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Wolfiporia cocos is commonly used as a traditional Chinese medicine for its diuretic, tonifying, and invigorating effects on the spleen. However, the epidermis of W. cocos is discarded as scrap during harvesting because of its low price, resulting in a great waste of resources and environmental pollution. In this work, the epidermis of W. cocos was studied and three new lanostane triterpenoids were isolated. The structures were determined using NMR and HRESIMS, with absolute configurations established by comparison of the calculated and experimental ECD spectra. The three new compounds were evaluated for their antimicrobial activities in vitro against Staphylococcus aureus, Escherichia coli, and Saccharomyces cerevisiae. None of the tested compounds showed inhibition against these three strains of indicator microbes at a concentration of 128 μg/ml. This study provides a reference for further medicinal development and the utilization of the epidermis of W. cocos.

Alpha-pinene is an important forest chemical resource, and the cis-pinane obtained by its hydrogenation reaction is used in spices, medicine, and other industries. A hollow nanospheric material with amphiphilic properties in a two-sided structure was prepared, with a nitrogen-doped carbon layer towards the inside and mesoporous silica in the outer layer of the nanospheres. The amphiphilic catalyst with non-precious nickel as the active component was synthesized by loading nickel onto the nanospheres using a simple impregnation method and applied to the aqueous phase hydrogenation reaction of α-pinene. The mesoporous structure of the catalyst shortened the mass transfer distance and thus reduced the mass transfer resistance. The nitrogen atoms doped in the carbon matrix provided anchor points for stabilizing the metal nanoparticles; the hydrophilic outer surface and hydrophobic hollow cavity enabled the catalyst to be well dispersed in water while still enriching the organic matter in aqueous solution. The effect of various reaction conditions on the catalytic reaction was investigated. The catalysts showed excellent activity and good stability, suggesting a new green and efficient method for more effective exploitation of biomass pine resin resources, and providing a reference for expanding the application of non-precious metal catalysts.

P-N junctions or heterostructures are commonly used in the fabrication of self-driven photodetectors because they serve critical roles in influencing the electrical characteristics of two-dimensional (2D) materials. For stable 2D heterostructures, planar WSe2 monolayers have attracted a lot of interest. Using first-principles energetic and dynamic calculations, we find that the transition from the indirect band gap of WSe2 bulk phase to the direct band gap of a two-dimensional plane is caused by the formation of p-n hetero junctions. Furthermore, it affects the carrier concentration transport mode and results in a significant orbital spin coupling. There is no virtual frequency in the phonon dispersion curve across the Brillouin zone at zero pressure. The interaction of the nearest neighbour atoms causes the frequency of the two acoustic modes of the G-point to be zero, as well as the frequency of the two optical films to merge. The theoretical analysis can provide support for the transport of two-dimensional planar carriers in electronics and photonics.

Development of solid oxide fuel cell (SOFC) anode with high resistance to coking and sulfur poisoning is highly desirable for the direct application of natural gas in SOFC. Herein, a (Cu, Sm)CeO2 anode with anchored Cu nanoparticles has been prepared. Most of Cu nanoparticles particle size ranges from 20 to 50 nm, which can increase the conductivity and catalytic activity of the anode. The Cu/CSCO10 supported cell exhibits a maximum power density of 404.6 mW/cm2 at 600 ⁰C when dry methane is used as fuel while its ohmic resistance is only 0.39 Ω·cm2. The single SOFC shows good stability when H2S content in the fuel is less than 150 ppm. Up to 900 hours of continuous stable operation with simulated natural gas and commercial natural gas as fuel prove the advantages and application potential of this anode.

