, Alan G. Ramsay, Andrew Clear, Maria Calaminici, Finlay MacDougall, Abigail M. Lee, Gavin Kelly, T. Andrew Lister, John G. Gribben, and Simon Hallam
Subjects: Pathology, medicine.medical_specialty, Angiogenesis, Biopsy, Immunology, Follicular lymphoma, Antigens, Differentiation, Myelomonocytic, Receptors, Cell Surface, Biology, Biochemistry, Neovascularization, Antigens, CD, Biomarkers, Tumor, medicine, Humans, Lymphoma, Follicular, Lymphoid Neoplasia, Tissue microarray, Neovascularization, Pathologic, medicine.diagnostic_test, Macrophages, Cell Biology, Hematology, Prognosis, medicine.disease, Lymphoma, Platelet Endothelial Cell Adhesion Molecule-1, cardiovascular system, medicine.symptom, CD163, Sprouting
Abstract: Follicular lymphoma has considerable clinical heterogeneity, and there is a need for easily quantifiable prognostic biomarkers. Microvessel density has been shown to be a useful prognostic factor based on numerical assessment of vessel numbers within histologic sections in some studies, but assessment of tumor neovascularization through angiogenic sprouting may be more relevant. We therefore examined the smallest vessels, single-staining structures measuring less than 30 μm2 in area, seen within histologic sections, and confirmed that they were neovascular angiogenic sprouts using extended focal imaging. Tissue microarrays composing diagnostic biopsies from patients at the extremes of survival of follicular lymphoma were analyzed with respect to numbers of these sprouts. This analysis revealed higher angiogenic activity in the poor prognostic group and demonstrated an association between increased sprouting and elevated numbers of infiltrating CD163+ macrophages within the immediate microenvironment surrounding the neovascular sprout.
Published: 2010
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28. Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34− fraction

Author: Emmanuel Griessinger, John G. Gribben, Dominique Bonnet, Tina Luke, Debra M. Lillington, T. Andrew Lister, Jamie Cavenagh, Kirsty Sharrock, Jacques Vargaftig, Samir G. Agrawal, Farideh Miraki-Moud, Heather Oakervee, and David Taussig
Subjects: medicine.medical_specialty, Myeloid, Immunology, CD34, Antigens, CD34, Cell Separation, Mice, SCID, Biology, Immunotherapy, Adoptive, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Antigen, Mice, Inbred NOD, hemic and lymphatic diseases, Internal medicine, medicine, Animals, Humans, 030304 developmental biology, Erythroid Precursor Cells, Mice, Knockout, 0303 health sciences, Nucleophosmin, Myeloid Neoplasia, Hematology, Nuclear Proteins, Myeloid leukemia, Cell Biology, medicine.disease, ADP-ribosyl Cyclase 1, Xenograft Model Antitumor Assays, 3. Good health, Leukemia, Myeloid, Acute, Haematopoiesis, Leukemia, Phenotype, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Cancer research, Mutant Proteins
Abstract: Leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) are believed to be restricted to the CD34+ fraction. However, one of the most frequently mutated genes in AML is nucleophosmin (NPM), and this is associated with low CD34 expression. We, therefore, investigated whether NPM-mutated AMLs have LICs restricted to the CD34+ fraction. We transplanted sorted fractions of primary NPM-mutated AML into immunodeficient mice to establish which fractions initiate leukemia. Approximately one-half of cases had LICs exclusively within the CD34− fraction, whereas the CD34+ fraction contained normal multilineage hematopoietic repopulating cells. Most of the remaining cases had LICs in both CD34+ and CD34− fractions. When samples were sorted based on CD34 and CD38 expression, multiple fractions initiated leukemia in primary and secondary recipients. The data indicate that the phenotype of LICs is more heterogeneous than previously realized and can vary even within a single sample. This feature of LICs may make them particularly difficult to eradicate using therapies targeted against surface antigens.
Published: 2010
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29. WASP-24 b: A New Transiting Close-in Hot Jupiter Orbiting a Late F-star

Author: Don Pollacco, T. A. Lister, Damian J. Christian, I. Skillen, Andrew Norton, Joao Bento, I. Todd, Michaël Gillon, E. K. Simpson, Richard G. West, B. Enoch, Eric Stempels, Coel Hellier, David R. Anderson, Pierre F. L. Maxted, S. C. C. Barros, Peter J. Wheatley, Amaury H. M. J. Triaud, Yogesh C. Joshi, A. Collier Cameron, Damien Ségransan, Stéphane Udry, N. R. Parley, Leslie Hebb, Barry Smalley, P. Cathaway-Kjontvedt, D. Queloz, Rachel Street, Francesco Pepe, É Depagne, and S. J. Bentley
Subjects: Physics, 010308 nuclear & particles physics, Giant planet, Astronomy, Astronomy and Astrophysics, Astrophysics, Effective temperature, Planetary system, Surface gravity, 01 natural sciences, Radial velocity, Space and Planetary Science, Planet, 0103 physical sciences, Hot Jupiter, 010303 astronomy & astrophysics, Planetary mass
Abstract: We report the discovery of a new transiting close-in giant planet, WASP-24 b, in a 2.341 day orbit, 0.037 AU from its F8-9 type host star. By matching the star's spectrum with theoretical models, we infer an effective temperature T-eff = 6075 +/- 100 K and a surface gravity of log g = 4.15 +/- 0.10. A comparison of these parameters with theoretical isochrones and evolutionary mass tracks places only weak constraints on the age of the host star, which we estimate to be 3.8(-1.2)(+1.3) Gyr. The planetary nature of the companion was confirmed by radial velocity measurements and additional photometric observations. These data were fit simultaneously in order to determine the most probable parameter set for the system, from which we infer a planetary mass of 1.071(-0.038)(+0.036) M-Jup and radius 1.3(-0.037)(+0.039) R-Jup.
Published: 2010
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30. Negative immunomagnetic selection of T cells from peripheral blood of presentation AML specimens

