1. Tumour type and size are prognostic factors in gastric neuroendocrine neoplasia: A multicentre retrospective study
- Author
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Panzuto F., Campana D., Massironi S., Faggiano A., Rinzivillo M., Lamberti G., Sciola V., Lahner E., Manuzzi L., Colao A., Annibale B., LAMBERTI, GIUSEPPE, Panzuto F., Campana D., Massironi S., Faggiano A., Rinzivillo M., Lamberti G., Sciola V., Lahner E., Manuzzi L., Colao A., and Annibale B.
- Subjects
Gastritis, Atrophic ,Male ,medicine.medical_specialty ,Multivariate analysis ,gastric carcinoid ,Ki67 ,neuroendocrine neoplasia ,prognosis ,risk factors ,Prognosi ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Tumor type ,Grading (tumors) ,Male gender ,Aged ,Neoplasm Staging ,Retrospective Studies ,Neuroendocrine neoplasia ,Angioinvasion ,Hepatology ,business.industry ,Retrospective cohort study ,Middle Aged ,Prognosis ,Survival Rate ,Neuroendocrine Tumors ,Logistic Models ,Italy ,030220 oncology & carcinogenesis ,Multivariate Analysis ,030211 gastroenterology & hepatology ,Female ,Gastritis ,medicine.symptom ,business - Abstract
Background Gastric neuroendocrine neoplasias (gNEN) are defined as type I if associated with atrophic body gastritis and type III when tumour is sporadic. This classification, together with grading and size, plays a crucial prognostic role. Nevertheless, the impact of these features on clinical outcome is not clear. Aim To identify factors predicting poor outcome. Patients and methods Analysis of type I and type III gNEN. A composite endpoint was defined if tumour-related death or metastases or angioinvasion were observed. Results 156 gNENs were evaluated: 137 (87.8%) type I and 19 (12.2%) type III. Among type I, 103 were G1 (75.2%) and 34 (24.8%) were G2. In type III group, 8 were G1 (42.1%), 10 were G2 (52.6%), and 1 was G3 (5.3%). Negative endpoint occurred in 18 patients including 10 type III and 8 type I. Male gender (p = 0.032), tumour type (p = 0.003) and size >10 mm (p = 0.024) were predictors for poor outcome, whereas Ki67 was not confirmed on multivariate analysis (p = 0.192). 5-yr survival rates in type I and type III were 100% and 76.2%, respectively (p = 0.0002). Conclusions Tumour size, tumour type and gender affect clinical outcome in gNENs. In contrast to NENs rising from other sites, Ki67 plays a less important role.
- Published
- 2018