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The current of the distribution networks under 66kV is widely operating in small current grounding mode. The problem of extracting the fault feature in each line would be quite difficult due to the short duration of the transient zero sequence current with the non-stationary and non-linear characteristics when the single-phase-to-ground fault occurs in the system. Therefore, a novel method of single-phase-to-ground fault line selection for small current based on Fast S-transform (FST) is developed in this paper. Firstly, FST is presented to transform the transient electric current signal in each feeder, after that the one-dimension modulus and phase angle value can been obtained. Then, the feeder with the largest energy value calculated by the modulus obtained above is selected as the alternative possible fault line. Finally, line failure or bus failure can been determined by evaluating the difference of the phase angle between the fault line and the comparison line that has been selected from the non-alternative feeders before. The results of the simulative and experimental circuits reveal that the proposed method using FST can avoid the influence of neural point grounding type. Additionally, the method of line selection is quite accurate and real-time.

DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, (5hmC) leading to eventual DNA demethylation. It has been reported that TET1 is a tumour suppressor in several cancers. However, whether TET1 plays a role in glioma development is largely unclear. Different glioma specimens and corresponding normal controls were collected to analyse the expression of TET1. At the same time, TET1 of glioma U251 cells was knocked down or overexpressed to observe its effect on glioma cell proliferation and invasion as well as autophagy level. Here, we reported that the expression of TET1 in glioma tissue was significantly lower than the corresponding non-tumour normal tissues, and the concentration of TET1 is negatively correlated with the glioma WHO classification. When TET1 gene in glioma U251 cells was knocked down by CRISPR/Caspase-9 system, the proliferation and invasive ability of U251 increased remarkably. But when TET1 was overexpressed in U251 cells, the proliferation and invasion were impaired. Following the down-expression of TET1, the level of autophagy in U251 cells decreased accordingly.However, when TET1 was overexpressed in U251 cells, the level of autophagy incraesed. Furthermore, bafilomycin A1 (Baf-A1) but not 3-methyladenine (3-MA) could decrease the autophagy level of TET1−/− U251 cells as the wild-type controls. It suggests that the tumour suppressor effect of TET1 seems to be mediated by regulating the level of autophagy, and the regulation of TET1 on autophagy is at an early stage.

Professional football league has been held for 14 years in China, the occurrence of soccer violence is rising year by year. Violence control is such a complicated problem that depends on the joint cooperation and effort of Chinese football association, football clubs, media, and football players. The soccer violence in China is the interaction outcome of social, mental and environment factors. In the long run, the key to solve problem lays in the referee management, player enlightenment, as well as the perfection of soccer competition regulations.