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Your search keyword '"Surendran, P"' showing total 9 results
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9 results on '"Surendran, P"'

1. Analytical Investigation on Behaviour of Cold Formed Deep Joist Channel Section

Author

null Surendran P. N. and null Satheesh Kumar KRP

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

The application of cold formed steel elements in construction is becoming very popular due to several advantages like Speedy construction, higher strength to weight ratio, dimensional stability and recycled material. CFS is proposed to use as building components as beams, columns, Joists, wall panels etc. The load carrying capacity of cold-formed steel (CFS) joists can be enhanced by employing optimization techniques. Recent research studies have mainly focused on optimizing the bending capacity of conventional channel with and without lips that are used as joists. The objective of the study is to examine the flexural strength, failure mode and load-deflection of the cold formed steel double furred channel section with and without web openings under flexure.

Published
2022
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2. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Author

Howson, JMM, Zhao, W, Barnes, DR, Ho, W-K, Young, R, Paul, DS, Waite, LL, Freitag, DF, Fauman, EB, Salfati, EL, Sun, BB, Eicher, JD, Johnson, AD, Sheu, WHH, Nielsen, SF, Lin, W-Y, Surendran, P, Malarstig, A, Wilk, JB, Tybjærg-Hansen, A, Rasmussen, KL, Kamstrup, PR, Deloukas, P, Erdmann, J, Kathiresan, S, Samani, NJ, Schunkert, H, Watkins, H, CARDIoGRAMplusC4D, Do, R, Rader, DJ, Johnson, JA, Hazen, SL, Quyyumi, AA, Spertus, JA, Pepine, CJ, Franceschini, N, Justice, A, Reiner, AP, Buyske, S, Hindorff, LA, Carty, CL, North, KE, Kooperberg, C, Boerwinkle, E, Young, K, Graff, M, Peters, U, Absher, D, Hsiung, CA, Lee, W-J, Taylor, KD, Chen, Y-H, Lee, I-T, Guo, X, Chung, R-H, Hung, Y-J, Rotter, JI, Juang, J-MJ, Quertermous, T, Wang, T-D, Rasheed, A, Frossard, P, Alam, DS, Majumder, AAS, Di Angelantonio, E, Chowdhury, R, EPIC-CVD, Chen, Y-DI, Nordestgaard, BG, Assimes, TL, Danesh, J, Butterworth, AS, Saleheen, D, Howson, Joanna [0000-0001-7618-0050], Barnes, Daniel [0000-0002-3781-7570], Paul, Dirk [0000-0002-8230-0116], Sun, Ben [0000-0001-6347-2281], Surendran, Praveen [0000-0002-4911-6077], Di Angelantonio, Emanuele [0000-0001-8776-6719], Chowdhury, Rajiv [0000-0003-4881-5690], Danesh, John [0000-0003-1158-6791], Butterworth, Adam [0000-0002-6915-9015], and Apollo - University of Cambridge Repository

Subjects
Male, Genotype, Quantitative Trait Loci, Coronary Artery Disease, Cardiovascular, Medical and Health Sciences, Risk Factors, Vascular, Cell Adhesion, Genetics, Humans, 2.1 Biological and endogenous factors, Genetic Predisposition to Disease, Polymorphism, Aetiology, EPIC-CVD, Heart Disease - Coronary Heart Disease, screening and diagnosis, Chemotaxis, Human Genome, Arteries, Single Nucleotide, Leukocyte, Biological Sciences, Atherosclerosis, cardiovascular diseases, Histone Code, Detection, Heart Disease, genome-wide association studies, Muscle, Female, Smooth, Energy Metabolism, CARDIoGRAMplusC4D, Genome-Wide Association Study, Biotechnology, 4.2 Evaluation of markers and technologies, Developmental Biology
Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10(-8), in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms.

Published
2017

6. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Author

Ferkingstad, E., Magnusson, Magnus K., Bell, S., Rigas, A. S., Allara, E., Bjornsdottir, G., Ramond, A., Sorensen, E., Halldorsson, G. H., Paul, D. S., Burgdorf, K. S., Eggertsson, H. P., Kristmundsdottir, S., Astle, W. J., Erikstrup, C., Sigurdsson, J. K., Vuckovic, D., Tragante, V., Surendran, P., Vidarsson, B., Jonsdottir, I., Torben Hansen, Sigurdardottir, O., Stefansson, H., Rye, D., Peters, J. E., Westergaard, D., Holm, H., Soranzo, N., Karina Banasik, Thorleifsson, G., Ouwehand, W. H., Thorsteinsdottir, U., Sulem, P., Butterworth, A. S., Gudbjartsson, D. F., Danesh, J., Søren Brunak, Di Angelantonio, E., Henrik Ullum, Stefansson, K., and Dbds, Genomic Consortium

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