43 results on '"Sophie Pilleron"'
Search Results
2. International trends in cancer incidence in middle-aged and older adults in 44 countries
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Sophie Pilleron, Naser Alqurini, Jacques Ferlay, Kristen R. Haase, Michelle Hannan, Maryska Janssen-Heijnen, Kumud Kantilal, Kota Katanoda, Cindy Kenis, Grace Lu-Yao, Tomohiro Matsuda, Erna Navarrete, Nikita Nikita, Martine Puts, Fay J. Strohschein, Eva J.A. Morris, Epidemiologie, and RS: GROW - R1 - Prevention
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RISK ,Male ,Skin Neoplasms ,Epidemiology ,IMPACT ,MORTALITY ,Incidence ,Breast Neoplasms ,CHEMOTHERAPY ,Population-based cancer registries ,Middle Aged ,PROSTATE-CANCER ,Oncology ,Neoplasms ,Older adults ,Republic of Korea ,BREAST-CANCER ,Humans ,Female ,Registries ,Trends ,Geriatrics and Gerontology ,POPULATION ,Aged - Abstract
Objective: We examine international incidence trends of lung, colorectal, prostate, and breast cancers, as well as all cancers combined excluding non-melanoma skin cancer (NMSC) in adults aged 50 and older, over a fifteen-year period using data from 113 high quality population-based cancer registries included in the Cancer in Five Continents (CI5) series and NORDCAN. Materials and methods: We calculated annual incidence rates between 1998 and 2012 for ages 50–64, 65–74, and 75+, by sex and both sexes combined. We estimated average annual percentage change (AAPC) in rates using quasi-Poisson regression models. Results: From 1998 to 2012, incidence trends for all cancers (excluding NMSC) have increased in most countries across all age groups, with the greatest increase observed in adults aged 75+ in Ecuador (AAPC = +3%). Colorectal cancer incidence rates increased in the majority of countries, across all age groups. Lung cancer rates among females have increased but decreased for males. Prostate cancer rates have sharply increased in men aged 50–64 with AAPC between 5% and 15% in 24 countries, while decreasing in the 75+ age group in 21 countries, by up to −7% in Bahrain. Female breast cancer rates have increased across all age groups in most countries, especially in the 65–74 age group and in Asia with AAPC increasing to 7% in the Republic of Korea. Conclusions: These findings assist with anticipating changing patterns and needs internationally. Due to the specific needs of older patients, it is urgent that cancer systems adapt to address their growing number.
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- 2022
3. Age-related differences in colon and rectal cancer survival: An analysis of United States SEER-18 data
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Sophie Pilleron, Diana Withrow, Brian D Nicholson, and Eva JA Morris
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Age-related differences in colon and rectal cancer survival have been observed, even after accounting for differences in background mortality. To determine to what extent stage, tumour site, or histology could contribute to these differences, we estimated 1-year relative survival (RS) age stratified by these factors. Colon and rectal cancer cases diagnosed between 2012 and 2016 and followed up until 2017 were retrieved from 18 United States Surveillance Epidemiology and End Results cancer registries. For colon cancer, 1-year RS ranged from 87.8% [95% Confidence Interval: 87.5-88.2] in the 50–64-year-old age group to 62.3% [61.3-63.3] in the 85–99-year-old age group and for rectal cancer ranged from 92.3% [91.8-82.7] to 65.0% [62.3-67.5]. With respect to stage, absolute differences in RS between 50–64-year-old and 75–84-year-old in RS increased with increasing stage (from 6 [5-7] %-points in localized disease to 27 [25-29] %-points in distant disease) and were the highest for cancers of unknown stage (>28%-points). With respect to topography, age-related differences in survival were smallest for those in right-sided colon (8 [7-9] %-points) and largest for tumours of the colon without topography further specified (25 [21-29] %-points). While age-related differences in survival varied by histology and tumour site, the overall age-related differences in survival could not be explained by differences in distribution of these factors by age, consistent with a hypothesis that stage at diagnosis or treatment are more likely drivers. Incorporating data on geriatric conditions such as frailty and comorbidity would support further understanding of the age gap in colon and rectal cancer survival.
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- 2022
4. Age-related differences in cancer relative survival in the US: a SEER-18 analysis
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Diana R Withrow, Brian D Nicholson, Eva JA Morris, Melisa L Wong, and Sophie Pilleron
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Cancer survival has improved since the 1990s, but to different extents across age groups, with a disadvantage for older adults. We aimed to quantify age-related differences in relative survival (RS - one-year, and one-year conditioning on surviving one year) for 10 common cancer types by stage at diagnosis. We used data from 18 United States Surveillance Epidemiology and End Results cancer registries and included cancers diagnosed between 2012-2016 followed until December 31, 2017. We estimated absolute differences in RS between the 50-64 age group and the 75-84 age group. The smallest differences were observed for prostate and breast cancers (1.8%-points [95% confidence interval (CI):1.5-2.1] and 1.9%-points [95%CI:1.5-2.3], respectively). The largest was for ovarian cancer (27%-points, 95%CI:24-29). For other cancers, differences ranged between 7 (95%CI:5-9, esophagus) and 18%-points (95%CI: 17-19, pancreas). Except for pancreatic cancer, cancer type and stage combinations with very high (>95%) or very low (Novelty and ImpactIn this analysis of United States population-based cancer registry data, age-related differences in cancer survival varied widely, ranging from less than 1% absolute difference in localized breast and prostate cancer survival to over 30% absolute difference in localized pancreatic cancer survival. Focused efforts to reduce age-related differences in cancer survival may have greatest impact by prioritizing cancer site and stage combinations with the widest differences.
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- 2022
5. Causal and Associational Language in Observational Health Research: A Systematic Evaluation
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Cathrine Axfors, Arthur Chatton, Elizabeth A. Stuart, Ariadne E. Rivera Aguirre, Julia M. Rohrer, Ian Schmid, Palwasha Khan, Daloha Rodríguez-Molina, Sebastián Peña, Sophie Pilleron, Camila Olarte Parra, Mark Kelson, Saman Khalatbari-Soltani, Jessie Seiler, Mi-Suk Kang Dufour, Eleanor J Murray, Peter W. G. Tennant, Anna Booman, Meg G. Salvia, Daniel J. Dunleavy, Taym M. Alsalti, Thomas Rhys Evans, Philipp Schoenegger, Rachel A. Hoopsick, Sarah Wieten, Sze Tung Lam, Gideon Meyerowitz-Katz, Stefanie Do, Rebekah Baglini, Sarah E. Twardowski, Sarah J Howcutt, Matthew P. Fox, Mari Takashima, Onyebuchi A. Arah, Julia Dabravolskaj, Clemence Leyrat, Emily Riederer, Shashank Suresh, Ashley L. O’Donoghue, Alberto Antonietti, Noah Haber, Eric Au, Nnaemeka U. Odo, Taylor McLinden, José Andrés Calvache, Alison E. Simmons, Talal S. Alshihayb, Nicholas Judd, and Andreea Steriu
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medicine.medical_specialty ,Phrase ,Biomedical Research ,Epidemiology ,Public health ,association ,BF ,Sample (statistics) ,Causality ,Medical and Health Sciences ,causal language ,Mathematical Sciences ,Action (philosophy) ,medicine ,Humans ,Observational study ,observational study ,causal inference ,Association (psychology) ,Psychology ,Social psychology ,Sentence ,Language - Abstract
Background Avoiding “causal” language with observational study designs is common publication practice, often justified as being a more cautious approach to interpretation. Objectives We aimed to i) estimate the degree to which causality was implied by both the language linking exposures to outcomes and by action recommendations in the high-profile health literature, ii) examine disconnects between language and recommendations, iii) identify which linking phrases were most common, and iv) generate estimates by which these phrases imply causality. Methods We identified 18 of the most prominent general medical/public health/epidemiology journals, and searched and screened for articles published from 2010 to 2019 that investigated exposure/outcome pairs until we reached 65 non-RCT articles per journal (n=1,170). Two independent reviewers and an arbitrating reviewer rated the degree to which they believed causality had been implied by the language in abstracts based on written guidance. Reviewers then rated causal implications of linking words in isolation. For comparison, additional review was performed for full texts and for a secondary sample of RCTs. Results Reviewers rated the causal implication of the sentence and phrase linking the exposure and outcome as None (i.e., makes no causal implication) in 13.8%, Weak in 34.2%, Moderate in 33.2%, and Strong in 18.7% of abstracts. Reviewers identified an action recommendation in 34.2% of abstracts. Of these action recommendations, reviewers rated the causal implications as None in 5.3%, Weak in 19.0%, Moderate in 42.8% and Strong in 33.0% of cases. The implied causality of action recommendations was often higher than the implied causality of linking sentences (44.5%) or commensurate (40.3%), with 15.3% being weaker. The most common linking word root identified in abstracts was “associate” (n=535/1,170; 45.7%) (e.g. “association,” “associated,” etc). There were only 16 (1.4%) abstracts using “cause” in the linking or modifying phrases. Reviewer ratings for causal implications of word roots were highly heterogeneous, including those commonly considered non-causal. Discussion We found substantial disconnects between causal implications used to link an exposure to an outcome and the action implications made. This undercuts common assumptions about what words are often considered non-causal and that policing them eliminates causal implications. We recommend that instead of policing words, editors, researchers, and communicators should increase efforts at making research questions, as well as the potential of studies to answer them, more transparent. Summary box
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- 2022
6. Age-related differences in colon and rectal cancer survival by stage, histology, and tumour site: An analysis of United States SEER-18 data
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Sophie Pilleron, Diana R. Withrow, Brian D. Nicholson, and Eva J.A. Morris
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Cancer Research ,Oncology ,Epidemiology - Published
- 2023
7. Loneliness in older adults living with cancer: A scoping review of the quantitative and qualitative evidence on behalf of the International Society of Geriatric Oncology Nursing and Allied Health Interest Group
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Sophie Pilleron, Virginia Sun, Ana Patricia Ayala, Kristen R. Haase, Elizabeth Kinkade Arthur, Cindy Kenis, Sigrid Roggendorf, Jessica L. Krok-Schoen, Kelly Trevino, Heike Schmidt, Michelle Hannan, Nikita Nikita, Susie Monginot, Erna Navarrete, and Martine Puts
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Oncology ,Geriatrics and Gerontology - Published