Author: John G. Gribben, Rifca Le Dieu, David Taussig, and T. Andrew Lister
Subjects: CD36 Antigens, CD4-Positive T-Lymphocytes, Myeloid, T cell, Sialic Acid Binding Ig-like Lectin 3, Immunology, Interleukin-3 Receptor alpha Subunit, CD34, Antigens, Differentiation, Myelomonocytic, Antigens, CD34, CD8-Positive T-Lymphocytes, Biology, Antibodies, Immune system, Antigen, Antigens, CD, medicine, Humans, Immunology and Allergy, Cytotoxic T cell, Granulocyte Precursor Cells, Immunomagnetic Separation, Flow Cytometry, medicine.disease, CD11c Antigen, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, T cell selection
Abstract: To date, studies on T cells in acute myeloid leukemia (AML) have been limited to flow cytometric analysis of whole peripheral blood mononuclear cell (PBMC) specimens or functional work looking at the impact of AML myeloblasts on normal or remission T cells. This lack of information on T cells at the time of presentation with disease is due in part to the difficulty in isolating sufficiently pure T cells from these specimens for further study. Negative immunomagnetic selection has been the method of choice for isolating immune cells for functional studies due to concerns that binding antibodies to the cell surface may induce cellular activation, block ligand-receptor interactions or result in immune clearance. In order specifically to study T cells in presentation AML specimens, we set out to develop a method of isolating highly pure CD4 and CD8 T cells by negative selection from the peripheral blood (PB) of newly diagnosed AML patients. This technique, unlike T cell selection from PB from normal individuals or from patients with chronic lymphocytic leukaemia, was extremely problematic due to properties of the leukaemic myeloblasts. A successful method was eventually optimized requiring the use of a custom antibody cocktail consisting of CD33, CD34, CD123, CD11c and CD36, to deplete myeloblasts.
Published: 2009
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31. Array-based DNA methylation profiling in follicular lymphoma

Author: Louis M. Staudt, Ciaran O'Riain, Andreas Rosenwald, C. Fleischmann, Elias Campo, J. Yeboah-Afari, G. W. Wright, Erlend B. Smeland, Karin E. Summers, W. C. Chan, Tim Crook, T. A. Lister, Rita M. Braziel, Derville O’Shea, S. Reimer, R. Le Dieu, Lisa M. Rimsza, Nathalie A. Johnson, Leena Bhaw-Rosun, German Ott, Randy D. Gascoyne, Charles A. Mein, G. Kelly, Paul Smith, Youwen Yang, Jude Fitzgibbon, and John G. Gribben
Subjects: Adult, Cancer Research, Adolescent, Follicular lymphoma, Biology, Methylation, Article, Epigenesis, Genetic, Young Adult, 03 medical and health sciences, 0302 clinical medicine, follicular lymphoma, Gene expression, medicine, Humans, Child, Lymphoma, Follicular, Aged, Oligonucleotide Array Sequence Analysis, 030304 developmental biology, Aged, 80 and over, Regulation of gene expression, 0303 health sciences, Gene Expression Profiling, transformation, Hematology, DNA Methylation, Middle Aged, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Gene expression profiling, Haematopoiesis, Oncology, CpG site, Child, Preschool, 030220 oncology & carcinogenesis, DNA methylation, gene expression, Cancer research, CpG Islands, Lymph Nodes, polycomb
Abstract: Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated Follicular Lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples and purified B & T cells from two FL cases. Methylation values allowed separation of untreated FL samples from controls with one exception based primarily on tumour-specific gains of methylation typically occurring within CpG islands. Genes which are targets for epigenetic repression in stem cells by Polycomb Repressor Complex 2 were significantly overrepresented among hypermethylated genes. Methylation profiles were conserved in sequential FL and t-FL biopsies suggesting that widespread methylation represents an early event in lymphomagenesis and may not contribute substantially to transformation. Significant (p
Published: 2009
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32. Combined Granulocyte and Platelet Transfusions: Inter-Relationship between Granulocyte and Platelet Recoveries in the Presence and Absence of Complicating Factors

