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18 results on '"Sommer N"'

1. Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure

Author

Husain-Syed, F., Birk, Hw, Claudio Ronco, Schörmann, T., Tello, K., Richter, M., Wilhelm, J., Sommer, N., Steyerberg, E., Bauer, P., Walmrath, Hd, Seeger, W., Mccullough, P., Gall, H., Ghofrani, Ha, Public Health, and Epidemiology

Subjects
cardiorenal syndromes, intrarenal venous flow patterns, pulmonary hypertension, venous congestion, renal Doppler ultrasonography
Published
2019

2. Mitochondrial respiratory states and rates

Author

Gnaiger, Erich, Aasander Frostner, Eleonor, Abdul Karim, Norwahidah, Abumrad, Nada A, Acuna-Castroviejo, Dario, Adiele, Reginald C, Ahn, Bumsoo, Ali, Sameh S, Alton, Lesley, Alves, Marco G, Amati, Francesca, Amoedo, Nivea Dias, Andreadou, Ioanna, Arago, Marc, Aral, Cenk, Arandarcikaite, Odeta, Armand, Anne-Sophie, Arnould, Thierry, Avram, Vlad Florian, Bailey, Damian M, Bajpeyi, Sudip, Bajzikova, Martina, Bakker, Barbara M, Barlow, Jonathan, Bastos Sant'Anna Silva, Ana Carolina, Batterson, Philip, Battino, Maurizio, Bazil, Jason, Beard, Daniel A, Bednarczyk, Piotr, Bello, Fiona, Ben-Shachar, Dorit, Bergdahl, Andreas, Berge, Rolf K, Bergmeister, Lisa, Bernardi, Paolo, Berridge, Michael V, Bettinazzi, Stefano, Bishop, David, Blier, Pierre U, Blindheim, Dan Filip, Boardman, Neoma T, Boetker, Hans Erik, Borchard, Sabine, Boros, Mihaly, Borsheim, Elisabet, Borutaite, Vilma, Botella, Javier, Bouillaud, Frederic, Bouitbir, Jamal, Boushel, Robert C, Bovard, Josh, Breton, Sophie, Brown, David A, Brown, Guy C, Brown, Robert A, Brozinick, Joseph T, Buettner, Garry R, Burtscher, Johannes, Calabria, Elisa, Calbet, Jose A, Calzia, Enrico, Cannon, Daniel T, Cano Sanchez, Maria, Canto Alvarez, Carlos, Cardoso, Luiza Helena Daltro, Carvalho, Eugenia, Casado Pinna, Marta, Cassar, Samantha, Cassina, Adriana M, Castelo, Maria P, Gonzalez-Franquesa, A, Cavalcanti-de-Albuquerque, Joao Paulo, Cervinkova, Zuzana, Chabi, Beatrice, Chakrabarti, Lisa, Chakrabarti, Sasanka, Chaurasia, Bhagirath, Chen, Qi, Chicco, Adam J, Chinopoulos, Christos, Chowdhury, Subir K, Cizmarova, Beata, Clementi, Emilio, Coen, Paul M, Cohen, Bruce H, Coker, Robert H, Collin, Anne, Crisostomo, Luis, Dahdah, Norma, Dalgaard, Louise T, Dambrova, Maija, Danhelovska, Tereza, Darveau, Charles A, Das, Anibh M, Dash, Ranjan K, Davidova, Eliska, Davis, Michael S, De Goede, Paul, De Palma, Clara, Dembinska-Kiec, Aldona, Detraux, Damien, Devaux, Yvan, Di Marcello, Marco, Dias, Tania R, Distefano, Giovanna, Doermann, Niklas, Doerrier, Carolina, Dong, Lan-Feng, Donnelly, Chris, Drahota, Zdenek, Duarte, Filipe Valente, Dubouchaud, Herve, Duchen, Michael R, Dumas, Jean-Francois, Durham, William J, Dymkowska, Dorota, Dyrstad, Sissel E, Dyson, Alex, Dzialowski, Edward M, Eaton, Simon, Ehinger, Johannes, Elmer, Eskil, Endlicher, Rene, Engin, Ayse B, Escames, Germaine, Ezrova, Zuzana, Falk, Marni Joy, Fell, David A, Ferdinandy, Peter, Ferko, Miroslav, Ferreira, Julio Cesar Batista, Ferreira, Rita, Ferri, Alessandra, Fessel, Joshua P, Filipovska, Aleksandra, Fisar, Zdenek, Fischer, Christine, Fischer, Michael, Fisher, Gordon, Fisher, Joshua J, Ford, Ellen, Fornaro, Mara, Galina, Antonio, Galkin, Alexander, Gallee, Leon, Galli, Gina L, Gama Perez, Pau, Gan, Zhenji, Ganetzky, Rebecca, Garcia-Rivas, Gerardo, Garcia-Roves, Pablo Miguel, Garcia-Souza, Luiz Felipe, Garipi, Enis, Garlid, Keith D, Garrabou, Gloria, Garten, Antje, Gastaldelli, Amalia, Gayen, Jiaur, Genders, Amanda J, Genova, Maria Luisa, Giovarelli, Matteo, Goncalo Teixeira da Silva, Rui, Goncalves, Debora Farina, Gonzalez-Armenta, Jenny L, Gonzalez-Freire, Marta, Gonzalo, Hugo, Goodpaster, Bret H, Gorr, Thomas A, Gourlay, Campbell W, Granata, Cesare, Grefte, Sander, Guarch, Meritxell Espino, Gueguen, Naig, Gumeni, Sentiljana, Haas, Clarissa B, Haavik, Jan, Haendeler, Judith, Haider, Markus, Hamann, Andrea, Han, Jin, Han, Woo Hyun, Hancock, Chad R, Hand, Steven C, Handl, Jiri, Hargreaves, Ian P, Harper, Mary Ellen, Harrison, David K, Hassan, Hazirah, Hausenloy, Derek J, Heales, Simon JR, Heiestad, Christina, Hellgren, Kim T, Hepple, Russell T, Hernansanz-Agustin, Pablo, Hewakapuge, Sudinna, Hickey, Anthony J, Ho, Dieu Hien, Hoehn, Kyle L, Hoel, Frederik, Holland, Olivia J, Holloway, Graham P, Hoppel, Charles L, Hoppel, Florian, Houstek, Josef, Huete-Ortega, Maria, Hyrossova, Petra, Iglesias-Gonzalez, Javier, Irving, Brian A, Isola, Raffaella, Iyer, Shilpa, Jackson, Christophe B, Jadiya, Pooja, Jana, Prado Fabian, Jang, David H, Jang, Young C, Janowska, Joanna, Jansen, Kirsten, Jansen-Duerr, Pidder, Jansone, Baiba, Jarmuszkiewicz, Wieslawa, Jaskiewicz, Anna, Jedlicka, Jan, Jespersen, Nichlas R, Jha, Rajan K, Jurczak, Michael J, Jurk, Diana, Kaambre, Tuuli, Kaczor, Jan J, Kainulainen, Heikki, Kampa, Rafal Pawel, Kandel, Sunil M, Kane, Daniel A, Kapferer, Werner, Kappler, Lisa, Karabatsiakis, Alexander, Karkucinska-Wieckowska, Agnieszka, Kaur, Sarbjot, Keijer, Jaap, Keller, Markus A, Keppner, Gloria, Khamoui, Andy V, Kidere, Dita, Kilbaugh, Todd, Kim, Hyoung Kyu, Kim, Julian KS, Klepinin, Aleksandr, Klepinina, Lyudmila, Klingenspor, Martin, Klocker, Helmut, Komlódi, Timea, Koopman, Werner JH, Kopitar-Jerala, Natasa, Kowaltowski, Alicia J, Kozlov, Andrey V, Krajcova, Adela, Krako Jakovljevic, Nina, Kristal, Bruce S, Krycer, Jamer R, Kuang, Jujiao, Kucera, Otto, Kuka, Janis, Kwak, Hyo Bum, Kwast, Kurt, Laasmaa, Martin, Labieniec-Watala, Magdalena, Lai, Nicola, Land, John M, Lane, Nick, Laner, Verena, Lanza, Ian R, Larsen, Terje S, Lavery, Gareth G, Lazou, Antigone, Lee, Hong Kyu, Leeuwenburgh, Christiaan, Lehti, Maarit, Lemieux, Helene, Lenaz, Giorgio, Lerfall, Jorgen, Li, Pingan