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1. Risk factors associated with 10% weight change in treatment-naïve and treatment-experienced people living with HIV initiating or switching to an NNRTI- or INSTI-based antiretroviral therapy in four large cohort studies

Author: Robineau, O, Marongiu, A, Stellbrink, H-J, Meynard, JL, Brunetta, J, Turner, D, D’Arminio Monforte, A, Ángel Castaño-Carracedo, M, Van Welzen, B, Williams, L, Haubrich, R, Heinzkill, M, Sahali, S, Schreiber, S, Gruber, J, Cohen, C, and Esser, S
Abstract: Background: Pooled analyses of randomised controlled trials have shown weight gain (WG) following initiation/switching of antiretroviral therapy (ART) in people living with HIV (PLWHIV) [1,2]. We explored risk factors associated with ≥10% WG/weight loss (WL) in PLWHIV after initiating/switching ART. Materials and methods: Weight data were analysed from treatment-experienced (TE) and treatment-naïve (TN) PLWHIV enrolled in four Gilead-sponsored, post-authorisation, observational HIV cohort studies (2010 to 2020) and who initiated/switched non-nucleoside reverse transcriptase inhibitor (NNRTI)– or integrase strand transfer inhibitor (INSTI)–based ART. Participants had weight data available at baseline and 10 to 15 months post-baseline. Adjusted odds ratios (ORs) for potential risk factors for ≥10% WG/WL at 12 months in participants were estimated using multivariable logistic regression. Results: Two thousand, six hundred and sixty-six participants were included. Median age: 38 (TN)/47 years (TE). Of TE participants, 914/1939 (47%) switched from emtricitabine (F)/tenofovir disoproxil fumarate (TDF) backbone to F/tenofovir alafenamide (TAF), and 162/1939 (8%) from abacavir (ABC)/lamivudine (3TC) to F/TAF. Two hundred and twenty-nine of 727 (31%) TN participants had ≥10% WG (Table 1). Risk factors for ≥10% WG were F/TAF backbone (vs F/TDF; p < 0.001), low baseline CD4 (vs higher; p = 0.010), and being underweight (vs normal; p= 0.024; Figure 1). Eight of 727 (1%) TN participants had ≥10% WL. No significant risk factors for ≥10% WL were identified. Four hundred and fifty-one of 1939 (23%) TE participants had ≥10% WG (Table 1). Risk factors for ≥10% WG were INSTI-based ART (vs NNRTI; p = 0.029), F/TAF backbone (vs F/TDF; p < 0.001), being female (vs male; p = 0.002), switching from F/TDF to F/TAF (vs no switch; p = 0.001), being underweight (vs normal; p < 0.001), and having comorbidities associated with obesity (vs not; p = 0.046). Forty of 1939 (2%) TE participants had ≥10% WL. Only comedications associated with WL were predictors for ≥10% WL (OR 2.73 [95% CI 1.02 to 7.31]; p = 0.046). Conclusions: After initiating ART, WG was associated with F/TAF backbone, low baseline CD4 count, and being underweight in TN participants. In TE participants, WG was associated with INSTI-based ART, F/TAF backbone, switching from F/TDF to F/TAF, being female, and being underweight at baseline. Findings are consistent with the documented WG suppressive effect of F/TDF [3-6]. These data cannot determine the contribution of F/TAF to WG beyond the absence of the F/TDF WG suppressive effect. References: 1. Sax PE, Erlandson KM, Lake JE, Mccomsey GA, Orkin C, Esser S, et al. Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials. Clin Infect Dis. 2020;71:1379-89. 2. Erlandson KM, Carter CC, Melbourne K, Brown TT, Cohen C, Das M, et al. Weight change following antiretroviral therapy switch in people with viral suppression: pooled data from randomized clinical trials. Clin Infect Dis. 2021;73:1440-51. 3. Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, et al. Metabolic effects of preexposure prophylaxis with coformulated tenofovir disoproxil fumarate and emtricitabine. Clin Infect Dis. 2018;67:411-9. 4. Ogbuagu O, Ruane PJ, Podzamczer D, Salazar LC, Henry K, Asmuth DM, et al. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet HIV. 2021;8:e397-e407. 5. Landovitz RJ, Donnell D, Clement M, Hanscom B, Cottle L, Coelho L, et al. HPTN 083 final results: Pre-exposure prophylaxis containing long-acting injectable cabotegravir is safe and highly effective for cisgender men and transgender women who have sex with men. 23rd International AIDS Conference; 2020 Jul 6-10. Oral OAXLB01. 6. Shah S, Pilkington V, Hill A. Use of tenofovir disoproxil fumarate shows weight loss vs placebo: a meta-analysis of 7 clinical trials in 19,359 HIV-negative individuals. IDWeek 2021; 2021 Sep 29-Oct 3; virtual. Poster P882.
Published: 2022

2. Activation of distinct antiviral T-cell immunity: A comparison of bi- and trispecific T-cell engager antibodies with a chimeric antigen receptor targeting HBV envelope proteins

Author: Debelec-Butuner, B., Quitt, O., Schreiber, S., Momburg, F., Wisskirchen, K., and Protzer, U.
Subjects: Expansion, Virus-Replication, Hepatitis B virus, T-Lymphocytes, Immunology, T-cell engager antibody, Expression, Antiviral Agents, Cccdna, Viral Envelope Proteins, CD28 Antigens, Antibodies, Bispecific, Immunology and Allergy, Humans, chronic hepatitis B, Cancer, HBV cure, adoptive T-cell therapy, drug development, immunotherapy, chimeric antigen receptor, Receptors, Chimeric Antigen, Dna, Adoptive T-cell Therapy, Chimeric Antigen Receptor, Chronic Hepatitis B, Drug Development, Hbv Cure, Immunotherapy, T-cell Engager Antibody, ddc, Hepatocytes, Leukocytes, Mononuclear, Cytokines, Therapy, DNA, Circular
Abstract: Despite the availability of an effective prophylactic vaccine, 820,000 people die annually of hepatitis B virus (HBV)-related liver disease according to WHO. Since current antiviral therapies do not provide a curative treatment for the 296 million HBV carriers around the globe, novel strategies to cure HBV are urgently needed. A promising approach is the redirection of T cells towards HBV-infected hepatocytes employing chimeric antigen receptors or T-cell engager antibodies. We recently described the effective redirection of T cells employing a second-generation chimeric antigen receptor directed against the envelope protein of hepatitis B virus on the surface of infected cells (S-CAR) as well as bispecific antibodies that engage CD3 or CD28 on T cells employing the identical HBV envelope protein (HBVenv) binder. In this study, we added a trispecific antibody comprising all three moieties to the tool-box. Cytotoxic and non-cytolytic antiviral activities of these bi- and trispecific T-cell engager antibodies were assessed in co-cultures of human PBMC with HBV-positive hepatoma cells, and compared to that of S-CAR-grafted T cells. Activation of T cells via the S-CAR or by either a combination of the CD3- and CD28-targeting bispecific antibodies or the trispecific antibody allowed for specific elimination of HBV-positive target cells. While S-CAR-grafted effector T cells displayed faster killing kinetics, combinatory treatment with the bispecific antibodies or single treatment with the trispecific antibody was associated with a more pronounced cytokine release. Clearance of viral antigens and elimination of the HBV persistence form, the covalently closed circular (ccc) DNA, through cytolytic as well as cytokine-mediated activity was observed in all three settings with the combination of bispecific antibodies showing the strongest non-cytolytic, cytokine-mediated antiviral effect. Taken together, we demonstrate that bi- and trispecific T-cell engager antibodies can serve as a potent, off-the-shelf alternative to S-CAR-grafted T cells to cure HBV., Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [SFB-TRR 338/1 2021-452881907, SFB-TRR 179/2 2020 -272983813]; Scientific and Technological Research Council of Turkey 2219 Postdoctoral fellowship program; SCG Cell Therapy., The study was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - SFB-TRR 338/1 2021-452881907 and SFB-TRR 179/2 2020 -272983813 and by a research collaboration with SCG Cell Therapy. The funders had no influence on the content of the manuscript. BDB was supported by The Scientific and Technological Research Council of Turkey 2219 Postdoctoral fellowship program.