Author: Anthony J. C. Fulford, Linda M. Brown, M. M. Roberts, T. Andrew Lister, Michael H. Cullen, and J. M. Ford
Subjects: Blood Platelets, Fever, Neutrophils, Prednisolone, Platelet Transfusion, Granulocyte, Oral prednisolone, Leukocyte Count, Transfusion reaction, Humans, Medicine, Blood Transfusion, Platelet, In patient, Platelet Count, business.industry, Transfusion Reaction, Hematology, Transplantation, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Blood Group Incompatibility, Immunology, Myeloid leukaemia, business, Cytapheresis
Abstract: 191 combined collections of granulocytes (PMN) and platelets (PLT) obtained by discontinuous cytapheresis were given to 23 patients with acute myeloid leukaemia (AML). The circulation in recipients of the concomitantly transfused cells was compared by measuring the % recovery of PMN at 1 h, and of PLT at 1 and 20 h. The recovery of both cells was greatly reduced in transfusions accompanied by a transfusion reaction. Fever in recipients had no effect on the recovery of either cell, but PMN recovery was significantly higher in patients receiving oral prednisolone. Alloimmunization to PLT, defined as recovery levels less than 15% at 1 h and/or less than 10% at 20 h, was recorded in 42 transfusions, and PMN recovery was significantly reduced in this group. In transfusions where PMN recovery was 'low' (less than 5%); the recovery of the coincidentally transfused PLT was significantly reduced only in transfusions accompanied by a reaction. These results emphasize the deleterious effects of transfusion reactions and suggest that donor PMN frequently circulate less well in recipients alloimmunized to PLT from the same donor.
Published: 2009
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33. BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations

Author: Teresa Marafioti, David Y. Mason, Margaret Jones, Lisa J. Campbell, Andrew Clear, Jacqueline Cordell, Abigail M. Lee, T. Andrew Lister, Noraidah Masir, and Lindsey K. Goff
Subjects: DNA Mutational Analysis, Follicular lymphoma, Somatic hypermutation, Biology, Immunofluorescence, medicine.disease_cause, Translocation, Genetic, Epitope, immune system diseases, hemic and lymphatic diseases, Biomarkers, Tumor, medicine, Humans, Lymphoma, Follicular, neoplasms, In Situ Hybridization, Fluorescence, Cell Proliferation, Chromosomes, Human, Pair 14, Mutation, medicine.diagnostic_test, Hematology, medicine.disease, Immunohistochemistry, Molecular biology, Genes, bcl-2, Lymphoma, Ki-67 Antigen, Proto-Oncogene Proteins c-bcl-2, biology.protein, biological phenomena, cell phenomena, and immunity, Antibody, Chromosomes, Human, Pair 18, Immunostaining
Abstract: The t(14;18)(q32;q21) chromosomal translocation induces BCL2 protein overexpression in most follicular lymphomas. However the expression of BCL2 is not always homogeneous and may demonstrate a variable degree of heterogeneity. This study analysed BCL2 protein expression pattern in 33 cases of t(14;18)-positive follicular lymphomas using antibodies against two different epitopes (i.e. the widely used antibody BCL2/124 and an alternative antibody E17). 16/33 (49%) cases demonstrated strong BCL2 expression. In 10/33 (30%) cases, BCL2 expression was heterogeneous and in some of these, its loss appeared to be correlated with cell proliferation, as indicated by Ki67 expression. Double immunofluorescence labelling confirmed an inverse BCL2/Ki67 relationship, where in 24/28 (86%) cases cellular expression of BCL2 and Ki67 was mutually exclusive. In addition, seven BCL2 'pseudo-negative' cases were identified in which immunostaining was negative with antibody BCL2/124, but positive with antibody E17. Genomic DNA sequencing of these 'pseudo-negative' cases demonstrated eleven mutations in four cases and nine of these were missense mutations. It can be concluded that in follicular lymphomas, despite carrying the t(14;18) translocations, BCL2 protein expression may be heterogeneous and loss of BCL2 could be related to cell proliferation. Secondly, mutations in translocated BCL2 genes appear to be common and may cause BCL2 pseudo-negative immunostaining.
Published: 2009
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34. Mutation of the Wilms’ Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party

Author: David C. Linch, Claire Green, Alan Kenneth Burnett, Jane Stevens, T. Andrew Lister, Hilmar Quentmeier, Rosemary E. Gale, Hans G. Drexler, Robert Kerrin Hills, Christopher Allen, Ioannis Kakkas, Jude Fitzgibbon, Priya Virappane, Karin E. Summers, and Dominique Bonnet
Subjects: Cancer Research, medicine.medical_specialty, Myeloid, business.industry, Myeloid leukemia, Induction chemotherapy, Wilms' tumor, Gene mutation, medicine.disease, Minimal residual disease, Gastroenterology, Leukemia, medicine.anatomical_structure, Oncology, Internal medicine, Immunology, Medicine, Cumulative incidence, business
Abstract: Purpose To determine the clinical relevance of Wilms’ tumor 1 (WT1) gene mutations in acute myeloid leukemia (AML) with normal karyotype (NK). Patients and Methods Exons 7 and 9 of WT1 were screened in samples from 470 young adult NK AMLs using a combination of direct sequencing and high-resolution capillary electrophoresis. Results Overall, 51 mutations were detected in 47 cases (10%): 46 frameshift mutations with insertion/deletion of one to 28 base pairs in exon 7 (n = 45) or exon 9 (n = 1), with a median mutant level of 45% (range, 8% to 86%), and five substitutions in exon 9: D396N (n = 3), H397Y (n = 1) and H397Q (n = 1). Patients with WT1 mutations had an inferior response to induction chemotherapy compared with wild-type cases (complete remission rate, 79% v 90%, odds ratio [OR] = 3.02; 95% CI, 1.17 to 7.82; P = .02), a higher rate of resistant disease (15% v 4%; OR = 9.33; 95% CI, 2.38 to 36.6; P = .001), an increased cumulative incidence of relapse (67% v 43%, hazard ratio [HR] = 3.02; 95% CI, 1.69 to 5.38; P = .0008), with a reduction in both relapse-free survival (22% v 44%; HR = 2.16; 95% CI, 1.32 to 3.55; P = .005) and overall survival (26% v 47%; HR = 1.91; 95% CI, 1.23 to 2.95; P = .007) at 5 years. In multivariate analysis, which included FLT3 internal tandem duplication and NPM1 mutation status, the presence of a WT1 mutation remained an independent adverse prognostic factor. Conclusion WT1 mutations are a negative prognostic indicator in NK AML and may be suitable for the development of targeted therapy.
Published: 2008
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35. A Cross-matching Procedure for the Selection of Platelet Donors for Alloimmunized Patients

