Search

Additional file 1: Table S1.Simulation results and standard deviations - 100 kVp, front cell, without AuFeNPs. Table S2. Simulation results and standard deviations - 100 kVp, front cell, with AuFeNPs. Table S3. Simulation results and standard deviations - 100 kVp, center cell, without AuFeNPs. Table S4. Simulation results and standard deviations - 100 kVp, center cell, with AuFeNPs. Table S5. Simulation results and standard deviations - 100 kVp, back cell, without AuFeNPs. Table S6. Simulation results and standard deviations - 100 kVp, back cell, with AuFeNPs. Table S7. Simulation results and standard deviations - 200 kVp, front cell, without AuFeNPs. Table S8. Simulation results and standard deviations - 200 kVp, front cell, with AuFeNPs. Table S9. Simulation results and standard deviations - 200 kVp, center cell, without AuFeNPs. Table S10. Simulation results and standard deviations - 200 kVp, center cell, with AuFeNPs. Table S11. Simulation results and standard deviations - 200 kVp, back cell, without AuFeNPs. Table S12. Simulation results and standard deviations - 200 kVp, back cell, with AuFeNPs.

The major stress-inducible Hsp70 (HSPA1A) is overexpressed in highly aggressive tumor cells including glioblastoma multiforme and presented on their plasma membrane. Ionizing irradiation increases cytosolic and membrane-bound Hsp70 (mHsp70) on tumor cells. Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for the innate immune system. To define the optimal window for a therapy with Hsp70-tageting NK cells the kinetics of the mHsp70 density on the plasma membrane of human glioma cells (U87) has been studied after radiotherapy by multiparameter flow cytometry. Cell cycle dependent alterations in the mHsp70 expression were excluded by seeding different cell numbers on day 0. Low dose irradiation (2 Gy) results in a slow upregulation of the mHsp70 density in U87 cells which peaks on day 4 and starts to decline from day 7 onwards. In contrast, higher radiation doses (4 Gy, 6 Gy) resulted in a faster upregulation of mHsp70 expression on days 2 and 1, respectively, followed by a decline from day 5 onwards. Functionally, elevated mHsp70 densities correlate with an improved lysis by Hsp70-targeting NK cells. In summary, the kinetics of changes in the mHsp70 density upon irradiation on tumor cells is time and dose-dependent.

Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüft Abweichender Titel laut Übersetzung des Verfassers/der Verfasserin Karl-Franzens-Universität Graz, Diplomarbeit, 2019 (VLID)3678312

Comprehensive knowledge about the heat transfer mechanisms and the temperature field inside hermetic compressors is very important for the thermal management and thus their performance. A numerical model to predict the temperature field in a hermetic reciprocating compressor for household refrigeration appliances is presented in this work. The model combines a high resolution three-dimensional heat conduction formulation of the compressor’s solid parts, a three-dimensional computational fluid dynamics (CFD) approach for the gas line domain and lumped formulations of the shell gas and the lubrication oil. Heat transfer coefficients are determined by applying CFD to the gas line side and correlations from the literature on the shell gas and oil side, respectively. The valve in the gas line simulation is modelled as a parallel moving flat plate. By means of an iterative loop the temperature field of the solid parts acts as boundary condition for the CFD calculation of the gas line which returns a cycle averaged quantity of heat to the solid parts. Using an iteration method which is based on the temperature deviation between two iteration steps, the total number of iterations and consequently the computational time can be reduced. The loop is continued until a steady-state temperature field is obtained. Calculated temperatures of the solid parts are verified against temperature measurements of a calorimeter test bench. The numerical results show reasonable agreement with the measured data.

Generally, domestic refrigerators and freezers are running in non-continuous operation mode most of the time, which is a necessity to match cooling capacity to thermal loads. In currently available domestic appliances it can be observed, that this matching is mainly realized in two different ways: On the one hand, a simple on/off control of the hermetic compressor is installed in lower priced appliances with limited energy efficiency for the mass market. On the other hand, modern top efficiency class appliances have a variable frequency controlled compressor installed. Both control strategies have a repetitive and transient change of thermodynamic states of the refrigerant in common. For better understanding of these cyclic patterns in terms of internal temperature distribution, a state of the art domestic refrigeration compressor with a displacement of approximately 6 cubic centimeters is integrated in a commercial freezer. The compressor which has an on/off control is equipped with extensive measurement instrumentation. Several temperature probes are inserted and temperatures on surfaces inside and outside the compressor as well as refrigerant temperatures are logged for both cyclic and steady state behavior. Finally, a comparison between transient experimental data and steady-state data from a standardized calorimeter test bench is done.