- 2023
8. Digital twins for geriatric oncology: Double trouble or twice as nice?
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Sophie Pilleron and Shane O'Hanlon
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Oncology ,Geriatrics and Gerontology - Published
- 2023
9. All-Cause Mortality Risk Prediction in Older Adults with Cancer: Practical Approaches and Limitations
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Andrea Perez-de-Acha, Sophie Pilleron, and Enrique Soto-Perez-de-Celis
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Life Expectancy ,Oncology ,Neoplasms ,Decision Making ,Humans ,Mass Screening ,Decision Making, Shared ,Geriatric Assessment ,Aged - Abstract
The prediction of all-cause mortality is an important component of shared decision-making across the cancer care continuum, particularly in older adults with limited life expectancy, for whom there is an increased risk of over-diagnosis and treatment.Currently, several international societies recommend the use of all-cause mortality risk prediction tools when making decisions regarding screening and treatment in geriatric oncology. Here, we review some practical aspects of the utilization of those tools and dissect the characteristics of those most employed in geriatric oncology, highlighting both their advantages and their limitations.
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- 2022
10. A scoping review of ageism towards older adults in cancer care
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Kristen R. Haase, Schroder Sattar, Sophie Pilleron, Yentl Lambrechts, Michelle Hannan, Erna Navarrete, Kavita Kantilal, Lorelei Newton, Kumud Kantilal, Rana Jin, Hanneke van der Wal-Huisman, Fay J. Strohschein, Mackenzi Pergolotti, Kevin B. Read, Cindy Kenis, and Martine Puts
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Ageism ,Oncology ,Age-related bias ,Geriatric oncology ,Geriatrics and Gerontology ,Gerontology ,cancer care - Abstract
Introduction: Ageism towards older adults with cancer may impact treatment decisions, healthcare interactions, and shape health/psychosocial outcomes. The purpose of this review is twofold: (1) To synthesize the literature on ageism towards older adults with cancer in oncology and (2) To identify interventions that address ageism in the healthcare context applicable to oncology. Materials and methods: We conducted a scoping review following Arksey and O'Malley and Levac methods and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted an exhaustive multi-database search, screening 30,926 titles/abstracts. Following data abstraction, we conducted tabular, narrative, and textual synthesis. Results: We extracted data on 133 papers. Most (n = 44) were expert opinions, reviews, and letters to editors highlighting the negative impacts of ageism, expressing the need for approaches addressing heterogeneity of older adults, and calling for increased clinical trial inclusion for older adults. Qualitative studies (n = 3) described healthcare professionals' perceived influence of age on treatment recommendations, whereas quantitative studies (n = 32) were inconclusive as to whether age-related bias impacted treatment recommendations/outcomes or survival. Intervention studies (n = 54) targeted ageism in pre/post-licensure healthcare professionals and reported participants' improvement in knowledge and/or attitudes towards older adults. No interventions were found that had been implemented in oncology. Discussion: Concerns relating to ageism in cancer care are consistently described in the literature. Interventions exist to address ageism; however, none have been developed or tested in oncology settings. Addressing ageism in oncology will require integration of geriatric knowledge/interventions to address conscious and unconscious ageist attitudes impacting care and outcomes. Interventions hold promise if tailored for cancer care settings.
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- 2022
11. Chemotherapy use and outcomes in patients with stage III or IV small-cell lung cancer in relation to age: An analysis of the English Systemic Anti-Cancer Treatment (SACT) dataset
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David Dodwell, Eva Morris, Kevin Franks, and Sophie Pilleron
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epidemiology ,Articles ,small cell lung cancer ,General Medicine ,chemotherapy ,geriatric oncology ,Research Article - Abstract
IntroductionSurvival from small cell lung cancer (SCLC) is poor and there has been little progress in treatment. There is little evidence on outcomes in patients aged 75+. We described patterns of chemotherapy use and outcomes using the national Systemic Anti-Cancer Treatment dataset in patients with stage III or IV SCLC in relation to age.MethodWe included 7,966 SCLC (67.6% stage IV) diagnosed between 2014-17 in England, treated with chemotherapy and followed up through 2017. Patterns of chemotherapy use, 30- and 90-mortality rates, 6-,12-month and median overall survival (OS) from the start of the first chemotherapy cycle were compared between those below and above the age of 75. OS was estimated using Kaplan Meier estimator and modeled using a flexible hazard regression model.ResultsOlder patients were 6-7 times less likely to receive curative treatment than younger patients regardless of stage. There were more frequent adjustments of treatment and dose reduction (stage III) in older than younger patients but no age-related differences in reduction of doses (stage IV), treatment delayed or stopped earlier than planned. Although 30-day mortality rates were similar across age groups in stage III SCLC (∼4%), older patients had higher early mortality and poorer OS than younger peers. In both stages, 6 and 12-month OS by age decreased around the age of 70-75 and were worse in patients with performance status scores ≥2.ConclusionThis study offers a snapshot of chemotherapy use and outcomes in advanced SCLC, notably in older patients, in the pre-immunotherapy era.
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- 2023
12. Current and projected number of years of life lost due to prostate cancer: A global study
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Diana Withrow, Sophie Pilleron, Nikita Nikita, Jacques Ferlay, Swapnil Sharma, Brian Nicholson, Timothy R. Rebbeck, and Grace Lu‐Yao
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Male ,Life Expectancy ,Oncology ,Caribbean Region ,Urology ,Humans ,Prostatic Neoplasms ,Aged - Abstract
Background:Prostate cancer is an important cause of death worldwide. The number of years of life lost (YLL) due to prostate cancer is a metric of the toll of prostate cancer and using projections of demographic changes, can be used to measure future burden. Methods:Prostate cancer mortality data by country and world region was retrieved from the Global Cancer Observatory and the World Health Organization mortality data set, and life expectancy was from the United Nations Department of Economic and Social Affairs. We estimated YLL as the difference between age at death in people with prostate cancer and remaining life expectancy for people of the same age in the general population. We also estimated the age-standardized YLL rates per 100,000 males over 50 and the average annual percentage change in YLL rates over the period 2000–2019 and the number of YLL for the year 2040 by applying population projections to the 2020 YLL rates. Results:In 2020, 3.5 million person-years of life were lost due to prostate cancer in males over 50, and 40% of YLL were in those aged over 75. Age-standardized rates varied greatly between and within regions. Over the last two decades, rates of YLL have increased in many Asian and African countries while they have decreased in northern American and European countries. Globally, YLL are anticipated to double by 2040 to reach 7.5 million, with the greatest increases in Africa, Asia, and Latin America and the Caribbean. Conclusion:There are wide variations in the burden of prostate cancer globally as measured by YLL. The burden of prostate cancer is projected to increase over time and appears to be highest in Sub-Saharan Africa, Eastern Europe, and Latin America and the Caribbean. It will be critical to plan and implement programs to reduce the burden of prostate cancer globally.