Author: R.M. Minchinton, R. Bell, A. H. Waters, J. M. Ford, and T. A. Lister
Subjects: Adult, Male, Fever, Lymphocyte, medicine.medical_treatment, Splenectomy, Fluorescent Antibody Technique, Platelet Transfusion, Immunofluorescence, Isoantibodies, HLA Antigens, medicine, Humans, Blood Transfusion, Platelet, Prospective Studies, Retrospective Studies, medicine.diagnostic_test, biology, business.industry, Donor selection, Transfusion Reaction, Hematology, Thrombocytopenia, medicine.anatomical_structure, Platelet transfusion, Blood Grouping and Crossmatching, Immunology, biology.protein, Female, Antibody, business
Abstract: A platelet cross-matching procedure has been assessed for selecting compatible donors for alloimmunized patients. This confirms the clinical value of combining an indirect platelet immunofluorescence test (PIFT) with a lymphocytotoxicity test (LCT) in predicting the survival of single-donor platelets. There was good agreement between the PIFT cross-match and post-transfusion platelet recovery. Compatibility in the LCT alone was insufficient for platelet donor selection, as this test did not detect all antibodies affecting platelet survival. Positive LCT and PIFT cross-matches indicated the presence of HLA antibodies. Inclusion of an indirect lymphocyte immunofluorescence test (LIFT) helped to classify the platelet antibody when the LCT cross-match was negative. In such cases, parallel positive findings with the LIFT and PIFT suggested a cytotoxic-negative antibody of probable HLA specificity active against platelets. Disparity between the LIFT and PIFT was also observed; a strongly positive PIFT along with a weak reaction in the LIFT suggested that a platelet-specific antibody was responsible for the poor platelet survival in these cases. This study has also shown the presence in multitransfused patients of LIFT-positive antibodies not reacting in the LCT and PIFT, which do not affect the survival of transfused platelets. A positive granulocyte cross-match was demonstrated in patients with febrile rigors associated with compatible platelet transfusions. Splenectomy and steroids may improve the survival of incompatible platelets depending on the nature of the platelet antibody.
Published: 2008
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36. author index

Author: T. A. Lister, P. Johnson, A. Z. S. Rohatiner, John Radford, Kim Linton, A. J. Davies, and Janet Matthews
Subjects: Oncology, medicine.medical_specialty, Follicular Non-Hodgkin's Lymphoma, Consolidation (soil), business.industry, Internal medicine, First line, First remission, Medicine, 90Y ibritumomab tiuxetan, Hematology, business
Published: 2008
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37. Co-ordinated Follow-Up of Transiting Planet Candidates with Robotic Telescope Facilities

Author: T. A. Lister and R. A. Street
Subjects: Physics, Robotic telescope, Space and Planetary Science, Planet, Astronomy, Astronomy and Astrophysics, Remote sensing
Abstract: There are now several large photometric surveys scanning millions of stellar light-curves for signs of planetary transits. All produce large candidate lists with a high false alarm rate, so that further observations are required to confirm new detections. One such survey, SuperWASP, produced ~150 candidates during the 2007–2008 season. Here we describe our campaign to follow-up 86 of these candidates using the robotic facilities of Las Cumbres Observatory Global Telescope Network and the Tenagra-II robotic telescope in Arizona. The aim of these observations was to eliminate false positives as far as possible ahead of spectroscopic follow-up and to provide additional photometry to help characterise the surviving targets.
Published: 2008
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38. Chemosensitization of B-Cell Lymphomas by Methylseleninic Acid Involves Nuclear Factor-κB Inhibition and the Rapid Generation of Other Selenium Species

