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Poor sleep quality, decreased physical activity (PA) and increased sedentary behavior (SB) are common characteristics of older adults. Notably, these factors play an important role in brain health. We examined the relationship between sleep quality, PA, SB and brain white matter integrity (WM) in older adults with osteoarthritis (OA). We retained data on 16 participants (mean age 60, SD=7.7) from a larger Monitor-OA cohort recruited from Metro Vancouver, BC, Canada. Sleep efficiency and duration, amount of time spent on PA and SB daily over a period of one week was acquired with an objective measure – the multi-sensor monitor SenseWear Mini which integrates tri-axial accelerometer data, physiological sensor data and personal demographic information. Brain WM tractography was calculated from fractional anisotropy data obtained with diffusion weighted magnetic resonance imaging. Voxelwise group-level statistics examined the effects of our variables of interest on the integrity of brain WM tracts while controlling for participants age. We found that lower sleep efficiency was related to decreased integrity in WM tracts of frontal, temporal lobes, precuneus and thalamus (Bonferroni corrected p

Insomnia is prevalent in caregivers of persons living with dementia (PLWD); however, more research is needed to identify which dyadic factors most impact caregiver sleep. This study aimed to identify the factors associated with caregiver insomnia in the baseline component of a randomized clinical trial. A linear regression was conducted with caregiver variables (e.g., depression), and PLWD variables (e.g., disruptive nighttime behaviors) as independent variables in relation to insomnia, as assessed with Insomnia Severity Index (ISI). Caregivers (n=49) were on average 63 years, mostly female (65.3%), White (69.4%), and spouses (65.3%). Mean ISI was 6.8, indicating mild-to-moderately disturbed sleep. Multiple linear regression (F(11,32) = 13.4, p