1. Feasibility of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: First Evidence from Studies in Mali and Senegal
- Author
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Moussa D. Sarr, Seyni Tourée, Mamadou O. Traoré, Konimba Doumbia, Lamine Diawara, Laurent Toe, Kalifa Mounkoro, Amadou F. Seck, Lassana Konate, Jan H. F. Remme, Alioune Badji, Yiriba Bissan, and Soula F. Goita
- Subjects
Infectious Diseases/Epidemiology and Control of Infectious Diseases ,Adult ,Male ,Veterinary medicine ,lcsh:Arctic medicine. Tropical medicine ,Endemic Diseases ,lcsh:RC955-962 ,Helminth genetics ,Mali ,Onchocerciasis ,Polymerase Chain Reaction ,Filariasis ,law.invention ,Young Adult ,Ivermectin ,law ,parasitic diseases ,Prevalence ,medicine ,Animals ,Humans ,Helminths ,Simuliidae ,Longitudinal Studies ,biology ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,DNA, Helminth ,biology.organism_classification ,medicine.disease ,Onchocerca volvulus ,Senegal ,Filaricides ,Infectious Diseases ,Transmission (mechanics) ,Vector (epidemiology) ,Female ,Research Article ,medicine.drug - Abstract
Background Mass treatment with ivermectin is a proven strategy for controlling onchocerciasis as a public health problem, but it is not known if it can also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors are highly efficient. A longitudinal study was undertaken in three hyperendemic foci in Mali and Senegal with 15 to 17 years of annual or six-monthly ivermectin treatment in order to assess residual levels of infection and transmission and test whether ivermectin treatment could be safely stopped in the study areas. Methodology/Principal Findings Skin snip surveys were undertaken in 126 villages, and 17,801 people were examined. The prevalence of microfilaridermia was, Author Summary The control of onchocerciasis, or river blindness, is based on annual or six-monthly ivermectin treatment of populations at risk. This has been effective in controlling the disease as a public health problem, but it is not known whether it can also eliminate infection and transmission to the extent that treatment can be safely stopped. Many doubt that this is feasible in Africa. A study was undertaken in three hyperendemic onchocerciasis foci in Mali and Senegal where treatment has been given for 15 to 17 years. The results showed that only few infections remained in the human population and that transmission levels were everywhere below postulated thresholds for elimination. Treatment was subsequently stopped in test areas in each focus, and follow-up evaluations did not detect any recrudescence of infection or transmission. Hence, the study has provided the first evidence that onchocerciasis elimination is feasible with ivermectin treatment in some endemic foci in Africa. Although further studies are needed to determine to what extent these findings can be extrapolated to other areas in Africa, the principle of onchocerciasis elimination with ivermectin treatment has been established.
- Published
- 2009