Published: 2021

3. Critical appraisal and future outlook on anti-inflammatory biosimilar use in chronic immune-mediated inflammatory diseases

Author: Schreiber, S, Puig, L, Gonçalves, J, Mease, PJ, Panaccione, R, and Emery, P
Subjects: Europe, Anesthesiology and Pain Medicine, Rheumatology, Anti-Inflammatory Agents, Humans, Biosimilar Pharmaceuticals, United States
Abstract: Biosimilars represent a novel category in the world of follow-up medicinal products with the requirement that they are highly similar but not identical to an approved originator biologic medicine, with no clinically meaningful differences in safety, purity, and potency. In this review, we discuss recent pivotal biosimilar developments for anti-inflammatory therapy in rheumatology, gastroenterology, and dermatology, and the influence of biosimilar availability on patients and payers. Finally, we provide our perspective on the evolution of biosimilar use in these indications in the United States (US) and in Europe and on where this evolution in biopharmaceuticals may lead in the future. Although biosimilars are commonly used in the European Union (EU), there will be an inevitable sea change of acceptance by clinicians, patients, payers, and regulators in the US. It is paramount to educate about biosimilarity, highlighting currently available data gathered from other geographies, in addition to gradually providing clinicians and patients with the necessary experience with these agents ultimately restoring competition in the biologics landscape.
Published: 2022

4. Quality control and conduct of genome-wide association meta-analyses

Author: Winkler, T, Day, F, Croteau Chonka, D, Wood, A, Locke, A, Mägi, R, Ferreira, T, Fall, T, Graff, M, Justice, A, Luan, J, Gustafsson, S, Randall, J, Vedantam, S, Workalemahu, T, Kilpeläinen, T, Scherag, A, Esko, T, Kutalik, Z, Heid, I, Loos, R, Abecasis GR, Absher D, Alavere H, Albrecht E, Allen HL, Almgren P, Amin N, Amouyel P, Anderson D, Arnold AM, Arveiler D, Aspelund T, Asselbergs FW, Assimes TL, Atalay M, Attwood AP, Atwood LD, Bakker SJ, Balkau B, Balmforth AJ, Barlassina C, Barroso I, Basart H, Bauer S, Beckmann JS, Beilby JP, Bennett AJ, Ben Shlomo Y, Bergman RN, Bergmann S, Berndt SI, Biffar R, Di Blasio AM, Boehm BO, Boehnke M, Boeing H, Boerwinkle E, Bolton JL, Bonnefond A, Bonnycastle LL, Boomsma DI, Borecki IB, Bornstein SR, Bouatia Naji N, Boucher G, Bragg Gresham JL, BRAMBILLA, PAOLO, Bruinenberg M, Buchanan TA, Buechler C, Cadby G, Campbell H, Caulfield MJ, Cavalcanti Proença C, CESANA, GIANCARLO, Chanock SJ, Chasman DI, Chen YD, Chines PS, Clegg DJ, Coin L, Collins FS, Connell JM, Cookson W, Cooper MN, Croteau Chonka DC, Cupples LA, Cusi D, Day FR, Day IN, Dedoussis GV, Dei M, Deloukas P, Dermitzakis ET, Dimas AS, Dimitriou M, Dixon AL, Dörr M, van Duijn CM, Ebrahim S, Edkins S, Eiriksdottir G, Eisinger K, Eklund N, Elliott P, Erbel R, Erdmann J, Erdos MR, Eriksson JG, Esko T, Estrada K, Evans DM, de Faire U, Fall T, Farrall M, Feitosa MF, Ferrario MM, Ferreira T, Ferrières J, Fischer K, Fisher E, Fowkes G, Fox CS, Franke L, Franks PW, Fraser RM, Frau F, Frayling T, Freimer NB, Froguel P, Fu M, Gaget S, Ganna A, Gejman PV, Gentilini D, Geus EJ, Gieger C, Gigante B, Gjesing AP, Glazer NL, Goddard ME, Goel A, Grallert H, Gräßler J, Grönberg H, Groop LC, Groves CJ, Gudnason V, Guiducci C, Gustafsson S, Gyllensten U, Hall AS, Hall P, Hallmans G, Hamsten A, Hansen T, Haritunians T, Harris TB, van der Harst P, Hartikainen AL, Hassanali N, Hattersley AT, Havulinna AS, Hayward C, Heard Costa NL, Heath AC, Hebebrand J, Heid IM, den Heijer M, Hengstenberg C, Herzig KH, Hicks AA, Hingorani A, Hinney A, Hirschhorn JN, Hofman A, Holmes CC, Homuth G, Hottenga JJ, Hovingh KG, Hu FB, Hu YJ, Huffman JE, Hui J, Huikuri H, Humphries SE, Hung J, Hunt SE, Hunter D, Hveem K, Hyppönen E, Igl W, Illig T, Ingelsson E, Iribarren C, Isomaa B, Jackson AU, Jacobs KB, James AL, Jansson JO, Jarick I, Jarvelin MR, Jöckel KH, Johansson Å, Johnson T, Jolley J, Jørgensen T, Jousilahti P, Jula A, Justice AE, Kaakinen M, Kähönen M, Kajantie E, Kanoni S, Kao WH, Kaplan LM, Kaplan RC, Kaprio J, Kapur K, Karpe F, Kathiresan S, Kee F, Keinanen Kiukaanniemi SM, Ketkar S, Kettunen J, Khaw KT, Kiemeney LA, Kilpeläinen TO, Kinnunen L, Kivimaki M, Kivmaki M, Van der Klauw MM, Kleber ME, Knowles JW, Koenig W, Kolcic I, Kolovou G, König IR, Koskinen S, Kovacs P, Kraft P, Kraja AT, Kristiansson K, KrjutÅjkov K, Kroemer HK, Krohn JP, Krzelj V, Kuh D, Kulzer JR, Kumari M, Kutalik Z, Kuulasmaa K, Kuusisto J, Kvaloy K, Laakso M, Laitinen JH, Lakka TA, Lamina C, Langenberg C, Lantieri O, Lathrop GM, Launer LJ, Lawlor DA, Lawrence RW, Leach IM, Lecoeur C, Lee SH, Lehtimäki T, Leitzmann MF, Lettre G, Levinson DF, Li G, Li S, Liang L, Lin DY, Lind L, Lindgren CM, Lindström J, Liu J, Liuzzi A, Locke AE, Lokki ML, Loley C, Loos RJ, Lorentzon M, Luan J, Luben RN, Ludwig B, Madden PA, Mägi R, Magnusson PK, Mangino M, Manunta P, Marek D, Marre M, Martin NG, März W, Maschio A, Mathieson I, McArdle WL, McCaroll SA, McCarthy A, McCarthy MI, McKnight B, Medina Gomez C, Medland SE, Meitinger T, Metspalu A, van Meurs JB, Meyre D, Midthjell K, Mihailov