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Objective: To investigate the effect of hyperbaric oxygen therapy (HBOT) on the iNOS mRNA-iNOS-NO signaling pathway and neurofunction protected in a rat spinal cord injury model. Methods: A total of 36 Sprague-Dawley rats were randomly divided into 3 groups: control group (n=12), SCI group (n=12) and SCI + HBOT group (n=12). SCI + HBOT group In the SCI group and SCI + HBOT groups, SCI was performed on rats. In the SCI + HBOT group, rats with SCI underwent HBO treatment 30 min after SCI for 24 sessions. After HBO therapy, measurement of motor evoked potential (MEP), Basso, Beattie, Bresnahan (BBB) scoring and pathological examination were done. RT-PCR and immunohistochemistry were employed to detect the mRNA and protein expression of iNOS, respectively. Diazo colorimetry was performed to detect the serum NO content. Results: The mRNA and protein expression of iNOS in the spinal cord and the serum NO content were markedly increased in the SCI group as compared to the control group (P

To compare the therapeutic effect of hyperbaric oxygen (HBO) treatment and pharmacotherapy with that of pharmacotherapy alone in sudden deafness (SD) patients, and to evaluate the impact of therapeutic time window on the therapeutic effect, a total of 264 patients with SD were assigned into HBO group and control group. Patients in the HBO group received routine pharmacotherapy and HBO treatment, and those in the control group were only routinely treated with drugs. Acoustic impedance measurement and pure tone audiometry were performed before and after treatment. The hearing after treatment at different time windows was compared with that before treatment. The overall efficacy in the HBO group was significantly superior to that of the control group (P 0.05). The results demonstrated that the efficacy of HBO combined treatment was superior to that of routine pharmacotherapy for SD patients, and HBO treatment can favorably improve the hearing of these patients. HBO treatment initiated early after symptom onset (