Search

Additional file 1. Table S1. Proportion of correct responses to the knowledge survey questions. Table S2. Sociodemographic and clinical characteristics of respondents (n=123) and non-respondents (n=169) of the ‘knowledge survey’. Table S3. Sociodemographic and clinical characteristics of Indigenous Australians according to recruitment method: ‘second opportunity’ pathway (n=6) versus mainstream recruitment (all patients n=117 and Indigenous patients n=6). Table S4. Mean SF-36 scores according to patient knowledge. Table S5. Adjusted incidence rate ratios and cost ratios according to knowledge score: sensitivity analyses carried using a cut-off of 57.1% on the 8-item score; and using a cut-off of ≥60.0% on the 11-item survey among 121 patients ‡.

Drosophila larval crawling is easily-observable and relatively stereotyped. Crawling consists of linear locomotion interrupted by periods when the larvae pause, swing their heads, and change direction (a ‘search’). Here we identify Numb, a peripheral membrane adaptor protein, as an important regulator of searching behavior. When Numb RNAi transgenes were expressed in all neurons, searching frequency increased while linear movement appeared normal. Numb’s role in suppressing searching behavior was verified by rescuing this phenotype with a Numb homologue from mice. Such behavioral specificity suggests that further analysis of searching might help identify additional, evolutionarily-conserved interactors of the Numb protein.