E, Milani L, Min JL, Moebus S, Moffatt MF, Mohlke KL, Molony C, Monda KL, Montgomery GW, Mooser V, Morken MA, Morris AD, Morris AP, Mühleisen TW, Müller Nurasyid M, Munroe PB, Musk AW, Narisu N, Navis G, Neale BM, Nelis M, Nemesh J, Neville MJ, Ngwa JS, Nicholson G, Nieminen MS, Njølstad I, Nohr EA, Nolte IM, North KE, Nöthen MM, Nyholt DR, O'Connell JR, Ohlsson C, Oldehinkel AJ, van Ommen GJ, Ong KK, Oostra BA, Ouwehand WH, Palmer CN, Palmer LJ, Palotie A, Paré G, Parker AN, Paternoster L, Pawitan Y, Pechlivanis S, Peden JF, Pedersen NL, Pedersen O, Pellikka N, Peltonen L, Penninx B, Perola M, Perry JR, Person T, Peters A, Peters MJ, Pichler I, Pietiläinen KH, Platou CG, Polasek O, Pouta A, Power C, Pramstaller PP, Preuss M, Price JF, Prokopenko I, Province MA, Psaty BM, Purcell S, Pütter C, Qi L, Quertermous T, Radhakrishnan A, Raitakari O, Randall JC, Rauramaa R, Rayner NW, Rehnberg E, Rendon A, Ridderstråle M, Ridker PM, Ripatti S, Rissanen A, Rivadeneira F, Rivolta C, Robertson NR, Rose LM, Rudan I, Saaristo TE, Sager H, Salomaa V, Samani NJ, Sambrook JG, Sanders AR, Sandholt C, Sanna S, Saramies J, Schadt EE, Scherag A, Schipf S, Schlessinger D, Schreiber S, Schunkert H, Schwarz PE, Scott LJ, Shi J, Shin SY, Shuldiner AR, Shungin D, Signorini S, Silander K, Sinisalo J, Skrobek B, Smit JH, Smith AV, Smith GD, Snieder H, Soranzo N, Sørensen TI, Sovio U, Spector TD, Speliotes EK, Stančáková A, Stark K, Stefansson K, Steinthorsdottir V, Stephens JC, Stirrups K, Stolk RP, Strachan DP, Strawbridge RJ, Stringham HM, Stumvoll M, Surakka I, Swift AJ, Syvanen AC, Tammesoo ML, Teder Laving M, Teslovich TM, Teumer A, Theodoraki EV, Thomson B, Thorand B, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tönjes A, Tregouet DA, Tremoli E, Trip MD, Tuomi T, Tuomilehto J, Tyrer J, Uda M, Uitterlinden AG, Usala G, Uusitupa M, Valle TT, Vandenput L, Vatin V, Vedantam S, de Vegt F, Vermeulen SH, Viikari J, Virtamo J, Visscher PM, Vitart V, Van Vliet Ostaptchouk JV, Voight BF, Vollenweider P, Volpato CB, Völzke H, Waeber G, Waite LL, Wallaschofski H, Walters GB, Wang Z, Wareham NJ, Watanabe RM, Watkins H, Weedon MN, Welch R, Weyant RJ, Wheeler E, White CC, Wichmann HE, Widen E, Wild SH, Willemsen G, Willer CJ, Wilsgaard T, Wilson JF, van Wingerden S, Winkelmann BR, Winkler TW, Witte DR, Witteman JC, Wolffenbuttel BH, Wong A, Wood AR, Workalemahu T, Wright AF, Yang J, Yarnell JW, Zgaga L, Zhao JH, Zillikens MC, Zitting P, Zondervan KT, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Winkler, T, Day, F, Croteau Chonka, D, Wood, A, Locke, A, Mägi, R, Ferreira, T, Fall, T, Graff, M, Justice, A, Luan, J, Gustafsson, S, Randall, J, Vedantam, S, Workalemahu, T, Kilpeläinen, T, Scherag, A, Esko, T, Kutalik, Z, Heid, I, Loos, R, Abecasis, G, Absher, D, Alavere, H, Albrecht, E, Allen, H, Almgren, P, Amin, N, Amouyel, P, Anderson, D, Arnold, A, Arveiler, D, Aspelund, T, Asselbergs, F, Assimes, T, Atalay, M, Attwood, A, Atwood, L, Bakker, S, Balkau, B, Balmforth, A, Barlassina, C, Barroso, I, Basart, H, Bauer, S, Beckmann, J, Beilby, J, Bennett, A, Ben Shlomo, Y, Bergman, R, Bergmann, S, Berndt, S, Biffar, R, Di Blasio, A, Boehm, B, Boehnke, M, Boeing, H, Boerwinkle, E, Bolton, J, Bonnefond, A, Bonnycastle, L, Boomsma, D, Borecki, I, Bornstein, S, Bouatia Naji, N, Boucher, G, Bragg Gresham, J, Brambilla, P, Bruinenberg, M, Buchanan, T, Buechler, C, Cadby, G, Campbell, H, Caulfield, M, Cavalcanti Proença, C, Cesana, G, Chanock, S, Chasman, D, Chen, Y, Chines, P, Clegg, D, Coin, L, Collins, F, Connell, J, Cookson, W, Cooper, M, Cupples, L, Cusi, D, Day, I, Dedoussis, G, Dei, M, Deloukas, P, Dermitzakis, E, Dimas, A, Dimitriou, M, Dixon, A, Dörr, M, van Duijn, C, Ebrahim, S, Edkins, S, Eiriksdottir, G, Eisinger, K, Eklund, N, Elliott, P, Erbel, R, Erdmann, J, Erdos, M, Eriksson, J, Estrada, K, Evans, D, de Faire, U, Farrall, M, Feitosa, M, Ferrario, M, Ferrières, J, Fischer, K, Fisher, E, Fowkes, G, Fox, C, Franke, L, Franks, P, Fraser, R, Frau, F, Frayling, T, Freimer, N, Froguel, P, Fu, M, Gaget, S, Ganna, A, Gejman, P, Gentilini, D, Geus, E, Gieger, C, Gigante, B, Gjesing, A, Glazer, N, Goddard, M, Goel, A, Grallert, H, Gräßler, J, Grönberg, H, Groop, L, Groves, C, Gudnason, V, Guiducci, C, Gyllensten, U, Hall, A, Hall, P, Hallmans, G, Hamsten, A, Hansen, T, Haritunians, T, Harris, T, van der Harst, P, Hartikainen, A, Hassanali, N, Hattersley, A, Havulinna, A, Hayward, C, Heard Costa, N, Heath, A, Hebebrand, J, den Heijer, M, Hengstenberg, C, Herzig, K, Hicks, A, Hingorani, A, Hinney, A, Hirschhorn, J, Hofman, A, Holmes, C, Homuth, G, Hottenga, J, Hovingh, K, Hu, F, Hu, Y, Huffman, J, Hui, J, Huikuri, H, Humphries, S, Hung, J, Hunt, S, Hunter, D, Hveem, K, Hyppönen, E, Igl, W, Illig, T, Ingelsson, E, Iribarren, C, Isomaa, B, Jackson, A, Jacobs, K, James, A, Jansson, J, Jarick, I, Jarvelin, M, Jöckel, K, Johansson, Å, Johnson, T, Jolley, J, Jørgensen, T, Jousilahti, P, Jula, A, Kaakinen, M, Kähönen, M, Kajantie, E, Kanoni, S, Kao, W, Kaplan, L, Kaplan, R, Kaprio, J, Kapur, K, Karpe, F, Kathiresan, S, Kee, F, Keinanen Kiukaanniemi, S, Ketkar, S, Kettunen, J, Khaw, K, Kiemeney, L, Kinnunen, L, Kivimaki, M, Kivmaki, M, Van der