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- 2022
13. Immortal time bias in older vs younger age groups: a simulation study with application to a population-based cohort of patients with colon cancer
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Eva Morris, Sophie Pilleron, Camille Maringe, and Clémence Leyrat
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BackgroundIn observational studies, the risk of immortal time bias (ITB) increases with the likelihood of early death, itself increasing with age. We investigated how age impacts the magnitude of ITB when estimating the effect of surgery on one-year overall survival (OS) in patients with stage IV colon cancer aged 50-74 and 75-99 in England.MethodUsing simulations, we compared estimates from a time-fixed exposure model to three methods addressing ITB: time-varying exposure, delayed entry, and landmark methods. We then estimated the effect of surgery on one-year OS using a national population-based cohort of patients derived from the CORECT-R resource.ResultsIn simulations, the magnitude of ITB was larger among older patients when their probability of early death increased or treatment was delayed. The bias was corrected using the methods addressing ITB. When applied to CORECT-R data, these methods yielded smaller effects than the time-fixed exposure approach but effects were similar in both age groups.ConclusionITB must be addressed in all longitudinal studies, particularly, when investigating the effect of an exposure on an outcome in different groups of people (e.g., age groups) with different distributions of exposure and outcomes.
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- 2022
14. ERRATUM
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Sophie Pilleron
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Cancer Research ,Oncology - Published
- 2021
15. The impact of timely cancer diagnosis on age disparities in colon cancer survival
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Camille Maringe, Hadrien Charvat, Diana Sarfati, June Atkinson, Eva Morris, and Sophie Pilleron
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medicine.medical_specialty ,Time Factors ,Colorectal cancer ,Population ,Ethnic group ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,education ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,education.field_of_study ,business.industry ,Cancer ,medicine.disease ,Cancer registry ,Oncology ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Observational study ,Geriatrics and Gerontology ,business ,New Zealand - Abstract
Objective We described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50–99 using New Zealand population-based cancer registry data linked to hospitalisation data. Method We included 21,270 new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to end 2019. We modelled the effect of age at diagnosis, sex, ethnicity, deprivation, comorbidity, and emergency presentation on colon cancer survival by stage at diagnosis using flexible excess hazard regression models. Results The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first eighteen months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, emergency presentation for regional and distant cancers, and comorbidity for cancer with missing stages. Ethnicity and deprivation did not influence age disparities in colon cancer survival. Conclusion Factors reflecting timeliness of cancer diagnosis most affected age-related disparities in colon cancer survival, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand.
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- 2020
16. The impact of timely cancer diagnosis on age disparities in colon cancer survival in New Zealand
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Sophie Pilleron, Hadrien Charvat, Eva Morris, Diana Sarfati, Camille Maringe, and June Atkinson
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Excess mortality ,medicine.medical_specialty ,education.field_of_study ,Colorectal cancer ,business.industry ,Population ,Cancer ,medicine.disease ,Comorbidity ,Cancer registry ,Internal medicine ,medicine ,Stage (cooking) ,education ,business ,Net Survival - Abstract
ObjectiveWe described the role of patient-related and clinical factors on age disparities in colon cancer survival among patients aged 50-99 using New Zealand population-based cancer registry data linked to hospitalization data.DesignWe included new colon cancer cases diagnosed between 1 January 2006 and 31 July 2017, followed up to 31 December 2019. We linked these cases to hospitalisation data for the five years before the cancer diagnosis. We modelled the effect of age at diagnosis, sex, deprivation, comorbidity, and route to diagnosis on colon cancer survival by stage at diagnosis (localized, regional, distant, missing).ResultsNet survival decreased as the age at diagnosis increased, notably in advanced stages and missing stage. The excess mortality in older patients was minimal for localised cancers, maximal during the first six months for regional cancers, the first 18 months for distant cancers, and over the three years for missing stages. The age pattern of the excess mortality hazard varied according to sex for distant cancers, the route to diagnosis for regional and distant cancers, and comorbidity for cancer with missing stages.ConclusionThe present population-based study shows that factors reflecting timeliness of cancer diagnosis most affected the difference in survival between middle-aged and older patients, probably by impacting treatment strategy. Because of the high risk of poor outcomes related to treatment in older patients, efforts made to improve earlier diagnosis in older patients are likely to help reduce age disparities in colon cancer survival in New Zealand.
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- 2020
17. Global cancer incidence in older adults, 2012 and 2035: A population-based study
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Sophie Pilleron, Maryska L.G. Janssen-Heijnen, Isabelle Soerjomataram, Jacques Ferlay, Freddie Bray, Jérôme Vignat, and Diana Sarfati
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Cancer Research ,Population ageing ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Cancer ,medicine.disease ,Population based study ,03 medical and health sciences ,Projections of population growth ,0302 clinical medicine ,Oncology ,Cancer incidence ,030220 oncology & carcinogenesis ,Epidemiology ,Global health ,medicine ,business ,Demography - Abstract
Population ageing has substantially contributed to the rising number of new cancer cases worldwide. We document cancer incidence patterns in 2012 among older adults globally, and examine the changing magnitude of cancer in this age group over the next decades. Using GLOBOCAN 2012 data, we presented the number and proportion of new cancer cases, and the truncated age-standardised incidence rates among adults aged 65 years and older for all cancer sites combined and for the five most common cancer sites by world region. We calculated the incidence in 2035 by applying population projections, assuming no changes in rates. In 2012, 6.7 million new cancer cases (47.5% of all cancers) were diagnosed among older adults worldwide, with marked regional disparities. Nearly 48% of these cases occurred in less developed regions. Lung, colorectal, prostate, stomach and breast cancers represented 55% of the global incidence, yet distinct regional patterns were observed. We predict 14 million new cancer cases by 2035, representing almost 60% of the global cancer incidence. The largest relative increase in incidence is predicted in the Middle East and Northern Africa (+157%), and in China (+155%). Less developed regions will see an increase of new cases by 144%, compared to 54% in more developed regions. The expected increase in cancer incidence at older ages will have substantial economic and social impacts globally, posing considerable and unique challenge to healthcare systems in every world region, especially in those with limited resources and weaker health systems.
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- 2018
18. The impact of historical breastfeeding practices on the incidence of cancer in France in 2015
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Isabelle Heard, Isabelle Soerjomataram, Sabina Rinaldi, Kevin D. Shield, Freddie Bray, Agnès Fournier, Claire Marant Micallef, Laure Dossus, Agnès Rogel, and Sophie Pilleron
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Adult ,Cancer Research ,medicine.medical_specialty ,Population ,Breastfeeding ,Breast Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Risk Factors ,030225 pediatrics ,Epidemiology ,Humans ,Medicine ,Registries ,030212 general & internal medicine ,education ,Aged ,Ovarian Neoplasms ,education.field_of_study ,business.industry ,Obstetrics ,Incidence ,Incidence (epidemiology) ,Cancer ,Middle Aged ,medicine.disease ,Breast Feeding ,Oncology ,Cohort ,Female ,France ,business ,Cohort study - Abstract
The purpose of the study was to estimate the number of new breast cancer cases in France in 2015 attributable to breastfeeding for durations below recommendations (at least 6 months per child), and cases prevented through historical breastfeeding. As a secondary analysis, the corresponding numbers for ovarian cancer were estimated. Historical breastfeeding data were obtained from population surveys. Duration of breastfeeding data were obtained from the French Epifane cohort study. Relative risks were obtained from meta-analyses, cohort, and case–control studies. Cancer incidence data were obtained from the French Network of Cancer Registries. A 10-year latency period was assumed. Among parous women 25 years of age and older, 14.1% breastfed for at least 6 months per child born before 2006. As a result, 1,712 new breast cancer cases (3.2% of all new breast cancer cases) were attributable to breastfeeding for
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- 2018
19. The Role of Family Caregivers in the Care of Older Adults with Cancer
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Virginia Sun, Fay J. Strohschein, Sophie Pilleron, Michelle Hannan, Schroder Sattar, Martine Puts, and Kristen R. Haase
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Gerontology ,High prevalence ,Oncology (nursing) ,business.industry ,Family caregivers ,Psychological intervention ,Cancer ,Comorbidity ,medicine.disease ,Caregivers ,Geriatric oncology ,Quality of life ,Neoplasms ,Preparedness ,Quality of Life ,Humans ,Medicine ,Professional association ,business ,Aged - Abstract
Objectives To provide an overview on the role of family caregivers (FCGs) in the care of older adults with cancer and review quality of life needs for FCGs. Data Sources Journal articles, research reports, state of the science papers, position papers, and clinical guidelines from professional organizations were used. Conclusion The high prevalence of multiple comorbidities and the associated burden of geriatric events in older adults have a substantial impact on the quality of life of their FCGs. Practical and efficient models of comprehensive assessment, interventions, and caregiving preparedness support are needed to improve outcomes for both older adults with cancer and their FCGs. Implications for Nursing Practice Oncology nurses practicing in clinical and research settings have a responsibility to prepare themselves with evidence-based knowledge and resources to include the needs of FCGs in the care provided to older adults with cancer.