A, Li Puma, Lance, Liepins, Edgars, Lionett, Sofie, Liu, Jiankang, Lopez, Luis C, Lucchinetti, Eliana, Ma, Tao, Macedo, Maria P, Maciej, Sarah, MacMillan-Crow, Lee Ann, Majtnerova, Pavlina, Makarova, Elina, Makrecka-Kuka, Marina, Malik, Afshan N, Markova, Michaela, Martin, Daniel S, Martins, Ana Dias, Martins, Joao D, Maseko, Tumisang Edward, Maull, Felicia, Mazat, Jean Pierre, McKenna, Helen T, McKenzie, Matthew, Menze, Michael A, Merz, Tamara, Meszaros, Andras T, Methner, Axel, Michalak, Slawomir, Moellering, Douglas R, Moisoi, Nicoleta, Molina, Anthony JA, Montaigne, David, Moore, Anthony L, Moreau, Kerrie, Moreira, Bruno P, Moreno-Sanchez, Rafael, Mracek, Tomas, Muccini, Anna Maria, Muntane, Jordi, Muntean, Danina M, Murray, Andrew J, Musiol, Eva, Nabben, Miranda, Nair, K Sreekumaran, Nehlin, Jan O, Nemec, Michal, Neufer, P Darrell, Neuzil, Jiri, Neviere, Remi, Newsom, Sean A., Nozickova, Katerina, O'Brien, Katie A, O'Gorman, Donal, Olgar, Yusuf, Oliveira, Ben, Oliveira, Marcus F, Oliveira, Marcos Tulio, Oliveira, Pedro F, Oliveira, Paulo J, Orynbayeva, Zulfiya, Osiewacz, Heinz D, Pak, Youngmi K, Pallotta, Maria L, Palmeira, Carlos M, Parajuli, Nirmala, Passos, Joao F, Passrugger, Manuela, Patel, Hemal H, Pavlova, Nadia, Pecina, Petr, Pedersen, Tina M, Pereira da Silva Grilo da Silva, Filomena, Perez Valencia, Juan A, Perks, Kara L, Pesta, Dominik, Petit, Patrice X, Pettersen, Ina Katrine Nitschke, Pichaud, Nicolas, Pichler, Irene, Piel, Sarah, Pietka, Terri A, Pino, Maria F, Pirkmajer, Sergej, Plangger, Mario, Porter, Craig, Porter, Richard K, Procaccio, Vincent, Prochownik, Edward V, Prola, Alexandre, Pulinilkunnil, Thomas, Puskarich, Michael A, Puurand, Marju, Radenkovic, Filip, Ramzan, Rabia, Rattan, Suresh IS, Reboredo, Patricia, Renner-Sattler, Kathrin, Rial, Eduardo, Robinson, Matthew M, Roden, Michael, Rodriguez, Enrique, Rodriguez-Enriquez, Sara, Roesland, Gro Vatne, Rohlena, Jakub, Rolo, Anabela Pinto, Ropelle, Eduardo R, Rossignol, Rodrigue, Rossiter, Harry B, Rubelj, Ivica, Rybacka-Mossakowska, Joanna, Saada, Ann, Safaei, Zahra, Sarlak, S, Salin, Karine, Salvadego, Desy, Sandi, Carmen, Saner, Nicholas, Sanz, Alberto, Sazanov, Leonid A, Scatena, Roberto, Schartner, Melanie, Scheibye-Knudsen, Morten, Schilling, Jan M, Schlattner, Uwe, Schoenfeld, Peter, Schots, Pauke C, Schulz, Rainer, Schwarzer, Christoph, Scott, Graham R, Selman, Colin, Shabalina, Irina G, Sharma, Pushpa, Sharma, Vipin, Shevchuk, Igor, Shirazi, Reza, Shiroma, Jonathan G, Siewiera, Karolina, Silber, Ariel M, Silva, Ana Maria, Sims, Carrie A, Singer, Dominique, Singh, Brijesh Kumar, Skolik, Robert A, Smenes, Benedikte Therese, Smith, James, Soares, Félix Alexandre Antunes, Sobotka, Ondrej, Sokolova, Inna, Sonkar, Vijay K, Sowton, Alice P, Sparagna, Genevieve C, Sparks, Lauren M, Spinazzi, Marco, Stankova, Pavla, Starr, Jonathan, Stary, Creed, Stelfa, Gundega, Stepto, Nigel K, Stiban, Johnny, Stier, Antoine, Stocker, Roland, Storder, Julie, Sumbalova, Zuzana, Suomalainen, Wartiovaara Anu, Suravajhala, Prashanth, Svalbe, Baiba, Swerdlow, Russel H, Swiniuch, Daria, Szabo, Ildiko, Szewczyk, Adam, Szibor, Marten, Tanaka, Masashi, Tandler, Bernard, Tarnopolsky, Mark A, Tausan, Daniel, Tavernarakis, Nektarios, Tepp, Kersti, Thakkar, Himani, Thapa, Maheshwo, Thyfault, John P, Tomar, Dhanendra, Ton, Riccardo, Torp, May-Kristin, Towheed, Atif, Tretter, Laszlo, Trewin, Adam J, Trifunovic, Aleksandra, Trivigno, Catherine, Tronstad, Karl Johan, Trougakos, Ioannis P, Truu, Laura, Tuncay, Erkan, Turan, Belma, Tyrrell, Daniel J, Urban, Tomas, Valentine, Joseph Marco, Van Bergen, Nicole J, Van Hove, Johan, Varricchio, Frederick, Vella, Joanna, Vendelin, Marko, Vercesi, Anibal E, Victor, Victor Manuel, Vieira Ligo Teixeira, Camila, Vidimce, Josif, Viel, Christian, Vieyra, Adalberto, Vilks, Karlis, Villena, Joseph A, Vincent, Vinnyfred, Vinogradov, Andrey D, Viscomi, Carlo, Vitorino, Rui Miguel Pinheiro, Vogt, Sebastian, Volani, Chiara, Volska, Kristine, Votion, Dominique-Marie, Vujacic-Mirski, Ksenija, Wagner, Brett A, Ward, Marie Louise, Warnsmann, Verena, Wasserman, David H, Watala, Cezary, Wei, Yau-Huei, Whitfield, Jamie, Wickert, Anika, Wieckowski, Mariusz R, Wiesner, Rudolf J, Williams, Caroline M, Winwood-Smith, Hugh, Wohlgemuth, Stephanie E, Wohlwend, Martin, Wolff, Jonci Nikolai, Wrutniak-Cabello, Chantal, Wuest, Rob C I, Yokota, Takashi, Zablocki, Krzysztof, Zanon, Alessandra, Zanou, Nadege, Zaugg, Kathrin, Zaugg, Michael, Zdrazilova, Lucie, Zhang, Yong, Zhang, Yi Zhu, Zikova, Alena, Zischka, Hans, Zorzano, Antonio, Zvejniece, Liga, Lagarrigue, Sylviane, Munro, Daniel, Pereira, Susana, Laranjinha, Joäo, Almeida, Angeles, Diederich, M, Hecker, M, Jusic, A, Prigione, A, Sommer, N, Weissig, V, Abdel-Rahman, EA, Sova, M, Amorim, R, Beleza, J, Bravo-Sagua, R, Celen, MC, Coxito, P, Crispim, M, Dias, C, Evinova, A, Fuertes Agudo, M, Gao, Y, Garcia, G, Goikoetxea Usandizaga, N, Grilo, L, Minuzzi, LM, Hachmo, Y, Hajrulahovic, A, Hatokova, Z, Henrique, A, Holzner, L, Kimoloi, S, Ledo, AM, Machado, IF, Magalhaes, J, Magri, A, Nunes, S, Oliveira, J, Pinho, SA, Preguica, I, Reano, S, Rodrigues, AS, Santos, D, Sardao, V, Stevanovic, J, Teodoro, J, Van der Ende, M, Zujovic, T, Djafarzadeh, S, Schneider Gasser, EM, Jaspers, RT, Arias-Reyes, C, Bairam, A, Laouafa, S, Marcouiller, F, Soliz, J, Glatz, J, Antunes, D, Bach de Courtade, SM, Bardal, T, Di Paola, FJ, Fulton, M, Grams, B, Joseph, V, Kwon, OS, Liang, L, Mila Guasch, M, Moore, C, Norman, J, O'Brien, K, Olsen, RE, Paez, H, Rees, BB, Roshanravan, B, Scaife, P, Sendon, PM, Vlachaki Walker, J, Crossland, H, Jones, JG, Bento, G, Perales, JC, and Aragones Lopez, J