Klauw, M, Kleber, M, Knowles, J, Koenig, W, Kolcic, I, Kolovou, G, König, I, Koskinen, S, Kovacs, P, Kraft, P, Kraja, A, Kristiansson, K, Krjutåjkov, K, Kroemer, H, Krohn, J, Krzelj, V, Kuh, D, Kulzer, J, Kumari, M, Kuulasmaa, K, Kuusisto, J, Kvaloy, K, Laakso, M, Laitinen, J, Lakka, T, Lamina, C, Langenberg, C, Lantieri, O, Lathrop, G, Launer, L, Lawlor, D, Lawrence, R, Leach, I, Lecoeur, C, Lee, S, Lehtimäki, T, Leitzmann, M, Lettre, G, Levinson, D, Li, G, Li, S, Liang, L, Lin, D, Lind, L, Lindgren, C, Lindström, J, Liu, J, Liuzzi, A, Lokki, M, Loley, C, Lorentzon, M, Luben, R, Ludwig, B, Madden, P, Magnusson, P, Mangino, M, Manunta, P, Marek, D, Marre, M, Martin, N, März, W, Maschio, A, Mathieson, I, Mcardle, W, Mccaroll, S, Mccarthy, A, Mccarthy, M, Mcknight, B, Medina Gomez, C, Medland, S, Meitinger, T, Metspalu, A, van Meurs, J, Meyre, D, Midthjell, K, Mihailov, E, Milani, L, Min, J, Moebus, S, Moffatt, M, Mohlke, K, Molony, C, Monda, K, Montgomery, G, Mooser, V, Morken, M, Morris, A, Mühleisen, T, Müller Nurasyid, M, Munroe, P, Musk, A, Narisu, N, Navis, G, Neale, B, Nelis, M, Nemesh, J, Neville, M, Ngwa, J, Nicholson, G, Nieminen, M, Njølstad, I, Nohr, E, Nolte, I, North, K, Nöthen, M, Nyholt, D, O'Connell, J, Ohlsson, C, Oldehinkel, A, van Ommen, G, Ong, K, Oostra, B, Ouwehand, W, Palmer, C, Palmer, L, Palotie, A, Paré, G, Parker, A, Paternoster, L, Pawitan, Y, Pechlivanis, S, Peden, J, Pedersen, N, Pedersen, O, Pellikka, N, Peltonen, L, Penninx, B, Perola, M, Perry, J, Person, T, Peters, A, Peters, M, Pichler, I, Pietiläinen, K, Platou, C, Polasek, O, Pouta, A, Power, C, Pramstaller, P, Preuss, M, Price, J, Prokopenko, I, Province, M, Psaty, B, Purcell, S, Pütter, C, Qi, L, Quertermous, T, Radhakrishnan, A, Raitakari, O, Rauramaa, R, Rayner, N, Rehnberg, E, Rendon, A, Ridderstråle, M, Ridker, P, Ripatti, S, Rissanen, A, Rivadeneira, F, Rivolta, C, Robertson, N, Rose, L, Rudan, I, Saaristo, T, Sager, H, Salomaa, V, Samani, N, Sambrook, J, Sanders, A, Sandholt, C, Sanna, S, Saramies, J, Schadt, E, Schipf, S, Schlessinger, D, Schreiber, S, Schunkert, H, Schwarz, P, Scott, L, Shi, J, Shin, S, Shuldiner, A, Shungin, D, Signorini, S, Silander, K, Sinisalo, J, Skrobek, B, Smit, J, Smith, A, Smith, G, Snieder, H, Soranzo, N, Sørensen, T, Sovio, U, Spector, T, Speliotes, E, Stančáková, A, Stark, K, Stefansson, K, Steinthorsdottir, V, Stephens, J, Stirrups, K, Stolk, R, Strachan, D, Strawbridge, R, Stringham, H, Stumvoll, M, Surakka, I, Swift, A, Syvanen, A, Tammesoo, M, Teder Laving, M, Teslovich, T, Teumer, A, Theodoraki, E, Thomson, B, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Timpson, N, Tönjes, A, Tregouet, D, Tremoli, E, Trip, M, Tuomi, T, Tuomilehto, J, Tyrer, J, Uda, M, Uitterlinden, A, Usala, G, Uusitupa, M, Valle, T, Vandenput, L, Vatin, V, de Vegt, F, Vermeulen, S, Viikari, J, Virtamo, J, Visscher, P, Vitart, V, Van Vliet Ostaptchouk, J, Voight, B, Vollenweider, P, Volpato, C, Völzke, H, Waeber, G, Waite, L, Wallaschofski, H, Walters, G, Wang, Z, Wareham, N, Watanabe, R, Watkins, H, Weedon, M, Welch, R, Weyant, R, Wheeler, E, White, C, Wichmann, H, Widen, E, Wild, S, Willemsen, G, Willer, C, Wilsgaard, T, Wilson, J, van Wingerden, S, Winkelmann, B, Witte, D, Witteman, J, Wolffenbuttel, B, Wong, A, Wright, A, Yang, J, Yarnell, J, Zgaga, L, Zhao, J, Zillikens, M, Zitting, P, Zondervan, K, Psychiatry, EMGO - Mental health, Plastic, Reconstructive and Hand Surgery, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Cardiology, Biological Psychology, EMGO+ - Mental Health, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Abecasis, GR., Absher, D., Alavere, H., Albrecht, E., Allen, HL., Almgren, P., Amin, N., Amouyel, P., Anderson, D., Arnold, AM., Arveiler, D., Aspelund, T., Asselbergs, FW., Assimes, TL., Atalay, M., Attwood, AP., Atwood, LD., Bakker, SJ., Balkau, B., Balmforth, AJ., Barlassina, C., Barroso£££Inês£££ I., Basart, H., Bauer, S., Beckmann, JS., Beilby, JP., Bennett, AJ., Ben-Shlomo, Y., Bergman, RN., Bergmann, S., Berndt, SI., Biffar, R., Di Blasio AM., Boehm, BO., Boehnke, M., Boeing, H., Boerwinkle, E., Bolton, JL., Bonnefond, A., Bonnycastle, LL., Boomsma, DI., Borecki, IB., Bornstein, SR., Bouatia-Naji, N., Boucher, G., Bragg-Gresham, JL., Brambilla, P., Bruinenberg, M., Buchanan, TA., Buechler, C., Cadby, G., Campbell, H., Caulfield, MJ., Cavalcanti-Proença, C., Cesana, G., Chanock, SJ., Chasman, DI., Chen, YD., Chines, PS., Clegg, DJ., Coin, L., Collins, FS., Connell, JM., Cookson, W., Cooper, MN., Croteau-Chonka, DC., Cupples, LA., Cusi, D., Day, FR., Day, IN., Dedoussis, GV., Dei, M., Deloukas, P., Dermitzakis, ET., Dimas, AS., Dimitriou, M., Dixon, AL., Dörr, M., van Duijn CM., Ebrahim, S., Edkins, S., Eiriksdottir, G., Eisinger, K., Eklund, N., Elliott, P., Erbel, R., Erdmann, J., Erdos, MR., Eriksson, JG., Esko£££Tõnu£££ T., Estrada, K., Evans, DM., de Faire, U., Fall, T., Farrall, M., Feitosa, MF., Ferrario, MM., Ferreira, T., Ferrières, J., Fischer, K., Fisher, E., Fowkes, G., Fox, CS., Franke, L., Franks, PW., Fraser, RM., Frau, F., Frayling, T., Freimer, NB., Froguel, P., Fu, M., Gaget, S., Ganna, A., Gejman, PV., Gentilini, D., Geus, EJ., Gieger, C., Gigante, B., Gjesing, AP., Glazer, NL., Goddard, ME., Goel, A., Grallert, H., Gräßler, J., Grönberg, H., Groop, LC., Groves, CJ., Gudnason, V., Guiducci, C., Gustafsson, S., Gyllensten, U., Hall, AS., Hall, P., Hallmans, G., Hamsten, A., Hansen, T., Haritunians, T., Harris, TB., van