193 results on '"Shanbao Tong"'
Search Results
2. Evaluation of Brain Source Localization Methods Based on Test-retest Reliability with Multiple Session EEG Data
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Xuewei Qin, Lizhao Du, Xiong Jiao, Jingyi Wang, Shanbao Tong, Tifei Yuan, and Junfeng Sun
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Biomedical Engineering - Published
- 2023
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Catalog
3. The efficacy of low-intensity transcranial ultrasound stimulation on negative symptoms in schizophrenia: A double-blind, randomized sham-controlled study
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Zhaolin Zhai, Liyuan Ren, Zhenhua Song, Qiong Xiang, Kaiming Zhuo, Suzhen Zhang, Xuan Li, Yi Zhang, Xiong Jiao, Shanbao Tong, Junfeng Sun, and Dengtang Liu
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General Neuroscience ,Biophysics ,Neurology (clinical) - Published
- 2023
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4. Transmissive multifocal laser speckle contrast imaging through thick tissue
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Ruoyu Chen, Peng Miao, and Shanbao Tong
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Biomedical Engineering ,Medicine (miscellaneous) ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Abstract
Laser speckle contrast imaging (LSCI) is a powerful tool for monitoring blood flow changes in tissue or vessels in vivo, but its applications are limited by shallow penetration depth under reflective imaging configuration. The traditional LSCI setup has been used in transmissive imaging for depth extension up to [Formula: see text]–[Formula: see text] ([Formula: see text] is the transport mean free path), but the blood flow estimation is biased due to the depth uncertainty in large depth of field (DOF) images. In this study, we propose a transmissive multifocal LSCI for depth-resolved blood flow in thick tissue, further extending the transmissive LSCI for tissue thickness up to [Formula: see text]. The limited-DOF imaging system is applied to the multifocal acquisition, and the depth of the vessel is estimated using a robust visibility parameter [Formula: see text] in the coherent domain. The accuracy and linearity of depth estimation are tested by Monte Carlo simulations. Based on the proposed method, the model of contrast analysis resolving the depth information is established and verified in a phantom experiment. We demonstrated its effectiveness in acquiring depth-resolved vessel structures and flow dynamics in in vivo imaging of chick embryos. more...
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- 2023
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5. Test-retest reliability of duration-related and frequency-related mismatch negativity
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Shanbao Tong, Jingyi Wang, Liu Kai, Xiong Jiao, Junfeng Sun, and Tingting Chen
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medicine.medical_specialty ,Mismatch negativity ,Electroencephalography ,Audiology ,behavioral disciplines and activities ,Correlation ,Physiology (medical) ,medicine ,Humans ,Attention ,In patient ,Oddball paradigm ,Reliability (statistics) ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,General Medicine ,Healthy Volunteers ,Acoustic Stimulation ,Psychotic Disorders ,Neurology ,Duration (music) ,Potential biomarkers ,Evoked Potentials, Auditory ,Neurology (clinical) ,business - Abstract
Objectives –Mismatch negativity (MMN) has been demonstrated as a potential biomarker for pre-attentive processing and prognosis in patients with psychosis. However, previous studies mainly evaluated the reliability of MMN across only two repeated sessions, which is inadequate to draw a convincing conclusion. The current study aimed to assess multi-session test-retest reliability in duration-related MMN (dMMN) and frequency-related MMN (fMMN). Methods –We recorded four repeated sessions of electroencephalography (EEG) from 16 healthy participants in an oddball task. MMNs were extracted and their reliability was evaluated by intra-class coefficient (ICC). We also analyzed the correlation between fMMN and dMMN. Results –Both dMMN and fMMN amplitudes exhibited good test-retest reliability, and fMMN had better reliability (average ICC = 0.7279) than dMMN (average ICC = 0.6974). Moreover, dMMN and fMMN showed more than moderate linear correlation in amplitudes (r = 0.598, CI: [0.100, 0.857]). Conclusion –Both the duration- and frequency-related MMN amplitudes were highly reliable across four-session experiments. These results provide further evidence for the potential utility of MMNs as biomarkers in research into brain function, and prognosis in psychotic illness. more...
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- 2021
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6. Transcranial Ultrasound Stimulation
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Junfeng Sun and Shanbao Tong
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- 2023
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7. Motor network reorganization after motor imagery training in stroke patients with moderate to severe upper limb impairment
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Hewei Wang, Xin Xiong, Kexu Zhang, Xu Wang, Changhui Sun, Bing Zhu, Yiming Xu, Mingxia Fan, Shanbao Tong, Xiaoli Guo, and Limin Sun
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Pharmacology ,Psychiatry and Mental health ,Physiology (medical) ,Pharmacology (medical) - Abstract
Motor imagery training (MIT) has been widely used to improve hemiplegic upper limb function in stroke rehabilitation. The effectiveness of MIT is associated with the functional neuroplasticity of the motor network. Currently, brain activation and connectivity changes related to the motor recovery process after MIT are not well understood.We aimed to investigate the neural mechanisms of MIT in stroke rehabilitation through a longitudinal intervention study design with task-based functional magnetic resonance imaging (fMRI) analysis.We recruited 39 stroke patients with moderate to severe upper limb motor impairment and randomly assigned them to either the MIT or control groups. Patients in the MIT group received 4 weeks of MIT therapy plus conventional rehabilitation, while the control group only received conventional rehabilitation. The assessment of Fugl-Meyer Upper Limb Scale (FM-UL) and Barthel Index (BI), and fMRI scanning using a passive hand movement task were conducted on all patients before and after treatment. The changes in brain activation and functional connectivity (FC) were analyzed. Pearson's correlation analysis was conducted to evaluate the association between neural functional changes and motor improvement.The MIT group achieved higher improvements in FM-UL and BI relative to the control group after the treatment. Passive movement of the affected hand evoked an abnormal bilateral activation pattern in both groups before intervention. A significant Group × Time interaction was found in the contralesional S1 and ipsilesional M1, showing a decrease of activation after intervention specifically in the MIT group, which was negatively correlated with the FM-UL improvement. FC analysis of the ipsilesional M1 displayed the motor network reorganization within the ipsilesional hemisphere, which correlated with the motor score changes.MIT could help decrease the compensatory activation at both hemispheres and reshape the FC within the ipsilesional hemisphere along with functional recovery in stroke patients. more...
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- 2022
8. Upper-Limb Amputation Disrupts the Interhemispheric Structural Rather than Functional Connectivity
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Kexu Zhang, Chaowei Wu, Yuanyuan Lyu, Jianbo Xiang, Changjie Pan, Xiaoli Guo, and Shanbao Tong
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General Neuroscience - Published
- 2022
9. Nodal Memberships to Communities of Functional Brain Networks Reveal Functional Flexibility and Individualized Connectome
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Wen Jin, Xiaoke Xu, Jie Zhou, Junfeng Sun, Shanbao Tong, and Hong Zhu
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Theoretical computer science ,Resting state fMRI ,Computer science ,Cognitive Neuroscience ,Feature vector ,Community structure ,Brain ,Flexibility (personality) ,Bayes Theorem ,Cognition ,Magnetic Resonance Imaging ,Non-negative matrix factorization ,Cellular and Molecular Neuroscience ,Node (computer science) ,Connectome ,Humans ,Nerve Net - Abstract
Human brain network is organized as interconnected communities for supporting cognition and behavior. Despite studies on the nonoverlapping communities of brain network, overlapping community structure and its relationship to brain function remain largely unknown. With this consideration, we employed the Bayesian nonnegative matrix factorization to decompose the functional brain networks constructed from resting-state fMRI data into overlapping communities with interdigitated mapping to functional subnetworks. By examining the heterogeneous nodal membership to communities, we classified nodes into three classes: Most nodes in somatomotor and limbic subnetworks were affiliated with one dominant community and classified as unimodule nodes; most nodes in attention and frontoparietal subnetworks were affiliated with more than two communities and classified as multimodule nodes; and the remaining nodes affiliated with two communities were classified as bimodule nodes. This three-class paradigm was highly reproducible across sessions and subjects. Furthermore, the more likely a node was classified as multimodule node, the more flexible it will be engaged in multiple tasks. Finally, the FC feature vector associated with multimodule nodes could serve as connectome “fingerprinting” to gain high subject discriminability. Together, our findings offer new insights on the flexible spatial overlapping communities that related to task-based functional flexibility and individual connectome “fingerprinting.” more...
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- 2021
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10. The lateralization and reliability of spatial mismatch negativity elicited by auditory deviants with virtual spatial location
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Shanbao Tong, Jijun Wang, Xiong Jiao, Junfeng Sun, Chunwei Ying, and Yingying Tang
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medicine.medical_specialty ,Mismatch negativity ,Audiology ,behavioral disciplines and activities ,Head-related transfer function ,050105 experimental psychology ,Lateralization of brain function ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,medicine ,Humans ,0501 psychology and cognitive sciences ,Oddball paradigm ,Reliability (statistics) ,Spatial mismatch ,General Neuroscience ,05 social sciences ,Reproducibility of Results ,Electroencephalography ,Negativity effect ,Neuropsychology and Physiological Psychology ,Acoustic Stimulation ,Auditory Perception ,Evoked Potentials, Auditory ,Psychology ,Binaural recording ,030217 neurology & neurosurgery - Abstract
Mismatch negativity (MMN) is an intensively studied event-related potential component that reflects pre-attentive auditory processing. Existing spatial MMN (sMMN) studies usually use loud-speakers in different locations or deliver sound with binaural localization cues through earphones to elicit MMN, which either was practically complicated or sounded unnatural to the subjects. In the present study, we generated head related transfer function (HRTF)-based spatial sounds and verified that the HRTF-based sounds retained the left and the right spatial localization cues. We further used them as deviants to elicit sMMN with conventional oddball paradigm. Results showed that sMMN was successfully elicited by the HRTF-based deviants in 18 of 21 healthy subjects in two separate sessions. Furthermore, the left deviants elicited higher sMMN amplitudes in the right hemisphere compared to the left hemisphere, while the right deviants elicited sMMN with similar amplitudes in both hemispheres, which supports a combination of contralateral and right-hemispheric dominance in spatial auditory information processing. In addition, the sMMN in response to the right deviants showed good test-retest reliability, while the sMMN in response to the left deviants had weak test-retest reliability. These findings implicate that HRTF-based sMMN could be a robust paradigm to investigate spatial localization and discrimination abilities. more...
