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The COSINUS direct dark matter experiment situated at Laboratori Nazionali del Gran Sasso in Italy is set to investigate the nature of the annually modulating signal detected by the DAMA/LIBRA experiment. COSINUS has already demonstrated that sodium iodide crystals can be operated at mK temperature as cryogenic scintillating calorimeters using transition edge sensors, despite the complication of handling a hygroscopic and low melting point material. With results from a new COSINUS prototype, we show that particle discrimination on an event-by-event basis in NaI is feasible using the dual-channel readout of both phonons and scintillation light. The detector was mounted in the novel remoTES design and operated in an above-ground facility for 9.06 g$\cdot$d of exposure. With a 3.7 g NaI crystal, e$^-$/$\gamma$ events could be clearly distinguished from nuclear recoils down to the nuclear recoil energy threshold of 15 keV., Comment: 7 pages, 9 figures

296 Background: Quantifying the performance of a cancer center’s cancer registry is important to plan for resources needed to address shortcomings and projected increases in workload. The objective of this project was to understand the workflow, reporting requirements, and existing documentation of the cancer registry at Dana-Farber Cancer Institute (DFCI) in order to build a dashboard that quantifies monthly performance. Methods: Current state workflow maps were created detailing the three phases of the cancer registry’s operations: case finding, case abstraction, and case follow-up. Individual meetings and a workshop with the cancer registry staff were held to validate workflows, gather operational challenges and improvement ideas, and set performance metrics. Leveraging information already being collected by staff as part of their workflow, a database was designed to collect and auto-visualize monthly performance using Excel and Tableau. Results: The performance dashboard shows monthly trends of ‘on target’ status of the cancer registry’s case finding, case abstraction, and case follow-up efforts. It also quantifies how delayed the cancer registry is in case finding or abstraction and provides new case count trends by care facility, staffing capacity based on case load, and trends in lost to follow-up patients. One hundred percent of the performance dashboard data is from documentation already generated by the cancer registry staff on a routine basis. Data on monthly case load from September 2017 through March 2018 are presented in the table below; given a maximum limit of 86 cases to abstract per abstractor per month, the cancer registry is currently at more than full capacity. Conclusions: A well-designed cancer registry performance dashboard that leverages existing data does not add burden to registry staff and informs how best to manage and utilize resources according to case load. [Table: see text]

One night, about one in the morning, Fabrice was lying along the window sill with his head thrust through the opening made in the shutter; he was looking at the stars and the vast horizon which can be seen from the top of the Farnese...

The Jew who owned the room had found a discreet surgeon who, in his turn grasping that there was money in the purse, told Ludovic that his ‘conscience’ obliged him to make a report to the police concerning the wounds of the young man whom...

Thus, less than a month after arriving at court, Fabrice knew all the vexations of a courtier, and the intimate friendship that had made his life happy was poisoned. One evening, tormented by these thoughts, he left the Duchess’s drawing-room where he seemed too like...

The Charterhouse of Parma (1839) is a compelling novel of passion and daring, of prisons and heroic escape, of political chicanery and sublime personal courage. Set at the beginning of the nineteenth century, amidst the golden landscapes of northern Italy, it traces the joyous but ill-starred amorous exploits of a handsome young aristocrat called Fabrice del Dongo, and of his incomparable aunt Gina, her suitor Prime Minister Mosca, and Clélia, a heroine of ethereal beauty and earthly passion. These characters are rendered unforgettable by Stendhal's remarkable gift for psychological insight. ‘Never before have the hearts of princes, ministers, courtiers, and women been depicted like this,’ wrote Honoré de Balzac. ‘Stendhal's tableau has the dimensions of a fresco but the precision of the Dutch masters.’ The great achievement of The Charterhouse of Parma is to conjure up the excitement and romance of youth while never losing sight of the harsh realities which beset the pursuit of happiness, nor the humour and patient irony with which these must be viewed. This new translation captures Stendhal's narrative verve, while the Introduction explores the novel's reception and the reasons for its enduring popularity and power.

Fabrice’s soul was in a state of exaltation from the old man’s words, from the profound attention with which he had listened, and from his extreme fatigue. He found it very difficult to fall asleep, and his sleep was disturbed by dreams, perhaps portents of...

This whole adventure had lasted less than a minute; Fabrice’s wounds were not serious; they bandaged his arm with strips of the colonel’s shirt. They wanted to fix up a bed for him on the first floor of the inn: ‘But while I’m up here...