der Harst, P., Hartikainen, AL., Hassanali, N., Hattersley, AT., Havulinna, AS., Hayward, C., Heard-Costa, NL., Heath, AC., Hebebrand, J., Heid, IM., den Heijer, M., Hengstenberg, C., Herzig, KH., Hicks, AA., Hingorani, A., Hinney, A., Hirschhorn, JN., Hofman, A., Holmes, CC., Homuth, G., Hottenga, JJ., Hovingh, KG., Hu, FB., Hu, YJ., Huffman, JE., Hui, J., Huikuri, H., Humphries, SE., Hung, J., Hunt, SE., Hunter, D., Hveem, K., Hyppönen, E., Igl, W., Illig, T., Ingelsson, E., Iribarren, C., Isomaa, B., Jackson, AU., Jacobs, KB., James, AL., Jansson, JO., Jarick, I., Jarvelin, MR., Jöckel, KH., Johansson£££Åsa£££ Å., Johnson, T., Jolley, J., Jørgensen, T., Jousilahti, P., Jula, A., Justice, AE., Kaakinen, M., Kähönen, M., Kajantie, E., Kanoni, S., Kao, WH., Kaplan, LM., Kaplan, RC., Kaprio, J., Kapur, K., Karpe, F., Kathiresan, S., Kee, F., Keinanen-Kiukaanniemi, SM., Ketkar, S., Kettunen, J., Khaw, KT., Kiemeney, LA., Kilpeläinen, TO., Kinnunen, L., Kivimaki, M., Kivmaki, M., Van der Klauw MM., Kleber, ME., Knowles, JW., Koenig, W., Kolcic, I., Kolovou, G., König, IR., Koskinen, S., Kovacs, P., Kraft, P., Kraja, AT., Kristiansson, K., KrjutÅjkov, K., Kroemer, HK., Krohn, JP., Krzelj, V., Kuh, D., Kulzer, JR., Kumari, M., Kutalik£££Zoltán£££ Z., Kuulasmaa, K., Kuusisto, J., Kvaloy, K., Laakso, M., Laitinen, JH., Lakka, TA., Lamina, C., Langenberg, C., Lantieri, O., Lathrop, GM., Launer, LJ., Lawlor, DA., Lawrence, RW., Leach, IM., Lecoeur, C., Lee, SH., Lehtimäki, T., Leitzmann, MF., Lettre, G., Levinson, DF., Li, G., Li, S., Liang, L., Lin, DY., Lind, L., Lindgren, CM., Lindström, J., Liu, J., Liuzzi, A., Locke, AE., Lokki, ML., Loley, C., Loos, RJ., Lorentzon, M., Luan£££Jian'an£££ J., Luben, RN., Ludwig, B., Madden, PA., Mägi, R., Magnusson, PK., Mangino, M., Manunta, P., Marek, D., Marre, M., Martin, NG., März, W., Maschio, A., Mathieson, I., McArdle, WL., McCaroll, SA., McCarthy, A., McCarthy, MI., McKnight, B., Medina-Gomez, C., Medland, SE., Meitinger, T., Metspalu, A., van Meurs JB., Meyre, D., Midthjell, K., Mihailov, E., Milani, L., Min, JL., Moebus, S., Moffatt, MF., Mohlke, KL., Molony, C., Monda, KL., Montgomery, GW., Mooser, V., Morken, MA., Morris, AD., Morris, AP., Mühleisen, TW., Müller-Nurasyid, M., Munroe, PB., Musk, AW., Narisu, N., Navis, G., Neale, BM., Nelis, M., Nemesh, J., Neville, MJ., Ngwa, JS., Nicholson, G., Nieminen, MS., Njølstad, I., Nohr, EA., Nolte, IM., North, KE., Nöthen, MM., Nyholt, DR., O'Connell, JR., Ohlsson, C., Oldehinkel, AJ., van Ommen GJ., Ong, KK., Oostra, BA., Ouwehand, WH., Palmer, CN., Palmer, LJ., Palotie, A., Paré, G., Parker, AN., Paternoster, L., Pawitan, Y., Pechlivanis, S., Peden, JF., Pedersen, NL., Pedersen, O., Pellikka, N., Peltonen, L., Penninx, B., Perola, M., Perry, JR., Person, T., Peters, A., Peters, MJ., Pichler, I., Pietiläinen, KH., Platou, CG., Polasek, O., Pouta, A., Power, C., Pramstaller, PP., Preuss, M., Price, JF., Prokopenko, I., Province, MA., Psaty, BM., Purcell, S., Pütter, C., Qi, L., Quertermous, T., Radhakrishnan, A., Raitakari, O., Randall, JC., Rauramaa, R., Rayner, NW., Rehnberg, E., Rendon, A., Ridderstråle, M., Ridker, PM., Ripatti, S., Rissanen, A., Rivadeneira, F., Rivolta, C., Robertson, NR., Rose, LM., Rudan, I., Saaristo, TE., Sager, H., Salomaa, V., Samani, NJ., Sambrook, JG., Sanders, AR., Sandholt, C., Sanna, S., Saramies, J., Schadt, EE., Scherag, A., Schipf, S., Schlessinger, D., Schreiber, S., Schunkert, H., Schwarz, PE., Scott, LJ., Shi, J., Shin, SY., Shuldiner, AR., Shungin, D., Signorini, S., Silander, K., Sinisalo, J., Skrobek, B., Smit, JH., Smith, AV., Smith, GD., Snieder, H., Soranzo, N., Sørensen, TI., Sovio, U., Spector, TD., Speliotes, EK., Stančáková, A., Stark, K., Stefansson, K., Steinthorsdottir, V., Stephens, JC., Stirrups, K., Stolk, RP., Strachan, DP., Strawbridge, RJ., Stringham, HM., Stumvoll, M., Surakka, I., Swift, AJ., Syvanen, AC., Tammesoo, ML., Teder-Laving, M., Teslovich, TM., Teumer, A., Theodoraki, EV., Thomson, B., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Timpson, NJ., Tönjes, A., Tregouet, DA., Tremoli, E., Trip, MD., Tuomi, T., Tuomilehto, J., Tyrer, J., Uda, M., Uitterlinden, AG., Usala, G., Uusitupa, M., Valle, TT., Vandenput, L., Vatin, V., Vedantam, S., de Vegt, F., Vermeulen, SH., Viikari, J., Virtamo, J., Visscher, PM., Vitart, V., Van Vliet-Ostaptchouk JV., Voight, BF., Vollenweider, P., Volpato, CB., Völzke, H., Waeber, G., Waite, LL., Wallaschofski, H., Walters, GB., Wang, Z., Wareham, NJ., Watanabe, RM., Watkins, H., Weedon, MN., Welch, R., Weyant, RJ., Wheeler, E., White, CC., Wichmann, HE., Widen, E., Wild, SH., Willemsen, G., Willer, CJ., Wilsgaard, T., Wilson, JF., van Wingerden, S., Winkelmann, BR., Winkler, TW., Witte, DR., Witteman, JC., Wolffenbuttel, BH., Wong, A., Wood, AR., Workalemahu, T., Wright, AF., Yang, J., Yarnell, JW., Zgaga, L., Zhao, JH., Zillikens, MC., Zitting, P., and Zondervan, KT.
