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Background Few studies have been done on inpatient antibiotic use in Japan and antibiotic stewardship programs with dedicated full-time equivalents are rare. We sought to better understand inpatient antibiotic use in Okinawa, Japan. We applied the World Health Organization (WHO) Access, Watch and Reserve (AWaRe) Classification to compare our findings to international literature. Access antibiotics are common front-line antibiotics, Watch antibiotics are high-priority antibiotics with toxicity or resistance concerns, and Reserve antibiotics are last-line treatments for multi-drug resistant infections. Methods A point prevalence study was conducted in five hospitals in Okinawa, Japan on Oct 1, 2020. Physicians conducted chart reviews of all patients receiving intravenous antibiotics. Type of antibiotic, reason for use, duration, and microbiologic data was collected. The primary aim was to evaluate the proportion of patients who received antibiotics on the assessment date; secondary aims were to categorize antibiotics according to indication, class and AWaRe classification. Descriptive statistics were used to derive the distribution of AWaRe Classifications and drug class. Results 1,728 unique patients were included and 504 (29%) received ≥1 antibiotic on the assessment date. A total of 559 antibiotics were used for 504 patients and 22.0% (n=123) were for prophylaxis. Of those receiving antibiotics for treatment (N=436), 385 (88.3%) patients had a documented infection source. The most common indications for antibiotic use were pneumonia (24.2% n=93), urinary tract infection (19.7% n=76), and intraabdominal (17.9% n=69). Overall, 43.1% (n=241) of the antibiotics were categorized Access and 54.4% (n=304) Watch [Figure 1]. Cephalosporins were the most common antibiotic class (56% n=313), followed by β-lactam inhibitors (18% n=106) and narrow penicillins (8.2% n=46) [Figure 2]. Conclusion 29% of inpatients in these 5 Okinawan hospitals were prescribed an antibiotic on the survey date. A majority of antibiotics used fall under the WHO AWaRe Watch classification which are antibiotics that may be more likely to cause resistance. Understanding appropriateness of antibiotics used in this population could inform antibiotic stewardship strategies and reduce antibiotic resistance. Figure 1. Antibiotic Distribution According to World Health Organization (WHO) Access, Watch and Reserve (AWaRe) Classification Figure 2. Antibiotic Distribution by Class in Okinawan Hospitals Disclosures All Authors: No reported disclosures

We present a theoretical model for Type Ib supernova (SN) 2006jc. We calculate the evolution of the progenitor star, hydrodynamics and nucleosynthesis of the SN explosion, and the SN bolometric light curve (LC). The synthetic bolometric LC is compared with the observed bolometric LC constructed by integrating the UV, optical, near-infrared (NIR), and mid-infrared (MIR) fluxes. The progenitor is assumed to be as massive as $40M_\odot$ on the zero-age main-sequence. The star undergoes extensive mass loss to reduce its mass down to as small as $6.9M_\odot$, thus becoming a WCO Wolf-Rayet star. The WCO star model has a thick carbon-rich layer, in which amorphous carbon grains can be formed. This could explain the NIR brightening and the dust feature seen in the MIR spectrum. We suggest that the progenitor of SN 2006jc is a WCO Wolf-Rayet star having undergone strong mass loss and such massive stars are the important sites of dust formation. We derive the parameters of the explosion model in order to reproduce the bolometric LC of SN 2006jc by the radioactive decays: the ejecta mass $4.9M_\odot$, hypernova-like explosion energy $10^{52}$ ergs, and ejected $^{56}$Ni mass $0.22M_\odot$. We also calculate the circumstellar interaction and find that a CSM with a flat density structure is required to reproduce the X-ray LC of SN 2006jc. This suggests a drastic change of the mass-loss rate and/or the wind velocity that is consistent with the past luminous blue variable (LBV)-like event., Comment: 12 pages, 11 figures. Accepted for publication in the Astrophysical Journal