We will in all candour admit that Canon Borda’s jealousy was not entirely without foundation; on his return from France Fabrice had seemed, to the Countess’s eyes, like a handsome stranger whom she had once known very well. If he had spoken of love, she...

Marie-Henri Beyle (1783–1842), better known by his pen name Stendhal, is remembered today for such novels as Le Rouge et le Noir. Over the course of his life, he wrote in a variety of literary genres and under a multitude of names, or anonymously. Reissued here is the 1824 English translation of his Vie de Rossini of the same year, which was accused of being partly plagiarised from Giuseppe Carpani's Le Rossiniane, following similar claims regarding his biographies of Haydn and Mozart (which are also reissued together in translation in this series). Best known for William Tell and The Barber of Seville, Gioachino Rossini (1792–1868) was by far the most popular opera composer of his day, adored by his public. Colourful, vigorous and forthright, Stendhal's brilliant though somewhat unreliable biography offers an opinionated contemporary critique of 'Signor Crescendo'.

Marie-Henri Beyle (1783–1842), better known by his pen name Stendhal, is remembered today for such novels as Le Rouge et le Noir. In his lifetime, he wrote in a variety of literary genres and under a multitude of names. Louis-Alexandre-César Bombet was his choice of pseudonym for these early works, originally published in French in 1814. His lives of Haydn and Mozart were substantially derived from works by Giuseppe Carpani and Théophile Winckler respectively. Despite this audacious plagiarism, Stendhal's passion for music is evident, especially for Mozart, whose Clemenza di Tito he had enjoyed in Königsberg during the winter of 1812 whilst serving in Napoleon's army. Of especial interest to the modern reader are Stendhal's frequent digressions expressing his forthright opinions on the issues and figures of his day. This reissue is of Robert Brewin's English translation of 1817, with additional notes by the composer William Gardiner.

Avec Le Rouge et le Noir Stendhal invente le roman réaliste. Vérité des temps : cette « chronique du XIXe siècle » brosse un tableau sans concession de la société française sous la Restauration. Vérité du cœur : entre « l'amour de cœur » et « l'amour de tête », comment se trouver soi ?, Stendhal invents the realist novel with Le Rouge et le Noir. By painting an uncompromising portrait of French society under the Restoration, this “chronicle of the nineteenth century” tells the truth of the age. It also tells the truth on behalf of the heart: between “love of the heart” and “love of the head”, how to really be yourself?

212 Background: The ability to link cancer registry data to clinical and administrative data sets for quality improvement has long been desired. We sought to integrate registry data into a central data warehouse in an effort to make available for the first time consistent and reliable diagnosis and staging data to a broad hospital user group. Methods: After a short period of data analysis, the tables for Cancer Registry data (Oracle) were modeled. The source data (SQL Server) was conformed and integrated using an ETL tool (Informatica). All ETL QA work was performed with SQL queries. Cancer registry data was integrated into reporting architecture (Microstrategy) to facilitate design of standardized and ad hoc reports. Results: 140 distinct fields on demographics, staging (clinical, pathological, collaborative), site specific categories, diagnosis, and treatment were integrated into the Dana-Farber Analytics Reporting Tool (DART) for historic Cancer Registry data beginning with January 2010 newly diagnosed cancers. All Cancer Registry data and patient files (new and old) are updated in DART on a monthly basis. Conclusions: Individuals across the hospital now have the ability to link clinical and administrative data from our EMR, institutional QI data from varied systems, and pharmacy data to Cancer Registry data in the DART tool. One example of the integration of these multiple data sets is the linkage of staging data from the Cancer Registry data set and time to referral data from the administrative data set by patient MRN. As DFCI aims to cohort its patients based on their primary diagnosis for quality improvement and other internal reporting needs, the ability to analyze patients in this way becomes critical. This project sets an example for other centers as they integrate Cancer Registry data into user friendly business intelligence systems to help meet federal reporting mandates and aid internal improvement work. [Table: see text]