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- 2021
20. Undernutrition and obesity among elderly people living in two cities of developing countries: Prevalence and associated factors in the EDAC study
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Philippe Fayemendy, Jean Claude Desport, Alain Maxime Mouanga, Maëlenn Guerchet, Sophie Pilleron, Pascal M'Belesso, Pierre-Marie Preux, and Pierre Jésus
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Male ,0301 basic medicine ,Gerontology ,Waist ,Endocrinology, Diabetes and Metabolism ,Population ,Nutritional Status ,Developing country ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Environmental health ,Prevalence ,medicine ,Humans ,Elderly people ,Obesity ,030212 general & internal medicine ,Cities ,education ,Developing Countries ,Aged ,Aged, 80 and over ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Body Weight ,Malnutrition ,Central africa ,medicine.disease ,Diet ,Central African Republic ,Cross-Sectional Studies ,Nutrition Assessment ,Congo ,Socioeconomic Factors ,Dementia ,Female ,Waist Circumference ,business ,Body mass index - Abstract
Summary Background Nutritional status among elderly people living in Sub-Saharan Africa is poorly studied, even though undernutrition and obesity are known to cause many complications and are risk factors for progression and death in several diseases. The aims of this study were to assess the nutritional status of the elderly in Central Africa and to study the factors associated with nutritional disorders (undernutrition and obesity). Methods Two cross-sectional population-based studies were carried out in the capitals of Central African Republic (CAR) and Republic of Congo (ROC) between 2008 and 2009. Participants were aged ≥65 years old and underwent nutritional assessment including the following measurements: weight, height, body mass index (BMI), waist circumference (WC). Diet was also investigated. Nutritional status was defined according to the WHO BMI classification ( Results 990 elderly people underwent nutritional assessment (482 in CAR and 508 in ROC). Mean BMI was 22.7 ± 4.8 kg/m2. The prevalence of undernutrition was 19.2% and was lower in ROC than in CAR (9.5% vs. 29.5%; p Conclusions The prevalence of undernutrition is high in the elderly population of these countries, in contrast to obesity. Undernutrition and obesity are associated with different socio-economic factors and food consumption. Simple nutritional advice could contribute to improving the nutritional status of elderly people in Central Africa.
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- 2017
21. Letter to the editor
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Sophie Pilleron
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medicine.medical_specialty ,Letter to the editor ,business.industry ,media_common.quotation_subject ,education ,Medical decision making ,Pleasure ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Geriatric oncology ,Older patients ,Multidisciplinary approach ,030220 oncology & carcinogenesis ,Family medicine ,Cancer management ,medicine ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,media_common - Abstract
We read with pleasure the study of Bolle and colleague titled “Medical decision making for older patients during multidisciplinary oncology team meetings” published in Journal of Geriatric Oncology in January 2019. We commented it in regards to the importance of decision-making in cancer management for older patients.
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- 2020
22. Prevalence of toxoplasmosis and its association with dementia in older adults in Central Africa: a result from the EPIDEMCA programme
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Pascal M'Belesso, Sophie Pilleron, Jean-François Dartigues, Pierre-Marie Preux, Nathalie Bouscaren, Bébène Ndamba-Bandzouzi, Jean-Pierre Clément, Marie-Laure Dardé, Maëlenn Guerchet, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre INSERM U897-Epidemiologie-Biostatistique (ISPED), Université de Bordeaux (UB), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Psychiatrie [CHU Limoges], CHU Limoges, Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Parasitologie Mycologie [CHU Limoges], Institute of Psychiatry, Psychology & Neuroscience, King's College London, and King‘s College London
- Subjects
0301 basic medicine ,sub-Saharan Africa ,Male ,medicine.medical_specialty ,Multivariate analysis ,Population ,Toxoplasma gondii ,Comorbidity ,Logistic regression ,Alzheimer's Disease ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Epidemiology ,parasitic diseases ,medicine ,Prevalence ,Dementia ,Seroprevalence ,Humans ,Africa, Central ,education ,Geriatric Assessment ,older adults ,Aged ,Aged, 80 and over ,education.field_of_study ,seroprevalence ,business.industry ,Public Health, Environmental and Occupational Health ,Alzheimer's disease ,medicine.disease ,Toxoplasmosis ,Confidence interval ,3. Good health ,030104 developmental biology ,Infectious Diseases ,Cross-Sectional Studies ,Parasitology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,business ,Toxoplasma ,030217 neurology & neurosurgery ,Demography ,dementia - Abstract
International audience; OBJECTIVE:We aimed at estimating the seroprevalence of Toxoplasma gondii infection in older adults living in Central Africa and investigating its association with dementia using data from the Epidemiology of Dementia in Central Africa (EPIDEMCA) programme.METHODS:A cross-sectional multicentre population-based study was carried out among participants aged 73 (±7) years on average, living in rural and urban areas of the Central African Republic and the Republic of Congo between November 2011 and December 2012. Blood samples were collected from each consenting participant. The detection of anti-T.gondii immunoglobulin G antibodies was performed in 2014 in France using a commercially available ELISA kit. Participants were interviewed using a standardized questionnaire including sociodemographic characteristics. DSM-IV criteria were required for a diagnosis of dementia. Multivariate binary logistic regression models were used to estimate the association between toxoplasmosis infection and dementia.RESULTS:Among 1,662 participants, the seroprevalence of toxoplasmosis was 63.0% (95% confidence interval (CI): 60.7-65.3) overall, 66.6% (95%CI: 63.4-69.8) in Central African Republic and 59.4% (95%CI: 56.1-62.7) in the Republic of Congo. In multivariate analyses, toxoplasmosis status was significantly associated with increasing age (p=0.006), Republic of Congo (p=0.002), urban area (p=0.001) and previous occupation (p=0.002). No associations between dementia and toxoplasmosis status or anti- T.gondii IgG titres were found.CONCLUSION:T.gondii infection was not associated with dementia among older adults in Central Africa. Our findings are consistent with previous studies and add to the knowledge on the relationship between T.gondii infection and neurological disorders. This article is protected by copyright. All rights reserved.
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- 2018
23. Dietary patterns and risk of self-reported activity limitation in older adults from the Three-City Bordeaux Study
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Jean-François Dartigues, Marthe-Aline Jutand, Catherine Helmer, Sophie Pilleron, Cécilia Samieri, Karine Pérès, and Catherine Féart
- Subjects
0301 basic medicine ,Male ,Activities of daily living ,Medicine (miscellaneous) ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Activity limitation ,Activities of Daily Living ,Dietary Carbohydrates ,Daily living ,Humans ,030212 general & internal medicine ,Prospective Studies ,Mobility Limitation ,10. No inequality ,Prospective cohort study ,Biosimilar Pharmaceuticals ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Snacking ,Hazard ratio ,Feeding Behavior ,Diet Records ,Diet ,Nutrition Assessment ,Cohort ,Mental Recall ,Female ,France ,Independent Living ,Self Report ,Diet, Healthy ,Snacks ,Energy Intake ,human activities ,Demography ,Cohort study - Abstract
Few studies have been interested in the relationship between dietary patterns and activity limitation in older adults yet. We analysed the association between dietary patterns and the risk of self-reported activity limitation – that is mobility restriction, limitation in instrumental activities in daily living (IADL) and in activities in daily living (ADL) – in community-dwellers aged 67+ years initially free of activity limitation in 2001–2002 and re-examined at least once over 10 years – that is 583 participants for mobility restriction, 1114 for IADL limitation and 1267 for ADL limitation. At baseline, five sex-specific dietary clusters were derived by hybrid clustering method from weekly frequency of intake of twenty food and beverage items. Self-reported mobility restriction, limitations in IADL and in ADL were assessed using the Rosow–Breslau, the Lawton–Brody and the Katz scales, respectively. Associations between dietary clusters and the risk of each activity limitation were assessed using Cox proportional hazard models. In models adjusted for socio-demographic and health-related covariates, compared with the ‘Healthy’ cluster the ‘Biscuits and snacking’ cluster was associated with a higher risk of mobility restriction (hazard ratio (HR)=3·0; 95 % CI 1·6, 5·8) and limitation in IADL (HR=2·1; 95 % CI 1·1, 4·2) in men and limitation in ADL in women (HR=2·3; 95 % CI 1·3, 4·0). In this French cohort of community-dwellers aged 67+ years, some unhealthy dietary patterns may increase the risk of activity limitation all along the disablement process in older adults.