Subjects
uncoupling, Mitochondrial respiratory control, coupling control, protonmotive force, oxidative phosphorylation, mitochondrial respiratory control, NARILIS, ET [electron transfer], electron transfer, residual oxygen consumption, flux, normalization, efficiency, flow, oxygen, mitochondrial preparations, proton leak
Abstract

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow guidelines of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of databases of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.

Published
2019
Full Text
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3. Magnitude Estimation of Velocity in the X, Y, and Z Axes

Author

Sommer N. Thompson, Mark W. Scerbo, and Nathan R. Bailey

Subjects
Medical Terminology, Geography, law, Geometry, Cartesian coordinate system, Partial support, Medical Assisting and Transcription, law.invention
Abstract

The present study examined the perception of velocity along different axes. Participants viewed the movement of two small circles on a computer display and gave verbal responses for the perceived velocity of one of the circles relative to the other using the psychophysical method of magnitude estimation. Stimuli were presented along the x, y, and z axes. Other variables included direction traveled, time and distance constant, and velocity. Movement in the z axis was represented through angular expansion. As expected, results indicated that velocity judgments increased with increases in stimulus velocity. Perceived velocity was expected to be higher for vertical as compared to horizontal stimuli. The results provided partial support for this hypothesis. Estimates for velocity along the z axis were qualitatively different than for the other two axes. Further, velocity estimates depended upon whether the time or distance was held constant and suggest that the perception of velocity is tied to both spatial and temporal properties of the stimuli.

Published
2005

4. Interferon β-1b-neutralizing antibodies 5 years after clinically isolated syndrome

Author

Hartung, Hp, Strasser Fuchs, S, Berger, T, Vass, K, Sindic, C, Dubois, B, Dive, D, Debruyne, J, Metz, L, Rice, G, Duquette, P, Lapierre, Y, Freedman, M, Traboulsee, A, O'Connor, P, Stourac, P, Taláb, R, Zapletalová, O, Kováøová, I, Medová, E, Fiedler, J, Frederiksen, J, Brochet, B, Moreau, T, Vermersch, P, Pelletier, J, Edan, G, Clanet, M, Clavelou, P, Lebrun Frenay, C, Gout, O, Kallela, M, Pirttilä, T, Ruutiainen, J, Koivisto, K, Reunanen, M, Elovaara, I, Villringer, A, Altenkirch, H, Wessel, K, Steinke, W, Kölmel, H, Oschmann, P, Diem, R, Dressel, A, Hoffmann, F, Baum, K, Jung, S, Petereit, Hf, Reske, D, Sailer, M, Köhler, J, Sommer, N, Hohlfeld, R, Henn, Kh, Steinbrecher, A, Tumani, H, Gold, R, Rieckmann, P, Komoly, R, Gács, G, Jakab, G, Csiba, L, Vécsei, L, Miller, A, Karussis, D, Chapman, J, Ghezzi, A, Comi, G, Gallo, Paolo, Cosi, V, Durelli, L, Anten, B, Visser, L, Myhr, Km, Szczudlik, A, Selmaj, K, Stelmasiak, Z, Podemski, R, Maciejek, Z, Cunha, L, Sega Jazbec, S, Montalba, X, Arbizu, T, Saiz, A, Bárcena, J, Arroyo, R, Fernández, O, Izquierdo, G, Casanova, B, Lycke, J, Kappos, L, Mattle, H, Beer, K, Coleman, R, Chataway, J, O'Riordan, J, and Howell, S. .