SN 2002ic is a unique supernova which shows the typical spectral features of Type Ia supernovae (SNe Ia) near maximum light, but also apparent hydrogen features that have been absent in SNe Ia. We have calculated hydrodynamical models for the interaction between the SN Ia ejecta and the H-rich circumstellar medium (CSM) to reproduce the observed features of SN 2002ic. Based on our modeling, we suggest that CSM is aspherical (or highly clumpy) and contains about 4-5 solar masses. Possible progenitor systems of SN 2002ic are discussed., Comment: 8 pages, 4 figures. Published in "Frontier in Astroparticle Physics and Cosmology", ed. K. Sato and S. Nagataki (Tokyo: Universal Academy Press) pp. 323-330 (2004 May)

Recently the evidence of the neutrinoless double $��$ ($0������$) decay has been announced. This means that neutrinos are Majorana particles and their mass hierarchy is forced to inverted mass hierarchy (Type B) or degenerate mass (Type C) patterns in the diagonal basis of charged lepton mass matrix. We estimate the magnitude of $0������$ decay in the degenerate neutrinos including the cosmological constraint of neutrino dark matter, since the inverted mass hierarchy pattern always satisfies the cosmological constraint. The absolute value of neutrino mass is constrained by $0������$ experiment or cosmology depending on the relative signs (Majorana CP phases) of neutrino masses., 13 pages, 4 figures, LaTeX

Recently the evidence of the neutrinoless double $��$ ($0������$) decay has been announced. This means that neutrinos are Majorana particles and their mass hierarchy is forced to certain patterns in the diagonal basis of charged lepton mass matrix. We estimate the magnitude of $0������$ decay in the classification of the neutrino mass hierarchy patterns as Type A, $m_{1,2} \ll m_{3}$, Type B, $m_1 \sim m_2 \gg m_3$, and Type C, $m_1 \sim m_2 \sim m_3$, where $m_{i}$ is the $i$-th generation neutrino absolute mass. The data of $0������$ decay experiment suggests the neutrino mass hierarchy pattern should be Type B or C. Type B predicts a small magnitude of $0������$ decay which is just edge of the allowed region of experimental value in $95% \mathrm{c.l.}$, where Majorana CP phases should be in a certain parameter region. Type C can induce the suitably large amount of $0������$ decay which is consistent with the experimental data, where overall scale of degenerate neutrino mass plays a crucial role, and its large value can induce the large $0������$ decay in any parameter regions of Majorana CP phases., 12 pages, 7 figures, LaTeX

We suggest a simple grand unified theory where the fifth dimensional coordinate is compactified on an $S^1/(Z_2 \times Z_2')$ orbifold. This model contains additional ${\bf 10 + \overline{10}}$, (${\bf 15 + \overline{15}}$) and two ${\bf 24}$ Higgs multiplets in the non-supersymmetric SU(5) grand unified theory. Although this model is non-supersymmetric theory, the gauge coupling unification is realized due to the mass splittings of Higgs multiplets by $S^1/(Z_2 \times Z_2')$ orbifolding. The constraints from the $b \to s \gamma$, $\mu \to e \gamma$, and electron and muon anomalous magnetic moments are also discussed., Comment: 7 pages, LaTeX

We suggest a simple grand unified theory where the fifth dimensional coordinate is compactified on an $S_1/(Z_2 \times Z_2')$ orbifold. This model is based on the supersymmetric flipped $SU(5) \times U(1)$ grand unified theory, which can realize not only the triplet-doublet splitting but also the natural fermion mass hierarchies. The triplet-doublet splitting is realized by $S_1/(Z_2 \times Z_2')$ orbifolding, which also reduces the gauge group as $SU(5) \times U(1) \to SU(3)_c \times SU(2)_L \times U(1)_Z \times U(1)_X$. The suitable fermion mass hierarchies are generated by integrating out extra three sets of vector-like heavy fields which can propagate in five dimensions. The radiative corrections to the large Yukawa coupling of right-handed neutrinos can reduce the gauge group to $SU(3)_c \times SU(2)_L \times U(1)_Y$., Comment: LaTeX,12pages