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- 2018
24. Cancer incidence in older adults in selected regions of sub-Saharan Africa, 2008-2012
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Eric Chokunonga, Nontuthuzelo I. M. Somdyala, Sophie Pilleron, Ahmedin Jemal, Henry Wabinga, D. Maxwell Parkin, Anne Korir, Hadrien Charvat, Isabelle Soerjomataram, and Freddie Bray
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Population ,03 medical and health sciences ,Prostate cancer ,Young Adult ,0302 clinical medicine ,Breast cancer ,Neoplasms ,Epidemiology ,medicine ,Humans ,Registries ,education ,Child ,Africa South of the Sahara ,education.field_of_study ,Health Services Needs and Demand ,business.industry ,Health Policy ,Incidence ,Age Factors ,Infant, Newborn ,Cancer ,Infant ,Middle Aged ,medicine.disease ,Oncology ,Cancer incidence ,Geriatric oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Sarcoma ,business ,Demography - Abstract
Although the countries of Sub-Sharan Africa represent among the most rapidly growing and aging populations worldwide, no previous studies have examined the cancer patterns in older adults in the region as a means to inform cancer policies. Using data from Cancer Incidence in Five Continents, we describe recent patterns and trends in incidence rates for the major cancer sites in adults aged ≥60 years and in people aged 0-59 for comparison in four selected population-based cancer registries in Kenya (Nairobi), the Republic of South Africa (Eastern Cape Province), Uganda (Kyadondo country), and Zimbabwe (Harare blacks). Over the period 2008-2012, almost 9,000 new cancer cases were registered in older adults in the four populations, representing one-third of all cancer cases. Prostate and esophageal cancers were the leading cancer sites in older males, while breast, cervical and esophageal cancers were the most common among older females. Among younger people, Kaposi sarcoma and non-Hodgkin lymphoma were common. Over the past 20 years, incidence rates among older adults have increased in both sexes in Uganda and Zimbabwe while rates have stabilized among the younger age group. Among older adults, the largest rate increase was observed for breast cancer (estimated annual percentage change: 5% in each country) in females and for prostate cancer (6-7%) in males. Due to the specific needs of older adults, tailored considerations should be given to geriatric oncology when developing, funding and implementing national and regional cancer programmes.
- Published
- 2018
25. Development of the Central Africa Daily Functioning Interference Scale for Dementia Diagnosis in Older Adults: The EPIDEMCA Study
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Maëlenn Guerchet, Bébène Ndamba-Bandzouzi, Jean-François Dartigues, Jean-Pierre Clément, Arlette Edjolo, Pascal M'Belesso, Karine Pérès, Sophie Pilleron, Pierre-Marie Preux, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, King‘s College London, Service de Psychiatrie [CHU Limoges], CHU Limoges, Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
- Subjects
Male ,Psychometrics ,Cognitive Neuroscience ,Participation restrictions ,Item response theory ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Cronbach's alpha ,Dementia diagnosis ,Activities of Daily Living ,medicine ,Dementia ,Cutoff ,Humans ,Africa, Central ,030212 general & internal medicine ,Internal validity ,Psychometric evaluation ,Reliability (statistics) ,Aged ,Aged, 80 and over ,Refusal to Participate ,Central Africa ,Reproducibility of Results ,medicine.disease ,Daily functioning interference ,Activity limitations ,Psychiatry and Mental health ,Scale (social sciences) ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Geriatrics and Gerontology ,Patient Participation ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background: There are a few validated tools capable of assessing the dimensions essential for the diagnosis of dementia and cognitive disorders in sub-Saharan Africa. Objectives: Our aim was to develop an adapted tool, the Central African – Daily Functioning Interference (DFI) scale. Methods: An initial 16-item scale of activity limitations and participation restrictions was completed by 301 participants with low cognitive performances to assess their level of DFI. A psychometric evaluation was performed using Item Response Theory. Results: A unidimensional 10-item scale emerged with a reasonable coverage of DFI (thresholds range: –1.067 to 1.587) with good item discrimination properties (1.397–4.076) and a high reliability (Cronbach’s al pha = 0.92). The cutoff for detecting 96% of those with dementia was with a latent score ≥0.035 that corresponds to the LAUNDRY limitation. Conclusions: These results provide valuable support for the reliability and internal validity of an operational 10-item scale for DFI assessment used in Central Africa for the diagnosis of dementia in the elderly.
- Published
- 2018
26. Global cancer incidence in older adults, 2012 and 2035: A population-based study
- Author
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Sophie, Pilleron, Diana, Sarfati, Maryska, Janssen-Heijnen, Jérôme, Vignat, Jacques, Ferlay, Freddie, Bray, and Isabelle, Soerjomataram
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Aged, 80 and over ,Male ,Geography ,Incidence ,Neoplasms ,Population Surveillance ,Humans ,Female ,Registries ,Global Health ,Aged - Abstract
Population ageing has substantially contributed to the rising number of new cancer cases worldwide. We document cancer incidence patterns in 2012 among older adults globally, and examine the changing magnitude of cancer in this age group over the next decades. Using GLOBOCAN 2012 data, we presented the number and proportion of new cancer cases, and the truncated age-standardised incidence rates among adults aged 65 years and older for all cancer sites combined and for the five most common cancer sites by world region. We calculated the incidence in 2035 by applying population projections, assuming no changes in rates. In 2012, 6.7 million new cancer cases (47.5% of all cancers) were diagnosed among older adults worldwide, with marked regional disparities. Nearly 48% of these cases occurred in less developed regions. Lung, colorectal, prostate, stomach and breast cancers represented 55% of the global incidence, yet distinct regional patterns were observed. We predict 14 million new cancer cases by 2035, representing almost 60% of the global cancer incidence. The largest relative increase in incidence is predicted in the Middle East and Northern Africa (+157%), and in China (+155%). Less developed regions will see an increase of new cases by 144%, compared to 54% in more developed regions. The expected increase in cancer incidence at older ages will have substantial economic and social impacts globally, posing considerable and unique challenge to healthcare systems in every world region, especially in those with limited resources and weaker health systems.
- Published
- 2018
27. MON-PO511: A New Equation Using Knee Height to Predict Overall Height Among Older People in Sub-Saharan Africa
- Author
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Jean Claude Desport, Pierre Jésus, Philippe Fayemendy, Maëlenn Guerchet, Dismand Houinato, Bébène Ndamba-Bandzouzi, Benoît Marin, P.M. Preux, R. Mas, Sophie Pilleron, Carmelle Mizéhoun-Adissoda, and Pascal M'Belesso
- Subjects
Nutrition and Dietetics ,Sub saharan ,business.industry ,Knee height ,Medicine ,Critical Care and Intensive Care Medicine ,business ,Older people ,Demography - Published
- 2019
28. Création et validation d’équations prédictives de mesure de la taille à partir de la hauteur talon-genou pour les personnes âgées d’Afrique Centrale
- Author
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Benoît Marin, Pascal M'Belesso, Pierre Jésus, Pierre-Marie Preux, Maëlenn Guerchet, Philippe Fayemendy, Bébène Ndamba-Bandzouzi, Sophie Pilleron, and Jean Claude Desport
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Introduction et but de l’etude Nous avons retrouve precedemment que la formule de Chumlea pour les noirs americains, validee pour la prediction de la taille a partir de la hauteur talon-genou (HTG), ne fournit une bonne prediction (± 5 cm) de la taille que dans 67 % des cas chez les personnes âgees (PA) d’Afrique Centrale (AC). Aucune formule n’est validee pour cette population. Le but de ce travail etait de creer et valider une formule predictive de la taille utilisant la HTG dans une population de PA d’AC. Materiel et methodes L’etude EPIDEMCA, a ete realisee chez des 1754 PA de plus de 65 ans au Congo et en Republique Centrafricaine. Les PA incluses ont beneficie d’une evaluation nutritionnelle avec mesure de la taille (cm) et de la HTG (cm). Les formules predictives ont ete creees a la suite d’une regression lineaire multiple selon le sexe, l’âge (ans) et la HTG a partir d’un sous-echantillon randomise (n = 877). La precision de cette nouvelle formule a ete testee sur l’autre moitie (n = 877). Des tests de correlation intraclasse et le pourcentage de bonne prediction ± 5 cm par rapport a la taille mesuree etaient calcules. Resultats et analyse statistique L’âge moyen etait de 72,9 ± 6,5 ans et la taille moyenne de 157,4 ± 9,2 cm. La sex-ratio H/F etait de 0,6 dans les deux pays. Une formule ajustee sur le sexe (FAS) a ete creee : taille (cm) = 72,75 + (1,86 × HTG)–(0,13 × âge) + 3,41 [si homme] ainsi que deux formules stratifiees sur le sexe (FSS), pour les hommes : taille (cm) = 82,77 + (1,76 × HTG)–(0,14 * âge [ans]) ; pour les femmes : taille (cm) = 74,09 + (1,78 × HTG)–(0,09 × âge). Le pourcentage de prediction et le coefficient de correlation intraclasse des deux formules dans la population test sont presentes dans le Tableau 1. Le pourcentage de bonne prediction ± 5 cm etait de 71,3 % et de 70,9 % pour les formules FAS et FSS, respectivement. Le pourcentage de bonne prediction etait significativement meilleur avec les formules FAS et FSS par rapport a la formule CPNA (p = 0,008 et p = 0,01, respectivement). L’indice de masse corporelle et le statut nutritionnel n’etaient significativement pas differents que ce soit en utilisant la taille mesuree ou les tailles predites (Tableau 1). Conclusion Les formules creees semblent applicables pour l’evaluation de la taille par la HTG chez les PA d’AC dans environ 71 % des cas. Ces formules pourront etre testees et validees dans d’autre pays d’Afrique pour l’estimation de la taille chez les PA afin d’etendre leur utilisation.
