1. Concurrent Anemia and Elevated C-Reactive Protein Predicts HIV Clinical Treatment Failure, Including Tuberculosis, After Antiretroviral Therapy Initiation
- Author
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Shivakoti, Rupak, Yang, Wei-Teng, Gupte, Nikhil, Berendes, Sima, Rosa, Alberto La, Cardoso, Sandra W, Mwelase, Noluthando, Kanyama, Cecilia, Pillay, Sandy, Samaneka, Wadzanai, Riviere, Cynthia, Sugandhavesa, Patcharaphan, Santos, Brento, Poongulali, Selvamuthu, Tripathy, Srikanth, Bollinger, Robert C, Currier, Judith S, Tang, Alice M, Semba, Richard D, Christian, Parul, Campbell, Thomas B, Gupta, Amita, and New Work Concept Sheet 319 and The Prospective Evaluation of Antiretrovirals in Resource-Limited Settings Study Team
- Subjects
Adult ,Male ,New Work Concept Sheet 319 and The Prospective Evaluation of Antiretrovirals in Resource-Limited Settings Study Team ,antiretroviral therapy ,HIV Infections ,Medical and Health Sciences ,Microbiology ,Young Adult ,Risk Factors ,Clinical Research ,Humans ,Treatment Failure ,Prospective Studies ,Aged ,Incidence ,Prevention ,HIV ,Evaluation of treatments and therapeutic interventions ,Anemia ,Hematology ,Middle Aged ,Biological Sciences ,C-Reactive Protein ,Infectious Diseases ,Good Health and Well Being ,Anti-Retroviral Agents ,inflammation ,Case-Control Studies ,6.1 Pharmaceuticals ,HIV/AIDS ,Female ,CRP ,Infection - Abstract
BackgroundAnemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV) treatment outcomes, yet their joint effect is not known. The objective of this study was to assess prevalence and risk factors of anemia in HIV infection and to determine whether anemia and elevated CRP jointly predict clinical failure post-ART.MethodsA case-cohort study (N = 470 [236 cases, 234 controls]) was nested within a multinational randomized trial of ART efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings [PEARLS]). Cases were incident World Health Organization stage 3, 4, or death by 96 weeks of ART treatment (clinical failure). Multivariable logistic regression was used to determine risk factors for pre-ART (baseline) anemia (females: hemoglobin
- Published
- 2015