Author: Simon P. Joel, T. Andrew Lister, Jude Fitzgibbon, Heidi Goenaga-Infante, and Simone Jüliger
Subjects: Cancer Research, Lymphoma, B-Cell, Time Factors, Cell Survival, chemistry.chemical_element, Antineoplastic Agents, Apoptosis, Biology, Transfection, Selenium, chemistry.chemical_compound, Cell Line, Tumor, Organoselenium Compounds, medicine, Humans, Cytotoxic T cell, Doxorubicin, Etoposide, Selenium Compound, Cell Death, NF-kappa B, Biological activity, Methylselenocysteine, Oncology, chemistry, Biochemistry, Cancer research, Comet Assay, Intracellular, DNA Damage, medicine.drug
Abstract: Although recent reports suggest that selenium can modulate the activity of cytotoxic drugs, the mechanism underlying this activity remains unclear. This has been investigated using a panel of human B-cell lymphoma cell lines. The cytotoxic effects of chemotherapeutic agents (e.g., doxorubicin, etoposide, 4-hydroperoxycyclophosphamide, melphalan, and 1-β-d-arabinofuranosylcytosine) were increased by up to 2.5-fold when combined with minimally toxic concentrations (EC5-10) of the organic selenium compound, methylseleninic acid (MSA). DNA strand breaks were identified using comet assays, but the measured genotoxic activity of the combinations did not explain the observed synergistic effects in cell death. However, minimally toxic (EC10) concentrations of MSA induced a 50% decrease in nuclear factor-κB (NF-κB) activity after an exposure of 5 h, similar to that obtained with the specific NF-κB inhibitor, BAY 11-7082. Combinations of BAY 11-7082 with these cytotoxic drugs also resulted in synergism, suggesting that the chemosensitizing activity of MSA is mediated, at least in part, by its effects on NF-κB. Basal intracellular selenium concentration was higher in a MSA-sensitive cell line. After exposure to MSA, methylselenocysteine and selenomethionine were identified as the main intracellular species generated. Volatile selenium species, trapped using solid-phase microextraction fibers, were identified as dimethylselenide and dimethyldiselenide. These volatile species are thought to be the most biologically active forms of selenium. Taken together, these results show that the NF-κB pathway is one target for MSA underlying the interaction between MSA and chemotherapy. These data encourage the further clinical development of selenium as a potential modulator of cytotoxic drug activity in B-cell lymphomas. [Cancer Res 2007;67(22):10984–92]
Published: 2007
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39. Efficient identification of exoplanetary transit candidates from SuperWASP light curves

Author: Peter J. Wheatley, A. Collier Cameron, Ian Skillen, Xiaobin Wang, Stéphane Udry, Carole A. Haswell, Pierre F. L. Maxted, D. M. Wilson, Eike W. Guenther, T. A. Lister, Frederic Pont, Jonathan Irwin, François Bouchy, Massimiliano Esposito, Coel Hellier, R. A. Street, Damian J. Christian, Will Clarkson, Michel Mayor, Suzanne Aigrain, Don Pollacco, Guillaume Hébrard, Didier Queloz, B. Enoch, C. Moutou, Keith Horne, Richard G. West, Robert Ryans, Stephen R. Kane, B. Loeillet, N. R. Parley, and Leslie Hebb
Subjects: Physics, Astronomy and Astrophysics, Astrophysics, Radius, Light curve, Exoplanet, Jupiter, Stars, Space and Planetary Science, Primary (astronomy), Planet, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Transit (astronomy)
Abstract: Transiting extrasolar planets constitute only a small fraction of the range of stellar systems found to display periodic, shallow dimmings in wide-field surveys employing small-aperture camera arrays. Here we present an efficient selection strategy for follow-up observations, derived from analysis of the light curves of a sample of 67 SuperWASP targets that passed the selection tests we used in earlier papers, but which have subsequently been identified either as planet hosts or as astrophysical false positives. We determine the system parameters using Markov-chain Monte Carlo analysis of the SuperWASP light curves. We use a constrained optimisation of chi-squared combined with a Bayesian prior based on the main-sequence mass and radius expected from the 2MASS J-H colour. The Bayesian nature of the analysis allows us to quantify both the departure of the host star from the main-sequence mass-radius relation and the probability that the companion radius is less than 1.5 Jupiter radii. When augmented by direct light curve analyses that detect binaries with unequal primary and secondary eclipses, and objects with aperture blends that are resolved by SuperWASP, we find that only 13 of the original 67 stars, including the three known planets in the sample, would qualify for follow-up. This suggests that planet discovery "hit rates" better than one-in-five should be achievable. In addition, the stellar binaries that qualify are likely to have astrophysically interesting stellar or sub-stellar secondaries.
Published: 2007
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40. SuperWASP-North extrasolar planet candidates: candidates from fields 17 h < RA < 18 h

Author: C. Hellier, P. J. Wheatley, Will Clarkson, R. A. Street, Andrew Norton, Carole A. Haswell, S. T. Hodgkin, D. L. Pollacco, Robert Ryans, J. M. Irwin, A. Collier Cameron, T. A. Lister, Damian J. Christian, I. Skillen, J. P. Osborne, S. R. Kane, A. Evans, Keith Horne, John R. Barnes, Richard G. West, N. R. Parley, Alan Fitzsimmons, B. Enoch, Francis P. Keenan, and D. M. Wilson
Subjects: Physics, Stars, Space and Planetary Science, Planet, Astronomy and Astrophysics, Transit (astronomy), Astrophysics, Exoplanet
Abstract: We have performed photometric observations of nearly 7 million stars with 8 < V < 15 with the SuperWASP-North instrument from La Palma between 2004 May-September. Fields in the RA range 17-18hr, yielding over 185,000 stars with sufficient quality data, have been searched for transits using a modified box least-squares (BLS) algorithm. We find a total of 58 initial transiting candidates which have high S/N in the BLS, show multiple transit-like dips and have passed visual inspection. Analysis of the blending and inferred planetary radii for these candidates leaves a total of 7 transiting planet candidates which pass all the tests plus 4 which pass the majority. We discuss the derived parameters for these candidates and their properties and comment on the implications for future transit searches., Comment: 17 pages, 24 figures, accepted by MNRAS
Published: 2007
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41. Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study