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- 2021
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11. The Resilience and Vulnerability of Human Brain Networks Across the Lifespan
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Jie Zhou, Wen Jin, Pin Shu, Junfeng Sun, Shanbao Tong, and Hong Zhu
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Adult ,Brain network ,Aging ,Brain Mapping ,General Neuroscience ,Longevity ,Rehabilitation ,Biomedical Engineering ,Vulnerability ,Brain ,Human brain ,Biology ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,Internal Medicine ,medicine ,Humans ,Resilience index ,Resilience (network) ,Brain aging ,Neuroscience ,Critical property ,Diffusion MRI - Abstract
Resilience, the ability for a system to maintain its basic functionality when suffering from lesions, is a critical property for human brain, especially in the brain aging process. This study adopted a novel metric of network resilience, the Resilience Index (RI), to assess human brain resilience with three different lifespan datasets. Based on the structural brain networks constructed from diffusion tensor imaging (DTI), we observed an inverted-U relationship between RI and age, that is, RI increased during development and early adulthood, reached a peak at about 35 years old, and then decreased during aging, which suggested that brain resilience could be quantified by RI. Furthermore, we studied brain network vulnerability by the decreases in RI when virtual lesions occurred to nodes (i.e., brain regions) or edges (i.e., structural brain connectivity). We found that the strong edges were markedly vulnerable, and the homotopic edges were the most prominent representatives of vulnerable edges. In other words, an arbitrary attack on homotopic edges would have a high probability to degrade brain network resilience. These findings suggest the change of human brain resilience across the lifespan and provide a new perspective for exploring human brain vulnerability. more...
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- 2021
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12. Optogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia
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Shanbao Tong, Wanlu Li, Bin Bo, Yongting Wang, and Yao Li
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Male ,Intracellular pH ,Biophysics ,Ischemia ,Rodentia ,Stimulation ,Optogenetics ,Neuroprotection ,050105 experimental psychology ,Brain Ischemia ,lcsh:RC321-571 ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,0501 psychology and cognitive sciences ,Laser speckle contrast imaging ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Acidosis ,Neurons ,Chemistry ,General Neuroscience ,Penumbra ,05 social sciences ,Interhemispheric lateralization ,medicine.disease ,pH imaging ,Rats ,Disease Models, Animal ,Cerebral blood flow ,Cerebrovascular Circulation ,Neurology (clinical) ,Protons ,medicine.symptom ,Optogenetic ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Background Intracellular acidosis in the ischemic penumbra can contribute to further cell death, effectively enlarging the infarct core. Restoring the acid-base balance may enhance tissue survivability after cerebral ischemia. Objective This study investigated whether translocating protons out of penumbral neurons could mitigate tissue acidification and induce neuroprotection in a rodent model of acute cerebral ischemia. Methods We modulated the penumbral neurons via a light-driven pump to translocate protons out (i.e., archaerhodopsin/ArchT group) or into (i.e., channelrhodopsin-2/ChR2 group) neurons after focal cerebral ischemia in rats. Intracellular pH values were imaged via neutral red (NR) fluorescence and cerebral blood flow (CBF) was monitored through laser speckle contrast imaging (LSCI). Global CBF responses to electrical stimulation of the hindlimbs were obtained 24 h and 48 h after ischemia to assess neurological function. Behavioral and histological outcomes were evaluated 48 h after ischemia. A control group without gene modification was included. Results The reduction of relative pH (RpH), the amplitude of negative peak of hypoemic response (RNP) and the hemispheric lateralization index (LI) in ArchT group were significantly less than those of the ChR2 or control group. Moreover, RpH was strongly correlated with RNP (r = 0.60) and LI (r24h = 0.80, r48h = 0.59). In addition, behavioral and histological results supported a neuroprotective effect of countering neuronal acidosis in penumbra through optogenetic stimulation. Conclusion(s) These results indicate that countering intracellular acidosis by optogenetically translocating protons out of penumbral neurons during the acute ischemic stage could induce protection after ischemic brain injury. more...
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- 2020
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13. The effects of pre-cue posterior alpha on post-cue alpha activity and target processing in visual spatial attention tasks with instructional and probabilistic cues
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Jiaqi Wang, Jianan Wang, Junfeng Sun, Chunbo Li, Shanbao Tong, and Xiangfei Hong
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Cellular and Molecular Neuroscience ,Cognitive Neuroscience - Abstract
The electroencephalography alpha-band (8–13 Hz) activity may represent a crucial neural substrate of visual spatial attention. However, factors likely contributing to alpha activity have not been adequately addressed, which impedes understanding its functional roles. We investigated whether pre-cue alpha power was associated with post-cue alpha activity in 2 independent experiments (n = 30 each) with different cueing strategies (instructional vs. probabilistic) by median-splitting subjects (between-subject) or trials (within-subject) according to pre-cue alpha. In both experiments, only subjects with higher pre-cue alpha showed significant post-cue alpha desynchronization and alpha lateralization, while whether trials had higher or lower pre-cue alpha affected post-cue alpha desynchronization but not alpha lateralization. Furthermore, significant attentional modulation of target processing indexed by N1 component was observed in subjects and trials regardless of higher or lower pre-cue alpha in the instructional cueing experiment. While in the probabilistic cueing experiment, N1 attentional modulation was only observed in higher pre-cue alpha subjects and lower pre-cue alpha trials. In summary, by demonstrating the effects of pre-cue alpha and cueing strategy on post-cue alpha activity and target processing, our results suggest the necessity of considering these 2 contributing factors when investigating the functional roles of alpha activity in visual spatial attention. more...
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- 2022
14. Deep-learning-based 3D blood flow reconstruction in transmissive laser speckle imaging
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Ruoyu Chen, Shanbao Tong, and Peng Miao
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Atomic and Molecular Physics, and Optics - Abstract
Transmissive laser speckle imaging (LSI) is useful for monitoring large field-of-view (FOV) blood flow in thick tissues. However, after longer transmissions, the contrast of the transmitted speckle images is more likely to be blurred by multiple scattering, resulting in decreased accuracy and spatial resolution of deep vessels. This study proposes a deep-learning-based strategy for high spatiotemporal resolution three-dimensional (3D) reconstruction from a single transilluminated laser speckle contrast image, providing more structural and functional details without multifocus two-dimensional (2D) imaging or 3D optical imaging with point/line scanning. Based on the correlation transfer equation, a large training dataset is generated by convolving vessel masks with depth-dependent point spread functions (PSF). The UNet and ResNet are used for deblurring and depth estimation. The blood flow in the reconstructed 3D vessels is estimated by a depth-dependent contrast model. The proposed method is evaluated with simulated data and phantom experiments, achieving high-fidelity structural reconstruction with a depth-independent estimation of blood flow. This fast 3D blood flow imaging technique is suitable for real-time monitoring of thick tissue and the diagnosis of vascular diseases. more...
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- 2023
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15. Spectral domain isolation of ballistic component in visible light OCT based on random matrix description
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Danlei Qiao, Ian S. Rubinoff, Jibo Zhou, John B. Troy, Hao F. Zhang, Shanbao Tong, and Peng Miao
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Computer Networks and Communications ,Atomic and Molecular Physics, and Optics - Abstract
Visible light optical coherence tomography (vis-OCT) provides a unique tool for imaging both structure and oxygen metabolism in ophthalmology. Working in visible light bandwidth, it suffers from noises due to strong scattering, especially in the blood. This work established the random matrix (RM) description of vis-OCT’s k-space data as ballistic and multiple scattering components. The eigenvalue density of the hybrid RM follows a low-rank biased Marčenko–Pastur law. The ballistic component can thus be separated out using a generalized likelihood ratio test algorithm. The RM-based method was validated by both the Monte Carlo simulation and ex vivo pure blood phantom study. We further demonstrated that the RM-based method could significantly improve the imaging quality in the human fundus, showing more details of the layered structure than current vis-OCT with [Formula: see text] increase of signal-to-noise ratio, measuring the blood oxygen value more accurately, and enabling better structure visualization than the traditional method, a 1.6-fold higher contrast-to-noise ratio in raster scan mode. The isolated ballistic component also fits the Beer–Lambert law better, giving more accurate oxygen saturation in arc scan mode. The RM-based method significantly improves the reconstruction quality in 3D and facilitates clinical diagnostics. As a general framework, random matrix description also provides a new separation strategy to estimate the ballistic component in other spectral domain OCT techniques. more...
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- 2023
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16. Separating single- and multiple-scattering components in laser speckle contrast imaging of tissue blood flow
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Yifan Zhang, Cheng Wang, Shanbao Tong, and Peng Miao
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Quantitative Biology::Tissues and Organs ,Physics::Medical Physics ,Article ,Atomic and Molecular Physics, and Optics ,Biotechnology - Abstract
Random matrix theory provides new insights into multiple scattering in random media. In a recent study, we demonstrated the statistical separation of single- and multiple-scattering components based on a Wishart random matrix. The first- and second-order moments were estimated with a Wishart random matrix constructed using dynamically backscattered speckle images. In this study, this new strategy was applied to laser speckle contrast imaging (LSCI) of in vivo blood flow. The random matrix-based method was adopted and parameterized using electric field Monte Carlo simulations and in vitro blood flow phantom experiments. The new method was further applied to in vivo experiments, demonstrating the benefits of separating the single- and multiple-scattering components, and the method was compared with the traditional temporal laser speckle contrast analysis (LASCA) method. More specifically, the new method separates the stimulus-induced functional changes in blood flow and tissue perfusion in the superficial (l t , l t is the transport mean free path) and deep layers (1l t ∼ 7l t ), extending LSCI to the evaluation of functional and pathological changes. more...
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- 2022
17. Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex
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Liyuan Ren, Zhaolin Zhai, Qiong Xiang, Kaiming Zhuo, Suzhen Zhang, Yi Zhang, Xiong Jiao, Shanbao Tong, Dengtang Liu, and Junfeng Sun
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Cellular and Molecular Neuroscience ,Biomedical Engineering - Abstract
Background. Low-intensity transcranial ultrasound stimulation (TUS) could induce both immediate and long-lasting neuromodulatory effects in human brains. Interhemispheric imbalance at prefrontal or motor cortices generally associates with various cognitive decline in aging and mental disorders. However, whether TUS could modulate the interhemispheric balance of excitability in human brain remains unknown. Objective. This study aims to explore whether repetitive TUS (rTUS) intervention can modulate the interhemispheric balance of excitability between bilateral motor cortex (M1) in healthy subjects. Approach. Motor evoked potentials (MEPs) at bilateral M1 were measured at 15 min and 0 min before a 15 min active or sham rTUS intervention on left M1 and at 0 min, 15 min and 30 min after the intervention, and the Chinese version of brief neurocognitive test battery (C-BCT) was conducted before and after the intervention respectively. Cortical excitability was quantified by MEPs, and the long-lasting changes of MEP amplitude was used as an index of plasticity. Results. In the active rTUS group (n = 20), the ipsilateral MEP amplitude increased significantly compared with baselines and lasted for up to 30 min after intervention, while the contralateral MEP amplitude decreased lasting for 15 min, yielding increased laterality between bilateral MEPs. Furthermore, rTUS intervention induced changes in some C-BCT scores, and the changes of scores correlated with the changes of MEP amplitudes induced by rTUS intervention. The sham rTUS group (n = 20) showed no significant changes in MEPs and C-BCT scores. In addition, no participants reported any adverse effects during and after the rTUS intervention, and no obvious temperature increase appeared in skull or brain tissues in simulation. Significance. rTUS intervention modulated the plasticity of ipsilateral M1 and the interhemispheric balance of M1 excitability in human brain, and improved cognitive performance, suggesting a considerable potential of rTUS in clinical interventions. more...
