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Your search keyword '"Shao, Jiang-Yang"' showing total 3 results
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3 results on '"Shao, Jiang-Yang"'

1. Downregulation of SATB1 increases the invasiveness of Jurkat cell via activation of the WNT/β-catenin signaling pathway in vitro

Author

Li Tan, Lihua Xu, Yaya Wang, Huo Tan, Xiaodan Luo, Xiaohong Wu, Shao-Jiang Yang, Runhui Zheng, Jiani Wang, and Dan Liu

Subjects
Adult, 0301 basic medicine, T-cell leukemia, Down-Regulation, Biology, Jurkat cells, Metastasis, Jurkat Cells, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Humans, Leukemia-Lymphoma, Adult T-Cell, Neoplasm Invasiveness, RNA, Messenger, RNA, Neoplasm, RNA, Small Interfering, Wnt Signaling Pathway, Gene knockdown, Gene Expression Profiling, Wnt signaling pathway, Matrix Attachment Region Binding Proteins, General Medicine, SATB1, medicine.disease, Neoplasm Proteins, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, RNA Interference, Signal transduction
Abstract

Special AT-rich sequence-binding protein-1 (SATB1) is critical for genome organizer that reprograms chromatin organization and transcription profiles, and associated with tumor growth and metastasis in several cancer types. Many studies suggest that SATB1 overexpression is an indicator of poor prognosis in various cancers, such as breast cancer, malignant cutaneous melanoma, and liver cancer. However, their expression patterns and function values for adult T cell leukemia (ATL) are still largely unknown. The aim of this study is to examine the levels of SATB1 in ATL and to explore its function and mechanisms in Jurkat cell line. Here, we reported that SATB1 expressions were decreased in ATL cells (p

Published
2015

2. Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia with Chromothripsis in an Old Woman

Author

Li-Hua Xu, Shao-Jiang Yang, Li Tan, and Hai-Bo Liu

Subjects
Lymphoma, B-Cell, Chromothripsis, Single Nucleotide Polymorphism Array, Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia, Chronic lymphocytic leukemia, Isochromosome, lcsh:Medicine, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Malignant transformation, Clinical Practice, medicine, Humans, SNP, In Situ Hybridization, Fluorescence, Genetics, medicine.diagnostic_test, lcsh:R, Karyotype, General Medicine, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Karyotyping, Cancer research, Female, Fluorescence in situ hybridization
Abstract

Cell karyotyping in patients with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) is not easy to success, and small genomic lesions (

Published
2015

3. Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML

Author

Li Tan, Hai-Bo Liu, Shao-Jiang Yang, Jincai Zeng, Xiaoping Wei, Lixia Zheng, and Huo Tan

Subjects
0301 basic medicine, Adult, Male, Cancer Research, Adolescent, Mice, Nude, HL-60 Cells, Cell Growth Processes, Flow cytometry, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, HMGA2, hemic and lymphatic diseases, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, Protein kinase B, PI3K/AKT/mTOR pathway, In Situ Hybridization, Fluorescence, Aged, Gene knockdown, Mice, Inbred BALB C, biology, medicine.diagnostic_test, Cell growth, TOR Serine-Threonine Kinases, HMGA2 Protein, Gene Amplification, General Medicine, Cell cycle, Middle Aged, Molecular biology, Leukemia, Myeloid, Acute, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Cancer research, biology.protein, Heterografts, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

The aim of this study was to investigate how the amplification of HMGA2 contributes to acute myeloid leukemia (AML) cell proliferation. The amplification and expression of HMGA2 were examined by FISH, qRT-PCR and Western blot in AML cases. The effect of HMGA2 knockdown on cell proliferation was analyzed with XTT, colony-forming assays and BrdUrd incorporation assays. The effects of HMGA2 knockdown on cell cycle were studied by flow cytometry analysis. The progression of AML cells in vivo was examined by the xenografted tumor model. The interaction between Akt pathway and HMGA2 was examined by Western blot. HMGA2 is amplified in AML, and the levels of HMGA2 messenger RNA (mRNA) and protein expressed in AML cells were significantly higher than those in normal cells, which may be related to NR and prognosis of AML patients. Reduction in HMGA2 expression in AML cells inhibited cell proliferation through a decrease in the protein expression of pAkt and pmTOR, compared with control cells. HMGA2 is predominantly amplified and expressed in AML cells, and that aberrant expression of HMGA2 induces AML cell proliferation through the PI3K/Akt/mTOR signaling pathway. Inhibition of HMGA2 expression represents an attractive target for AML therapy.

Published
2015

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