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1. Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues

Author

Kuyper, LF, Roth, B, Baccanari, DP, Ferone, R, Beddell, CR, Champness, JN, Stammers, DK, Dann, JG, Norrington, FE, Baker, DJ, and Goodford, PJ

Subjects
Models, Molecular, Methotrexate, X-Ray Diffraction, Receptors, Drug, Drug Discovery, Escherichia coli, Molecular Conformation, Molecular Medicine, Folic Acid Antagonists, Trimethoprim, Enzymes
Published
1982

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