BACKGROUND: Pulmonary carcinoids (PC), including typical (TC) and atypical carcinoids (AC), are low-grade neuroendocrine tumors (NETs) which account for 1–5% of all lung tumors. Due to the low prevalence of PC and extreme rarity of anaplastic lymphoma kinase (ALK) rearrangements in patients with PC, the advances in targeted therapy development in PC are still limited and there is no standard treatment. Even though in patients with PC harboring ALK rearrangements there is a room for a success in targeted therapy. To our knowledge, case 1 was the first report to detect ALK gene p.I1171N mutation after taking alectinib and sensitive to ceritinib in patients with atypical carcinoid. CASE DESCRIPTION: Herein, we report the cases of 2 non-smoking patients, 51 year-old female with tumor in left lower lobe and 49 year-old female with tumor in right upper lobe, both with metastatic PC who harbored EML4-ALK fusion and were sensitive to small-molecule ALK inhibitors. The first patient initially received alectinib, then therapy was switched to ceritinib after developing drug resistance due to the missense mutation of ALK gene p.I1171N mutation in exon 22 detected by next-generation sequencing (NGS), and finally died of intracranial disease progression. The second patient also received alectinib, and her treatment is currently ongoing with good effect and tolerance. After conducting comprehensive review of literature, we found that 14 lung NETs with ALK rearrangements have been reported to date. The clinical outcome was partial response for 6 NETs patients and 5 patients exhibited stable disease after treatment with ALK inhibitors. CONCLUSIONS: According to the effectiveness of ALK inhibitors in our cases and previous articles, we recommend alectinib for the first-line treatment of metastatic PC with EML4-ALK fusion and highlight the need for molecular profiling of metastatic lung NETs patients and that ALK inhibitors are feasible in the treatment for metastatic lung NETs patients with ALK rearrangements. Finally, further studies to assess the real prevalence of ALK gene fusions and their spectrum of sensitivity to different ALK inhibitors are needed in larger cohorts.

Background: Primary gallbladder gastrinoma is an exceptionally uncommon tumor which is a rare form of neuroendocrine neoplasm. Until now, no cases of primary gallbladder gastrinoma and rare cases of primary gastrinoma from the biliary system have been reported. Case presentation: We reported a 50-year-old female with watery diarrhea and intermittently received proton pump inhibitors as treatment. Enhanced computed tomography (CT) imaging and Octreotide imaging uncovered a solitary tumor at the hepatic hilar region. The tumor was found originated from the wall of the gallbladder during the surgery and a subsequent laparoscopic cholecystectomy was exerted. Histological analysis revealed a primary neuroendocrine tumor from the gallbaldder. Conclusion: This case confirmed that primary gallbladder gastrinoma represents a distinct nosological entity. Immunohistochemical analysis plays a pivotal role in the diagnosis process. Due to limited knowledge regarding primary gallbladder gastrinoma, we aim to contribute valuable insights into this rare condition by providing unique information and present the therapeutic value of surgery.

Background: As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning researches got progress in this field. This study sought to investigate the development pattern of TIME-related research in recent years from a bibliometric perspective. Methods: We acquired both articles and reviews related to TIME from the Web of Science Core Collection (WoSCC) (retrieved on September 14, 2022). R package “Bibliometrix” was used to calculate the basic bibliometric features, present the collaborative conditions of countries and authors and generate a three-field plot to show the relationships among authors, affiliations, and keywords. VOSviewer was utilized for co-authorship analysis of country and institution and keyword co-occurrence analysis. CiteSpace was used for citation burst analysis of keywords and cited references. Results: A total of 2545 publications on TIME were included. China, the USA, and Japan had the highest number of publications. Frontiers in Oncology had the highest number of publications. Apart from “expression,” “cancer,” and “cells,” the terms “survival,” “immunotherapy,” and “T-cells” were coequally the most frequently mentioned keywords. Conclusions: This bibliometric study analyzed 16 years of TIME-related research and sketched out a basic knowledge framework that includes publications, countries, journals, authors, institutions, and keywords. The results provided a thorough overview on the broad landscape of this research area.

Gradually aggravated disease caused by phytopathogenic bacteria severely restricts food security and crop yield, and few pesticides can relieve this severe situation. Thus, development and excavation of new agrochemicals with high bioactivity and novel action mechanism may be a feasible strategy to control intractable bacterial diseases. As a privileged molecular framework, steroid molecules exhibit diversiform bioactivities. Herein, a series of novel androst-4-ene derivatives were designed, synthesised and investigated for their antibacterial behaviour to excavate novel agrochemicals on the base of steroid molecules.Bioassay results indicated that target compounds displayed high bioactivities toward three destructive phytopathogenic bacteria, including Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac) and Pseudomonas syringae pv. actinidiae (Psa). Compound IIIGiven these profiles of target compounds, we highlight a new strategy for controlling intractable plant bacterial diseases by inducing plant resistance and targeting the bacterial cell membrane. © 2022 Society of Chemical Industry.

