1. Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort
- Author
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Neofytos, Dionysios, Hirzel, Cédric, Boely, Elsa, Lecompte, Thanh, Khanna, Nina, Mueller, Nicolas J, Boggian, Katia, Cusini, Alexia, Manuel, Oriol, Banz Wüthrich, Vanessa, Beldi, Guido, Stirnimann, Guido, van Delden, Christian, Swiss Transplant, Cohort Study, Swiss Transplant Cohort Study, Amico, P., Aubert, J.D., Banz, V., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Boëly, E., Bucher, H., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Elkrief, L., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Soccal, P.G., Gaudet, C., Giostra, E., Golshayan, D., Hadaya, K., Halter, J., Heim, D., Hess, C., Hillinger, S., Hirsch, H.H., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Laesser, B., Lehmann, R., Lovis, C., Majno, P., Marti, H.P., Martin, P.Y., Meylan, P., Mohacsi, P., Morel, P., Mueller, U., Mueller-McKenna, H., Müller, A., Müller, T., Müllhaupt, B., Pascual, M., Passweg, J., Posfay-Barbe, K., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Seiler, C., Sprachta, J., Stampf, S., Steiger, J., Stirnimann, G., Toso, C., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, and Neofytos, Dionysios
- Subjects
0301 basic medicine ,Male ,Epidemiology ,2747 Transplantation ,Pneumocystis carinii ,Adult ,Aged ,Anti-Bacterial Agents/therapeutic use ,Antibiotic Prophylaxis/methods ,Antibiotic Prophylaxis/standards ,Female ,Humans ,Incidence ,Middle Aged ,Mortality ,Organ Transplantation/adverse effects ,Pneumocystis carinii/isolation & purification ,Pneumonia, Pneumocystis/drug therapy ,Pneumonia, Pneumocystis/epidemiology ,Pneumonia, Pneumocystis/microbiology ,Pneumonia, Pneumocystis/prevention & control ,Practice Guidelines as Topic ,Prospective Studies ,Switzerland/epidemiology ,Treatment Outcome ,Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ,Young Adult ,Pneumocystis jirovecii pneumonia ,Solid organ transplant recipients ,10234 Clinic for Infectious Diseases ,0302 clinical medicine ,030212 general & internal medicine ,Prospective cohort study ,610 Medicine & health ,education.field_of_study ,ddc:617 ,Incidence (epidemiology) ,Pneumonia, Pneumocystis ,Anti-Bacterial Agents ,Infectious Diseases ,10219 Clinic for Gastroenterology and Hepatology ,Cohort ,10209 Clinic for Cardiology ,10178 Clinic for Pneumology ,Switzerland ,medicine.drug ,medicine.medical_specialty ,030106 microbiology ,Population ,03 medical and health sciences ,Internal medicine ,parasitic diseases ,Trimethoprim, Sulfamethoxazole Drug Combination ,medicine ,education ,Transplantation ,business.industry ,2725 Infectious Diseases ,Organ Transplantation ,Antibiotic Prophylaxis ,medicine.disease ,Trimethoprim ,Pneumonia ,Complication ,business - Abstract
BACKGROUND Descriptive data on Pneumocystis jirovecii pneumonia (PJP) in solid organ transplant recipients (SOTr) in the era of routine Pneumocystis-prophylaxis are lacking. METHODS All adult SOTr between 2008-2016 were included. PJP was diagnosed based on consensus guidelines. Early-onset PJP was defined as PJP within the 1st-year-post-transplant. RESULTS 41/2842 SOTr (1.4%) developed PJP (incidence rate: 0.01/1000 person-days) at a mean of 493-days post-transplant: 21 (51.2%) early vs 20 (48.8%) late-onset PJP. 2465 (86.7%) SOTr received Pneumocystis-prophylaxis for a mean 316 days. PJP incidence was 0.001% and 0.003% (log-rank
- Published
- 2018
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