Published
2012

5. Interferon β-1b-neutralizing antibodies 5 years after clinically isolated syndrome

Author

Hartung, Hp, Strasser Fuchs, S, Berger, T, Vass, K, Sindic, C, Dubois, B, Dive, D, Debruyne, J, Metz, L, Rice, G, Duquette, P, Lapierre, Y, Freedman, M, Traboulsee, A, O'Connor, P, Stourac, P, Taláb, R, Zapletalová, O, Kováøová, I, Medová, E, Fiedler, J, Frederiksen, J, Brochet, B, Moreau, T, Vermersch, P, Pelletier, J, Edan, G, Clanet, M, Clavelou, P, Lebrun Frenay, C, Gout, O, Kallela, M, Pirttilä, T, Ruutiainen, J, Koivisto, K, Reunanen, M, Elovaara, I, Villringer, A, Altenkirch, H, Wessel, K, Steinke, W, Kölmel, H, Oschmann, P, Diem, R, Dressel, A, Hoffmann, F, Baum, K, Jung, S, Petereit, Hf, Reske, D, Sailer, M, Köhler, J, Sommer, N, Hohlfeld, R, Henn, Kh, Steinbrecher, A, Tumani, H, Gold, R, Rieckmann, P, Komoly, R, Gács, G, Jakab, G, Csiba, L, Vécsei, L, Miller, A, Karussis, D, Chapman, J, Ghezzi, A, Comi, G, Gallo, Paolo, Cosi, V, Durelli, L, Anten, B, Visser, L, Myhr, Km, Szczudlik, A, Selmaj, K, Stelmasiak, Z, Podemski, R, Maciejek, Z, Cunha, L, Sega Jazbec, S, Montalba, X, Arbizu, T, Saiz, A, Bárcena, J, Arroyo, R, Fernández, O, Izquierdo, G, Casanova, B, Lycke, J, Kappos, L, Mattle, H, Beer, K, Coleman, R, Chataway, J, O'Riordan, J, Howell, S. ., Neurology, Radiology and nuclear medicine, NCA - Multiple Sclerosis and Other Neuroinflammatory Diseases, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, and UCL - (SLuc) Service de neurologie

Subjects
Multiple Sclerosis, Injections, Subcutaneous, Relapse rate, Brain mri, Medicine, Humans, Longitudinal Studies, Prospective Studies, Clinically isolated syndrome, biology, business.industry, Immunogenicity, Interferon-beta, Antibodies, Neutralizing, Titer, Interferon β 1b, Cross-Sectional Studies, Immunology, biology.protein, Neurology (clinical), Antibody, business, Demyelinating Diseases, Follow-Up Studies, Interferon beta-1b
Abstract

To determine the frequency and consequences of neutralizing antibodies (NAbs) in patients with a first event suggestive of multiple sclerosis (MS) treated with interferon β-1b (IFNβ-1b).In the Betaseron/Betaferon in Newly Emerging MS For Initial Treatment (BENEFIT) study, patients were randomly assigned to 250 μg IFNβ-1b (Betaferon) or placebo subcutaneously every other day for 2 years or until diagnosis of clinically definite MS (CDMS). Patients were then offered open-label IFNβ-1b for up to 5 years. NAb status was assessed every 6 months by the myxovirus protein A induction assay. A titer20 NU/mL was considered NAb-positive, with low (≥20-100 NU/mL), medium (≥100-400 NU/mL), and high (≥400 NU/mL) titer categories. Here we examine early-treated patients, who received IFNβ-1b for up to 5 years.NAbs were measured in 277 of 292 early-treated patients and detected at least once in 88 (31.8%) patients, with 53 (60.2%) reverting to NAb negativity by year 5. Time to CDMS, time to confirmed disability progression, and annualized relapse rate did not differ between NAb-positive and NAb-negative patients or between periods of NAb positivity vs NAb negativity within patients. Increases in newly active lesion number and T2 lesion volume and conversion to McDonald MS were associated with NAb positivity and were more pronounced with higher titers.Although NAb positivity was associated with increased brain MRI activity, no discernible effects on clinical outcomes were found. This finding may reflect the greater power of MRI compared with clinical outcomes to detect the treatment effects of IFNβ-1b and may also result from temporal changes in NAb titers and biology.

Published
2011

6. 250 mu g or 500 mu g interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study

Author

O'Connor, P., Filippi, M., Arnason, B., Comi, G., Cook, S., Goodin, D., Hartung, H., Jeffery, D., Kappos, L., Boateng, F., Filippov, V., Groth, M., Knappertz, V., Kraus, C., Sandbrink, R., Pohl, C., BogumilAbramsky O, T., Achiron, A, Agius, M, Aichner, F, Altenkirch, H, Amato, Mp, Anten, B, Arbizu, T, Ash, P, Ballario, C, Bashir, K, Baum, K, Baumhackl, U, Beaver, G, Belova, A, Berger, J, Berger, T, Berlit, P, Beuche, W, Bhan, V, Bigley, K, Bissay, V, Blake, C, Bö, L, Boyko, A, Brochet, B, Brown, M, Callegaro, D, Carra, A, Carroll, W, Cascione, M, Christie, S, Clanet, M, Clavelou, P, Clementino, Vi, Confavreux, C, Cooper, J, Cross, A, Csanyi, A, Czlonkowska, A, D'Hooghe, M, Damier, P, Debouverie, M, Defer, G, Demina, T, Deri, N, Diem, R, Dressel, A, Dubois, B, Dunne, P, Duquette, P, Durelli, L, Edan, G, Elias, S, Elovaara, I, Esfahani, F, Evtushenko, S, Fabijan, Th, Fernández, O, Ferreira, Ml, Fink, A, Flechter, S, Ford, C, Francesconi, C, Freedman, M, Fryze, W, Gabbai, A, Gács, G, Gallo, Paolo, Gazda, S, Gerloff, C, Glyman, S, Goodman, A, Gottesman, M, Grand'Maison, F, Guarnaccia, J, Gutierrez, A, Haas, J, Hansen, Hj, Hardiman, O, Heard, R, Heidenreich, F, Herbert, J, Herminia Scola, R, Hodgkinson, S, Hoffmann, F, Holub, R, Huddlestone, J, Hughes, B, Hughes, M, Hunter, S, Hurwitz, B, Izquierdo, G, Jacobasch, E, Jacques, F, Jakab, G, Jongen, P, Karageorgiou, C, Karni, A, Kasper, L, Kaufman, M, Keidel, M, Khatri, B, Kiefer, R, Kirzinger, S, Kita, M, Komoly, S, Kotov, S, Kozubski, W, Kumlien, E, Kwiecinski, H, Labouge, P, Laganke, C, Lapierre, Y, Lebrun Frenay, C, Leist, T, Leon, Sa, Luetic, G, Lynch, S, Lynch, T, Malkova, N, Maltezou, M, Markowitz, C, Martin, C, Mattle, H, Mattson, D, Metra, M, Meyding Lamadé, U, Milo, R, Milonas, I, Miller, A, Miller, T, Minagar, A, Mitchell, G, Moreau, T, Mosberg, R, Murphy, R, Nehrych, T, Nikl, J, Odinak, M, Oschmann, P, Owen King, J, Pagani, L, Pereira Damasceno, B, Podemski, R, Pöhlau, D, Pozzilli, C, Rammohan, K, Reunanen, M, Rice, G, Richardson, P, Rivera, V, Rizvi, S, Rogozhyn, V, Rolak, L, Rosenkranz, T, Rotta, R, Sanders, E, Sater, R, Satgur Gupta, A, Schwartz, R, Sedal, L, Sega Jazbec, S, Selchen, D, Selmaj, K, Sheremata, W, Shvets, T, Silver, D, Simsarian, J, Skoromets, A, Smiroldo, J, Sokolova, L, Solovyova, Y, Sommer, N, Spirin, N, Stangel, M, Stark, E, Steinbrecher, A, Stemper, B, Stolyarov, I, Strasser Fuchs, S, Sweeney, B, Tettenborn, B, Thrower, B, Tilbery, Cp, Traboulsee, A, Trojano, M, Tubridy, N, Tyor, W, Valikovics, A, Vermersch, P, Vollmer, T, Voloshyna, N, Vrech, C, Wajgt, A, Weller, B, Wendt, J, Yakhno, N, Yeung, M, Zavalishin, I., O'Connor, P, Filippi, Massimo, Arnason, B, Comi, G, Cook, S, Goodin, D, Hartung, Hp, Jeffery, D, Kappos, L, Boateng, F, Filippov, V, Groth, M, Knappertz, V, Kraus, C, Sandbrink, R, Pohl, C, Bogumil, T., and Dubois, Bénédicte

