1. Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas
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Héloïse de Kermadec, P.-L. Bastier, Cécile Rumeau, Philippe Herman, Olivier Choussy, Louis Crampette, André Coste, Sébastien Vergez, Justin Michel, Elie Serrano, Christian Righini, Anjarasoa Tsaranazy, Emile Reyt, Benjamin Verillaud, Ludovic de Gabory, V. Trevillot, Geoffrey Mortuaire, Roger Jankowski, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Hôpital Lariboisière, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Intercommunal de Créteil (CHIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'ORL et de chirurgie cervicale, CHU Grenoble, Service d'ORL, chirurgie cervico-faciale [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service d'ORL, Hôpital Gui de Chauliac (CHRU de Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Hôpital de Rangueil, CHU Toulouse [Toulouse], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7) more...
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Adult ,Male ,Natural Orifice Endoscopic Surgery ,medicine.medical_specialty ,medicine.medical_treatment ,Nose Neoplasms ,Esthesioneuroblastoma, Olfactory ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,olfactory cleft ,Disease-Free Survival ,endoscopic surgery ,neuroblastoma ,03 medical and health sciences ,0302 clinical medicine ,Neuroblastoma ,Positive Margins ,sinus cancer ,Humans ,Medicine ,Pathological ,Craniotomy ,Aged ,Retrospective Studies ,Periorbita ,Olfactory Neuroblastoma ,business.industry ,Head and neck cancer ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Survival Rate ,Treatment Outcome ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Female ,Nasal Cavity ,business ,Meningitis ,030217 neurology & neurosurgery - Abstract
International audience; BACKGROUND:Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy.METHODS:Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy.RESULTS:The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate.CONCLUSION:Exclusively endoscopic treatment proved efficient and reliable in a large controlled series. more...
- Published
- 2018
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