By theoretical calculation, the crystal structure, stability, and electron-phonon interactions of calcium dinitride (CaN2) have been described, and CaN2 is predicted to be a superconducting material. The action mechanism of thermodynamics about CaN2 are induced through the Debye-Grüneisen model. The dispersion curves of CaN2 show large pseudo-gaps in the 400–1300 cm−1 range. The total of the electron-phonon coupling constants for CaN2 is given by λ = 0.37, with a corresponding estimated superconducting temperature of Tc ≈ 1 K. The estimated superconducting temperature of CaN2 rose to 28.8 K as the pressure increased to 10 GPa, and then decreased monotonically at higher pressures to almost zero at 50 GPa.

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin lymphoma and is a very aggressive malignancy with tumor growing rapidly in organs like lymph nodes. The pathogenesis of DLBCL is not clear and the prognosis of DLBCL requires improvement. Here, we investigated the mechanisms of DLBCL, with the focus on lncRNA PVT1/miR-34b-5p/Foxp1 axis. Human DLBCL tissues from diagnosed DLBCL patients and four human DLBCL cell lines, one normal human B lymphoblastoid cell line were used. qRT-PCR and western blotting were employed to measure expression levels of lncRNA PVT1, Foxp1, miR-34b-5p, β-catenin, and proliferation-related proteins. MTT assay and colony formation assay were performed to determine cell proliferation. Flow cytometry was used to examine cell apoptosis. ChIP and Dual-luciferase assay were utilized to validate interactions of Foxp1/promoters, PVT1/miR-34b-5p and miR-34b-5p/Foxp1. Mouse tumor xenograft model was used to determine the effect of sh-PVT1 on tumor growth in vivo. In this study, we found PVT1 and Foxp1 were elevated in DLBCL tissues and cells while miR-34b-5p was decreased. Knockdown of PVT1, overexpression of miR-34b-5p, or Foxp1 knockdown repressed DLBCL cell proliferation but enhanced cell apoptosis. PVT1 directly bound miR-34b-5p to disinhibit Foxp1/β-catenin signaling. Foxp1 regulated CDK4, CyclinD1, and p53 expression via binding with their promoters. Knockdown of Foxp1 partially reversed the effects of miR-34b-5p inhibitor on DLBCL cell proliferation and apoptosis. Inhibition of PVT1 through shRNA suppressed DLBCL tumor growth in vivo. All in all, lncRNA PVT1 promotes DLBCL progression via acting as a miR-34b-5p sponge to disinhibit Foxp1/β-catenin signaling.

The Nickel-Salen precursor was pyrolyzed to Ni/NiOx nanostructure OER/UOR electrocatalysts, where the process was tracked by TG-MS technology detecting small-molecule fragments.

Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the pathogenesis of which is still unclear. Renal tubulointerstitial lesions have been identified as a key pathological hallmark of RF pathology. Renal tubular epithelial cells are the resident cells of the tubulointerstitium and play an important role in kidney recovery versus renal fibrosis following injury. Studies in recent years have shown that senescence of renal tubular epithelial cells can accelerate the progression of renal fibrosis. Oxidative stress(OS), telomere attrition and DNA damage are the major causes of renal tubular epithelial cell senescence. Current interventions and therapeutic strategies for cellular senescence include calorie restriction and routine exercise, Klotho, senolytics, senostatics, and other related drugs. This paper provides an overview of the mechanisms and the key signaling pathways including Wnt/β-catenin/RAS, Nrf2/ARE and STAT-3/NF-κB pathway involved in renal tubular epithelial cell senescence in RF and therapies targeting renal tubular epithelial cell senescence future therapeutic potential for RF patients. These findings may offer promise for the further treatment of RF and CKD.

