1. Long-Term Efficacy of Serenoa repens Treatment in Patients with Mild and Moderate Symptomatic Benign Prostatic Hyperplasia
- Author
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Ioiart I, Bogdan Petrut, Ioan Coman, Gangu C, Miclea F, Constantin T, Geavlete P, Bogdan Feciche, Ambert, Sinescu I, and Multescu R
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,media_common.quotation_subject ,Serenoa repens ,Hyperplasia ,medicine.disease ,Urination ,medicine.anatomical_structure ,Quality of life ,Prostate ,Lower urinary tract symptoms ,medicine ,International Prostate Symptom Score ,Sexual function ,business ,media_common - Abstract
Introduction: The study aimed to evaluate the long-term efficacy of treatment with extract of Serenoa repens (Prostamol Uno) in patients with lower urinary tract symptoms (LUTS) induced by benign prostatic hyperplasia (BPH). Patients and Methods: We studied 120 patients with mild or moderate LUTS induced by BPH, maximal urinary flow (Qmax) Serenoa repens. Results: Statistically significant improvements in the International Prostate Symptom Score (5.5 points), quality of life (QoL; 1.8 points), Qmax (5.6 ml/s), International Index of Erectile Function (IIEF; 6.4 points) and reduction in residual urinary volume were observed during the study period. The mean prostate volume at 24 months was 36 ml, compared to 39.8 ml at baseline. Conclusions: Long-term treatment with 320 mg ethanolic extract of Serenoa repens proved to be efficient in reducing urinary obstruction, improving symptomatology and QoL of BPH patients. It also had a positive effect on sexual function, demonstrated by the statistically significant increase in the IIEF.
- Published
- 2011
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