In this study, we have analysed the relationship between Ca2+ pumps and Ins(1,4,5)P3-sensitive Ca2+ channels in myeloid cells. To study whether sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA)-type Ca2+-ATPases are responsible for Ca2+ uptake into Ins(1,4,5)P3-sensitive Ca2+ stores, we used the three structurally unrelated inhibitors thapsigargin, 2,5-di-t-butylhydroquinone and cyclopiazonic acid. In HL-60 cells, all three compounds precluded formation of the phosphorylated intermediate of SERCA-type Ca2+-ATPases. They also decreased, in parallel, ATP-dependent Ca2+ accumulation and the amount of Ins(1,4,5)P3-releasable Ca2+. Immunoblotting with subtype-directed antibodies demonstrated that HL-60 cells contain the Ca2+ pump SERCA2 (subtype b), and the Ca2+-release-channel type-1 Ins(1,4,5)P3 receptor. In subcellular fractionation studies, SERCA2 and type-1 Ins(1,4,5)P3 receptor co-purified. Immunofluorescence studies demonstrated that both type-1 Ins(1,4,5)P3 receptor and SERCA2 were evenly distributed throughout the cell in moving neutrophils. During phagocytosis both proteins translocated to the periphagosomal space. Taken together, our results suggest that in myeloid cells (i) SERCA-type Ca2+-ATPases function as Ca2+ pumps of Ins(1,4,5)P3-sensitive Ca2+ stores, and (ii) SERCA2 and type-1 Ins(1,4,5)P3 receptor reside either in the same or two tightly associated subcellular compartments.

In this vigorous and fast-moving novel of post-Napoleonic France, Julien Sorel's plans to reach the higher echelons of society through the priesthood are defelected by his realization that the attainment of happiness is of greater consequence than the pursuit of ambition. Subtitled 'A Chronicle of 1830', Stendhal's depiction of a nation of smug hypocrites scandalized contemporary readers, who recognized themselves or their peers and felt uncomfortable with the energy, imagination, and sincerity of a hero so patently inspired by their lately deposed Emperor. Julien's restless energy is fully captured in this specially commissioned translation of one of the world's great novels. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

Previous studies have suggested that a cationic bactericidal/permeability-increasing protein (BPI) present in both rabbit and human polymorphonuclear leukocytes is the principal O2-independent bactericidal agent of these cells toward several strains of Escherichia coli and Salmonella typhimurium (1978. J. Biol. Chem. 253: 2664--2672; 1979. J. Biol. Chem. 254: 11000--11009). To further evaluate the possible role of this protein in the killing of gram-negative bacteria by polymorphonuclear leukocytes, we have measured the bactericidal activity of intact rabbit peritoneal exudate leukocytes under aerobic or anaerobic conditions and of intact human leukocytes from a patient with chronic granulomatous disease. Anaerobic conditions were created by flushing the cells under a nitrogen stream. Effective removal of oxygen was demonstrated by the inability of nitrogen-flushed leukocytes to mount a respiratory burst (measured as increased conversion of 1-[14C]glucose leads to 14CO2 or by superoxide production) during bacterial ingestion. At a bacteria/leukocyte ratio of 10:1, killing of gram-positive, BPI-resistant, Staphylococcus epidermidis is markedly impaired in the absence of oxygen (76.4 +/- 3.3% killing in room air, 29.2 +/- 8.2% killing in nitrogen). Essentially all increased bacterial survival is intracellular. In contrast, both a nonopsonized rough strain (MR-10) and an opsonized smooth strain (MS) of S. typhimurium 395 are killed equally well in room air and nitrogen. A maximum of 70--80 MR-10 and 30--40 MS are killed per leukocyte either in the presence or absence of oxygen. There is no intracellular bacterial survival in either condition indicating that intracellular O2-independent bactericidal system(s) of rabbit polymorphonuclear leukocytes can at least match the leukocyte's ingestive capacity. Whole homogenates and crude acid extracts manifest similar bactericidal capacity toward S. typhimurium 395. This activity can be accounted for by the BPI content of these cell fractions and is virtually eliminated by immune (anti-BPI), but not by preimmune goat IgG-rich fractions. Opsonization of smooth MS, required for bacterial killing by intact leukocytes, does not alter bacterial sensitivity to BPI in crude or purified form. Leukocytes of a patient with chronic granulomatous disease killed ingested S. typhimurium 396 MS nearly as well as did normal leukocytes. The bactericidal activity toward E. coli (J5) of crude acid extracts of the CGD and normal human leukocytes was virtually the same and was nearly completely inhibited by anti-BPI IgG-rich fractions, but not by preimmune IgG-rich fractions. These findings suggest that the killing of gram-negative bacteria such as S. typhimurium by intact polymorphonuclear leukocytes may also be attributed to the action of BPI.