Subjects
Adult, Male, medicine.medical_specialty, interferon beta-1b, Adolescent, Pharmacology, relapsing-remitting multiple sclerosis, law.invention, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Randomized controlled trial, Double-Blind Method, law, Internal medicine, medicine, Humans, Immunologic Factors, Glatiramer acetate, Adverse effect, Expanded Disability Status Scale, Dose-Response Relationship, Drug, business.industry, Multiple sclerosis, Interferon beta-1b, Brain, Glatiramer Acetate, Interferon-beta, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Clinical trial, Tolerability, glatiramer acetate, Female, Neurology (clinical), business, Peptides, medicine.drug
Abstract

BACKGROUND: The aim of the Betaferon Efficacy Yielding Outcomes of a New Dose (BEYOND) trial was to compare the efficacy, safety, and tolerability of 250 microg or 500 microg interferon beta-1b with glatiramer acetate for treating relapsing-remitting multiple sclerosis. METHODS: Between November, 2003, and June, 2005, 2447 patients with relapsing-remitting multiple sclerosis were screened and 2244 patients were enrolled in this prospective, multicentre, randomised trial. Patients were randomly assigned 2:2:1 by block randomisation with regional stratification to receive one of two doses of interferon beta-1b (250 microg or 500 microg) subcutaneously every other day or 20 mg glatiramer acetate subcutaneously every day. The primary outcome was relapse risk, defined as new or recurrent neurological symptoms separated by at least 30 days from the preceding event and that lasted at least 24 h. Secondary outcomes were progression on the expanded disability status scale (EDSS) and change in T1-hypointense lesion volume. Clinical outcomes were assessed quarterly for 2.0-3.5 years; MRI was done at screening and annually thereafter. Analysis was by per protocol. This study is registered, number NCT00099502. FINDINGS: We found no differences in relapse risk, EDSS progression, T1-hypointense lesion volume, or normalised brain volume among treatment groups. Flu-like symptoms were more common in patients treated with interferon beta-1b (p

Published
2009

7. Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer

Author

Sommer N. Knight, Mark Steven Miller, Libyadda J. Mosley, Edward A. Levine, L. Douglas Case, Lisa A. Carey, Lynda R. Sawyer, Hui-Yi Lin, Jennifer J. Hu, Nancy D. Perrier, Clara Milikowski, Beth O. Van Emburgh, Glenn O. Allen, Gary Bradley Sherrill, Mark C. Willingham, Peter Rubin, and Cindy S. Shaw

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, Genotype, Breast Neoplasms, Biology, medicine.disease_cause, Polymerase Chain Reaction, Article, GSTP1, Breast cancer, Polymorphism (computer science), Internal medicine, medicine, Humans, Molecular Biology, Polymorphism, Single-Stranded Conformational, Aged, DNA Primers, Genetics, Mutation, Polymorphism, Genetic, Base Sequence, Incidence (epidemiology), Smoking, Middle Aged, medicine.disease, Genes, p53, Null allele, Etiology, Female
Abstract

Polymorphisms in phase I and phase II enzymes may enhance the occurrence of mutations at critical tumor suppressor genes, such as p53, and increase breast cancer risk by either increasing the activation or detoxification of carcinogens and/or endogenous estrogens. We analyzed polymorphisms in CYP1B1, GSTM1, GSTT1, and GSTP1 and p53 mutations in 323 breast tumor samples. Approximately 11% of patients exhibited mutations in p53. Women with mutations had a significantly younger age of diagnosis (P = 0.01) and a greater incidence of tumors classified as stage II or higher (P = 0.002). More women with mutations had a history of smoking (55%) compared to women without mutations (39%). Although none of the genotypes alone were associated with p53 mutations, positive smoking history was associated with p53 mutations in women with the GSTM1 null allele [OR = 3.54; 95% CI = 0.97-12.90 P = 0.06] compared to women with the wild-type genotype and smoking history [OR = 0.62, 95% CI = 0.19-2.07], although this association did not reach statistical significance. To test for gene-gene interactions, our exploratory analysis in the Caucasian cases suggested that individuals with the combined GSTP1 105 VV, CYP1B1 432 LV/VV, and GSTM1 positive genotype were more likely to harbor mutations in p53 [OR = 4.94; 95% CI = 1.11-22.06]. Our results suggest that gene-smoking and gene-gene interactions may impact the prevalence of p53 mutations in breast tumors. Elucidating the etiology of breast cancer as a consequence of common genetic polymorphisms and the genotoxic effects of smoking will enable us to improve the design of prevention strategies, such as lifestyle modifications, in genetically susceptible subpopulations.

Published
2007

8. The efficacy of a medical virtual reality simulator for training phlebotomy

Author

Sommer N. Thompson, Elizabeth A. Schmidt, James P. Bliss, and Mark W. Scerbo

Subjects
Program evaluation, Adult, medicine.medical_specialty, Virtual reality simulator, Human Factors and Ergonomics, Virtual reality, 050105 experimental psychology, Education, Behavioral Neuroscience, Physical medicine and rehabilitation, Phlebotomy, medicine, Humans, 0501 psychology and cognitive sciences, Computer Simulation, 050107 human factors, Applied Psychology, business.industry, 05 social sciences, Virginia, Checklist, Test (assessment), Occupational training, Physical therapy, business, Program Evaluation
Abstract

Objective: The present study compared the effectiveness of a virtual reality (VR) simulator for training phlebotomy with that of a more traditional approach using simulated limbs. Background: Phlebotomy, or drawing blood, is one of the most common medical procedures; yet, there are no universal standards for training and assessing performance. The absence of any standards can lead to injuries and inaccurate test results if the procedure is improperly performed. Method: Twenty 3rd-year medical students were trained under one of the two methods and had their performance assessed with a 28-item checklist. Results: The results showed that performance improvements were limited to those who trained with the simulated limbs, and a detailed comparison of the two systems revealed several functional and physical differences that may explain these findings. Conclusion: Participants trained with simulated limbs performed better than those trained with a VR simulator; however, the metrics recorded by the VR system may address some aspects of performance that could eventually prove beneficial. Application: The present study highlights the potential for medical simulators to improve patient safety by enabling trainees to practice procedures on devices instead of patients. Applications of this research include training, performance assessment, and design of simulator systems.