Author: Shimon Slavin, Christian Gisselbrecht, G. Taghipour, L. Fouillard, Anna Sureda, N. Schmitz, H. Tilly, Silvia Montoto, Carmen Canals, Christophe Fruchart, T. A. Lister, Ama Z. S. Rohatiner, Augustin Ferrant, Veronique Leblond, Corinne Haioun, Eulogio Conde, Noel-Jean Milpied, and Anthony H. Goldstone
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Adolescent, Follicular lymphoma, Bone Marrow Cells, Transplantation, Autologous, Disease-Free Survival, Internal medicine, medicine, Humans, Registries, Progenitor cell, Lymphoma, Follicular, Bone Marrow Transplantation, Hematology, business.industry, Stem Cells, Remission Induction, Secondary Myelodysplastic Syndrome, Middle Aged, Hematopoietic Stem Cells, medicine.disease, Surgery, Lymphoma, Regimen, Haematopoiesis, Leukemia, Treatment Outcome, Female, business
Abstract: To evaluate the outcome of a large series of patients who received high-dose treatment (HDT) for follicular lymphoma (FL), 693 patients undergoing HDT (total-body irradiation (TBI)-containing regimen: 58%; autologous bone marrow (BM)/peripheral blood progenitor cells (PBPCs): 378/285 patients) were included in the study. A total of 375 patients (54%) developed recurrent lymphoma, 10-year progression-free survival (PFS) being 31%. On multivariate analysis, younger age (P=0.003) and HDT in first complete remission (CR1) (P
Published: 2007
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42. Myeloablative Therapy With Autologous Bone Marrow Transplantation for Follicular Lymphoma at the Time of Second or Subsequent Remission: Long-Term Follow-Up

Author: Arnold S. Freedman, John Apostolidis, Janet Matthews, Peter Mauch, Ama Z. S. Rohatiner, Donna Neuberg, Andrew Davies, Lee M. Nadler, John G. Gribben, and T. Andrew Lister
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Cyclophosphamide, Follicular lymphoma, Transplantation, Autologous, Recurrence, Humans, Medicine, Lymphoma, Follicular, Survival rate, Bone Marrow Transplantation, Retrospective Studies, business.industry, Remission Induction, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, Combined Modality Therapy, Lymphoma, Surgery, Survival Rate, Transplantation, Treatment Outcome, medicine.anatomical_structure, Oncology, Disease Progression, Female, Bone marrow, business, Whole-Body Irradiation, medicine.drug
Abstract: Purpose The aim of this retrospective analysis was to determine the outcome of patients with follicular lymphoma who received myeloablative therapy supported by autologous bone marrow transplantation as consolidation of second or subsequent remission, with a minimum follow-up of 12 years. Patients and Methods One hundred twenty-one adults received cyclophosphamide (CY) and total-body irradiation (TBI) supported by autologous bone marrow transplantation, with the marrow mononuclear cell fraction having been treated with monoclonal antibodies and complement. Data from St Bartholomew's Hospital and Dana-Farber Cancer Institute were combined for the purpose of this analysis because the patients were treated in an identical manner. Results Fifty-seven patients are alive, 41 without progression between 9 and 19 years; 64 patients have died, 20 without progression. With a median follow-up of 13.5 years, 60 patients have developed recurrent lymphoma. There is an apparent plateau on the remission duration curve at 48% at 12 years. Survival of patients treated in second remission was significantly longer than the survival of patients treated later in the course of the illness. Both remission duration and overall survival were also significantly longer for patients treated in second remission compared with an age-matched, remission-matched group of patients treated at St Bartholomew's Hospital before the introduction of this treatment. However, use of CY+TBI was associated with a significant risk of secondary myelodysplasia and secondary acute myeloblastic leukemia, resulting in 15 patient deaths. Conclusion These mature data confirm that prolonged freedom from recurrence may be achieved with myeloablative therapy and that a plateau on the curve seems to emerge with long follow-up.
Published: 2007
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43. Indoor radon measurements in south west England explained by topsoil and stream sediment geochemistry, airborne gamma-ray spectroscopy and geology

