1. Effect of ligustrazine on nitric oxide contents in cerebrospinal fluid and plasma of patients with cerebral infarction
- Author
-
Li Deyang, Shi Yiting, Chen Yuping, Li Ru, and Dai Feng
- Subjects
Curative effect ,medicine.medical_specialty ,business.industry ,Cerebral infarction ,General Medicine ,Brain tissue ,medicine.disease ,Gastroenterology ,Nitric oxide ,chemistry.chemical_compound ,Ischemic brain ,Cerebrospinal fluid ,chemistry ,Anesthesia ,Internal medicine ,Medicine ,Cerebral damage ,business ,After treatment - Abstract
Objective To probe into the significance of Nitric Oxide (NO) in ischemic cerebral damage and effect of ligustrazine on it. Methods The NO contents in cerebrospinal fluid (CSF) and plasma of 20 controls and 62 patients with arteriosclerotic thrombotic cerebral infarction (ligustrazine group and common treatment group) were determined with Griess method before and after treatment. Results The NO content in CSF before treatment was higher in severe type, it was higher than that in moderate type, and than that in mild type, again higher than that in control group (all P 0.05), but there was a trend that plasma NO content decreased as the patient's condition worsened. After treatment, the curative effect and plasma NO content of ligustrazine group were both markedly higher than those of common treatment group (P 0.05). Conclusions Excessive NO produced in brain tissue and insufficient plasma NO participate the course of ischemic brain damage. Ligustrazine could increase the contents of plasma NO selectively.
- Published
- 1998
- Full Text
- View/download PDF