1. Grading of MRI-detected skull-base invasion in nasopharyngeal carcinoma with skull-base invasion after intensity-modulated radiotherapy
- Author
-
Qiaoying Hu, Yanru Feng, Xiaozhong Chen, and Caineng Cao
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Oncology ,Male ,medicine.medical_specialty ,Intensity-modulated radiotherapy ,lcsh:R895-920 ,medicine.medical_treatment ,Skull-base invasion ,American joint committee on Cancer staging system ,lcsh:RC254-282 ,Skull Base Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Single entity ,Internal medicine ,Chart review ,medicine ,otorhinolaryngologic diseases ,Humans ,Radiology, Nuclear Medicine and imaging ,Neoplasm Invasiveness ,Progression-free survival ,Grading (tumors) ,Retrospective Studies ,Nasopharyngeal Carcinoma ,business.industry ,Research ,Radiotherapy Dosage ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Magnetic Resonance Imaging ,Radiation therapy ,Survival Rate ,Skull ,medicine.anatomical_structure ,Nasopharyngeal carcinoma ,030220 oncology & carcinogenesis ,Female ,Intensity modulated radiotherapy ,Radiotherapy, Intensity-Modulated ,Neoplasm Grading ,business ,Prognostic value ,Follow-Up Studies - Abstract
Background The aim of this study is to evaluate the prognostic value of grading MRI–detected skull-base invasion in nasopharyngeal carcinoma (NPC) with skull-base invasion after intensity-modulated radiotherapy (IMRT). Methods This study is a retrospective chart review of 469 non-metastatic NPC patients with skull-base invasion. Patients were classified as extensive skull-base invasion (ESBI) group and limited skull-base invasion (LSBI) group. Results Multivariate analysis showed that the skull-base invasion (LSBI vs. ESBI) was an independent prognostic predictor of progression free survival (PFS). The estimated 5-year local failure free survival (LFFS), distant metastasis free survival (DMFS), PFS, and overall survival (OS) rates for patients in the T3-LSBI and T3-ESBI group were 92.9% versus 93.5, 89.8% versus 86.1, 81.6% versus 76.4, and 93.5% versus 86.3%, respectively (P > 0.05). Conclusion Grading of MRI-detected skull-base invasion is an independent prognostic factor of NPC with skull-base invasion. It is scientific and reasonable for skull-base invasion as a single entity to be classified as T3 classification.
- Published
- 2018