Background/Aims The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. The present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on myocardial I/R injury by inhibiting complement activation and inflammation and whether exosomal heat shock protein 90 (HSP90) mediates these effects. Methods Rat hearts underwent 30 min of coronary ligation followed by 2 h of reperfusion. Plasma exosomes were isolated from RIPC rats and injected into the infarcted myocardium immediately after ligation. Sixty rats were randomly divided into Sham, I/R, I/R + RIPC-Exo (50 µg/µl), and RIPC-Exo + GA (geldanamycin, 1 mg/kg, administration 30 min before ligation) groups. Cardiomyocyte apoptosis, the release of myocardial markers (LDH, cTnI and CK-MB), infarct size, the expression of HSP90, complement component (C)3, C5a, c-Jun N-terminal kinase (JNK), interleukin (IL)-1β, tumor necrosis factor (TNF)-alpha and intercellular adhesion molecule -1 (ICAM-1) were assessed. Results RIPC-Exo treatment significantly reduced I/R-induced cardiomyocyte apoptosis, the release of myocardial markers (LDH, cTnI and CK-MB) and infarct size. These beneficial effects were accompanied by decreased C3 and C5a expression, decreased inflammatory factor levels (IL-1β, TNF-α, and ICAM-1), decreased JNK and Bax, and increased Bcl-2 expression. Meanwhile, the expression of HSP90 in the exosomes from rat plasma increased significantly after RIPC. However, treatment with HSP90 inhibitor GA significantly reversed the cardioprotection of RIPC-Exo, as well as activated complement component, JNK signalling and inflammation, indicating that HSP90 in exosomes isolated from the RIPC was important in mediating the cardioprotective effects during I/R. Conclusion Exosomal HSP90 induced by RIPC played a significant role in cardioprotection against I/R injury, and its function was in part linked to the inhibition of the complement system, JNK signalling and local and systemic inflammation, ultimately alleviating I/R-induced myocardial injury and apoptosis by the upregulation of Bcl-2 expression and the downregulation of proapoptotic Bax.

Ultracold polyatomic molecules offer intriguing new opportunities in cold chemistry, precision measurements, and quantum information processing, thanks to their rich internal structure. However, their increased complexity compared to diatomic molecules presents a formidable challenge to employ conventional cooling techniques. Here, we demonstrate a new approach to create ultracold polyatomic molecules by electroassociation in a degenerate Fermi gas of microwave-dressed polar molecules through a field-linked resonance. Starting from ground state NaK molecules, we create around $1.1\times 10^3$ tetratomic (NaK)$_2$ molecules, with a phase space density of $0.040(3)$ at a temperature of $134(3)\,\text{nK}$, more than $3000$ times colder than previously realized tetratomic molecules. We observe a maximum tetramer lifetime of $8(2)\,\text{ms}$ in free space without a notable change in the presence of an optical dipole trap, indicating these tetramers are collisionally stable. The measured binding energy and lifetime agree well with parameter-free calculations, which outlines pathways to further increase the lifetime of the tetramers. Moreover, we directly image the dissociated tetramers through microwave-field modulation to probe the anisotropy of their wave function in momentum space. Our result demonstrates a universal tool for assembling ultracold polyatomic molecules from smaller polar molecules, which is a crucial step towards Bose--Einstein condensation (BEC) of polyatomic molecules and towards a new crossover from a dipolar Bardeen-Cooper-Schrieffer (BCS) superfluid to a BEC of tetramers. Additionally, the long-lived FL state provides an ideal starting point for deterministic optical transfer to deeply bound tetramer states.

Optical mirrors determine cavity properties by means of light reflection. Imperfect reflection gives rise to open cavities with photon loss. We study an open cavity made of atom-dimer mirrors with a tunable reflection spectrum. We find that the atomic cavity shows anti-$\mathcal{PT}$ symmetry. The anti-$\mathcal{PT}$ phase transition controlled by atomic couplings in mirrors indicates the emergence of two degenerate cavity supermodes. Interestingly, a threshold of mirror reflection is identified for realizing strong coherent cavity-atom coupling. This reflection threshold reveals the criterion of atomic mirrors to produce a good cavity. Moreover, cavity quantum electrodynamics with a probe atom shows mirror-tuned properties, including reflection-dependent polaritons formed by the cavity and probe atom. Our work presents a non-Hermitian theory of an anti-$\mathcal{PT}$ atomic cavity, which may have applications in quantum optics and quantum computation., Comment: 7 pages, 5 figures

Exploring new noncovalent bonding motifs with reversibly tunable binding affinity is of fundamental importance in manipulating the properties and functions of supramolecular self-assembly systems and materials. Herein, for the first time, we demonstrate a unique visible-light-switchable telluro-triazole/triazolium-based chalcogen bonding (ChB) system in which the Te moieties are connected by azobenzene cores. The binding strengths between these azo-derived ChB receptors and the halide anions (Cl