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- 2023
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18. The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks
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Ting Xue, Benjamin Chiao, Tianjiao Xu, Han Li, Kai Shi, Ying Cheng, Yuan Shi, Xiaoli Guo, Shanbao Tong, Menglin Guo, Soo Hong Chew, Richard P. Ebstein, and Donghong Cui
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Proteomics ,Meditation ,Proteome ,Cardiovascular Diseases ,Monks ,Brain ,Humans ,General Medicine ,Cholesterol, LDL ,Tibet ,Cardiovascular System ,General Biochemistry, Genetics and Molecular Biology ,Apolipoproteins B - Abstract
There have been mixed reports on the beneficial effects of meditation in cardiovascular disease (CVD), which is widely considered the leading cause of death worldwide.To clarify the role of meditation in modulating the heart-brain axis, we implemented an extreme phenotype strategy, i.e., Tibetan monks (BMI30) who practised 19.20 ± 7.82 years of meditation on average and their strictly matched non-meditative Tibetan controls. Hypothesis-free advanced proteomics strategies (Data Independent Acquisition and Targeted Parallel Reaction Monitoring) were jointly applied to systematically investigate and target the plasma proteome underlying meditation. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B) and lipoprotein (a) [Lp(a)] as the potential cardiovascular risk factors were evaluated. Heart rate variability (HRV) was assessed by electrocardiogram.Obesity, hypertension, and reduced HRV is offset by long-term meditation. Notably, meditative monks have blood pressure and HRV comparable to their matched Tibetan controls. Meditative monks have a protective plasma proteome, related to decreased atherosclerosis, enhanced glycolysis, and oxygen release, that confers resilience to the development of CVD. In addition, clinical risk factors in plasma were significantly decreased in monks compared with controls, including total cholesterol, LDL-C, Apo B, and Lp(a).To our knowledge, this work is the first well-controlled proteomics investigation of long-term meditation, which opens up a window for individuals characterized by a sedentary lifestyle to improve their cardiovascular health with an accessible method practised for more than two millennia.See the Acknowledgements section. more...
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- 2021
19. Temporal Characteristics of Attentional Disengagement from Emotional Facial Cues in Depression
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Qiangfeng Zhao, Yingying Tang, Shanbao Tong, Shan Chen, Xiong Jiao, Junfeng Sun, and Jijun Wang
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Adult ,Male ,medicine.medical_specialty ,Emotions ,Contingent Negative Variation ,Audiology ,Electroencephalography ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Reaction Time ,medicine ,Humans ,Attention ,0501 psychology and cognitive sciences ,Disengagement theory ,Depression (differential diagnoses) ,Cued speech ,Depressive Disorder, Major ,Facial expression ,medicine.diagnostic_test ,05 social sciences ,Perspective (graphical) ,Brain ,General Medicine ,Contingent negative variation ,Facial Expression ,Neurology ,Female ,Neurology (clinical) ,Analysis of variance ,Cues ,Psychology ,Facial Recognition ,030217 neurology & neurosurgery - Abstract
Summary Objectives Studies have reported that depressed patients have difficulties in disengaging attention from negative information, but knowledge of the temporal characteristics of this disengagement is still rudimentary. Our objective is to reveal the temporal characteristics of attentional disengagement from emotional facial cues in depression. Methods We recruited 22 depressed patients and 22 healthy controls to participate in a cued target-response task with emotional facial expressions (happy, natural, and sad) as cues and three types of cue-target intervals (CTIs: 350 ms, 1000 ms, and 1500 ms). Both behavioral and electroencephalography (EEG) data were collected from each subject while performing the task. Then, both behavioral results and event-related potentials (ERPs) were analyzed across groups (depressed patients and normal controls), emotional types of facial cues (happy, natural, and sad), and CTIs. Results Both depressed patients and healthy controls had shorter response times in the conditions of CTI = 1000 ms and 1500 ms than in the condition of CTI = 350 ms but had no significant difference in response time between the conditions of CTI = 1000 ms and CTI = 1500 ms. The contingent negative variation (CNV), a well-documented ERP marker of cue-induced expectation of the forthcoming target, clearly appeared about 1000 ms following cue onset for normal controls and 1300 ms following cue onset for depressed patients. Statistical analysis by repeated-measures Anova showed that a main group effect exists for the average amplitudes of ERPs at electrode Cz 930 ms after cue onset, while there was no main effect of cue or interaction effect between cue and group. Discussion These results suggest that normal controls complete their attentional disengagement from emotional facial expression between 350 ms to 1000 ms after cue offset, while depressed patients complete their attentional disengagement later than that of normal controls but earlier than 1500 ms from the perspective of CNV onset, though the two groups have no significant difference in response time in the conditions of CTI = 1000 ms and CTI = 1500 ms respectively. more...
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- 2019
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20. Optogenetic Excitation of Ipsilesional Sensorimotor Neurons is Protective in Acute Ischemic Stroke: A Laser Speckle Imaging Study
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Wanlu Li, Bin Bo, Yongting Wang, Yao Li, and Shanbao Tong
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Male ,0206 medical engineering ,Biomedical Engineering ,Posterior parietal cortex ,02 engineering and technology ,Optogenetics ,Neuroprotection ,Brain Ischemia ,Rats, Sprague-Dawley ,Channelrhodopsins ,Animals ,Medicine ,Premovement neuronal activity ,cardiovascular diseases ,Stroke ,business.industry ,Optical Imaging ,Brain ,medicine.disease ,Neurovascular bundle ,020601 biomedical engineering ,Rats ,nervous system ,Cerebral blood flow ,Cerebrovascular Circulation ,Brain stimulation ,Sensorimotor Cortex ,business ,Neuroscience - Abstract
Objective: Directly modulating targeted cortical function, brain stimulation provides promising techniques for stroke intervention. However, the cellular level mechanisms underlying preserved neurovascular function remains unclear. Optogenetics provides a cell-specific approach to modulate the neuronal activity. This study aims to investigate whether the exclusive excitation of sensorimotor neurons using optogenetics in an acute stroke can protect neurovascular function and reduce infarct size. Methods: Sensorimotor neurons were transfected with channelrhodopsin-2 and excited by a 473-nm laser. The photothrombotic stroke was induced in the ipsilateral parietal cortex and the targeted area for modulation remained intact. Optogenetic stimulation was carried out within 2 h after stroke in the modulation group. Using a laser speckle contrast imaging technique, we measured the cerebral blood flow at baseline, 0, 2, and 24 h after stroke, and analyzed the hemodynamic changes in both modulation ( n = 12) and control ( n = 9) groups. Also, the neurovascular response was measured 24 h after stroke. Results: We found that neuronal-specific excitation of an ipsilesional sensorimotor cortex at an acute stage could reduce the expansion of an ischemic area and promote the neurovascular response at 24 h after stroke. The histological and behavioral results consolidate the protective effects of optogenetic-guided neuronal modulation in acute stroke. Conclusion: Excitatory stimulation of ipsilesional sensorimotor neurons in an acute stroke could protect neurovascular function and reduces the expansion of ischemic area. Significance: For the first time, this work demonstrates that specific neuronal modulation in the acute stroke is neuroprotective and reduces the infarct size. more...
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- 2019
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21. Progressive increase of high-frequency EEG oscillations during meditation is associated with its trait effects on heart rate and proteomics: a study on the Tibetan Buddhist
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Xiaoli Guo, Meiyun Wang, Xu Wang, Menglin Guo, Ting Xue, Zhuo Wang, Han Li, Tianjiao Xu, Bin He, Donghong Cui, and Shanbao Tong
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Proteomics ,Cellular and Molecular Neuroscience ,Meditation ,Heart Rate ,Cognitive Neuroscience ,Humans ,Buddhism ,Electroencephalography ,Tibet - Abstract
Meditation has been a spiritual and healing practice in the East for thousands of years. However, the neurophysiologic mechanisms underlying its traditional form remain unclear. In this study, we recruited a large sample of monks (n = 73) who practice Tibetan Buddhist meditation and compared with meditation-naive local controls (n = 30). Their electroencephalography (EEG) and electrocardiogram signals were simultaneously recorded and blood samples were collected to investigate the integrative effects of Tibetan Buddhist on brain, heart, and proteomics. We found that the EEG activities in monks shifted to a higher frequency from resting to meditation. Meditation starts with decrease of the (pre)frontal delta activity and increase of the (pre)frontal high beta and gamma activity; while at the deep meditative state, the posterior high-frequency activity was also increased, and could be specified as a biomarker for the deep meditation. The state increase of posterior high-frequency EEG activity was significantly correlated with the trait effects on heart rate and nueropilin-1 in monks, with the source of brain–heart correlation mainly locating in the attention and emotion networks. Our study revealed that the effects of Tibetan Buddhist meditation on brain, heart, and proteomics were highly correlated, demonstrating meditation as an integrative body–mind training. more...
- Published
- 2021
22. Test-retest reliability of mismatch negativity and gamma-band auditory steady-state response in patients with schizophrenia
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Xiong Jiao, Qiang Hu, Yingying Tang, Zhenying Qian, Shanbao Tong, Jijun Wang, and Junfeng Sun
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Psychiatry and Mental health ,Acoustic Stimulation ,Evoked Potentials, Auditory ,Schizophrenia ,Humans ,Reproducibility of Results ,Electroencephalography ,Female ,Biological Psychiatry - Abstract
Patients with schizophrenia show widespread impairments in clinical, cognitive and psychosocial functioning. Mismatch negativity (MMN) and gamma-band auditory steady-state response (ASSR) are two neurophysiological biomarkers widely used to inform diagnosis, guide treatments and track response to interventions in schizophrenia. However, evidence for the test-retest reliability of these indices across multiple sessions in schizophrenia patients remains scarce. In the present study, we included 34 schizophrenia patients (17 females) and obtained duration MMN (dMMN), frequency MMN (fMMN) and 40-Hz ASSR data across three sessions with intervals of 2 days. Event-related spectrum perturbation (ERSP) and inter-trial coherence (ITC) were calculated following Morlet wavelet time-frequency decomposition of ASSR data. The intra-class correlation coefficient (ICC) was used to quantify the reliability of MMN and ASSR measures among the three sessions. We found fair to good reliability for dMMN amplitudes but poor reliability for fMMN amplitudes. For the ASSR measures, ERSP showed good to excellent test-retest reliability while ITC had poor to fair test-retest reliability. In addition, the average of dMMN amplitudes was significantly correlated with that of ERSP across the three sessions. In summary, we established for the first time the short-term test-retest reliability of MMN and ASSR measures in schizophrenia patients. These findings demonstrate that dMMN amplitudes and ERSP of ASSR are reliable indices which may be used in longitudinal observational studies. more...