Author: Charlie Kirkwood, Z. Daraktchieva, Joanna Wragg, T. Robert Lister, António Ferreira, Mark Cave, David Beamish, and Kathryn Lee
Subjects: Health, Toxicology and Mutagenesis, Geochemistry, chemistry.chemical_element, Mineralogy, Radon, 010501 environmental sciences, 010502 geochemistry & geophysics, 01 natural sciences, Radiation Monitoring, Linear regression, Environmental Chemistry, Air Pollution, Radioactive, Waste Management and Disposal, 0105 earth and related environmental sciences, Radionuclide, Topsoil, Sediment, Geology, General Medicine, Explained variation, Pollution, Spectrometry, Gamma, chemistry, England, Air Pollutants, Radioactive, Gamma Rays, Air Pollution, Indoor, Soil water, Compositional data
Abstract: Predictive mapping of indoor radon potential often requires the use of additional datasets. A range of geological, geochemical and geophysical data may be considered, either individually or in combination. The present work is an evaluation of how much of the indoor radon variation in south west England can be explained by four different datasets: a) the geology (G), b) the airborne gamma-ray spectroscopy (AGR), c) the geochemistry of topsoil (TSG) and d) the geochemistry of stream sediments (SSG). The study area was chosen since it provides a large (197,464) indoor radon dataset in association with the above information. Geology provides information on the distribution of the materials that may contribute to radon release while the latter three items provide more direct observations on the distributions of the radionuclide elements uranium (U), thorium (Th) and potassium (K). In addition, (c) and (d) provide multi-element assessments of geochemistry which are also included in this study. The effectiveness of datasets for predicting the existing indoor radon data is assessed through the level (the higher the better) of explained variation (% of variance or ANOVA) obtained from the tested models. A multiple linear regression using a compositional data (CODA) approach is carried out to obtain the required measure of determination for each analysis. Results show that, amongst the four tested datasets, the soil geochemistry (TSG, i.e. including all the available 41 elements, 10 major – Al, Ca, Fe, K, Mg, Mn, Na, P, Si, Ti - plus 31 trace) provides the highest explained variation of indoor radon (about 40%); more than double the value provided by U alone (ca. 15%), or the sub composition U, Th, K (ca. 16%) from the same TSG data. The remaining three datasets provide values ranging from about 27% to 32.5%. The enhanced prediction of the AGR model relative to the U, Th, K in soils suggests that the AGR signal captures more than just the U, Th and K content in the soil. The best result is obtained by including the soil geochemistry with geology and AGR (TSG + G + AGR, ca. 47%). However, adding G and AGR to the TSG model only slightly improves the prediction (ca. +7%), suggesting that the geochemistry of soils already contain most of the information given by geology and airborne datasets together, at least with regard to the explanation of indoor radon. From the present analysis performed in the SW of England, it may be concluded that each one of the four datasets is likely to be useful for radon mapping purposes, whether alone or in combination with others. The present work also suggest that the complete soil geochemistry dataset (TSG) is more effective for indoor radon modelling than using just the U (+Th, K) concentration in soil.
Published: 2015

44. Central Nervous System Toxicity of Interferon

Author: P F Prior, A C Burton, Frances R. Balkwill, A. Z. S. Rohatiner, and T. A. Lister
Subjects: medicine.anatomical_structure, Interferon, Toxicity, Central nervous system, Immunology, medicine, Pharmacology, Biology, medicine.drug
Published: 2015
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45. Immunotherapy for Acute Myelogenous Leukemia

Author: G H Fairley, T. A. Lister, T McElwain, P. Alexander, D Crowther, and R L Powles
Subjects: medicine.medical_specialty, Chemotherapy, Myeloid, business.industry, medicine.medical_treatment, Induction chemotherapy, Spontaneous remission, Immunotherapy, medicine.disease, Surgery, Myelogenous, Leukemia, medicine.anatomical_structure, medicine, business, BCG vaccine
Abstract: One hundred and seven untreated patients with acute myelogenous leukemia (AML) were admitted to St. Bartholomew's Hospital between the 10th October 1970 and the 31st January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment, a group to receive chemotherapy alone and a group to receive the same chemotherapy with immunotherapy. The patients were then given induction chemotherapy and 45 of them attained complete remission. All patients in remission then received chemotherapy consisting of 5 days treatment every 28 days. Patients receiving immunotherapy were also given multiple weekly intradermal injections of irradiated stored AML cells and Glaxo BCG using a Heaf gun. There were 19 patients in the group which received only chemotherapy during remission; 7 of these patients remain alive (median survival after attaining remission--303 days) and only 5 are still in their first remission (median remission length 188 days). Twenty three patients were allocated to receive immunotherapy during remission in addition to chemotherapy and 16 remain alive (median 545 days) and 8 are in their first remission (median 312 days). The difference in survival of the 2 groups is significant with a sigma value of 0.003.
Published: 2015
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46. Neurotoxicity of High-Dose Cytosine Arabinoside

Author: T. A. Lister, H. S. Dhaliwal, M. A. Richards, A. Z. S. Rohatiner, B. F. Smith, J. H. Waxman, Trivadi S. Ganesan, M. L. Slevin, and M. J. Barnett
Subjects: business.industry, Neuro oncology, MEDLINE, Neurotoxicity, Pharmacology, medicine.disease, Clinical trial, chemistry.chemical_compound, chemistry, Toxicity, Cytarabine, Medicine, business, Cytosine, medicine.drug
Published: 2015
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47. Reply to B. Bennani-Baiti et al, H.J.A. Adams et al, E. Laffon et al, and E.A. Hawkes et al

Author: Lale Kostakoglu, Franco Cavalli, N. George Mikhaeel, Michael O'Doherty, Alberto Biggi, Lawrence H. Schwartz, Michel Meignan, Richard I. Fisher, Rodney J. Hicks, Roland Hustinx, Martin Hutchings, Judith Trotman, Emanuele Zucca, T. Andrew Lister, Bruce D. Cheson, Otto S. Hoekstra, Sally F. Barrington, and Stefan C. Mueller
Subjects: Cancer Research, medicine.diagnostic_test, Lymphoma, business.industry, Medizin, Nuclear magnetic resonance, Tomography x ray computed, Oncology, Positron emission tomography, X ray computed, Fluorodeoxyglucose F18, Positron-Emission Tomography, Medicine, Humans, Radiopharmaceuticals, business, Tomography, X-Ray Computed
Abstract: Korrespondenz zu 10.1200/JCO.2014.59.6833, 10.1200/JCO.2014.59.8193, 10.1200/JCO.2014.58.7360, 10.1200/JCO.2014.60.0486
Published: 2015

