1. Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate
- Author
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Shui-Mei Zhang, Kun Hu, Xiao-Nian Li, Han-Dong Sun, and Pema-Tenzin Puno
- Subjects
Pharmacology ,Organic Chemistry ,Plant Science ,Toxicology ,Biochemistry ,Food Science ,Analytical Chemistry - Abstract
A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculata. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. Graphical Abstract
- Published
- 2022