Published
2006

9. A comparison of the CathSim system and simulated limbs for teaching intravenous cannulation

Author

Mark W, Scerbo, James P, Bliss, Elizabeth A, Schmidt, Sommer N, Thompson, Theresa D, Cox, and Harry J, Poland

Subjects
User-Computer Interface, Virginia, Humans, Extremities, Venous Cutdown
Abstract

The present study describes a comparison between the CathSim VR simulator and simulated limbs for training IV cannulation. Two groups of physician assistant students underwent 2 hours of training on either method. Performance was assessed before and after training with a standardized assessment form. The results showed that all students improved after training, but the degree of improvement was greater for those trained with the simulated limbs. These findings may be due to differences between the two training methods as well as the methodology adopted in the present study.

Published
2004

11. VizieR Online Data Catalog: OzDES DR1 (Childress+, 2017)

Author

Childress, M. J., Lidman, C., Davis, T. M., Tucker, B. E., Asorey, J., Yuan, F., Abbott, T. M. C., Abdalla, F. B., Allam, S., Annis, J., Banerji, M., Benoit-Levy, A., Stephanie Bernard, Bertin, E., Brooks, D., Buckley-Geer, E., Burke, D. L., Rosell, A. Carnero, Carollo, D., Carrasco Kind, M., Carretero, J., Castander, F. J., Cunha, C. E., Costa, L. N. Da, D Andrea, C. B., Doel, P., Eifler, T. F., Evrard, A. E., Flaugher, B., Foley, R. J., Fosalba, P., Frieman, J., Garcia-Bellido, J., Glazebrook, K., Goldstein, D. A., Gruen, D., Gruendl, R. A., Gschwend, J., Gupta, R. R., Gutierrez, G., Hinton, S. R., Hoormann, J. K., James, D. J., Kessler, R., Kim, A. G., King, A. L., Kovacs, E., Kuehn, K., Kuhlmann, S., Kuropatkin, N., Lagattuta, D. J., Lewis, G. F., Li, T. S., Lima, M., Lin, H., Macaulay, E., Maia, M. A. G., Marriner, J., March, M., Marshall, J. L., Martini, P., Mcmahon, R. G., Menanteau, F., Miquel, R., Moller, A., Morganson, E., Mould, J., Mudd, D., Muthukrishna, D., Nichol, R. C., Nord, B., Ogando, R. L. C., Ostrovski, F., Parkinson, D., Plazas, A. A., Reed, S. L., Reil, K., Rome, R. A. K., Rykoff, E. S., Sako, M., Sanchez, E., Scarpine, V., Schindler, R., Schubnell, M., Scolnic, I. D., Sevilla-Noarbe, N., Seymour, R., Sharp, M., Smith, M., Soares-Santos, F., Sobreira, Sommer, N. E., Spinka, H., Suchyta, E., Sullivan, M., Swanson, M. E. C., Tarle, G., Uddin, S. A., Walker, A. R., Wester, W., and Zhang, B. R.

12. Classification of 17 DES supernova with OzDES

Author

Dale Mudd, Martini, P., Lewis, G. F., Moller, A., Sharp, R. G., Sommer, N. E., Tucker, B. E., Yuan, F., Zhang, B., Asorey, J., Davis, T. M., Hinton, S., Muthukrishna, D., Parkinson, D., Carnero, A., King, A., Lidman, C., Webb, S., Uddin, S., Kessler, R., Lasker, J., Scolnic, D., Brout, D. J., D Andrea, C., Gladney, L., March, M., Sako, M., Wolf, R. C., Brown, P. J., Krisciunas, K., Suntzeff, N., Macaulay, E., Nichol, R., Childress, M., Prajs, S., Smith, M., Sullivan, M., Maartens, R., Kovacs, E., Kuhlmann, S., Spinka, H., Ahn, E., Finley, D. A., Frieman, J., Marriner, J., Wester, W., Aldering, G., Gupta, R., Kim, A. G., Thomas, R. C., Barbary, K., Bloom, J. S., Goldstein, D., Nugent, P., Perlmutter, S., Foley, R. J., Pan, Y. -C, Casas, R., Castander, F. J., Papadopoulos, A., Morganson, E., Desai, S., Paech, K., Smith, R. C., Schubnell, M., and High Energy Astrophys. & Astropart. Phys (API, FNWI)

Abstract

We report new spectroscopic classifications by OzDES of supernovae discovered by the Dark Energy Survey (ATEL #4668). The spectra (370-885nm) were obtained with the AAOmega Spectrograph (Saunders et al. 2004, SPIE, 5492, 389) and the 2dF fibre positioner at the Anglo-Australian Telescope (AAT).

13. [Influence of genetic factors on multiple sclerosis]

Author

Sommer N, Zipp F, Rösener M, Dichgans J, and Roland Martin

Subjects
Male, Multiple Sclerosis, Tumor Necrosis Factor-alpha, T-Lymphocytes, Receptors, Antigen, T-Cell, Twins, Monozygotic, Autoimmune Diseases, HLA Antigens, Diseases in Twins, Cytokines, Humans, Twin Studies as Topic, Chromosomes, Human, Pair 6, Female
Abstract

Epidemiological studies have provided evidence for a genetic contribution to the susceptibility of multiple sclerosis (MS). One in six patients has at least one affected family member. The concordance rate is approximately 25% in monozygotic twins, and 3% in siblings, however the prevalence in adopted siblings is similar to the general population (0.1%) MS is thought to be a T cell-mediated autoimmune disease and therefore genes controlling the immune response have been studied intensively as potential susceptibility factors. The best documented association was found for genes of the human-leukocyte antigen complex. Other possible susceptibility genes may reside in the regions of the T cell receptors and the tumour necrosis factors. So far it is clear, that MS is a multifactorial disease in which several genes must be involved. Population genetics and molecular biology will help to characterise further these susceptibility factors.

14. Safety and tolerability of a 'refrigeration-free' formulation of interferon beta-1b - Results of a double-blind, multicentre, comparative study in patients with relapsing-remitting or secondary progressive multiple sclerosis

Author

Baum, K., Baumhackl, U., Schautzer, F., Seeldrayers, P., Moonen, G., Dive, D., Decoo, D., D Hooghe, M., Brochet, B., Confavreux, C., Roullet, E., Edan, G., Einhaeupl, K., Gehlen, W., Schimrigk, S., Sindern, E., Koelmel, W., Hufnagel, A., Hoffmann, F., Heidenreich, F., Petereit, H., Sommer, N., Zettl, U., Komoly, S., Csiba, L., Vecsei, L., Trojano, M., Maria Giovanna Marrosu, Mancardi, G., Pedrosa, R., Genis, D., Arbizu, T., Merino, A. G., Kappos, L., and Bannermerschult, R.

