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Your search keyword '"Schwer B"' showing total 2 results
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2 results on '"Schwer B"'

1. Editorial: Genomic Instability and Neurodegeneration

Author

Fuchs, J., Schwer, B., El-Khamisy, S.F., Sergi, Gianna, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of California [San Francisco] (UC San Francisco), University of California (UC), University of Sheffield [Sheffield], and University of Bradford

Subjects
[SDV] Life Sciences [q-bio], Aging, [SDV]Life Sciences [q-bio], Cognitive Neuroscience, neurodegeneration, DNA damage, DNA repair, genomic instability
Abstract

International audience; No abstract available

Published
2022

2. Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader

Author

Jan C. Vos, Paolo Visca, Hendrik G. Stunnenberg, Beate Schwer, Molecular and Computational Toxicology, AIMMS, Schwer, B, Visca, Paolo, Vos, Jc, and Stunnenberg, Hg

Subjects
RNA Processing, Transcription, Genetic, Messenger, RNA-dependent RNA polymerase, Post-Transcriptional, Vaccinia virus, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, Genetic, SDG 3 - Good Health and Well-being, Transcription (biology), Gene expression, Journal Article, Humans, RNA, Messenger, RNA Processing, Post-Transcriptional, Messenger RNA, Base Sequence, Intron, RNA, Promoter, Molecular biology, genomic DNA, Poly A, Transcription, HeLa Cells
Abstract

We have demonstrated by primer elongation and cap analysis that mature vaccinia virus late transcripts are discontinuously synthesized. We have shown that RNA transcripts from a translocated 11K and from the authentic 11K and 4b late promoters are extended by approximately 35 nucleotides beyond the "start site" determined by S1 mapping using vaccinia genomic DNA as a probe. Sequencing of the RNA and of the first strand cDNA reveal that a homopolymeric poly(A) sequence is linked to the 5' terminus of the RNA transcripts. S1 mapping of RNA transcripts with a DNA probe containing an A-stretch, replacing promoter sequences upstream of position -1, confirms the existence of a poly(A) leader of approximately 35 A-residues.

Published
1987

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