- Published
- 2018
29. Épidémiologie des démences en Afrique sub-saharienne
- Author
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Pierre-Marie Preux, Maëlenn Guerchet, Bébène Ndamba-Bandzouzi, Pascal Mbelesso, Sophie Pilleron, Iléana Désormais, Philippe Lacroix, Victor Aboyans, Jean-Claude Desport, Pierre Jésus, Achille Tchalla, Benoît Marin, Jean-Pierre Clément, Jean-Charles Lambert, and Jean-François Dartigues
- Subjects
medicine.medical_specialty ,education.field_of_study ,Population ageing ,Public health ,Population ,MEDLINE ,Developing country ,General Medicine ,medicine.disease ,Geography ,Environmental health ,parasitic diseases ,Epidemiology ,medicine ,Dementia ,Rural area ,education - Abstract
Given the ageing population worldwide and the consequent epidemiological transitions, dementia and related disorders are areas of increasing public health concern in developing countries. In sub-Saharan Africa, this issue is beginning to emerge. A literature review about epidemiology of dementia in these countries has been carried out. Few population-based studies conducted in Africa estimated prevalence from 2.3 % in Nigeria to 8.8 % in Central African Republic. However, the tests and criteria that were used are still not standardized. Further studies are needed to investigate possible diferences between urban and rural areas and the risk factors for dementia. Sub-Saharan Africa will soon face an important challenge for the management of these patients.
- Published
- 2015
30. Association between mild cognitive impairment and dementia and undernutrition among elderly people in Central Africa: some results from the EPIDEMCA (Epidemiology of Dementia in Central Africa) programme
- Author
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Sophie, Pilleron, Pierre, Jésus, Jean-Claude, Desport, Pascal, Mbelesso, Bébène, Ndamba-Bandzouzi, Jean-Pierre, Clément, Jean-François, Dartigues, Pierre-Marie, Preux, Maëlenn, Guerchet, Iléana, Désormais, Philippe, Lacroix, Victor, Aboyans, Achille, Tchalla, Benoît, Marin, Jean-Charles, Lambert, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), Service de Psychiatrie [CHU Limoges], Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Neuroépidémiologie Tropicale ( NET ), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ) -CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Mémoire de Ressources et de Recherches [Limoges] ( CMRR Limoges ), CHU Limoges-CH Esquirol [Limoges] ( CH Esquirol ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bordeaux Ségalen [Bordeaux 2], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] ( SIME ), Université de Limoges ( UNILIM ), and Grelier, Elisabeth
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Male ,medicine.medical_specialty ,Pediatrics ,Percentile ,Population ,Medicine (miscellaneous) ,Logistic regression ,Sensitivity and Specificity ,Body Mass Index ,Weight loss ,Epidemiology ,medicine ,Humans ,Dementia ,Africa, Central ,Cognitive Dysfunction ,education ,Life Style ,Aged ,Aged, 80 and over ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Malnutrition ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cognition ,medicine.disease ,Diet ,Diagnostic and Statistical Manual of Mental Disorders ,Cross-Sectional Studies ,Logistic Models ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Multivariate Analysis ,Physical therapy ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,medicine.symptom ,business - Abstract
Several studies in Western countries have shown an association between cognitive disorders and low BMI or weight loss in elderly people. However, few data are available in Africa. We analysed the association between cognitive disorders and undernutrition among elderly people in Central Africa. A cross-sectional, multicentre, population-based study using a two-phase design was carried out in subjects aged 65 years and above in the Central African Republic (CAR) and the Republic of Congo (ROC). All subjects were interviewed using the Community Screening Interview for Dementia, and those with low performance were clinically assessed by a neurologist and underwent further psychometrical tests. Diagnostic and Statistical Manual-IV and Petersen's criteria were required for the diagnoses of dementia and mild cognitive impairment (MCI), respectively. Undernutrition was evaluated using mid-upper arm circumference (MUAC) 2 and arm muscular circumference (AMC) 2 (OR 2·3, 95 % CI 1·6, 3·1), AMC
- Published
- 2015
31. [P2–306]: DEVELOPMENT AND EVALUATION OF THE CENTRAL AFRICA DEPENDENCY SCALE (CA‐D) FOR DEMENTIA DIAGNOSIS IN OLDER ADULTS WITH ITEM RESPONSE THEORY: THE EPIDEMCA STUDY
- Author
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Jean-Pierre Clément, B. Bandzouzi, Pierre-Marie Preux, Pascal M'Belesso, Sophie Pilleron, Maëlenn Guerchet, Arlette Edjolo, and Jean-François Dartigues
- Subjects
Gerontology ,030214 geriatrics ,Epidemiology ,Health Policy ,Central africa ,03 medical and health sciences ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Scale (social sciences) ,Item response theory ,Dementia diagnosis ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Dependency (project management) - Published
- 2017
32. [P3–547]: EARLY LIFE AND COGNITIVE RESERVE: ASSOCIATIONS WITH DEMENTIA AMONG OLDER PEOPLE IN CENTRAL AFRICA IN THE EPIDEMCA POPULATION‐BASED STUDY
- Author
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Jean-François Dartigues, Maëlenn Guerchet, Sophie Pilleron, B. Bandzouzi, Pascal M'Belesso, Jean-Pierre Clément, and Pierre-Marie Preux
- Subjects
Gerontology ,medicine.medical_specialty ,Epidemiology ,Health Policy ,Central africa ,medicine.disease ,Early life ,Population based study ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,Dementia ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Psychiatry ,Older people ,Cognitive reserve - Published
- 2017
33. International trends in cancer incidence and mortality among older adults, 1983–2012
- Author
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Freddie Bray, Isabelle Soerjomataram, Sophie Pilleron, and J. Ferlay
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education.field_of_study ,Epidemiology ,business.industry ,Incidence (epidemiology) ,Mortality rate ,Population ,Public Health, Environmental and Occupational Health ,Cancer ,medicine.disease ,Prostate cancer ,Breast cancer ,Geriatric oncology ,Medicine ,business ,education ,Lung cancer ,Demography - Abstract
Introduction In 2012, about half of all new cancer diagnoses and deaths were estimated to occur among people age 65 years and older; these will be around two third by 2035. Assessing trends in cancer incidence and mortality in this growing population is of great importance to understand the impact of cancer on this vulnerable population and to design cancer control and management plans. We therefore described temporal trends in incidence and mortality for the most common cancers–i.e. breast, prostate, colorectal and lung cancers–in adults aged 65 years or older in 17 countries with long history of population-based cancer registration. Methods Data on incidence for cancers of the colorectum, breast, prostate and lung from 1983 to 2012 were obtained from the Cancer Incidence in Five Continents in17 countries in Asia, northern America, central and south America, northern Europe, western and southern Europe and Oceania. Cancer mortality data were obtained from the World Health Organization mortality database. Country- and sex-specific truncated age-standardized rates (65 + ) and average annual percentage changes were calculated. Results Between 1983 and 2012, incidence rates of colorectal cancer have increased between +0.4–22% on average annually in older males and between +0.0–15.7% in older females in most countries under study, while incidence rate has significantly decreased in USA (−8.3% in females and −10.6% in males). In contrast, mortality from colorectal cancer has decreased in all countries from −10.5% in Switzerland to −0.8% in Singapore but it has significantly increased in Costa Rica (+5.5% in males and 2.8% in females) and Spain (8.7% in males and +1.6% in females). The incidence of prostate and breast cancers has increased in almost all countries between 2.6% in Canada and +38.8% in Japan for prostate cancer and between +1.1% in USA and 19.4% in Japan for breast cancer. However, prostate and breast cancer mortality rates have decreased in most countries, except in Costa Rica (+4.5% and +3.3% for prostate and breast cancers respectively), Japan (+8.6% and +13.4%) and Singapore (+9.4% and +6.1%). In almost all countries, incidence and mortality rates for lung cancer have greatly increased in females over the 30-year period following the smoking epidemic pattern (from 5.2% and 0.7% respectively in Japan to 35.8% and 26.0%, respectively in Netherlands), while lung cancer in males are largely decreasing, notably in UK, Netherlands and Finland (> −10% per year on average for incidence and mortality rates). Conclusion Decreasing deaths from cancer in older adults might probably be related to earlier cancer detection and better management. Yet, the rising incidence of the most common cancer sites will increase strain in national health care resources and therefore prevention programs needs to be strengthen. The expected rise in the number of new older cancer patients must encourage the development of geriatric oncology worldwide.