- Published
- 2021
23. Influences of Hypothermia on the Cortical Blood Supply by Laser Speckle Imaging
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Shanbao Tong, Yihong Qiu, Minheng Li, Jing Yu, Peng Miao, and Yisheng Zhu
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Diagnostic Imaging ,Male ,Cerebral arteries ,Biomedical Engineering ,Hemodynamics ,Body Temperature ,Rats, Sprague-Dawley ,Hypothermia, Induced ,Image Processing, Computer-Assisted ,Internal Medicine ,medicine ,Animals ,Rewarming ,Vein ,Cerebral Cortex ,business.industry ,Lasers ,General Neuroscience ,Rehabilitation ,Laser Speckle Imaging ,Blood flow ,Cerebral Arteries ,Hypothermia ,Cerebral Veins ,Capillaries ,Rats ,medicine.anatomical_structure ,Moderate hypothermia ,Cerebral blood flow ,Cerebrovascular Circulation ,Anesthesia ,medicine.symptom ,business ,Algorithms - Abstract
Induced hypothermia has been broadly applied in neurological intensive care unit (NICU). Meanwhile, accidental hypothermia is also a threatening condition in daily life. It is meaningful to investigate the influences of temperature change on the cerebral blood flow (CBF). In the present study, temporal laser speckle image contrast analysis (tLASCA) was implemented to study the relative CBF change in cerebral artery, vein and capillary level under mild (35 degrees C) and moderate (32 degrees C) hypothermia. Twelve male Sprague-Dawley rats (300 +/-50 g) were anesthetized with sodium pentobarbital and randomly assigned to mild and moderate hypothermia groups (n=9 each). Laser speckle imaging (LSI) trials were acquired from baseline (37 degrees C), hypothermia (35 degrees C or 32 degrees C), and post-rewarming (37 degrees C) phases. In the mild group, mean CBF in different vessels all increased throughout the hypothermic and post-rewarming phases. On the contrary, mean CBF reduced by 10%-20% at 32 degrees C and returned to approximately 95% of the baseline level during the post-rewarming session in the moderate group. Besides, in the moderate group, a CBF rebound in vein was found in the post-rewarming phase. Our results suggested that the CBF changed differently between mild and moderate hypothermia, which may be worth for further study in clinic. And we demonstrated LSI as a promising method to achieve high spatiotemporal resolution CBF change with minimal invasion. more...
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- 2021
24. Label-free Intraoperative Blood Flow Imaging and Augmented Reality Display in Surgical Microscope
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Peng Miao, Shanbao Tong, Yu Jingyi, and Guang Xu
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Surgical microscope ,medicine.diagnostic_test ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Medical equipment ,Blood flow ,01 natural sciences ,Visualization ,010309 optics ,03 medical and health sciences ,Speckle pattern ,0302 clinical medicine ,0103 physical sciences ,Angiography ,medicine ,Augmented reality ,030217 neurology & neurosurgery ,ComputingMethodologies_COMPUTERGRAPHICS ,Label free ,Biomedical engineering - Abstract
Surgical microscope is an important medical equipment in surgeries that require delicate operations. There have been demanding clinical needs for multi-modality functional information in the intraoperative setting, such as real-time blood flow monitoring and blood vessel visualization. Aiming at the shortcomings of ICG-based angiography technology that requires contrast agents, we propose a design scheme for surgical microscope based on laser speckle contrast imaging (LSCI) technology for an intraoperative full-field label-free blood flow monitoring, using augmented reality (AR) technology to superimpose the blood flow imaging results in the field of surgeon's eyepiece. With the high-speed processing capability of GPU, the system is capable of real-time blood flow monitoring, which would provide great assistance in neurosurgery. more...
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- 2021
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25. A Miniature Laser Speckle Contrast Imager for Monitoring the Neuromodulatory Effect of Transcranial Ultrasound Stimulation
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Fariba Aghabaglou, Amir Manbachi, Yinuo Zeng, Nicholas Theodore, Nitish V. Thakor, Junfeng Sun, Molly Acord, Eli J. Curry, Shanbao Tong, Tarana Parvez Kaovasia, and Peng Miao
- Subjects
business.industry ,media_common.quotation_subject ,Ultrasound ,Stimulation ,Blood flow ,Article ,Neuromodulation (medicine) ,Transcranial Doppler ,Speckle pattern ,Cerebral blood flow ,Medicine ,Contrast (vision) ,business ,Biomedical engineering ,media_common - Abstract
Transcranial focused ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. Such neuro-modulatory effects enable the treatment of brain diseases non-invasively, such as treating stroke. The neuro-modulatory effect on cerebral hemodynamics has been monitored using laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of this imaging technique on research that requires the animal to have different body positions or to be awake. We present the design of a system that combines a miniature microscope for laser speckle contrast imaging and transcranial focused ultrasound stimulation, as well as, test its capability to monitor cerebral hemodynamics during stimulation and compare the result with a benchtop imaging system. more...
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- 2021
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26. Different reorganizations of functional brain networks after first-ever and recurrent ischemic stroke
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Zheng Jin, Zhuo Wang, Xiaonan Liu, Xu Wang, Xiaoli Guo, and Shanbao Tong
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0301 basic medicine ,Male ,medicine.medical_specialty ,China ,Stroke patient ,medicine.medical_treatment ,Population ,Motor Activity ,Brain Ischemia ,03 medical and health sciences ,Functional brain ,0302 clinical medicine ,Recurrent stroke ,Internal medicine ,Neural Pathways ,medicine ,Humans ,cardiovascular diseases ,education ,Molecular Biology ,Stroke ,Aged ,Ischemic Stroke ,Nihss score ,Aged, 80 and over ,education.field_of_study ,Brain Mapping ,Rehabilitation ,business.industry ,General Neuroscience ,Stroke Rehabilitation ,Brain ,Recovery of Function ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,030104 developmental biology ,Ischemic stroke ,Cardiology ,Female ,Neurology (clinical) ,Nerve Net ,business ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Even though recurrent stroke patients constitute a large percentage of the stroke population, few studies specifically investigated their neural reorganization. In this study, we recruited seventeen first-ever stroke patients as well as fourteen recurrent stroke patients, and recorded their resting EEG signals and NIHSS score before and after two weeks of recovery, to compare their neural reorganization from network scale. The clinical improvements were comparable in two groups during the two weeks. However, their brain networks were differently reorganized, especially in the delta band. The recurrent stroke patients showed an increased clustering coefficient and a decreased characteristic path length of the delta network, along with increased ipsilesional intrahemispheric connectivity; while no such changes were observed in the first-ever stroke patients. Our results suggest that stroke history influences neural reorganization during recovery. more...
- Published
- 2021
27. Neural mechanisms of inhibitory control deficits in obesity revealed by P3 but not N2 event-related potential component
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Jianan Wang, Hongping Wang, Haoyong Yu, Jiaqi Wang, Xiaoli Guo, Shanbao Tong, Yuqian Bao, and Xiangfei Hong
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Inhibition, Psychological ,Nutrition and Dietetics ,Reaction Time ,Humans ,Electroencephalography ,Feeding Behavior ,Obesity ,Evoked Potentials ,General Psychology - Abstract
The lack of inhibitory control toward foods may cause unhealthy eating behavior and lead to obesity. However, previous research failed to reach consensus on the alterations in event-related potential (ERP) markers of inhibitory control, i.e., N2 and P3. We hypothesized that the ERP effects of inhibitory control reported in previous food-based Go/NoGo studies might be obscured by non-inhibitory processes associated with stimulus probability. We designed two food-based Go/NoGo tasks composed of stimuli with the same type and frequency of occurrence (60% non-foods, 20% high-calorie foods, 20% low-calorie foods), one with response inhibition toward high- and the other toward low-calorie foods. Such an experimental design allowed us to isolate neural activity associated with inhibitory control from that associated with non-inhibitory processes by constructing ERP difference waves between NoGo and Go trials with the same frequency of occurrence. Electroencephalography data were collected from 32 obese participants and 29 normal-weight controls. Obese participants showed significantly lower accuracy in NoGo trials than normal-weight controls in both tasks. ERP data suggested inhibition-related effects for P3 (P3d) but not N2 in the difference waves, and obese participants showed significantly decreased P3d amplitudes than normal-weight controls in both tasks. In addition, we found that across both groups, individuals with larger waist-to-hip ratios showed smaller P3d amplitudes in both tasks, while such correlations between body mass index and P3d amplitude were only observed in the high-calorie task. Our findings suggest that the decreased effect of P3, not N2, might reflect the neural substrate of inhibitory control deficits in obese people. Thus, P3 could serve as an important neural marker in the future development of new therapeutic strategy that aims to improve inhibitory control in obesity. more...
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- 2020
28. Cortical Hemodynamic Response to Multi-afferent Stimulation: an optical imaging study
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Yongting Wang, Bin Bo, Yao Li, Wanlu Li, and Shanbao Tong
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0301 basic medicine ,Sensory stimulation therapy ,Haemodynamic response ,business.industry ,Optical Imaging ,Hemodynamics ,Optogenetics ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Optical imaging ,nervous system ,Cerebral blood flow ,Brain stimulation ,Cerebrovascular Circulation ,Medicine ,Neurovascular Coupling ,business ,Neuroscience ,030217 neurology & neurosurgery ,Afferent stimulation - Abstract
Multisensory stimulation plays an important role in the recovery of ischemic stroke. However, little is known about the interactions between neuronal activities with multi-afferent stimulations and their effects on hemodynamic responses. Optogenetics has been a useful tool in neuroscience research to unravel the mechanisms of neurovascular coupling at cell-specific level. In this study, we applied laser speckle contrast imaging (LSCI) to map the cortical hemodynamic response with high spatiotemporal resolution. The results showed that optogenetic inhibition of pyramidal neurons in sensorimotor cortex induced both local and distant increases of cerebral blood flow (CBF) with dual peaks, and the full width at half maximum (FWHM) was significantly larger than that of the CBF response to optogenetic excitation. Furthermore, optogenetic excitation of pyramidal neurons could significantly increase the local CBF response to sensory stimulation, whereas optogenetic inhibition of pyramidal neurons decreased the local CBF response at the early stage after sensory stimulation and increased the distant CBF response during the recovery period. Our work provided useful insights into the mechanisms of brain stimulation, which might help in clinical neurological applications. more...
