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Additional file 1: Fig. S1 a. The fluorescence intensity values of Ru(bpy)3Cl2 and CMSN at various time points under the UV lamp. b The hydrated particle size of CMSN@Anti. (The mean particle sizes of NPs were 225.3 nm, 231.6 nm, 267.8 nm and 255.4 nm respectively). Fig. S2 a. The UV-vis absorption spectra of SRT1720 at different concentrations. b The corresponding linear regression equation. Fig. S3. Toxicity test of CMSN@SRT@Anti to RAW264.7 or NIH-3T3 cells (FRAW264.7 = 1.679, P = 0.142 > 0.05; FNIH-3T3 = 1.737, P = 0.128 > 0.05). Fig. S4. Representative blots and quantification of protein levels of CD36 to the β-actin levels before and after ox-LDL treatment. (*p < 0.05). Fig. S5. Blood index analysis of Kunming mice before and after CMSN@SRT@Anti intervention. ALT (P=0.624), TP (P=0.972), ALB (P=0.504), CREA (P=0.577), UREA (P=0.849), WBC (P=0.984), RBC (P=0.664), HGB (P=0.775), HCT (P=0.707), MCH (P=0.965), MCV (P=0.963), P values are all greater than 0.05. Compared with AST 0d group, P(AST 1d)= 0.0230.05, P (AST 21d)= 0.313>0.05. Fig. S6. Toxicity test of CMSN@SRT@Anti on Kunming mice. a The body weight of Kunming mice injected intraperitoneally with NMs or PBS changed with time. b Pathological section of major organs in Kunming mice (H&E, Scale bar: 100 μm). Table S1. EE and LE of CMSN@SRT@Anti at different concentrations of SRT1720. Table S2. Relative fluorescence intensity of liver and cholecyst of Kunming mice at each time point after intraperitoneal injection of CMSN@SRT@Anti determined by Tanon Image softerware.