1. Reduced Excretion of Vasodilator Prostaglandins in Preeclampsia
- Author
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Lechi A, M. Corsato, M. Degan, Minuz P, Probitzer P, Covi G, Francesca Paluani, Lechi C, and Spiazzi L
- Subjects
medicine.medical_specialty ,Prostaglandin ,Alpha (ethology) ,Vasodilation ,Kallikrein ,Urine ,medicine.disease ,Preeclampsia ,Excretion ,chemistry.chemical_compound ,Urinary excretion ,Endocrinology ,chemistry ,Internal medicine ,cardiovascular system ,medicine ,lipids (amino acids, peptides, and proteins) ,circulatory and respiratory physiology - Abstract
The role of prostaglandin (PG) system in preeclampsia (pre-E) was investigated. Urinary excretion of PGE2,6-keto PGF1 alpha,2,3 dinor 6-keto PGF1 alpha, TxB2 and 2,3-dinor-TxB2 and kallikrein were determined in 10 normotensive pregnant women and 14 with pre-E. 6-keto PGF1 alpha and 2,3-dinor 6-keto PGF1 alpha (the main renal and extrarenal metabolites of vasodilator PGI2) and PGE2 excretion was lower in pre-E. TxB2 metabolites in urine were similar in the two groups of women. Our data are consistent with the hypothesis of an imbalance between vasodilator and vasoconstrictor PGs in pre-E.
- Published
- 1987
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