- Published
- 2020
29. Neurovascular Coupling Impairment in Acute Ischemic Stroke by Optogenetics and Optical Brain Imaging
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Wanlu Li, Shanbao Tong, Bin Bo, Yongting Wang, and Yao Li
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medicine.medical_specialty ,Haemodynamic response ,Ischemia ,Neuroimaging ,Optogenetics ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Premovement neuronal activity ,cardiovascular diseases ,Stroke ,030304 developmental biology ,0303 health sciences ,business.industry ,Penumbra ,Brain ,medicine.disease ,Neurovascular bundle ,nervous system ,Cerebral blood flow ,cardiovascular system ,Cardiology ,Neurovascular Coupling ,business ,030217 neurology & neurosurgery ,circulatory and respiratory physiology - Abstract
The coupling between neuronal activity and cerebral blood flow (CBF), known as neurovascular coupling, has been reported to be impaired after stroke. This study aims to investigate the neurovascular coupling impairment at the acute stage after ischemic stroke. Laser speckle contrast imaging (LSCI) was applied to measure the hemodynamic response to optogenetic excitation of sensorimotor neurons in healthy and ischemic brain. The results showed that the hemodynamic response to optogenetic stimulation decreased and the regional CBF response was correlated with the distance from the ischemic core at the acute stage, regardless of the change in resting CBF. Our results also demonstrated that excitatory neuronal stimulation of intact area could promote the recovery of neurovascular coupling, whereas peri-infarct neuronal excitation failed to restore neurovascular function 24 hrs after ischemia. These results suggested the intact periphery of penumbra as the target for excitatory stimulation in aspect of restoring the perfusion after ischemic stroke. more...
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- 2020
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30. Correlates of Residual Limb Pain: From Residual Limb Length and Usage to Metabolites and Activity in Secondary Somatosensory Cortex
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Herta Flor, Jianbo Xiang, Shanbao Tong, Xiaoli Guo, Yuanyuan Lyu, Changjie Pan, Zhuo Wang, and Yao Li
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Adult ,Male ,medicine.medical_specialty ,Elbow ,Biomedical Engineering ,Pain ,Functional Laterality ,030218 nuclear medicine & medical imaging ,Upper Extremity ,03 medical and health sciences ,Oxygen Consumption ,0302 clinical medicine ,Physical medicine and rehabilitation ,Amputees ,Physical Stimulation ,Internal Medicine ,medicine ,Humans ,Aged ,Pain Measurement ,Sensory stimulation therapy ,medicine.diagnostic_test ,Secondary somatosensory cortex ,business.industry ,General Neuroscience ,Amputation Stumps ,Rehabilitation ,Magnetic resonance imaging ,Somatosensory Cortex ,Middle Aged ,Magnetic Resonance Imaging ,Peripheral ,Intensity (physics) ,body regions ,medicine.anatomical_structure ,Phantom Limb ,Creatinine ,Female ,Functional magnetic resonance imaging ,business ,030217 neurology & neurosurgery ,Residual limb - Abstract
Most recent studies attribute residual limb pain to peripheral pathological changes of the stump. However, in this paper, we focus on its associations with the residual limb length, usage, as well as the metabolic and functional alterations of the brain. The secondary somatosensory cortex (S2), one important area involved in pain intensity discrimination, was selected as the region of interest. Twenty-two upper-limb amputees were recruited and divided into two groups, i.e., amputees with residual limb pain (9/22) and without residual limb pain (13/22). The residual limb length, usage, as well as the metabolite concentration, resting-state activity and BOLD responses to the tactile stimulation in the contralateral S2, were compared between the two groups and correlated with the pain intensity. The amputees with residual limb pain showed significantly shorter length and less usage of the residual limb than the amputees without residual limb pain, and the pain intensity was significantly negatively correlated with the residual limb length and usage. In addition, the pain intensity was significantly correlated with the tNAA/tCr ratio, resting-state fALFF in the slow-4 band, and BOLD response to the tactile stimulation in the contralateral S2, although there were no significant group differences. Regression analysis suggested that residual limb pain is associated with shorter residual limb length and less residual limb usage. more...
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- 2019
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31. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
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Qi Liu, Wenzhong Liu, Shanbao Tong, Hao Zhang, Siyu Chen, and Brian T. Soetikno
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Pathology ,medicine.medical_specialty ,Biomedical Engineering ,Hemodynamics ,01 natural sciences ,Article ,010309 optics ,Mice ,03 medical and health sciences ,Speckle pattern ,0302 clinical medicine ,Optical coherence tomography ,0103 physical sciences ,medicine ,Animals ,Oximetry ,Stroke ,Monitoring, Physiologic ,medicine.diagnostic_test ,business.industry ,Infarction, Middle Cerebral Artery ,Laser Speckle Imaging ,medicine.disease ,Cerebral Angiography ,Mice, Inbred C57BL ,Disease Models, Animal ,Cerebral blood flow ,Angiography ,sense organs ,Tomography ,business ,Blood Flow Velocity ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging to guide Vis-OCT imaging and monitor the dynamic cerebral blood flow (CBF). Vis-OCT offers depth-resolved angiography and oxygen saturation (sO2) measurements. Results: Our results showed detailed CBF and vasculature changes before, during, and after dMCAO. After dMCAO, we observed insignificant sO2 variation in arteries and arterioles and location–dependent sO2 drop in veins and venules. We observed that higher branch-order veins had larger drops in sO2 at the reperfusion stage after dMCAO. Conclusion: This work suggests that integrated LSI and Vis-OCT is a promising tool for investigating ischemic stroke in mouse models. Significance: For the first time, LSI and Vis-OCT are integrated to investigate ischemic strokes in rodent models. more...
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- 2018
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32. Random matrix description of dynamically backscattered coherent waves propagating in a wide-field-illuminated random medium
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Peng Miao, Yifan Zhang, Cheng Wang, and Shanbao Tong
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Physics and Astronomy (miscellaneous) ,FOS: Physical sciences ,Physics - Applied Physics ,Applied Physics (physics.app-ph) ,Physics - Optics ,Optics (physics.optics) - Abstract
The wave propagation in random medium plays a critical role in optics and quantum physics. Multiple scattering of coherent wave in a random medium determines the transport procedure. Brownian motions of the scatterers perturb each propagation trajectory and form dynamic speckle patterns in the backscattered direction. In this study, we applied the random matrix theory (RMT) to investigate the eigenvalue density of the backscattered intensity matrix. We find that the dynamic speckle patterns can be utilized to decouple the singly and multiply backscattered components. The Wishart random matrix of multiple scattering component is well described by the Marcenko-Pastur law, while the single scattering part has low-rank characteristic. We therefore propose a strategy for estimating the first and the second order moments of single and multiple scattering components, respectively, based on the Marcenko-Pastur law and trace analysis. Electric field Monte Carlo simulation and in-vivo experiments demonstrate its potential applications in hidden absorbing object detection and in-vivo blood flow imaging. Our method can be applied to other coherent domain elastic scattering phenomenon for wide-filed propagation of microwave, ultrasound and etc., Comment: 6 pages, 5 figures more...
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- 2022
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33. Hypoperfusion Induced by Preconditioning Treadmill Training in Hyper-Early Reperfusion After Cerebral Ischemia: A Laser Speckle Imaging Study
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Xiaojiao Yang, Li Ding, Jie Jia, Guili Wang, Li Zhang, Zhijie He, Yi Wu, Wenxiu Niu, Hongyang Lu, and Shanbao Tong
- Subjects
Diagnostic Imaging ,Male ,0301 basic medicine ,Biomedical Engineering ,Ischemia ,Treadmill training ,Contrast imaging ,Neuroprotection ,Brain Ischemia ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Physical Conditioning, Animal ,Image Processing, Computer-Assisted ,medicine ,Animals ,Middle cerebral artery occlusion ,Behavior, Animal ,business.industry ,Reproducibility of Results ,Laser Speckle Imaging ,medicine.disease ,Rats ,030104 developmental biology ,Cerebral blood flow ,Cerebrovascular Circulation ,Reperfusion Injury ,Anesthesia ,cardiovascular system ,business ,Perfusion ,Algorithms ,030217 neurology & neurosurgery - Abstract
Exercise preconditioning induces neuroprotective effects during cerebral ischemia and reperfusion, which involves the recovery of cerebral blood flow (CBF). Mechanisms underlying the neuroprotective effects of re-established CBF following ischemia and reperfusion are unclear. The present study investigated CBF in hyper-early stage of reperfusion by laser speckle contrast imaging, a full-field high-resolution optical imaging technique. Rats with or without treadmill training were subjected to middle cerebral artery occlusion followed by reperfusion. CBF in arteries, veins, and capillaries in hyper-early stage of reperfusion (1, 2, and 3 h after reperfusion) and in subacute stage (24 h after reperfusion) were measured. Neurological scoring and 2,3,5-triphenyltetrazolium chloride staining were further applied to determine the neuroprotective effects of exercise preconditioning. In hyper-early stage of reperfusion, CBF in the rats with exercise preconditioning was reduced significantly in arteries and veins, respectively, compared to rats with no exercise preconditioning. Capillary CBF remained stable in the hyper-early stage of reperfusion, though it increased significantly 24 h after reperfusion in the rats with exercise preconditioning. As a neuroprotective strategy, exercise preconditioning reduced the blood perfusion of arteries and veins in the hyper-early stage of reperfusion, which indicated intervention-induced neuroprotective hypoperfusion after reperfusion onset. more...
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- 2018
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34. Low-intensity (400 mW/cm 2 , 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats
- Author
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Peter A. Lewin, Junfeng Sun, Daryl Omire-Mayor, Daqu Zhang, Shanbao Tong, and Li Hangdao
- Subjects
0301 basic medicine ,Low-intensity pulsed ultrasound ,Biophysics ,Ischemia ,Preconditioning ,Stimulation ,Focal cerebral ischemia ,Neuroprotection ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Transcranial stimulation ,medicine ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Stroke ,business.industry ,General Neuroscience ,Ultrasound ,Cerebral blood flow ,medicine.disease ,Transcranial Doppler ,030104 developmental biology ,Anesthesia ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background: Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke. Objective: This study's goal was to investigate whether the risk of stroke could be minimized or eliminated by prior exposure to low-intensity, pulsed transcranial ultrasound stimulation (pTUS). Methods: Rats were randomly assigned to control (n = 12) and pTUS preconditioning (pTUS-PC) groups (n = 14). The animals in pTUS-PC group were exposed to transcranial ultrasound stimulation before the induction of photothrombotic stroke, whereas control animals were handled identically but without the ultrasound stimulation. Cerebral blood flow was monitored using laser speckle imaging in both groups during stroke induction, as well as 24 and 48 h after stroke, respectively. Also, infarct volumes and edema were measured at 48 h after stroke. Results: pTUS-PC rats had smaller ischemic areas during stroke induction, and 24 and 48 h after the stroke, and smaller infarct volume (1.770 ± 0.169%) than the controls (3.215 ± 0.401%) (p more...