Subjects: Quality Control, Netherlands Twin Register (NTR), BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, media_common.quotation_subject, quality control, GWAMAS, Control (management), Medizin, Genome-wide association study, Biology, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Software, SDG 17 - Partnerships for the Goals, Meta-Analysis as Topic, Comparable size, Quality (business), 030304 developmental biology, media_common, Protocol (science), 0303 health sciences, business.industry, Software package, Data science, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Genome-Wide Association Study/methods, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], quality control, genome-wide association meta-analyses, business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract: Item does not contain fulltext Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.
Published: 2014

5. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

Author: Sands, B. E., Sandborn, W. J., Panaccione, R., O'Brien, C. D., Zhang, H., Johanns, J., Adedokun, O. J., Li, K., Peyrin-Biroulet, L., Van Assche, G., Danese, S., Targan, S., Abreu, M. T., Hisamatsu, T., Szapary, P., Brown S, Marano C., Connor, S, De Cruz, P, Ding, Nj, Florin, T, Hendy, P, Leong, R, Moore, G, Pavli, P, Sparrow, M, Gassner, S, Vogelsang, H, Baert, F, Colard, A, De Vos, M, D'Heygere, F, Ferrante, M, Louis, E, Staessen, D, Berova, T, Churchev, J, Draganova, R, Gancheva, D, Ivanova, N, Marinova, I, Markov, M, Nikolov, R, Tsonev, N, Vassileva, G, Afif, W, Berstein, C, Bressler, B, Jairath, V, Lachance, Jr, Singh, R, Tilbe, K, Komarek, V, Kozeluhova, J, Lukas, M, Volfova, M, Dahlerup, J, Altwegg, R, Beorchia, S, Bouguen, G, Cadiot, G, Dupas, Jl, Desreumaux, P, Flourie, B, Grimaud, Jc, Guillaud, O, Moreau, J, Roblin, X, Zerbib, F, Baumgart, D, Beckebaum, S, Bokemeyer, B, Ebert, M, Hasselblatt, P, Lügering, A, Maaser, C, Schiefke, I, Schreiber, S, Seidler, U, Altorjay, I, Kiss, Gg, Literati-Nagy, B, Patai, A, Pecsi, G, Salamon, A, Schnabel, R, Székely, A, Tulassay, Z, Varga, M, Fich, A, Fishman, S, Konikoff, F, Lichtenstein, L, Rainis, T, Sbeit, W, Schwartz, D, Annese, V, Biancone, L, Bossa, F, Costintino, R, Danese, S, Fries, W, Gasbarrini, A, Guidi, L, Kohn, A, Maconi, G, Rocca, R, Rogai, F, Villa, E, Zoli, G, Akiho, H, Aoyama, N, Arisawa, T, Hidaka, H, Hisamatsu, T, Horiki, N, Inaba, T, Inoue, S, Ishida, T, Ishida, H, Ishiguro, Y, Ishihara, S, Iwabuchi, M, Kato, J, Katsushima, S, Kobayashi, T, Kojima, Y, Kurihara, H, Masuo, T, Matsui, T, Matsumoto, T, Matsuoka, K, Mitsuyama, K, Motoya, S, Nakagawa, T, Nakai, K, Nakamura, S, Niihara, T, Ohnishi, Y, Ohta, A, Osada, T, Ryuichi, I, Sakai, Y, Sakata, Y, Sameshima, Y, Sano, K, Shibatoge, M, Shibuya, T, Suzuki, Y, Takeshima, F, Tanaka, S, Taruishi, M, Tokito, S, Ueo, T, Watanabe, K, Yamagami, H, Cheon, Jh, Cho, Kb, Knowles, Kim, Kim, Hj, Kim, Y, Lee, Km, Yang, Sk, D'Haens, G, Pierik, M, Gearry, R, Inns, S, Rowbotham, D, Schultz, M, Bochenek, A, Gawdis-Wojnarska, B, Kleczkowski, D, Leszczyszyn, J, Malecka-Panas, E, Mamos, A, Petryka, R, Regula, J, Rozciecha, J, Stefanuik, P, Wozniak-Stolarska, B, Cimpoeru, N, Craciun, E, Ovidiu, Cf, Goldis, E, Ionita-Radu, F, Lazar, D, Suciu, I, Abdulkhakov, R, Alikhanov, B, Apartsin, K, Bakulin, I, Belousova, E, Gofman, A, Grinevich, V, Kulyapin, A, Nizov, A, Osipenko, M, Simanenkov, V, Tkachev, A, Uspenskiy, Y, Valuyskikh, E, Jovanovic, I, Nagorni, A, Svorcan, P, Zdravkovic, N, Bunganic, I, Abrahamovych, O, Bilianskyi, L, Datsenko, O, Golovchenko, O, Kharchenko, N, Klymenko, V, Levchenko, O, Lozynskyy, Y, Murenets, N, Oliinyk, O, Prystupa, L, Pyrogovskyi, V, Reznikova, V, Rishko, I, Stanislavchuk, M, Vizir, V, Yatsyshyn, R, Arasaradnam, R, Bloom, S, Cummings, F, Iqbal, T, Irving, P, Kaser, A, Shonde, A, Subramanian, S, Aberra, F, Aguilar, H, Araya, V, Bakken, A, Beaulieu, D, Cappa, Ja, Chiorean, M, Cohen, N, Dryden, G, Duvall, G, Ehrlich, A, Eisner, M, Ertan, A, Fogel, R, Friedenberg, K, Gatof, D, Glover, S, Grosman, I, Gunaratnam, N, Gupta, N, Haynes, P, Hemaidan, A, Higgins, P, Hou, J, Hudesman, D, Iskandar, H, Jazrawi, S, Jones, M, Karnam, U, Khurana, S, Killpack, M, Kreines, M, Lawlor, G, Lee, S, Loftus, E, Lukin, Dj, Marcet, J, Mattar, M, Melmed, G, Minor, T, Mirkin, K, Mutlu, E, Nichols, M, Nudell, J, Rai, R, Ramos, C, Mcleod, Randall, Rausher, D, Ritter, T, Singh Saini, S, Salzberg, B, Saubermann, L, Scherl, E, Sedghi, S, Sellin, J, Shafran, I, Sorrentino, D, Suiter, D, Swaminath, A, Tiongco, F, Vrabie, R, Walp, K, Warner, N, Winstead, N, Wolf, Dc, Woods, J, Yen, E, Younes, Z., Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Maag Darm Lever (9), Interne Geneeskunde, Sands, Be, Sandborn, Wj, Panaccione, R, O'Brien, Cd, Zhang, H, Johanns, J, Adedokun, Oj, Li, K, Peyrin-Biroulet, L, Van Assche, G, Danese, S, Targan, S, Abreu, Mt, Hisamatsu, T, Szapary, P, and Marano, C
Subjects: Adult, Male, Infusions, [SDV]Life Sciences [q-bio], Injections, Subcutaneous, Anti-Inflammatory Agents, Ulcerative, Klinikai orvostudományok, Article, Injections, Maintenance Chemotherapy, Dose-Response Relationship, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, INFLIXIMAB, Colitis, Ulcerative, Dose-Response Relationship, Drug, Female, Humans, Induction Chemotherapy, Infusions, Intravenous, Patient Acuity, Remission Induction, Ustekinumab, ComputingMilieux_MISCELLANEOUS, ACTIVITY INDEXES, Subcutaneous, Orvostudományok, General Medicine, EFFICACY, Colitis, 3. Good health, INFECTIONS, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Drug, Intravenous