A photo-switchable hetero-complementary quadruple H-bonding array, which consists of an azobenzene-derived ureidopyrimidinone (UPy) module (Azo-UPy) and a nonphotoactive diamidonaphthyridine (DAN) derivative (Napy-1), is constructed based on a reversible photo-locking approach. Upon UV (390 nm)/Vis (460 nm) light irradiations, photo-switchable quadruple H-bonded dimerization between Azo-UPy and Napy-1 can be achieved with exhibiting 4.8×104 -fold differences in binding strength (ON/OFF ratios). Furthermore, smart polymeric gels with unique photo-controlled macroscopic self-assembly behavior can be fabricated by introducing such quadruple H-bonding array as photo-regulable noncovalent interfacial connections.

The transition from glacial to interglacial periods has been hypothesized to be linked to millennial-scale changes in oceanic/atmospheric circulation, but the relationships between these phenomena remain poorly constrained. Here we present a speleothem oxygen isotope record from Yongxing Cave, China, spanning 40.9 to 33.1 ka and compare this to existing Antarctic proxy records. We find that decadal-to-centennial rapid shifts in the Asian summer monsoon, Antarctic temperature, atmospheric methane and carbon dioxide are all coupled together during Dansgaard–Oeschger cycles, which may suggest an important role of the Intertropical Convergence Zone and Southern Ocean in driving the global greenhouse gas changes. Analogous to millennial-scale variations in trend, amplitude and internal sub-centennial-scale structures during Dansgaard–Oeschger 8 and Heinrich Stadial 4, the Younger Dryas and Heinrich Stadial 1 during the last ice termination provided critical positive feedbacks to changes in terrestrial vegetation and northern ice volume, and may have contributed to glacial to interglacial transition.

BackgroundDespite providing clinical benefit, immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in a number of patients. This study explored the development pattern in irAEs research from a bibliometric perspective.MethodsWe obtained articles and reviews related to irAEs from the Web of Science Core Collection (WoSCC) (retrieved on September 13, 2022). Using the R package “Bibliometrix”, the main bibliometric features were calculated, and a three-filed plot was generated to show the relationship between authors, institutions, and topics. VOSviewer was used for co-authorship and keyword co-occurrence analysis and visualization. CiteSpace was used to detect burst references and keywords.ResultsA total of 3995 publications on irAEs were included. The United States (US), Japan, and China had the highest publications. The Journal for ImmunoTherapy of Cancer had the highest number of publications. In addition to “immune-related adverse events”, “immune checkpoint inhibitors”, “immunotherapy”, and “nivolumab” were the most frequently used keywords.ConclusionsA bibliometric analysis of 17 years of irAEs research was conducted to map a basic knowledge structure including countries, institutions, authors, journals, and publications. The findings provided a comprehensive perspective on the broad future of this research area.

Pine wilt disease has caused huge losses in ecological and economic values in China, especially in the southern parts. Analyzing the spatial distribution of pine wilt disease and quantifying the impact of environmental factors on its occurrence were of great significance for its prevention and control. In this study, we examined the spatial pattern of pine wilt disease occurrence and its response to environmental variables in Nankang District, Ganzhou, Jiangxi Province, using kernel-smoothing density, Ripley's松材线虫病在中国大陆造成了巨大的生态与经济价值损失,南方地区尤为严重,分析松材线虫病空间分布、量化环境因素对其发生的影响对于松材线虫病的防控整治具有重要意义。本研究以江西省赣州市南康区松材线虫病为研究对象,采用核平滑密度、Ripley’s

