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Vortioxetine is a multimodal-acting antidepressant that provides improvements on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been found to be one of the most effective and best tolerated options for major depressive disorder (MDD) in head-to-head trials.The present review intends to gather the most relevant and pragmatic data of vortioxetine in MDD, specially focusing on new studies that emerged between 2015 and 2020.Vortioxetine is the first antidepressant that has shown improvements both in depression and cognitive symptoms, due to the unique multimodal mechanism of action that combine the 5-HT reuptake inhibition with modulations of other key pre- and post-synaptic 5-HT receptors (agonism of 5-HT

Aims. The structural inhomogeneities and kinematics of massive star nebulae are tracers of their mass-loss history. We conduct a three-dimensional morpho-kinematic analysis of the ejecta of eta Car outside its famous Homunculus nebula. Methods. We carried out the first large-scale integral field unit observations of eta Car in the optical, covering a field of view of 1'x1' centered on the star. Observations with the Multi Unit Spectroscopic Explorer (MUSE) at the Very Large Telescope (VLT) reveal the detailed three-dimensional structure of eta Car's outer ejecta. Morpho-kinematic modeling of these ejecta is conducted with the code SHAPE. Results. The largest coherent structure in eta Car's outer ejecta can be described as a bent cylinder with roughly the same symmetry axis as the Homunculus nebula. This large outer shell is interacting with the surrounding medium, creating soft X-ray emission. We establish the shape and extent of the ghost shell in front of the southern Homunculus lobe and confirm that the NN condensation can best be modeled as a bowshock in the orbital/equatorial plane. Conclusions. The SHAPE modeling of the MUSE observations indicates that the kinematics of the outer ejecta measured with MUSE can be described by a spatially coherent structure, and this structure also correlates with the extended soft X-ray emission associated with the outer debris field. The ghost shell just outside the southern Homunculus lobe hints at a sequence of eruptions within the time frame of the Great Eruption from 1837-1858 or possibly a later shock/reverse shock velocity separation. Our 3D morpho-kinematic modeling and the MUSE observations constitute an invaluable dataset to be confronted with future radiation-hydrodynamics simulations. Such a comparison may shed light on the yet elusive physical mechanism responsible for eta Car-like eruptions., Comment: 14 pages, 8 figures, accepted in A&A

The literature is unclear regarding the appropriate medical and psychological treatment of intersexuality: people who have genital, gonadal, or chromosomal characteristics that are neither all female nor all male. Medical and psychosocial management of such individuals is being reevaluated. Congenital adrenal hyperplasia (CAH), the most common cause of intersexual development among genetic females, is an inherited disorder that leads to varying degrees of masculinization of the external genitalia while internal genitals (ovaries, Fallopian tubes, and uterus) are typically female. The purpose of this study was to explore self-perceptions of adult women who have CAH and the impact of the condition on their relationships, sexuality, gender identity, gender roles, and self-concept. In addition, their perceptions of medical treatment were examined. Five women with CAH chose to participate. Participants reported: (a) a sense of isolation and embarrassment about sharing information concerning their cond...