- Published
- 2018
34. Dietary Patterns and 12-Year Risk of Frailty: Results From the Three-City Bordeaux Study
- Author
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Marthe-Aline Jutand, Soufiane Ajana, Jean-François Dartigues, Catherine Helmer, Sophie Pilleron, Cécilia Samieri, and Catherine Féart
- Subjects
0301 basic medicine ,Gerontology ,Male ,Frail Elderly ,Population ,Risk Assessment ,03 medical and health sciences ,Medicine ,Humans ,Prospective Studies ,Prospective cohort study ,education ,Geriatric Assessment ,General Nursing ,Aged ,Proportional Hazards Models ,education.field_of_study ,030109 nutrition & dietetics ,Snacking ,Proportional hazards model ,business.industry ,Health Policy ,Hazard ratio ,Absolute risk reduction ,General Medicine ,Feeding Behavior ,Confidence interval ,Diet ,Female ,Geriatrics and Gerontology ,Risk assessment ,business ,Demography - Abstract
Objective: To analyze the association between dietary patterns and the 12-year risk of frailty and its components in community-dwelling elderly French adults. Design: A prospective cohort study. Setting: The Bordeaux sample of the Three-City Study. Participants: A total of 972 initially nonfrail nondemented participants (336 men and 636 women) aged 73 years on average, re-examined at least once over 12 years. Measurements: Five sex-specific dietary clusters were previously derived at baseline. Frailty incident to the baseline visit was defined as having at least three out of the following 5 criteria: unintentional weight loss, exhaustion, low energy expenditure, slowness, and muscle weakness. Multivariate Cox proportional hazard models were used to assess the association between dietary clusters and the risk of frailty and its components. Results: In total, 78 men for 3719 person-years and 221 women for 7027 person-years became frail over the follow-up. In multivariate analyses, men in the “pasta” pattern and women in the “biscuits and snacking” pattern had a significantly higher risk of frailty compared with those in the “healthy” pattern [hazard ratio (HR) 2.2; 95% confidence interval (CI) 1.1–4.4 and HR 1.8; 95% CI 1.2–2.8, respectively; P = .09 and P = .13 for the global test of significance of risk difference across clusters, respectively]. In men, “biscuits and snacking” and “pasta” patterns were significantly associated with higher risk for muscle weakness (HR 3.3; 95% CI 1.6–7.0 and HR 2.1; 95% CI 1.2–3.7, respectively; P = .003 for global test). Conclusions: This 12-year prospective population-based study suggests that some particular unhealthy dietary patterns may increase the risk of frailty in older adults.
- Published
- 2016
35. 0579: Particularities of the epidemiology of hypertension in the elderly in Central Africa: the EPIDEMCA study
- Author
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B. Bandzouzi, Maëlenn Guerchet, Ileana Desormais, Sophie Pilleron, Victor Aboyans, Pierre-Marie Preux, Pascal M'Belesso, and Philippe Lacroix
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medicine.medical_specialty ,Blood pressure ,business.industry ,Epidemiology ,Central africa ,Medicine ,Elderly people ,Mean age ,Rural area ,business ,Older people ,Cardiology and Cardiovascular Medicine ,Demography - Abstract
BackgroundThe epidemiology of hypertension in the elderly is rarely reported in Africa and little is known about its specificities.ObjectiveTo study the prevalence of hypertension and associated factors in older people in Central Africa.MethodsIndividuals aged 65 years old and over living in two urban and two rural areas of the Republic of Congo (ROC) and the Central African Republic (CAR) were invited to participate into a comprehensive cross-sectional study assessing cognitive impairments and cardiovascular diseases. Demographic, clinical and biological data were collected. Hypertension was defined in case of self-reported on-going treatment and/or when averaged systolic blood pressure at rest was≥140mmHg and/or diastolic blood pressure was≥90mmHg.ResultsAmong 1990 participants (mean age=73 years; 62% females), the overall prevalence of hypertension was 61.1% (95% CI: 58.9-63.2), higher in ROC than in CAR (68.0% vs 53.7%, respectively; p
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- 2016
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36. Global cancer incidence in older adults in 2012
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Jérôme Vignat, M. Janssen-Heijnen, Diana Sarfati, Sophie Pilleron, Freddie Bray, and J. Ferlay
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Population ageing ,Epidemiology ,business.industry ,Incidence (epidemiology) ,Public Health, Environmental and Occupational Health ,Cancer ,medicine.disease ,Older population ,Population estimate ,medicine.anatomical_structure ,Cancer incidence ,Health care ,medicine ,business ,Cervix ,Demography - Abstract
Introduction Population aging has substantially contributed to the rising number of new cancer cases worldwide. Little has been done to study cancer incidence in older population globally. We thus presented the cancer incidence in people aged 65 years and older along with the projected number of new cancer cases in 2035 by world regions. Methods We extracted incident cancer cases for 184 countries from the GLOBOCAN 2012 database. We presented the number and the proportion of new cases, and the truncated age-standardized incidence rates among 65+ for all-sites combined and the 5 most common cancers by world regions. We also calculated the future incidence in 2035 by applying projected population estimates, assuming no changes in rates. Results In 2012, 6.7 million new cancer cases or (47.5% of all cancers) were diagnosed among older adults worldwide, with 48% occurring in the less developed regions. Over two thirds of all new cases were found in Europe and Asia including China. Lung, colorectal, prostate, stomach and breast cancers represented 55% of the global incidence among the elderly, yet distinct regional pattern was observed e.g. cervix uteri cancer in Sub-Saharan Africa. By 2035, 14 million new cancer cases (68% all cases) are expected in older population. The highest increase is predicted in the Middle East and Northern Africa (+157%), and in China (+155%). Less developed regions will see an increase of 144% of new cancer cases compared to 54% in more developed regions. Conclusion The expected increase of cancer incidence at older ages will have a major impact on the society and challenge oncological practices and health care systems in all global regions in particular those with limited economic resources.
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- 2018
37. Epidemca baseline & follow-up: Dementia prevalence, incidence and mortality among older adults in central africa
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Pascal M'Belesso, Maëlenn Guerchet, Jean-François Dartigues, Harielle Anne-Claire Samba, Gilles Kehoua, Bébène Ndamba-Bandzouzi, Pierre-Marie Preux, Philippe Lacroix, Jean-Pierre Clément, and Sophie Pilleron
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education.field_of_study ,business.industry ,Qualitative interviews ,Population ,Crude incidence ,Stigma (botany) ,Central africa ,medicine.disease ,Prevalence incidence ,Neurology ,medicine ,Dementia ,Neurology (clinical) ,Older people ,business ,education ,Demography - Abstract
A multicenter population-based study was carried out in Central African Republic (CAR) and Republic of Congo between 2011 and 2012 including both urban and rural sites in each country. Participants aged ≥65 years old were interviewed and participants in Congo were followed-up annually between 2012 and 2015 (EPIDEMCA-FU study). Qualitative interviews using an ethno-anthropological approach were also performed with people identified with dementia and their relatives in order to investigate social representations, beliefs and stigma. Results Overall, 2,002 elderly were interviewed in both countries, including 473 in Nola (rural CAR), 500 in Bangui (urban CAR), 529 in Gamboma (rural Congo) and 500 in Brazzaville (urban Congo). The crude prevalence of DSM-IV dementia was estimated at 8.5% (CI95%[6.1-11.3] in Nola, at 6.4% (CI95%[4.4-8.9]) in Bangui, 5.7% (CI95% [3.9-8.0] in Gamboma and at 6.6% (CI95%[4.6-9.1]) in Brazzaville. The crude incidence was estimated at 15.8 (95% CI 10.2 – 23.3) per 1000 PY. Factors associated with either prevalent or incident dementia in these studies, as well as the results of the qualitative interviews, will be detailed during the presentation. Conclusion The need for targeted social and health policies for older people, as well as strategies for dementia care, is evident and growing in sub-Saharan Africa (SSA).