15. Quasar Accretion Disk Sizes With Continuum Reverberation Mapping From the Dark Energy Survey

Author

Mudd, D., Martini, P., Zu, Y., Kochanek, C., Peterson, B., Kessler, R., Davis, T. M., Hoorman, J., King, A., Lidman, C., Sommer, N., Tucker, B. E., Asorey, J., Glazebrook, K., Kuehn, K., Lewis, G., Moller, A., O Neill, C., Abbott, T. M. C., Abdalla, F. B., Allam, S., Banerji, M., Benoit-Lévy, A., Bertin, E., Carnero Rosell, A., Carollo, D., Carrasco Kind, M., Carretero, J., Cunha, C. E., D Andrea, C. B., Da Costa, L. N., Davis, C., Desai, S., Doel, P., Fosalba, P., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Honscheid, K., James, D. J., Kuhlmann, S., Kuropatkin, N., Lima, M., Maia, M. A. G., Marshall, J. L., Mcmahon, R. G., Felipe Menanteau, Miquel, R., Plazas, A. A., Romer, A. K., Sanchez, E., Schindler, R., Schubnell, M., Smith, M., Smith, R. C., Soares-Santos, M., Sobreira, F., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., Tucker, D. L., and Walker, A. R.

17. First cosmology results using type Ia supernovae from the Dark Energy Survey: the effect of host galaxy properties on supernova luminosity

Author

Geraint F. Lewis, C. Frohmaier, David J. Brooks, Samuel Hinton, G. Gutierrez, Sunayana Bhargava, Jennifer L. Marshall, Brad E. Tucker, Eli S. Rykoff, Michel Aguena, A. R. Walker, Josh Frieman, Mark Sullivan, B. Flaugher, Elisabeth Krause, A. Carnero Rosell, M. Pursiainen, G. Tarle, R. R. Gupta, Tim Eifler, D. L. Burke, David J. James, Lluís Galbany, M. E. C. Swanson, Michael Schubnell, Pablo Fosalba, E. Macaulay, R. C. Thomas, S. Allam, Robert A. Gruendl, M. Carrasco Kind, I. Sevilla-Noarbe, J. De Vicente, Robert C. Nichol, Ramon Miquel, E. Suchyta, C. B. D'Andrea, K. Honscheid, Karl Glazebrook, Douglas L. Tucker, Antonella Palmese, N. Kuropatkin, Kyler Kuehn, M. A. G. Maia, Marcus Lima, P. Wiseman, T. N. Varga, L. N. da Costa, Tamara M. Davis, Juan Garcia-Bellido, Daniela Carollo, Peter Melchior, Peter Nugent, Claudia P. Gutiérrez, Felipe Menanteau, Daniel Scolnic, M. Costanzi, A. Roodman, M. Vincenzi, Enrique Gaztanaga, Ryan J. Foley, V. Scarpine, S. Everett, M. Sako, D. L. Hollowood, S. Serrano, Richard Kessler, A. A. Plazas, L. Kelsey, D. J. Brout, W. G. Hartley, N. E. Sommer, A. K. Romer, Paul Martini, F. Paz-Chinchón, M. Smith, Daniel Gruen, Anais Möller, E. Bertin, Peter Doel, H. T. Diehl, Niall MacCrann, J. Gschwend, C. Lidman, E. Swann, Daniel Thomas, E. Buckley-Geer, Santiago Avila, S. Desai, T. M. C. Abbott, E. J. Sanchez, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), DES, Smith, M., Sullivan, M., Wiseman, P., Kessler, R., Scolnic, D., Brout, D., D'Andrea, C. B., Davis, T. M., Foley, R. J., Frohmaier, C., Galbany, L., Gupta, R. R., Gutiérrez, C. P., Hinton, S. R., Kelsey, L., Lidman, C., Macaulay, E., Möller, A., Nichol, R. C., Nugent, P., Palmese, A., Pursiainen, M., Sako, M., Swann, E., Thomas, R. C., Tucker, B. E., Vincenzi, M., Carollo, D., Lewis, G. F., Sommer, N. E., Abbott, T. M. C., Aguena, M., Allam, S., Avila, S., Bertin, E., Bhargava, S., Brooks, D., Buckley-Geer, E., Burke, D. L., Carnero Rosell, A., Carrasco Kind, M., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Eifler, T. F., Everett, S., Flaugher, B., Fosalba, P., Frieman, J., García-Bellido, J., Gaztanaga, E., Glazebrook, K., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., James, D. J., Krause, E., Kuehn, K., Kuropatkin, N., Lima, M., Maccrann, N., Maia, M. A. G., Marshall, J. L., Martini, P., Melchior, P., Menanteau, F., Miquel, R., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Roodman, A., Rykoff, E. S., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., Tucker, D. L., Varga, T. N., Walker, A. R., Des, Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
transients: supernovae, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Stellar mass, astro-ph.GA, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, distance scale, 01 natural sciences, Cosmology, Luminosity, surveys, supernovae: general, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, survey, 010303 astronomy & astrophysics, STFC, Astrophysics::Galaxy Astrophysics, Physics, 010308 nuclear & particles physics, Star formation, Equation of state (cosmology), RCUK, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, Supernova, Space and Planetary Science, cosmology: observations, Astrophysics of Galaxies (astro-ph.GA), astro-ph.CO, Dark energy, Astrophysics::Earth and Planetary Astrophysics, supernovae [transients], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], general [supernovae], observation [cosmology], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present improved photometric measurements for the host galaxies of 206 spectroscopically confirmed type Ia supernovae discovered by the Dark Energy Survey Supernova Program (DES-SN) and used in the first DES-SN cosmological analysis. Fitting spectral energy distributions to the $griz$ photometric measurements of the DES-SN host galaxies, we derive stellar masses and star-formation rates. For the DES-SN sample, when considering a 5D ($z$, $x_1$, $c$, $\alpha$, $\beta$) bias correction, we find evidence of a Hubble residual `mass step', where SNe Ia in high mass galaxies ($>10^{10} \textrm{M}_{\odot}$) are intrinsically more luminous (after correction) than their low mass counterparts by $\gamma=0.040\pm0.019$mag. This value is larger by $0.031$mag than the value found in the first DES-SN cosmological analysis. This difference is due to a combination of updated photometric measurements and improved star formation histories and is not from host-galaxy misidentification. When using a 1D (redshift-only) bias correction the inferred mass step is larger, with $\gamma=0.066\pm0.020$mag. The 1D-5D $\gamma$ difference for DES-SN is $0.026\pm0.009$mag. We show that this difference is due to a strong correlation between host galaxy stellar mass and the $x_1$ component of the 5D distance-bias correction. To better understand this effect, we include an intrinsic correlation between light-curve width and stellar mass in simulated SN Ia samples. We show that a 5D fit recovers $\gamma$ with $-9$mmag bias compared to a $+2$mmag bias for a 1D fit. This difference can explain part of the discrepancy seen in the data. Improvements in modeling correlations between galaxy properties and SN is necessary to determine the implications for $\gamma$ and ensure unbiased precision estimates of the dark energy equation-of-state as we enter the era of LSST., Comment: 27 pages, 13 figures; Submitted to MNRAS

Published
2020
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18. Supernova Siblings: Assessing the Consistency of Properties of Type Ia Supernovae that Share the Same Parent Galaxies