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- 2017
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35. Motor Imagery Training After Stroke Increases Slow-5 Oscillations and Functional Connectivity in the Ipsilesional Inferior Parietal Lobule
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Xu Wang, Bing Zhu, Mingxia Fan, Yiming Xu, Shanbao Tong, Xiaoli Guo, Hewei Wang, Xin Xiong, Limin Sun, and Changhui Sun
- Subjects
Male ,medicine.medical_specialty ,Neural substrate ,medicine.medical_treatment ,Motor Activity ,computer.software_genre ,Motor imagery ,Physical medicine and rehabilitation ,Voxel ,Parietal Lobe ,Outcome Assessment, Health Care ,Connectome ,Medicine ,Humans ,Single-Blind Method ,Stroke ,Rehabilitation ,medicine.diagnostic_test ,Resting state fMRI ,business.industry ,Stroke Rehabilitation ,Inferior parietal lobule ,General Medicine ,Middle Aged ,medicine.disease ,Brain Waves ,Magnetic Resonance Imaging ,Imagination ,Female ,Nerve Net ,business ,Functional magnetic resonance imaging ,computer - Abstract
Background. Reorganization in motor areas have been suggested after motor imagery training (MIT). However, motor imagery involves a large-scale brain network, in which many regions, andnot only the motor areas, potentially constitute the neural substrate for MIT. Objective. This study aimed to identify the targets for MIT in stroke rehabilitation from a voxel-based whole brain analysis of resting-state functional magnetic resonance imaging (fMRI). Methods. Thirty-four chronic stroke patients were recruited and randomly assigned to either an MIT group or a control group. The MIT group received a 4-week treatment of MIT plus conventional rehabilitation therapy (CRT), whereas the control group only received CRT. Before and after intervention, the Fugl-Meyer Assessment Upper Limb subscale (FM-UL) and resting-state fMRI were collected. The fractional amplitude of low-frequency fluctuations (fALFF) in the slow-5 band (0.01-0.027 Hz) was calculated across the whole brain to identify brain areas with distinct changes between 2 groups. These brain areas were then targeted as seeds to perform seed-based functional connectivity (FC) analysis. Results. In comparison with the control group, the MIT group exhibited more improvements in FM-UL and increased slow-5 fALFF in the ipsilesional inferior parietal lobule (IPL). The change of the slow-5 oscillations in the ipsilesional IPL was positively correlated with the improvement of FM-UL. The MIT group also showed distinct alternations in FCs of the ipsilesional IPL, which were correlated with the improvement of FM-UL. Conclusions. The rehabilitation efficiency of MIT was associated with increased slow-5 oscillations and altered FC in the ipsilesional IPL. Clinical Trial Registration. http://www.chictr.org.cn . Unique Identifier. ChiCTR-TRC-08003005. more...
- Published
- 2020
36. Decoding attention control and selection in visual spatial attention
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Mingzhou Ding, Ke Bo, Shanbao Tong, Sreenivasan Meyyappan, and Xiangfei Hong
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Adult ,Male ,Support Vector Machine ,Adolescent ,decoding ,selective attention ,050105 experimental psychology ,Functional Laterality ,03 medical and health sciences ,Executive Function ,Young Adult ,0302 clinical medicine ,pattern classification ,Event-related potential ,event‐related potential ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Attention ,Set (psychology) ,Evoked Potentials ,Selection (genetic algorithm) ,Research Articles ,Cued speech ,reaction time ,Radiological and Ultrasound Technology ,Individual difference ,05 social sciences ,Probabilistic logic ,Attentional control ,Univariate ,Electroencephalography ,N1 ,Visual spatial attention ,Brain Waves ,Neurology ,Space Perception ,Visual Perception ,Female ,Neurology (clinical) ,Anatomy ,Cues ,Psychology ,030217 neurology & neurosurgery ,Decoding methods ,Psychomotor Performance ,Cognitive psychology ,Research Article - Abstract
Event‐related potentials (ERPs) are used extensively to investigate the neural mechanisms of attention control and selection. The univariate ERP approach, however, has left important questions inadequately answered. We addressed two questions by applying multivariate pattern classification to multichannel ERPs in two cued visual spatial attention experiments (N = 56): (a) impact of cueing strategies (instructional vs. probabilistic) on attention control and selection and (b) neural and behavioral effects of individual differences. Following cue onset, the decoding accuracy (cue left vs. cue right) began to rise above chance level earlier and remained higher in instructional cueing (~80 ms) than in probabilistic cueing (~160 ms), suggesting that unilateral attention focus leads to earlier and more distinct formation of the attention control set. A similar temporal sequence was also found for target‐related processing (cued target vs. uncued target), suggesting earlier and stronger attention selection under instructional cueing. Across the two experiments: (a) individuals with higher cue‐related decoding accuracy showed higher magnitude of attentional modulation of target‐evoked N1 amplitude, suggesting that better formation of anticipatory attentional state leads to stronger modulation of target processing, and (b) individuals with higher target‐related decoding accuracy showed faster reaction times (or larger cueing effects), suggesting that stronger selection of task‐relevant information leads to better behavioral performance. Taken together, multichannel ERPs combined with machine learning decoding yields new insights into attention control and selection that complement the univariate ERP approach, and along with the univariate ERP approach, provides a more comprehensive methodology to the study of visual spatial attention., Covert spatial attention can be decoded from multichannel event‐related potential patterns during both attention control (cue left vs. cue right) and attention selection (cued target vs. uncued target). Decoding accuracy (cue left vs. cue right) during attention control predicted the magnitude of attentional modulation of target‐related N1 component. Decoding accuracy (cued target vs. uncued target) during attention selection predicted behavioral performance. more...
- Published
- 2020
37. Optimal Trajectories of Brain State Transitions Indicate Motor Function Changes Associated with Aging
- Author
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Jie Zhou, Junfeng Sun, Shanbao Tong, Hong Zhu, and Pin Shu
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Adult ,Male ,Aging ,Adolescent ,Biology ,Motor function ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Humans ,Default mode network ,030304 developmental biology ,Aged ,Aged, 80 and over ,0303 health sciences ,Brain Mapping ,Functional integration (neurobiology) ,Putamen ,Motor Cortex ,Brain ,Middle Aged ,Optimal control ,Neuromodulation (medicine) ,Motor task ,Brain state ,Diffusion Magnetic Resonance Imaging ,Female ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Healthy aging is associated with structural and functional changes in sensorimotor systems, leading to a deterioration in motor function. However, most of the previous studies focused on the descriptive measures of alteration, little is known about how structural network facilitate functional dynamics during aging. Based on the structural brain network constructed by diffusion-weighted imaging, we employed recent network control theory to evaluate the control energy necessary to drive the state transition from baseline condition with default mode network (DMN) activation to motor network activation in a large cohort (n = 625; 18–88 years). We found at the whole, the control energy required to activate the motor network declined with aging, in which the motor network contributed most of the control energy. The control energy of nodes within motor network showed both positive and negative age effects, reflecting an aberrant functional integration associated with aging. Interestingly, the control energy of subcortical network most significantly increased with aging, suggesting an altered motor-subcortical circuit, thus requiring more energy for the optimal control. Moreover, the control energy of bilateral putamen showed the largest positive age effect, and this pattern was also supported by the energetic impact of nodes, implying a key role for motor modulation associated with aging. Taken together, our results offer insights of control energy cost necessary for the age-dependent decline in motor task, and provide new clues for brain optimal control of neuromodulation in older adults. more...
- Published
- 2020
38. A prototype system of portable laser speckle imager based on embedded graphics processing unit platform
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Bin Bo, Peng Miao, Yuanqi Li, Heping Chen, and Shanbao Tong
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Computer science ,business.industry ,Lasers ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Graphics processing unit ,Hemodynamics ,Laser ,Contrast imaging ,01 natural sciences ,law.invention ,010309 optics ,Computer graphics ,03 medical and health sciences ,Speckle pattern ,0302 clinical medicine ,law ,0103 physical sciences ,Personal computer ,Computer Graphics ,Laser-Doppler Flowmetry ,Humans ,business ,030217 neurology & neurosurgery ,Computer hardware - Abstract
Laser speckle contrast imaging (LSCI) is a high-resolution full-field optical technique for measuring blood flow, which has been widely used in clinical and biomedical research. However, most of the current LSCI instruments are bulky, limiting their application settings. In this work, we proposed a prototype system of portable laser speckle imager. Different from the desktop laser speckle systems that utilize personal computer (PC), our system was designed with embedded GPU system (Jetson TX2, NVIDIA, USA) and a LCD touch screen (16.5 × 12.4 cm in size, 380 g in weight). In-vivo experiments showed that the portable GPU-based system had comparable performance with our laboratory LSCI system. Such a portable LSCI imager could be potentially used in a situation that requires for easy operation and installation, such as intraoperative monitoring or bedside diagnosis. more...
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- 2020
39. supplemental_material_clean – Supplemental material for Motor Imagery Training After Stroke Increases Slow-5 Oscillations and Functional Connectivity in the Ipsilesional Inferior Parietal Lobule
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Wang, Xu, Hewei Wang, Xiong, Xin, Changhui Sun, Zhu, Bing, Yiming Xu, Mingxia Fan, Shanbao Tong, Limin Sun, and Xiaoli Guo
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FOS: Clinical medicine ,110308 Geriatrics and Gerontology ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, supplemental_material_clean for Motor Imagery Training After Stroke Increases Slow-5 Oscillations and Functional Connectivity in the Ipsilesional Inferior Parietal Lobule by Xu Wang, Hewei Wang, Xin Xiong, Changhui Sun, Bing Zhu, Yiming Xu, Mingxia Fan, Shanbao Tong, Limin Sun and Xiaoli Guo in Neurorehabilitation and Neural Repair more...