BackgroundCardiovascular complications in patients with acute upper gastrointestinal bleeding (AUGIB) have been associated with a high-risk of subsequent adverse consequences. This study aimed to analyze the risk factors for myocardial injury in AUGIB patients, predict the risk of myocardial injury, and explore the clinical prognosis and influencing factors in AUGIB patients with myocardial injury.Materials and methodsA retrospective case-control study based on AUGIB patients in the First Affiliated Hospital of Xi’an Jiaotong University from 2016 to 2020 was performed. We divided the enrolled patients into a myocardial injury group and a control group according to whether they developed myocardial injury. The variables significant in the univariate analysis were subjected to binary logistic regression for risk factor analysis and were used to establish a nomogram for predicting myocardial injury. In addition, logistic regression analysis was performed to better understand the risk factors for in-hospital mortality after myocardial injury.ResultOf the 989 AUGIB patients enrolled, 10.2% (101/989) developed myocardial injury. Logistic regression analysis showed that the strong predictors of myocardial injury were a history of hypertension (OR: 4.252, 95% CI: 1.149–15.730, P = 0.030), blood urea nitrogen (BUN) (OR: 1.159, 95% CI: 1.026–1.309, P = 0.018) and left ventricular ejection fraction (LVEF) P = 0.037). The patients with a tumor history (digestive system tumors and non-digestive system tumors) had no significant difference between the myocardial injury group and the control group (P = 0.246). A prognostic nomogram model was established based on these factors with an area under the receiver operator characteristic curve of 0.823 (95% CI: 0.730–0.916). The patients with myocardial injury had a much higher in-hospital mortality rate (10.9% vs. 2.0%, P < 0.001), and an elevated D-dimer level was related to in-hospital mortality among the AUGIB patients with myocardial injury (OR: 1.273, 95% CI: 1.085–1.494, P = 0.003).ConclusionA history of hypertension, renal dysfunction, and cardiac function with LVEF

Background Patients with non-alcoholic fatty liver disease (NAFLD) may be more susceptible to coronavirus disease 2019 (COVID-19) and even more likely to suffer from severe COVID-19. Whether there is a common molecular pathological basis for COVID-19 and NAFLD remains to be identified. The present study aimed to elucidate the transcriptional alterations shared by COVID-19 and NAFLD and to identify potential compounds targeting both diseases. Methods Differentially expressed genes (DEGs) for COVID-19 and NAFLD were extracted from the GSE147507 and GSE89632 datasets, and common DEGs were identified using the Venn diagram. Subsequently, we constructed a protein–protein interaction (PPI) network based on the common DEGs and extracted hub genes. Then, we performed gene ontology (GO) and pathway analysis of common DEGs. In addition, transcription factors (TFs) and miRNAs regulatory networks were constructed, and drug candidates were identified. Results We identified a total of 62 common DEGs for COVID-19 and NAFLD. The 10 hub genes extracted based on the PPI network were IL6, IL1B, PTGS2, JUN, FOS, ATF3, SOCS3, CSF3, NFKB2, and HBEGF. In addition, we also constructed TFs–DEGs, miRNAs–DEGs, and protein–drug interaction networks, demonstrating the complex regulatory relationships of common DEGs. Conclusion We successfully extracted 10 hub genes that could be used as novel therapeutic targets for COVID-19 and NAFLD. In addition, based on common DEGs, we propose some potential drugs that may benefit patients with COVID-19 and NAFLD.

Background: Microgrid is an effective integration mode of distributed generation (DG). It can eliminate the negative effect caused by the intermittent DG and consume the energy locally. Methods: For a public distribution network, a microgrid performs as a controllable and flexible unit. However, when the public distribution network has the demand of flexible regulation, there is no reasonable quantitative indexes to evaluate the flexibility of microgrid for dispatching decision. For this problem, the operational flexibility indexes of a microgrid are defined in this paper. Results: The indexes are quantified according to the maximum energy and active power regulation margin of each flexible equipment in the microgrid. The operational flexibility of microgrid is closely related to the scheduling strategy. Therefore the corresponding dispatching model of a microgrid is also provided in this paper. Conclusion: A case study shows how to calculate and use these flexibility indexes in an operation cycle of a microgrid system with energy storage (ES) facility and demonstrates the availability and practicability of the evaluation indexes and the method.

Carbonaceous materials present the promising anode candidates for sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs), however, the poor rate performance and low capacity due to limited interlayer spacing greatly impact their practical application. Herein, we report soybean roots-derived mesoporous hard carbon constructed by N, P co-doping (NPDCs) with enlarged interlayer distance and more active sites for high-performance SIBs and PIBs. As a result, the optimized NPDC achieves an excellent cyclic stability (197 mA g−1 after 2000 cycles at 2.0 A g−1) for SIBs, superior rate capability (a high reversible capacity of 179 mAh g−1 at 5.0 A g−1) for PIBs. Kinetic and first-principles calculation studies further demonstrate the dual-doping improves the Na (K) ions diffusion and adsorption as well as electrons transport. This work provides a facile and sustainable strategy to realize advanced carbon-based materials with heteratoms doping in application for energy storage devices.

