1. Polymer Resins with Amino Acid Containing Pendants for Sorption of Bilirubin. I. Comparison of Merrifield and Polyamide Resins
- Author
-
L. E. St-Pierre, Henning Ds, Brown Gr, St-Pierre S, and Lajoie Ga
- Subjects
chemistry.chemical_classification ,Aqueous solution ,Arginine ,010405 organic chemistry ,Lysine ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,Sorption ,General Medicine ,complex mixtures ,01 natural sciences ,0104 chemical sciences ,Amino acid ,Biomaterials ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Polyamide ,Polymer chemistry ,Peptide synthesis ,Organic chemistry ,Pendant group - Abstract
Merrifield resins with various amino acid containing pendants and a water swellable polyamide resin with the peptide alanine-alanine-alanine-arginine as the pendant group have been prepared by solid phase peptide synthesis. Merrifield resins with either arginine or lysine pendants are capable of sorbing bilirubin from aqueous solution (pH = 7.8) but those with other amino acid pendants gave no indication of sorption. The polyamide-arginine resin showed, on a functional group basis, a higher capacity for bilirubin than does cholestyramine. It is proposed that the formation of salt linkages causes a strong interaction of bilirubin with arginine and lysine.
- Published
- 1984