Author

W. G. Hartley, V. Scarpine, N. E. Sommer, I. Sevilla-Noarbe, David J. Brooks, David J. James, G. Tarle, N. Kuropatkin, A. A. Plazas, Jennifer L. Marshall, Ramon Miquel, K. D. Eckert, Ryan J. Foley, T. N. Varga, L. N. da Costa, L. Kelsey, K. Kuehn, Karl Glazebrook, Lluís Galbany, C. Lidman, Samuel Hinton, Robert Morgan, Anais Möller, E. Bertin, E. Suchyta, Marcus Lima, G. Gutierrez, Edward Macaulay, P. Doel, Geraint F. Lewis, Alex Drlica-Wagner, M. Costanzi, J. Gschwend, D. J. Brout, Daniela Carollo, Salcedo Romero de Ávila, A. Massiah, T. F. Eifler, Tianjun Li, Michael Schubnell, P. Wiseman, J. Annis, Brodie Popovic, Joshua A. Frieman, T. M. C. Abbott, P. Fosalba, R. D. Wilkinson, M. Pursiainen, S. Everett, E. J. Sanchez, H. T. Diehl, K. Honscheid, M. Carrasco Kind, M. Sako, Robert C. Nichol, D. L. Hollowood, M. E. C. Swanson, B. Flaugher, S. Serrano, Richard Kessler, S. Desai, Enrique Gaztanaga, M. N. K. Smith, Mark Sullivan, Felipe Menanteau, K. Bechtol, Juan Garcia-Bellido, A. Carnero Rosell, A. R. Walker, J. De Vicente, Antonella Palmese, Daniel Gruen, D. L. Burke, M. A. G. Maia, Daniel Scolnic, B. P. Thomas, D. W. Gerdes, S. Allam, Robert A. Gruendl, B. E. Tucker, Michel Aguena, J. Carretero, R. Hounsell, Tamara M. Davis, F. Paz-Chinchón, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), DES, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), National Aeronautics and Space Administration (US), European Commission, European Research Council, Department of Energy (US), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Scolnic, D., Smith, M., Massiah, A., Wiseman, P., Brout, D., Kessler, R., Davis, T. M., Foley, R. J., Galbany, L., Hinton, S. R., Hounsell, R., Kelsey, L., Lidman, C., Macaulay, E., Morgan, R., Nichol, R. C., Moller, A., Popovic, B., Sako, M., Sullivan, M., Thomas, B. P., Tucker, B. E., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Bechtol, K., Bertin, E., Brooks, D., Burke, D. L., Rosell, A. C., Carollo, D., Kind, M. C., Carretero, J., Costanzi Alunno Cerbolini, M., Da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Drlica-Wagner, A., Eckert, K., Eifler, T. F., Everett, S., Flaugher, B., Fosalba, P., Frieman, J., Garcia-Bellido, J., Gaztanaga, E., Gerdes, D. W., Glazebrook, K., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Kuropatkin, N., Lewis, G. F., Li, T. S., Lima, M., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Palmese, A., Paz-Chinchon, F., Plazas, A. A., Pursiainen, M., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Sommer, N. E., Suchyta, E., Swanson, M. E. C., Tarle, G., Varga, T. N., Walker, A. R., and Wilkinson, R.

Subjects
Observational cosmology, Cosmology and Nongalactic Astrophysics (astro-ph.CO), 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Type (model theory), 01 natural sciences, 7. Clean energy, Consistency (statistics), 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Line (formation), Physics, Astronomy and Astrophysics, Light curve, Astrophysics - Astrophysics of Galaxies, Galaxy, Supernova, Distance modulus, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Dark energy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

DES Collaboration: et al. arXiv:2002.00974v2, While many studies have shown a correlation between properties of the light curves of SNe Ia and properties of their host galaxies, it remains unclear what is driving these correlations. We introduce a new direct method to study these correlations by analyzing "parent" galaxies that host multiple SNe Ia "siblings." Here, we search the Dark Energy Survey SN sample, one of the largest samples of discovered SNe, and find eight galaxies that hosted two likely SNe Ia. Comparing the light-curve properties of these SNe and recovered distances from the light curves, we find no better agreement between properties of SNe in the same galaxy as any random pair of galaxies, with the exception of the SN light-curve stretch. We show at 2.8σ significance that at least one-half of the intrinsic scatter of SNe Ia distance modulus residuals is not from common host properties. We also discuss the robustness with which we could make this evaluation with LSST, which will find 100× more pairs of galaxies, and pave a new line of study on the consistency of SNe Ia in the same parent galaxies. Finally, we argue that it is unlikely that some of these SNe are actually single, lensed SN with multiple images., D.S. is supported by DOE grant DE-SC0010007, the David and Lucile Packard Foundation. D.S. and R.K. are supported in part by NASA under Contract No. NNG17PX03C issued through the WFIRST Science Investigation Teams Programme. D.B. and M.S. were supported by DOE grant DE-FOA0001358 and NSF grant AST-1517742. L.G. was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 839090. This research used resources of the National Energy Research Scientific Computing Center (NERSC), a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. We are grateful for the support of the University of Chicago Research Computing Center for assistance with the calculations carried out in this work. R.F. is supported in part by NSF grants AST-1518052 and AST1815935, the Gordon & Betty Moore Foundation, the HeisingSimons Foundation, and by fellowships from the David and Lucile Packard Foundation, as well as the NASA contract above. Funding for the DES Projects has been provided by the U.S. Department of Energy, the U.S. National Science Foundation, the Ministry of Science and Education of Spain, the Science and Technology Facilities Council of the United Kingdom, the Higher Education Funding Council for England, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign, the Kavli Institute of Cosmological Physics at the University of Chicago, the Center for Cosmology and Astro-Particle Physics at the Ohio State University, the Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University, Financiadora de Estudos e Projetos, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico and the Ministério da Ciência, Tecnologia e Inovação, the Deutsche Forschungsgemeinschaft and the Collaborating Institutions in the Dark Energy Survey. The Collaborating Institutions are Argonne National Laboratory, the University of California at Santa Cruz, the University of Cambridge, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas-Madrid, the University of Chicago, University College London, the DES-Brazil Consortium, the University of Edinburgh, the Eidgenössische Technische Hochschule (ETH) Zürich, Fermi National Accelerator Laboratory, the University of Illinois at UrbanaChampaign, the Institut de Ciències de l’Espai (IEEC/CSIC), the Institut de Física d’Altes Energies, Lawrence Berkeley National Laboratory, the Ludwig-Maximilians Universität München and the associated Excellence Cluster Universe, the University of Michigan, the National Optical Astronomy Observatory, the University of Nottingham, The Ohio State University, the University of Pennsylvania, the University of Portsmouth, SLAC National Accelerator Laboratory, Stanford University, the University of Sussex, Texas A&M University, and the OzDES Membership Consortium. Based in part on observations at Cerro Tololo InterAmerican Observatory, National Optical Astronomy Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. The DES data management system is supported by the National Science Foundation under grant Nos. AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MINECO under grants AYA2015-71825, ESP2015-66861, FPA2015-68048, SEV2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Australian Research Council Centre of Excellence for All-sky Astrophysics (CAASTRO), through project number CE110001020, and the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) e-Universe (CNPq grant 465376/2014-2). We acknowledge support from EU/FP7-ERC grant No. 615929. This manuscript has been authored by Fermi Research Alliance, LLC under Contract No. DE-AC02-07CH11359 with the U.S. Department of Energy, Office of Science, Office of High Energy Physics.

Published
2020

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