Tropomyosin (TM) is an important allergen in molluscans. However, there was a lack of information about TM as an allergen in oysters. TM was purified and identified from

The distribution pattern of forest fuel loading is driven by the interaction of environmental factors, such as terrain and vegetation. Based on field sampling data of surface dead fuels of seven main forest types in southern Jiangxi Province, and according to the classification standard of different time-lags, we constructed structural equation models to explore the relationship between surface fuel loadings and environmental factors such as terrain and vegetation森林可燃物载量分布格局是植被与地形等环境因子之间相互作用的结果。本研究通过野外实测赣南地区主要7种森林类型地表死可燃物载量数据,依据时滞可燃物分类标准,构建了地表可燃物载量与地形、植被等环境因子间的结构方程模型,并分析了各因子的影响路径及其直接、间接和总效应。结果表明: 7种不同森林类型中,1、10和100 h时滞可燃物载量均是针阔混交林内最高,毛竹林内最低。对1 h时滞载量影响最大的变量依次为:坡度(影响系数为0.40)＞树冠高度(0.07)＞树种(-0.03)＞郁闭度(0.01);对10 h时滞载量影响最大的变量依次为:胸径(0.15)＞树种(-0.09)＞坡向(-0.08)＞郁闭度(-0.06);对100 h时滞载量影响最大的变量依次为:坡向(0.25)＞胸径(0.19)＞郁闭度(-0.08)＞树种(0.02);对可燃物总载量影响最大的变量依次为:坡度(0.22)＞树种(-0.04)、郁闭度(-0.04)＞树冠高度(-0.01)。.

BackgroundFailure to CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), is an emerging clinical problem. There is no consensus on the treatment for these patients and treatment remains empirical.Case ReportWe reported a case of an elderly R/R DLBCL patient who had TP53 mutation and relapsed 12 months after initial response to CAR T-cell therapy. The patient did not respond to salvage chemotherapy with the GDP regimen and could not tolerate any aggressive chemotherapy. Thereafter, the patient was given chidamide and zanubrutinib. After two months of treatment, the patient achieved sustained complete remission. At the last follow-up, the patient remains in radiographic CR 22 months after CAR-T infusion and 10 months after the initiation of the combination treatment.ConclusionWe report the first successful case of dual inhibition of HDAC and BTK for the treatment of R/R DLBCL after failure to CAR-T cell therapy, which opens a new therapeutic possibility for the future.

Due to the sodium abundance and availability, sodium-ion batteries (SIBs) have the potential to meet the worldwide growing demand of electrical energy storage. P2-type sodium transition-metal layer oxides with a high energy density are considered as the most promising cathode materials for SIBs. We present here a detailed study of the enhanced rate capability and cyclic stability of the Ti-doped Na0.67Ni0.33Mn0.67O2 cathode material. The combined analysis of ex-situ X-ray absorption fine structure (XAFS) spectroscopy, aberration-corrected high resolution transmission electron microscopy (AB-HRTEM) and X-ray diffraction (XRD) show that the strong Ti–O bond in the transition metal layers stabilizes the local structure, destroy the Na+-vacancy ordering and arrest the irreversible multiphase transformation that occurs during the intercalation/deintercalation process. Actually, Na0.67Ni0.33Mn0.52Ti0.15O2 exhibits a reversible capacity of 89.6 mA h g−1 even at 5 C, an excellent cyclability with 88.78 % capacity retention after 200 cycles at 0.5 C. This study provides a better understanding in optimization of the design of high-energy cathode materials based on titanium doped layered oxides for SIBs.

Compressed materials of fossil foliage described here as Itea polyneura sp. nov. (Iteaceae) were collected from the Oligocene of Wenshan, Yunnan Province, southwestern China. The identification is based on the following characters: eucamptodromous secondary veins, strict scalariform tertiary veins, irregular tooth with setaceous apex. The leaf morphology of all modern and fossil species was compared with the new species from Wenshan and show that I. polyneura is most similar to the extant East Asian species Itea omeiensis, which inhabits subtropical forests of southern China. This discovery represents the first unambiguous leaf fossil record of Itea in East Asia. Together with other species in the Wenshan flora and evidence from several other flora in southern China, these findings demonstrate that Itea from East Asia arose with the Paleogene modernization. Copyright (C) 2020 Kunming Institute of Botany, Chinese Academy of Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.