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Presenting an extraordinary case of Eagle's syndrome (ES) with the classical and follicular variant of papillary thyroid microcarcinoma (PTmC) and an uncommon stylohyoid ligament calsification, aside from O'Carroll's System.A 52-year-old Turkish man with an histopathology of the follicular variant of PTmC (FVPTmC) of his right lobe and conventional PTmC of his left lobe of the thyroid with an adjuvant 100 mCi radioactive iodine (RAI) ablation was admitted. On the routine follow-up of the present case, a lineer structure at the 3rd compartment of neck in his ultrasonography, a styloid ligament calsification in his noncontrast computed tomography (CT), and a left styloid process of the temporal bone of 29 mm in size in his three-dimensional (3D) CT scanning had been revealed. Conclusively, an ES, Langlais Type III with The Calcification Pattern IV, was recognized.A noninvasive peroral medical management was administered as a first-line treatment for the neuropathic sequelae of ES and it has provided relief of signs and symptoms without any recurrence to date, for three years and three months.To our knowledge, it is an highly extreme and first case of ES in the English literature, recognized in the course of his programmed follow-up of his conventional PTmC and FVPTmC, simultaneously possessing an exceptional stylohyoid ligament calsification, apart from O'Carroll's System, even with an anatomic variation of the hyoid bone.Eagle's Syndrome Follicular variant of papillary thyroid microcarcinoma, Hyoid bone variation, Langlais classification, O'Carroll's System, Radioactive iodine, Papillary thyroid microcarcinoma.Presentare un caso straordinario di sindrome di Eagle (ES) con la variante convenzionale e follicolare del microcarcinoma papillare della tiroide (PTmC) e un raro calsificazione del legamento stiloideoide, a parte il sistema di O’Carroll.È stato ammesso un uomo Turco di 52 anni con un’istopatologia della variante follicolare di PTmC (FVPTmC) del lobo destro e PTmC convenzionale del lobo sinistro della tiroide con ablazione con iodio radioattivo (RAI) da 100 mCi adiuvante . Sul follow- up di routine del caso in esame, una struttura di lineer al terzo compartimento del collo nella sua ecografia, una calsificazione del legamento stiloideo nella sua tomografia computerizzata non controllata (CT) e un processo stiloideo sinistro dell’osso temporale di 29.0 mm in sono state rivelate le dimensioni nella sua scansione tridimensionale (3D). In conclusione, è stato rivelato un ES, Langlais Type III con The Calcification Pattern IV. DISCUSSIONE: una gestione medica orale non invasiva è stata somministrata come trattamento di prima linea per le sequele neuropatiche di ES e ha fornito sollievo da segni e sintomi senza alcuna recidiva fino ad oggi, per tre anni.A nostra conoscenza, si tratta di un caso estremamente estremo e primo di ES nella letteratura inglese, riconosciuto nel corso del suo follow-up programmato del suo PTMC e FVPTMC convenzionale, in possesso simultaneamente di un’eccezionale calsificazione del legamento stiloideoide, a parte O’Carroll’s Sistema, anche con una variazione anatomica dell’osso ioide.

Sengul, Ilker/0000-0001-5217-0755 WOS: 000458202600052 PubMed: 30941995 Purpose: The purpose of this study was to assess the performance of strain elastography (SE) in predicting malignancy for the thyroid nodules with undetermined cytology, Bethesda categories III and IV. The cut-off point was 20 mm of a thyroid nodule. Methods: A retrospective analysis from April 2012 to April 2016 was conducted by examining the records of 547 consecutive eligible patients with 655 thyroid nodules, the undetermined cytology of which surgery had been recommended. Results: A sum of 655 nodules in 547 patients were studied. Eighty-two (12.5%) of 655 thyroid nodules were Bethesda Category III and IV (undetermined cytology). Of the 655 thyroid nodules examined, 401 (61.2%) were less than 20 mm and 254 (38.8%) were more than 20 mm in diameter. No significant difference was detected between nodule sizes more than 20 mm in diameter and Tsukuba Elasticity score (TES) 4 and 5 by McNemar test and 0.677 area under the curve (AUC). No significant difference was detected between nodule sizes over 20 mm in diameter and Bethesda III and IV (undetermined cytology) by McNemar test and 0.632 AUC. In addition, no significant difference was detected between nodule size with the cut-off value of 20 mm and the histopathology of the thyroidectomies by McNemar test and 0.607 AUC. Conclusion: Nodules size 20 mm in diameter was not a useful cut-off point for distinguishing malignant from benign thyroid nodules among the nodules with TES 4 and 5, Bethesda III and IV, and malignant histopathology.

Sengul, Ilker/0000-0001-5217-0755 WOS: 000270313500014 PubMed: 19865584 Endometriosis is defined as a growth of ectopic endometrial tissue outside the uterine cavity that responds to hormonal stimulation. It occurs most commonly in pelvic sites such as the ovaries, posterior cul-de-sac, ligaments of the uterus, pelvic peritoneum and rectovaginal septum and is found in 8%–15% of all menstruating women. Extrapelvic endometriosis is less common but can affect many sites, including the lungs, appendix, nose, umblicus, peritoneum and even the intestinal wall.1

Sengul, Ilker/0000-0001-5217-0755 WOS: 000298225000005 PubMed: 21225496 Aims: Differential diagnosis between the group of trichoadenoma, trichofolliculoma, trichoepithelioma, trichoblastoma and basal cell carcinoma has been creating some difficulties for the pathologist and the clinicians, particularly in the presence of small specimens. Material and methods: A total of 30 cases of benign tumours of cutaneous appendages originating from the hair follicle and 30 cases of basal cell carcinoma were retrieved from the archives deposited from 2004 to 2008. Results: The expression of CD10 in both tumours was graded from [0] to [2+] for each case. The immunoreactivity of CD10 was comparatively examined among the groups and each subgroup. The stromal CD10 immunopositivity of benign tumours of cutaneous appendages originating from the hair follicle was stronger than the other (p = 0.003) regarding both the numerical and the degree of expression. However, peripheral CD10 of basal cell carcinoma was stronger than the other for [1+] immunopositivity (p = 0.03). It was exact opposite for [2+] (p = 0.013). Besides, central CD10 immunopositivity and CD10 reactivity for the subgroups was not significant. Conclusions: CD10 may be very useful for the differential diagnosis between them particularly in the small and superficial biopsies and it may be even a life-saving method in some selected cases.