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- 2020
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40. Extracting Individual Neural Fingerprint Encoded in Functional Connectivity by Silencing Indirect Effects
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Junfeng Sun, Pin Shu, Wen Jin, Shanbao Tong, and Hong Zhu
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Brain Mapping ,medicine.diagnostic_test ,Computer science ,business.industry ,Functional connectivity ,Biomedical Engineering ,Neurosciences ,Brain ,Reproducibility of Results ,Pattern recognition ,Fingerprint recognition ,behavioral disciplines and activities ,Magnetic Resonance Imaging ,Salience (neuroscience) ,medicine ,Gene silencing ,Artificial intelligence ,Functional magnetic resonance imaging ,business - Abstract
Objective: The possibility of subject discriminability based on whole-brain functional connectivity (FC) has been demonstrated. To extract more accurate “fingerprint” encoded in FC, we speculated that the indirect effects in FC might be unfavorable information for subject discriminability, then the remaining component of FC (referred as direct FC (dFC)) may constitute a better “fingerprint.” Methods: We adopted the silencing method to infer dFC from experimentally accessible FC and explained the superiority of dFC in subject discriminability from the perspective of test-retest reliability. Results: We showed that the subject discriminability of dFC (even with much shorter fMRI data) is significantly greater than that of FC (calculated from the whole available fMRI data) in three public datasets. Furthermore, we elucidated that the silencing method improved subject discriminability by increasing the test-retest reliability of reliable edges (i.e., edges with high intra-class correlation coefficient) and the reliable edges dominated the subject discriminability of functional brain networks. After silencing, the reliable edges were distributed throughout the brain, especially in the Fronto-parietal Task Control, Salience, Ventral Attention, and Dorsal Attention subnetworks. Finally, the subject discriminability of functional brain networks calculated from task-fMRI data outperformed that calculated from resting-state fMRI data, and the silencing method could significantly improve the subject discriminability of each task-fMRI data, respectively. Conclusion: These results demonstrated that the dFC estimated by the silencing method from FC might constitute an accurate “fingerprint” for subject discriminability. Significance: This study made a step forward to the personalized neuroscience with fMRI-based brain “fingerprint.” more...
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- 2019
41. Dynamic Alterations of EEG Oscillations and Networks from Resting to Deep Meditation
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Donghong Cui, Menglin Guo, Xu Wang, Bin He, Ting Xue, Tianjiao Xu, Xiaoli Guo, Zhuo Wang, Shanbao Tong, Meiyun Wang, and Han Li
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Gamma power ,media_common.quotation_subject ,05 social sciences ,050105 experimental psychology ,Eeg oscillations ,03 medical and health sciences ,0302 clinical medicine ,0501 psychology and cognitive sciences ,Meditation ,Global efficiency ,Psychology ,030217 neurology & neurosurgery ,media_common ,Cognitive psychology - Abstract
Meditation is a progressive process in which meditators may experience different stages to finally reach a deep meditation state. However, the temporal-dynamic process of meditation remains unclear. In this study, we recruited 38 experienced Tibetan Buddhism meditators to explore the dynamic process from resting to deep meditation from the aspects of EEG oscillations and networks. We found that the delta power was reduced and the transitivity of the delta network was increased immediately after the start of meditation. Then, the beta and gamma power increased, and the clustering coefficient and global efficiency of the gamma network increased at the deep meditation substage. Our results suggested that the participants entered into a wakeful and non-judgmental state immediately after the start of meditation, and then achieved a more efficient information processing and transferring only at a deep meditation state. Our study showed that meditation was a time-varying process, deep meditation was a different substage dominated by high frequency EEG oscillations and more small-world like brain networks. more...
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- 2019
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42. Alterations in Brain Structural Connectivity After Unilateral Upper-Limb Amputation
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Chaowei Wu, Xiaoli Guo, Shanbao Tong, Yuanyuan Lyu, Ruihao Liu, Jianbo Xiang, Zhuo Wang, Changjie Pan, and Jincheng Lu
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Adult ,Male ,medicine.medical_specialty ,Middle temporal gyrus ,medicine.medical_treatment ,Biomedical Engineering ,Phantom limb ,Artificial Limbs ,050105 experimental psychology ,Amputation, Surgical ,Upper Extremity ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Amputees ,Sensation ,Fractional anisotropy ,Internal Medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,Upper limb amputation ,Pain Measurement ,Postcentral gyrus ,business.industry ,General Neuroscience ,05 social sciences ,Rehabilitation ,Brain ,Somatosensory Cortex ,Middle Aged ,medicine.disease ,Healthy Volunteers ,Diffusion Tensor Imaging ,Amputation ,Phantom Limb ,Anisotropy ,Female ,Nerve Net ,business ,030217 neurology & neurosurgery ,Algorithms ,Diffusion MRI - Abstract
Previous studies have indicated that amputation induces reorganization of functional brain network. However, the influence of amputation on structural brain network remains unclear. In this study, using diffusion tensor imaging (DTI), we aimed to investigate the alterations in fractional anisotropy (FA) network after unilateral upper-limb amputation. We acquired DTI from twenty-two upper-limb amputees (15 dominant-side and 7 nondominant-side amputees) as well as fifteen healthy controls. Using DTI tractography and graph theoretical approaches, we examined the topological changes in FA network of amputees. Compared with healthy controls, dominant-side amputees showed reduced global mean strength, increased characteristic path length, and decreased nodal strength in the contralateral sensorimotor system and visual areas. In particular, the nodal strength of the contralateral postcentral gyrus was negatively correlated with residual limb usage, representing a use-dependent reorganization. In addition, the nodal strength of the contralateral middle temporal gyrus was positively correlated with the magnitude of phantom limb sensation. Our results suggested a degeneration of FA network after dominant-side upper-limb amputation. more...
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- 2019
43. Attention-related modulation of frontal midline theta oscillations in cingulate cortex during a spatial cueing Go/NoGo task
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Xiangfei Hong, Junfeng Sun, Shanbao Tong, Chunbo Li, and Jijun Wang
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Cingulate cortex ,Adult ,Male ,Adolescent ,Gyrus Cinguli ,050105 experimental psychology ,Task (project management) ,Conflict, Psychological ,03 medical and health sciences ,Executive Function ,Young Adult ,0302 clinical medicine ,Gyrus ,Event-related potential ,Physiology (medical) ,medicine ,Humans ,0501 psychology and cognitive sciences ,Attention ,Theta Rhythm ,Lateralized readiness potential ,General Neuroscience ,05 social sciences ,Cognition ,Executive functions ,Contingent negative variation ,Inhibition, Psychological ,Neuropsychology and Physiological Psychology ,medicine.anatomical_structure ,Pattern Recognition, Visual ,Space Perception ,Female ,Cues ,Psychology ,Neuroscience ,psychological phenomena and processes ,030217 neurology & neurosurgery ,Psychomotor Performance - Abstract
Recently frontal midline theta (FMθ, 4–8 Hz) oscillations have been consistently reported and proposed as the potential neural mechanism for response inhibition, a core component of human executive functions. However, it remains unclear to what extent the increase of FMθ power during response inhibition tasks is influenced by other non-inhibitory cognitive processes that are usually required for the tasks. In this study, we examined attention-related effects on FMθ during response inhibition by revisiting the EEG data from healthy young adults (N = 30) while performing a spatial cueing Go/NoGo task (Hong et al., 2017). Such an experimental design enabled us to manipulate selective attention that was voluntarily deployed to the stimuli triggering response inhibition. Although commission error rates were low for the NoGo trials, response preparation and prepotent motor activities were qualified by observing significant contingent negative variation (CNV) and lateralized readiness potential (LRP) in both the Go and the NoGo trials. We observed an increase of FMθ power in both attended and ignored conditions of the NoGo trials compared with the Go trials, while FMθ power was significantly smaller in the ignored condition than in the attended condition. Furthermore, source localization analysis suggested cingulate cortex as the main origin for FMθ in the NoGo trials, and FMθ power differences between the attended and ignored conditions were localized in cingulate gyrus. We further provided evidence for attention-dependent FMθ generation by correlating theta source density with ERP signatures of attention (N1), response preparation (CNV), and motor activity (LRP). Overall, our findings suggest that during the Go/NoGo task, the increase of FMθ power was not purely driven by response inhibition, and part of FMθ generators in cingulate gyrus was significantly modulated by attention-related processing (possibly conflict monitoring). more...
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- 2019
44. Camera-Based Mirror Visual Input for Priming Promotes Motor Recovery, Daily Function, and Brain Network Segregation in Subacute Stroke Patients
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Peng Shao, Xu Wang, Jifeng Rong, Shanbao Tong, Xiaoli Guo, Li Ding, Jie Jia, Shugeng Chen, Jing Tian, and Hewei Wang
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Computer science ,medicine.medical_treatment ,Rest ,Subacute stroke ,Electroencephalography ,Motor Activity ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Feedback, Sensory ,Neural Pathways ,medicine ,Humans ,Stroke ,Brain network ,Rehabilitation ,medicine.diagnostic_test ,Daily function ,Stroke Rehabilitation ,Brain ,General Medicine ,Recovery of Function ,Middle Aged ,medicine.disease ,Hand ,Treatment Outcome ,Mirror therapy ,Female ,0305 other medical science ,Priming (psychology) ,030217 neurology & neurosurgery - Abstract
Background. Camera technique–based mirror visual feedback (MVF) is an optimal interface for mirror therapy. However, its efficiency for stroke rehabilitation and the underlying neural mechanisms remain unclear. Objective. To investigate the possible treatment benefits of camera-based MVF (camMVF) for priming prior to hand function exercise in subacute stroke patients, and to reveal topological reorganization of brain network in response to the intervention. Methods. Twenty subacute stroke patients were assigned randomly to the camMVF group (MG, N = 10) or a conventional group (CG, N = 10). Before, and after 2 and 4 weeks of intervention, the Fugl-Meyer Assessment Upper Limb subscale (FMA_UL), the Functional Independence Measure (FIM), the modified Ashworth Scale (MAS), manual muscle testing (MMT), and the Berg Balance Scale (BBS) were measured. Resting-state electroencephalography (EEG) signals were recorded before and after 4-week intervention. Results. The MG showed more improvements in the FMA_UL, the FMA_WH (wrist and hand), and the FIM than the CG. The clustering coefficient (CC) of the resting EEG network in the alpha band was increased globally in the MG after intervention but not in the CG. Nodal CC analyses revealed that the CC in the MG tended to increase in the ipsilesional occipital and temporal areas, and the bilateral central and parietal areas, suggesting improved local efficiency of communication in the visual, somatosensory, and motor areas. The changes of nodal CC at TP8 and PO8 were significantly positively correlated with the motor recovery. Conclusions. The camMVF-based priming could improve the motor recovery, daily function, and brain network segregation in subacute stroke patients. more...