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- 2017
38. Is dependent personality disorder associated with mild cognitive impairment and dementia in Central Africa? A result from the EPIDEMCA programme
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Pierre-Marie Preux, Bébène Ndamba-Bandzouzi, Pascal M'Belesso, Jean-François Dartigues, Sophie Pilleron, Maëlenn Guerchet, Jean-Pierre Clément, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), Service de Psychiatrie [CHU Limoges], CHU Limoges, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
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medicine.medical_specialty ,media_common.quotation_subject ,Dependent personality disorder ,Population ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Personality ,Dementia ,Psychiatry ,education ,media_common ,education.field_of_study ,Cognition ,Odds ratio ,medicine.disease ,Personality disorders ,030227 psychiatry ,3. Good health ,Cognitive test ,Psychiatry and Mental health ,Clinical Psychology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Geriatrics and Gerontology ,Psychology ,Gerontology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background:To date, no studies have examined the relationship between cognitive disorders and personality disorders. Our aim was to investigate the association between dependent personality disorder (DPD) and cognitive disorders in Central Africa.Methods:Between 2011 and 2012, a cross-sectional multicenter population-based study was carried out in rural and urban areas of the Central African Republic (CAR) and the Republic of Congo (ROC). Participants aged ≥65 years were interviewed using the Community Screening Interview for Dementia (CSI-D). Elderly people who performed poorly (CSI-D cognitive tests score or COGSCORE ≤ 24.5/30) were clinically assessed by neurologists and underwent further psychometric testing. The Diagnostic and Statistical Manual of Mental Disorders, 4th Edition and Petersen criteria were required for the diagnosis of dementia and mild cognitive impairment (MCI) respectively. DPD was assessed using the Personality Diagnostic Questionnaire-4+. Socio-demographic, vascular, and psychological factors were also documented. Multivariate multinomial logistic regression models were used to estimate the associations.Results:Of the 2,002 participants screened, 860 and 912 had data for cognitive status and DPD in CAR and ROC respectively. In fully adjusted models, DPD was significantly associated with MCI in ROC (Odds Ratio (OR) = 2.2, 95% CI: 1.0–4.7) and CAR (OR = 2.1, 95% CI: 1.1–4.0) and with dementia only in ROC (OR = 4.8, 95% CI: 2.0–11.7).Conclusions:DPD was associated with cognitive disorders among elderly people in Central Africa. This association should be confirmed in other contexts. This study paves the way for research on the association between personality and cognitive impairment in Africa.
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- 2014
39. Association between Stressful Life Events and Cognitive Disorders in Central Africa: Results from the EPIDEMCA Program
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Pierre-Marie Preux, Jean-François Dartigues, Bébène Ndamba-Bandzouzi, Pascal M'Belesso, Jean Pierre Clément, Sophie Pilleron, Maëlenn Guerchet, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Prévention et prise en charge des traumatismes [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Centre de Mémoire de Ressources et de Recherches [Limoges] (CMRR Limoges), CHU Limoges-CH Esquirol [Limoges] (CH Esquirol), Service de Psychiatrie [CHU Limoges], Grelier, Elisabeth, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Neuroépidémiologie Tropicale ( NET ), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ) -CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] ( SIME ), Université de Limoges ( UNILIM ), Centre de Mémoire de Ressources et de Recherches [Limoges] ( CMRR Limoges ), CHU Limoges-CH Esquirol [Limoges] ( CH Esquirol ), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,medicine.medical_specialty ,Epidemiology ,MESH : Male ,MESH : Mild Cognitive Impairment ,[SDV]Life Sciences [q-bio] ,MEDLINE ,MESH : Aged ,MESH : Life Change Events ,Life Change Events ,mental disorders ,medicine ,Dementia ,Humans ,MESH : Female ,Cognitive Dysfunction ,Association (psychology) ,Psychiatry ,MESH : Aged, 80 and over ,Aged ,Aged, 80 and over ,MESH : Central African Republic ,Potential risk ,business.industry ,MESH : Humans ,Life events ,Central africa ,Cognition ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,medicine.disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,Central African Republic ,Congo ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Congo ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Neurology (clinical) ,business ,MESH : Dementia - Abstract
Background: Stressful life events (SLEs) are considered potential risk factors for cognitive disorders. Our objective was to investigate the association between SLEs and cognitive disorders among the elderly people in Central Africa. Method: A population-based study was conducted in the Central African Republic (CAR) and the Republic of Congo (ROC). Participants aged ≥65 were interviewed using the Community Screening Interview for Dementia. Those who performed poorly were clinically assessed by neurologists. DSM-IV and Petersen criteria were required for a diagnosis of dementia or mild cognitive impairment (MCI), respectively. SLEs were assessed through 18 questions about events that occurred during childhood, adulthood and late-life. Sociodemographic, vascular and psychological factors were also documented. Multivariate multinomial logistic regression models were used to estimate the associations. Results: MCI was positively associated with: the total number of SLEs (OR = 1.1, 95% CI: 1.0-1.2), the number of SLEs from the age of 65 (OR = 1.2, 95% CI: 1.0-1.3), the number of SLEs before the age of 16 among non-depressive participants (OR = 1.6, 95% CI: 1.2-2.2) and with a serious illness in a child experienced when the participant was aged 65 or more (OR = 2.8, 95% CI: 1.6-4.6). No association with dementia was observed. Conclusion: SLEs were positively associated with MCI but not dementia. More comprehensive studies are needed to further investigate this relationship.
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- 2014
40. SUN-PP213: Validity of Height Predictive Equations in 1754 Elderly People of Central Africa: Epidemca Study
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Pierre Jésus, P.M. Preux, Philippe Fayemendy, Bébène Ndamba-Bandzouzi, M. Pascal, Sophie Pilleron, Jean Claude Desport, and Maëlenn Guerchet
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Gerontology ,Nutrition and Dietetics ,business.industry ,Elderly people ,Central africa ,Medicine ,Critical Care and Intensive Care Medicine ,business - Published
- 2015
41. O4–04–04: Comparison of rural and urban dementia prevalences in two countries of Central Africa: The EPIDEMCA Study
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Pierre-Marie Preux, Maëlenn Guerchet, Pascal M'Belesso, Bébène Ndamba-Bandzouzi, Sophie Pilleron, Jean-François Dartigues, and Jean-Pierre Clément
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Epidemiology ,Health Policy ,Central africa ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Geography ,Developmental Neuroscience ,Environmental protection ,medicine ,Dementia ,Neurology (clinical) ,Geriatrics and Gerontology ,Socioeconomics - Published
- 2013
42. Association entre les troubles cognitifs et la dénutrition, d’une part, et les évènements de vie stressants, d’autre part, en Afrique Centrale : des résultats du programme EPIDEMCA
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Jean-Claude Desport, Sophie Pilleron, Bébène Ndamba-Bandzouzi, Jean-Pierre Clément, Pierre-Marie Preux, and Maëlenn Guerchet
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction La denutrition et les evenements de vie stressants (EVS) ont ete associes aux troubles cognitifs chez le sujet âge. Peu de donnees existent en Afrique. Notre objectif etait d’etudier l’association entre les TC (« Mild Cognitive Impairment » (MCI) et demences) et la denutrition, d’une part, et les EVS, d’autre part, en Afrique Centrale. Methodes Une enquete transversale multicentrique a ete menee en Republique Centrafricaine (RCA) et en Republique du Congo. Apres un depistage des TC en population generale, les sujets âges ≥ 65 ans ayant de faibles performances cognitives ont ete examines par un neurologue. Les diagnostics de demences et de MCI etaient poses selon les criteres du DSM-IV et de Petersen, respectivement. La denutrition a ete definie par un perimetre brachial (PB) 2 ou une circonference musculaire brachiale (CMB) e percentile. Les EVS ont ete evalues a l’aide de 18 items interrogeant sur trois periodes de vie (enfance, vie adulte et vieillesse). Des modeles de regression logistique multinomiale ont permis d’estimer les associations. Resultats Sur 2001 sujets depistes, le statut cognitif etait connu pour 1772 d’entre eux. En RCA, aucun marqueur de denutrition n’etait associe au MCI. Tous etaient positivement associes aux demences (PB 2 : OR = 2,7 [1,4–5,0]) ; CMB e percentile : OR = 2,9 [1,3–6,5]). Au Congo, seule la CMB e percentile restait associee au MCI (OR = 3,6 [1,7-7,6]). Aucun marqueur n’etait associe aux demences. Le MCI etait positivement associe au nombre total d’EVS en RCA (OR = 1,2 [1,1–1,3]) mais pas au Congo. Le MCI etait egalement associe au nombre d’EVS survenus a partir de 65 ans (OR = 1,1 [1,0–1,3]) et a la survenue d’une maladie chez un enfant a partir de 65 ans (OR = 2,6 [1,6–4,5]). Aucune association avec les demences n’a ete observee. Conclusion Concernant la denutrition, une difference d’association a ete observee selon le pays. Quant aux EVS, ils etaient associes au MCI mais pas aux demences. De futures etudes longitudinales devront approfondir ces relations.
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- 2014
43. Is dependent personality disorder associated with mild cognitive impairment and dementia in Central Africa? A result from the EPIDEMCA programme
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Sophie Pilleron
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