48. The impact of correlated noise on SuperWASP detection rates for transiting extrasolar planets

Author: Andra M. Smith, T. A. Lister, D. M. Wilson, Damian J. Christian, I. Skillen, J. M. Irwin, Andrew Norton, A. Collier Cameron, Carole A. Haswell, R. A. Street, D. L. Pollacco, Robert Ryans, N. R. Parley, Richard G. West, C. Hellier, A. H. M. J. Triaud, B. Enoch, Will Clarkson, P. J. Wheatley, S. R. Kane, A. Evans, and Keith Horne
Subjects: Physics, Metallicity, Astrophysics (astro-ph), FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Exoplanet, Space and Planetary Science, Planet, Range (statistics), Astrophysics::Earth and Planetary Astrophysics, Transit (astronomy), Detection rate, Noise (radio)
Abstract: We present a model of the stellar populations in the fields observed by one of the SuperWASP-N cameras in the 2004 observing season. We use the Besancon Galactic model to define the range of stellar types and metallicities present, and populate these objects with transiting extra-solar planets using the metallicity relation of Fischer & Valenti (2005). We investigate the ability of SuperWASP to detect these planets in the presence of realistic levels of correlated systematic noise (`red noise'). We find that the number of planets that transit with a signal-to-noise ratio of 10 or more increases linearly with the number of nights of observations. Based on a simulation of detection rates across 20 fields observed by one camera, we predict that a total of 18.6 \pm 8.0 planets should be detectable from the SuperWASP-N 2004 data alone. The best way to limit the impact of co-variant noise and increase the number of detectable planets is to boost the signal-to-noise ratio, by increasing the number of observed transits for each candidate transiting planet. This requires the observing baseline to be increased, by spending a second observing season monitoring the same fields., Omitted co-authors reinstated. 9 pages, 7 figures, accepted for publication in MNRAS
Published: 2006
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49. Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome

Author: T. Andrew Lister, Andrew Norton, Abigail M. Lee, Maria Calaminici, Finlay MacDougall, John G. Gribben, Andrew Clear, Janet Matthews, Suzanne Jordan, Lindsey K. Goff, and Andrew Davies
Subjects: CD4-Positive T-Lymphocytes, Cancer Research, Pathology, medicine.medical_specialty, Tissue microarray, business.industry, Protein Array Analysis, Follicular lymphoma, FOXP3, Forkhead Transcription Factors, medicine.disease, Stem cell marker, Immunohistochemistry, Survival Analysis, Follicular cell, Lymphoma, medicine.anatomical_structure, Oncology, medicine, Humans, IL-2 receptor, business, Lymphoma, Follicular, Lymph node
Abstract: Purpose To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance. Patients and Methods Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25). Results CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4+ staining cells and to have FOXP3-positive cells in a perifollicular location. Conclusion This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting.
Published: 2006
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50. Recombinant human granulocyte macrophage colony stimulating factor following alternating non cross resistant chemotherapy in hodgkin's disease

Author: J. A. L. Amess, M. A. Horton, T. A. Lister, E. Dorey, Peter F. M. Wrigley, A. M. Oza, A. Z. S. Rohatiner, M. Leahy, and C. L. Davis
Subjects: Adult, Male, Cancer Research, Vincristine, medicine.medical_specialty, Leukocytosis, medicine.medical_treatment, Procarbazine, Gastroenterology, Drug Administration Schedule, Immunophenotyping, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Infusions, Intravenous, Etoposide, Chemotherapy, Chlorambucil, business.industry, Remission Induction, Granulocyte-Macrophage Colony-Stimulating Factor, Hematology, General Medicine, Middle Aged, medicine.disease, Hodgkin Disease, Recombinant Proteins, Vinblastine, Endocrinology, Oncology, Prednisolone, Female, business, Progressive disease, medicine.drug
Abstract: Fourteen patients with Hodgkin's disease (two previously untreated, 12 following relapse or with refractory disease) were treated with a combination chemotherapy regimen comprising chlorambucil, vinblastine, procarbazine, prednisolone, etoposide, vincristine and adriamycin administered on days 1-8. Recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) (mammalian glycosylated, Sandoz/Schering-Plough) was administered after alternate cycles of chemotherapy from day 10 for 7 days by continuous intravenous (i.v.) infusion in 12 patients in a dose finding study (dose: 2 micrograms/kg/day in four patients, 4 micrograms/kg/day in four patients and 8 micrograms/kg/day in four patients) and by daily subcutaneous (s/c) injections in two patients (8 micrograms/kg/day). There was a rapid peripheral leucocytosis following the rhGM-CSF, reaching a peak at 1-2 days in 12/14 patients. The initial leucocytosis was composed of neutrophils followed by a rise in immature myeloid cells. There was no difference observed in the duration or depth of the nadir following chemotherapy or in the rate of recovery of peripheral white cell counts between cycles with and without rhGM-CSF in patients treated with 2 and 4 micrograms/kg/day. At the dose of 8 micrograms/kg/day, 3/6 patients had a shorter nadir duration in the cycle with rhGM-CSF, compared with cycle without rhGM-CSF. There was no difference in frequency of infection in cycles with and without rhGM-CSF. Following chemotherapy, six patients achieved clinical remission, six partial remission and two had progressive disease.
Published: 2006
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