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- 2019
45. Activation of Sympathetic Nervous System as a Biomarker for Deep Meditation
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Xu Wang, Zhuo Wang, Han Li, Menglin Guo, Meiyun Wang, Shanbao Tong, Bin He, Donghong Cui, Ting Xue, Tianjiao Xu, and Xiaoli Guo
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medicine.medical_specialty ,Sympathetic nervous system ,High frequency power ,business.industry ,Tibetan Buddhist ,media_common.quotation_subject ,Audiology ,Autonomic nervous system ,medicine.anatomical_structure ,Fractal scaling ,Biomarker (medicine) ,Heart rate variability ,Medicine ,Meditation ,business ,media_common - Abstract
It has been reported that meditation is a progressive procedure to achieve a thoughtless and transcendental deep meditation state. However, it remains difficult to know whether and when the practitioner has achieved deep meditation state for lack of a reliable and objective measure. The aim of this study is to explore an electrophysiological biomarker for the deep meditation stage by studying the autonomic nervous system (ANS) activities during meditation using heart rate variability (HRV). We recruited 70 experienced Tibetan Buddhist monks, and recorded electrocardiogram signal for ~10 min of rest followed by ~30 min of meditation. We found two different stages of meditation, i.e., light meditation (0-10min) and deep meditation (after 10min) stages, which can be distinguished by the increased very low frequency (VLF, 0.003-0.04Hz) and low frequency (LF, 0.04-0.15Hz) power. The light meditation stage was comparable with the rest in the ANS activities, while the deep meditation stage was significantly different from the rest and light meditation stage. We speculate that the deep meditation stage could be marked by significant increases of VLF and LF. Meanwhile, ratio of low and high frequency power, standard deviation of RR intervals and fractal scaling exponents of detrended fluctuation analysis also increased in the deep meditation stage. Our results indicated that meditation is a dynamic process and the deep meditation was dominated by activated sympathetic nervous system. more...
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- 2019
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46. Phase Transfer Entropy between Frontal and Posterior Regions during Visual Spatial Attention
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Jianan Wang, Junfeng Sun, Jiaqi Wang, Xiangfei Hong, and Shanbao Tong
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medicine.diagnostic_test ,media_common.quotation_subject ,Shifting attention ,05 social sciences ,Attentional control ,Visual spatial attention ,Electroencephalography ,Phase synchronization ,050105 experimental psychology ,Lateralization of brain function ,Visual field ,03 medical and health sciences ,0302 clinical medicine ,Perception ,medicine ,0501 psychology and cognitive sciences ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,media_common - Abstract
Voluntarily shifting attention to a location of the visual field improves the perception of stimulus at the attended location and suppresses information processing at unattended locations, something referred to as visual spatial attention. Previous studies have shown that alpha band phase synchronization between frontal and posterior regions was modulated by visual spatial attention. However, the causality of such long-range connectivity is still unknown, which makes it difficult to assess its relation to the underlying neural mechanisms of visual spatial attention. In this study, 64-channel scalp electroencephalography (EEG) was collected from 26 healthy adults when performing a visual spatial-cueing attention task, and a recently proposed algorithm, phase transfer entropy (PTE), was used to study the directed alpha phase interactions between frontal and posterior regions during attention orienting. We found that: (i) The PTE from frontal regions to posterior regions significantly increased after cue onset; (ii) The PTE from frontal regions (especially the right hemisphere) to posterior regions showed significant lateralization during late cue-target interval, with the greater PTE of contralateral frontal-to-posterior pair than that of ipsilateral pair relative to cue direction. These results suggest that alpha phase interactions might reveal top-down control signals from frontal to posterior regions during visual spatial attention, and support the right frontal regions as the causal role in top-down attentional control. more...
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- 2019
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47. Modulation of Functional Connectivity and Activation during Preparation for Hand Movement
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Junfeng Sun, Shanbao Tong, Lin Cheng, Hasan Ayaz, and Banu Onaral
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Movement (music) ,Functional connectivity ,05 social sciences ,Cognition ,Anticipation ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Modulation (music) ,Neuroergonomics ,Functional near-infrared spectroscopy ,0501 psychology and cognitive sciences ,Latency (engineering) ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
OCCUPATIONAL APPLICATIONS Our results illustrate the enhanced functional connectivity between motor-related brain regions and high-level cognitive brain regions during the transition period between rest and hand movements. These results suggest that the sensorimotor network is interacting with prefrontal areas during the transition period to maintain the preparation state. Both actual movement and the transition period without actual movement modulate brain activities. Capturing the detailed relationship of movement intention could be utilized to improve precision and latency of anticipation-based brain–computer interfaces. Furthermore, consistent with the neuroergonomic approach, this study demonstrates that functional near-infrared spectroscopy is a suitable tool for region-specific, task-related, and resting-state functional connectivity analysis. Our findings could enhance the development of more intuitive and natural interfaces between human and machine systems in diverse areas. The approach presente... more...
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- 2016
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48. Spatiotemporal differences of brain activation between internal and external strategies in mental rotation: A behavioral and ERD/ERS study
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Zhuo Wang, Xiaoli Guo, Shanbao Tong, Yuanyuan Lyu, and Hongzhou Chen
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Male ,Brain activation ,Rotation ,Electroencephalography Phase Synchronization ,Electroencephalography ,Brain mapping ,050105 experimental psychology ,Mental rotation ,Random Allocation ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,Beta Rhythm ,Behavior ,Brain Mapping ,Communication ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,05 social sciences ,Perspective (graphical) ,Brain ,Cognition ,Imagination ,Female ,business ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Subjects may voluntarily implement an internal or external strategy during mental rotation (MR) task. However, few studies have reported the spatiotemporal differences of brain activation between the two MR strategies. This study aims to compare the two strategies from the perspective of behavioral performance and spatiotemporal brain activations in each cognitive sub-stage using EEG measurements. Both the internal (IN) and external (EX) groups showed a significant 'angle effect' on reaction time (RT) and accuracy (ACC). However, a smaller increase of RT with rotation angle was observed in the EX group. Event-related (de)synchronization in the beta band revealed similar temporal patterns of brain activation in the two groups, but with a stronger activation in the MR sub-stage in the EX group. We speculate that MR of 3D abstract objects is easier when an external strategy is used, and would be promoted by an additional visual-spatial process involving the parietal-occipital areas. Our results suggested that the differences between the two strategies were mainly induced by main MR rather than other cognitive processes. more...
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- 2016
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49. Multifunctional Nanostructure RAP‐RL Rescues Alzheimer's Cognitive Deficits through Remodeling the Neurovascular Unit
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Xiaoling Gao, Gan Jiang, Shanbao Tong, Yong-Bo Hu, Yu Qiu, Meng Huang, Gang Wang, Rong Shao, Huan Chen, Qian Zhang, Qingxiang Song, Hao Wang, Hong-Zhuan Chen, Antian Wang, Mengna Zheng, Xiao Gu, Bin Bo, and Binyin Li more...
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NVU remodeling ,Apolipoprotein B ,General Chemical Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,RAGE (receptor) ,Pathogenesis ,Cerebral circulation ,Glycation ,Medicine ,General Materials Science ,Receptor ,multifunctional nanostructure ,Ganglioside ,Full Paper ,biology ,business.industry ,fungi ,General Engineering ,Antagonist ,Full Papers ,Alzheimer's disease ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,body regions ,biology.protein ,cerebrovasculature ,sense organs ,0210 nano-technology ,business ,Neuroscience - Abstract
Cerebrovascular dysfunction characterized by the neurovascular unit (NVU) impairment contributes to the pathogenesis of Alzheimer's disease (AD). In this study, a cerebrovascular‐targeting multifunctional lipoprotein‐biomimetic nanostructure (RAP‐RL) constituted with an antagonist peptide (RAP) of receptor for advanced glycation end‐products (RAGE), monosialotetrahexosyl ganglioside, and apolipoprotein E3 is developed to recover the functional NVU and normalize the cerebral vasculature. RAP‐RL accumulates along the cerebral microvasculature through the specific binding of RAP to RAGE, which is overexpressed on cerebral endothelial cells in AD. It effectively accelerates the clearance of perivascular Aβ, normalizes the morphology and functions of cerebrovasculature, and restores the structural integrity and functions of NVU. RAP‐RL markedly rescues the spatial learning and memory in APP/PS1 mice. Collectively, this study demonstrates the potential of the multifunctional nanostructure RAP‐RL as a disease‐modifying modality for AD treatment and provides the proof of concept that remodeling the functional NVU may represent a promising therapeutic approach toward effective intervention of AD., RAP‐RL, a multifunctional lipoprotein‐like nanostructure, which contains RAGE antagonist peptide (RAP), GM1 and ApoE3, is designed to rescue AD cognitive deficits through remodeling the neurovascular unit. RAP‐RL accumulates along the cerebral microvasculature through the specific binding of RAP to RAGE. It decreases neuroinflammation, accelerates the perivascular Aβ clearance, restores the structure and function of the cerebrovasculature system, and efficiently alleviates spatial learning and memory in AD model mice. more...
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- 2020
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50. Enhancing neural efficiency of cognitive processing speed via training and neurostimulation: An fNIRS and TMS study
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Shanbao Tong, Adrian Curtin, Jijun Wang, Yingying Tang, Junfeng Sun, and Hasan Ayaz
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Adult ,Male ,animal structures ,Brain activity and meditation ,Cognitive Neuroscience ,medicine.medical_treatment ,Prefrontal Cortex ,Neuropsychological Tests ,behavioral disciplines and activities ,050105 experimental psychology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cognition ,medicine ,Humans ,0501 psychology and cognitive sciences ,Effects of sleep deprivation on cognitive performance ,Neurostimulation ,Spectroscopy, Near-Infrared ,05 social sciences ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,Dorsolateral prefrontal cortex ,medicine.anatomical_structure ,Neurology ,Cognitive remediation therapy ,Practice, Psychological ,Functional near-infrared spectroscopy ,Female ,Psychology ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Speed of Processing (SoP) represents a fundamental limiting step in cognitive performance which may underlie General Intelligence. The measure of SoP is particularly sensitive to aging, neurological or cognitive diseases, and has become a benchmark for diagnosis, cognitive remediation, and enhancement. Neural efficiency of the Dorsolateral Prefrontal Cortex (DLPFC) is proposed to account for individual differences in SoP. However, the mechanisms by which DLPFC efficiency is shaped by training and whether it can be enhanced remain elusive. To address this, we monitored the brain activity of sixteen healthy participants using functional Near Infrared Spectroscopy (fNIRS) while practicing a common SoP task (Symbol Digit Substitution Task) across 4 sessions. Furthermore, in each session, participants received counterbalanced excitatory repetitive transcranial magnetic stimulation (rTMS) during mid-session breaks. Results indicate a significant involvement of the left-DLPFC in SoP, whose neural efficiency is consistently increased through task practice. Active neurostimulation, but not Sham, significantly enhanced the neural efficiency. These findings suggest a common mechanism by which neurostimulation may aid to accelerate learning. more...
- Published
- 2019
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