1. Home Self-tonometry Trials Compared with Clinic Tonometry in Patients with Glaucoma
- Author
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Pradeep Y. Ramulu, Thomas V. Johnson, Elyse J. McGlumphy, and Aleksandra Mihailovic
- Subjects
Male ,Intraocular pressure ,medicine.medical_specialty ,Younger age ,genetic structures ,Manometry ,Glaucoma ,01 natural sciences ,Article ,Tonometry, Ocular ,03 medical and health sciences ,0302 clinical medicine ,Filtering surgery ,Ophthalmology ,Humans ,Medicine ,In patient ,0101 mathematics ,Risk factor ,Male gender ,Retrospective Studies ,business.industry ,010102 general mathematics ,Self tonometry ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,Cross-Sectional Studies ,030221 ophthalmology & optometry ,sense organs ,business - Abstract
Purpose This study examined characteristics of intraocular pressure (IOP) as measured during home tonometry in comparison with in-clinic tonometry in patients with glaucoma. Design Retrospective cross-sectional study of glaucoma patients who completed 1 week of self-tonometry at a single academic center. Participants Patients with glaucoma who completed home tonometry trials with the iCare HOME tonometer (iCare USA) for any reason. Methods Home IOP measurements were compared with in-clinic tonometry performed during the 5 visits preceding home tonometry. Maximum daily IOP was correlated to time of day. Generalized estimating equations were used to evaluate patient characteristics and clinic-derived variables that predicted differences between home and clinic IOP. Main Outcome Measures IOP mean, maximum, minimum, range, standard deviation and coefficient of variation were compared between clinic and home tonometry. IOP mean daily maximum (MDM) and mean daily range were calulated to describe recurrent IOP spiking. Results A total of 107 eyes from 61 patients were analyzed. Mean age was 63.2 years (standard deviation [SD], 14.0 years) and 59.0% were women. Mean clinic and home IOPs were 14.5 mmHg (SD, 4.7 mmHg) and 13.6 mmHg (SD, 5.1 mmHg). Home tonometry identified significantly higher maximum IOP, lower minimum IOP, and greater IOP range than clinic tonometry (P am –5 pm ) on 50% of days assessed and occurred between 4:30 am and 8 am on 24% of days. Mean daily maximum IOP exceeded maximum clinic IOP in 44% of patients and exceeded target IOP by 3 mmHg, 5 mmHg, or 10 mmHg in 31%, 15%, and 6% of patients, respectively. Patient characteristics that predicted significant deviations between MDM and mean clinic IOP or target IOP in multivariate models included younger age, male gender, and absence of prior filtering surgery. Conclusions Self-tonometry provides IOP data that supplements in-clinic tonometry and would not be detectable over daytime in-clinic diurnal curves. A subset of patients in whom home tonometry was ordered by their glaucoma clinician because of suspicion of occult IOP elevation demonstrated reproducible IOP elevation outside of the clinic setting. Such patients tended to be younger and male and not to have undergone previous filtering surgery.
- Published
- 2021