Abstract: The efficacy of ustekinumab, an antagonist of the p40 subunit of interleukin-12 and interleukin-23, as induction and maintenance therapy in patients with ulcerative colitis is unknown.We evaluated ustekinumab as 8-week induction therapy and 44-week maintenance therapy in patients with moderate-to-severe ulcerative colitis. A total of 961 patients were randomly assigned to receive an intravenous induction dose of ustekinumab (either 130 mg [320 patients] or a weight-range-based dose that approximated 6 mg per kilogram of body weight [322]) or placebo (319). Patients who had a response to induction therapy 8 weeks after administration of intravenous ustekinumab were randomly assigned again to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 12 weeks [172 patients] or every 8 weeks [176]) or placebo (175). The primary end point in the induction trial (week 8) and the maintenance trial (week 44) was clinical remission (defined as a total score of ≤2 on the Mayo scale [range, 0 to 12, with higher scores indicating more severe disease] and no subscore1 [range, 0 to 3] on any of the four Mayo scale components).The percentage of patients who had clinical remission at week 8 among patients who received intravenous ustekinumab at a dose of 130 mg (15.6%) or 6 mg per kilogram (15.5%) was significantly higher than that among patients who received placebo (5.3%) (P0.001 for both comparisons). Among patients who had a response to induction therapy with ustekinumab and underwent a second randomization, the percentage of patients who had clinical remission at week 44 was significantly higher among patients assigned to 90 mg of subcutaneous ustekinumab every 12 weeks (38.4%) or every 8 weeks (43.8%) than among those assigned to placebo (24.0%) (P = 0.002 and P0.001, respectively). The incidence of serious adverse events with ustekinumab was similar to that with placebo. Through 52 weeks of exposure, there were two deaths (one each from acute respiratory distress syndrome and hemorrhage from esophageal varices) and seven cases of cancer (one each of prostate, colon, renal papillary, and rectal cancer and three nonmelanoma skin cancers) among 825 patients who received ustekinumab and no deaths and one case of cancer (testicular cancer) among 319 patients who received placebo.Ustekinumab was more effective than placebo for inducing and maintaining remission in patients with moderate-to-severe ulcerative colitis. (Funded by Janssen Research and Development; UNIFI ClinicalTrials.gov number, NCT02407236.).
Published: 2019

6. Cerebrovascular risk factors and their influence on neurodegenerative and vascular biomarkers in cognitive affected patients

Author: Bittner D, Hoehne M, Heinze Hj, Schneider, and Schreiber S
Subjects: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Cognition, business, Cerebrovascular risk
Published: 2019

7. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Author: Hinney, A., Kesselmeier, M., Huckins, Laura M, Hauser, Joanna, Karhunen, Leila, Meulenbelt, Ingrid, Slagboom, P Eline, Tortorella, Alfonso, Maj, Mario, Dedoussis, George, Dikeos, Dimitris, Gonidakis, Fragiskos, Tziouvas, Konstantinos, Southam, Lorraine, Tsitsika, Artemis, Papezova, Hana, Slachtova, Lenka, Martaskova, Debora, Kennedy, James L, Levitan, Robert D, Yilmaz, Zeynep, Huemer, Julia, Koubek, Doris, Merl, Elisabeth, Rayner, N William, Wagner, Gudrun, Lichtenstein, Paul, Breen, Gerome, Cohen-Woods, Sarah, Farmer, Anne, McGuffin, Peter, Cichon, Sven, Giegling, Ina, Herms, Stefan, Rujescu, Dan, Tachmazidou, Ioanna, Schreiber, Stefan, Wichmann, H-Erich, Dina, Christian, Sladek, Rob, Gambaro, Giovanni, Soranzo, Nicole, Julia, Antonio, Marsal, Sara, Rabionet, Raquel, Gaborieau, Valerie, Klump, Kelly L, Dick, Danielle M, Palotie, Aarno, Ripatti, Samuli, Widén, Elisabeth, Andreassen, Ole A, Espeseth, Thomas, Lundervold, Astri, Reinvang, Ivar, Steen, Vidar M, Hellard, Stephanie Le, Treasure, Janet, Mattingsdal, Morten, Ntalla, Ioanna, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Navratilova, Marie, Gallinger, Steven, Pinto, Dalila, Scherer, Stephen W, Aschauer, Harald, Lewis, Cathryn M, Carlberg, Laura, Schosser, Alexandra, Alfredsson, Lars, Ding, Bo, Klareskog, Lars, Padyukov, Leonid, Finan, Chris, Kalsi, Gursharan, Roberts, Marion, Logan, Darren W, Schmidt, Ulrike, Peltonen, Leena, Ritchie, Graham R S, Barrett, Jeff C, Estivill, Xavier, Hinney, Anke, Sullivan, Patrick F, Collier, David A, Zeggini, Eleftheria, Bulik, Cynthia M, Anderson, Carl A, Tozzi, Federica, Barrett, Jeffrey C, Floyd, James A B, Franklin, Christopher S, McGinnis, Ralph, Sambrook, Jennifer, Stephens, Jonathan, Ouwehand, Willem H, McArdle, Wendy L, iezebrink, Kirsty, Ring, Susan M, Strachan, David P, Alexander, Graeme, Conlon, Peter J, Dominiczak, Anna, Duncanson, Audrey, Hill, Adrian, Langford, Cordelia, Jall, S., Hebebrand, Johannes, Lord, Graham, Maxwell, Alexander P, Morgan, Linda, Sandford, Richard N, Sheerin, Neil, Vannberg, Frederik O, Blackburn, Hannah, Chen, Wei-Min, Edkins, Sarah, Gorwood, Philip, Gillman, Mathew, Gray, Emma, Hunt, Sarah E, Nengut-Gumuscu, Suna, Potter, Simon, Rich, Stephen S, Simpkin, Douglas, Whittaker, Pamela, Heid, I. M., Winkler, T. W., Adan, Roger A H, de Bakker, P., Bültmann, U., Geleijnse, M., Harst, P. V., Koppelman, G., Rosmalen, J. G., van Rossum, L., Smidt, H., Swertz, M. A., Stolk, R. P., Kas, Martien J H, Alizadeh, B., de Boer, R., Boezen, H. M., Bruinenberg, M., Franke, L., van der Harst, P., Hillege, H., van der Klauw, M., Navis, G., Ormel, J., Favaro, Angela, Postma, D., Rosmalen, J., Slaets, J., Snieder, H., Stolk, R., Wolffenbuttel, B., Wijmenga, C., Berg, J., Blackwood, D., Campbell, H., Santonastaso, Paolo, Cavanagh, J., Connell, J., Connor, M., Cunningham-Burley, S., Deary, I., Dominiczak, A., Ellis, P., FitzPatrick, B., Ford, I., Gertz, R., Fernández-Aranda, Fernando, Grau, A., Haddow, G., Jackson, C., Kerr, S., Lindsay, R., McGilchrist, M., McIntyre, D., Morris, A., Morton, R., Muir, W., Gratacos, Monica, Murray, G., Palmer, C., Pell, J., Philp, A., Porteous, D., Porteous, M., Procter, R., Ralston, S., Reid, D., Sinnott, R., Rybakowski, Filip, Smith, B., Clair, D. S., Sullivan, F., Sweetland, M., Ure, J., Watt, G., Wolf, R., Wright, A., Berndt, S. I., Gustafsson, S., Dmitrzak-Weglarz, Monika, Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau- Chonka, D. C., Day, F. R., Esko, T., Fall, T., Volckmar, A-L, Kaprio, Jaakko, Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Wood, A. R., Workalemahu, T., Keski-Rahkonen, Anna, Hu, Y. J., Lee, S. H., Liang, L., Lin, D. Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Raevuori-Helkamaa, Anu, Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J. J., Huffman, J. E., Jarick, I., Johansson, A., Van Furth, Eric F, Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., Slof-Op't Landt, Margarita C T, McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Hudson, James I, Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., Van Vliet- Ostaptchouk, J. V., Reichborn-Kjennerud, Ted, Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Knudsen, Gun Peggy S, Bonnycastle, L. L., Brambilla, P., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., Cookson, W., de Faire, U., Monteleone, Palmiero, de Vegt, F., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Kaplan, Allan S, Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A. L., Hayward, C., Heard-Costa, N. L., Föcker, M., Karwautz, Andreas, Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. 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A., Lehtimaki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Mccarthy, M. I., Melbye, M., Middeldorp, C., Millwood, I., Mohlke, K. L., Mook-Kanamori, D. O., Murray, J. C., Nivard, M., Nohr, E. A., Oken, E., Ong, K. K., O'Reilly, P. F., Palmer, L. J., Panoutsopoulou, K., Pararajasingham, J., Pearson, E. R., Pennell, C. E., Power, C., Price, T. S., Prokopenko, I., Raitakari, O. T., Rodriguez, A., Salem, R. M., Saw, S. M., Sebert, S., Siitonen, N., Simell, O., Sorensen, T. I., Sovio, U., Pourcain, B. S., Sunyer, J., Taal, H. R., Teo, Y. Y., Thiering, E., Tiesler, C., Timpson, N. J., Uitterlinden, A. G., Valcarcel, B., Warrington, N. M., White, S., Willemsen, G., Wilson, J. F., Yaghootkar, H., Elks, C. E., Perry, J. R., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Gudbjartsson, D. F., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., Smith, A. V., Stolk, L., van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K., Smith, E. N., Ulivi, S., Warrington, M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G. S., Bergmann, S., Boerwinkle, E., Buring, J. E., Busonero, F., Campbell, H., Chanock, S. J., Cornelis, M. C., Couper, D., Coviello, A. D., D'Adamo, P., de Faire, U., de Geus, E. J., Deloukas, P., Doring, A., Davey Smith, G., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Gieger, C., Gudnason, V., Hall, P., Hankinson, S. E., Ferreli, L., Heath, A. C., Hernandez, D. G., Hofman, A., Hu, F. B., Illig, T., Karasik, D., Khaw, K. T., Kiel, D. P., Kolcic, I., Kraft, P., Launer, L. J., Laven, J. S., Li, S., Liu, J., Levy, D., Martin, N. G., Mooser, V., Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., Oostra, B. A., Peacock, M., Pare, G., Parker, A. N., Pedersen, N. L., Pharoah, P., Polasek, O., Plump, A. S., Pouta, A., Porcu, E., Rafnar, T., Rice, J. P., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Scuteri, A., Segre, A. V., Shuldiner, A. R., Srinivasan, S. R., Tammesoo, M. L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R. M., van Meurs, J. B., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Weedon, M. N., Wright, A. F., Young, L., Zhai, G., Zhuang, W. V., Bierut, L. J., Boyd, H. A., Crisponi, L., Demerath, E. W., van Duijn, C. M., Econs, M. J., Harris, T. B., Hunter, D. J., Loos, R. J., Ridker, P. M., Spector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Murabito, J. M., Murray, A., Brandt, H., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C., La Via, M., Mitchell, J., Strober, M., Rotondo, A., Woodside, D. B., Keel, P., Lilenfeld, L., Plotnicov, K., Magistretti, P., Montgomery, G. W., Blackburn, H., Schork, N. J., Hinney, Anke, Kesselmeier, Miriam, Jall, Sigrid, Volckmar, Anna-Lena, Föcker, Manuel, Hebebrand, J, GCAN, WTCCC3, GIANT, EGG, Price Foundation Collaborative Group, Children’s Hospital of Philadelphia/Price Foundation, Cardiology, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, ACS - Atherosclerosis & ischemic syndromes, Hinney, A, Kesselmeier, M, Jall, S, Volckmar, Al, Focker, M, Antel, J, Gcan, Wtccc3, Heid, Im, Winkler, Tw, Grant, Sfa, Giant, Manunta, P, Sfa, Grant, Egg, Guo, Y, Bergen, Aw, Kaye, W, Berrettini, W, Hakonarson, H, Price Foundation Collaborative, Group, Children’s Hospital of Philadelphia/Price, Foundation, Herpertz-Dahlmann, B, de Zwaan, M, Herzog, W, Ehrlich, S, Zipfel, S, Egberts, Km, Adan, R, Brandys, M, van Elburg, A, Perica, Vb, Franklin, C, Tschop, Mh, Zeggini, E, Bulik, Cm, Collier, D, Scherag, A, Muller, Td, Animal Ecology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Methodology, Volckmar, A-L, Föcker, M, Gcan, Wtccc, Gasparini, P, D'Adamo, A, Children’S Hospital of Philadelphia/Price, Foundation, Boraska Perica, V, Tschöp, Mh, and Müller, Td
Subjects: Netherlands Twin Register (NTR), Male, Anorexia Nervosa, Genome-wide association study, Cardiovascular, Linkage Disequilibrium, Body Mass Index, 0302 clinical medicine, Databases, Genetic, WTCCC3, Aetiology, Cancer, 0303 health sciences, Loci, Genetic Predisposition to Disease/genetics, Cross-disorder, Anorèxia nerviosa, anorexia nervosa (AN), Shared, 3. Good health, Psychiatry and Mental health, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Human, Alleles, Body Weight, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Obesity, Polymorphism, Single Nucleotide, Risk Factors, Molecular Biology, Psychiatry and Mental Health, Cellular and Molecular Neuroscience, medicine.medical_specialty, Locus (genetics), Single-nucleotide polymorphism, ta3111, Article, 03 medical and health sciences, Genetic, SDG 3 - Good Health and Well-being, Genetics, EGG, Polymorphism, Children’s Hospital of Philadelphia/Price Foundation, body mass index (BMI), genome-wide association meta-analysis (GWAMA), Prevention, ta1184, medicine.disease, 030104 developmental biology, Endocrinology, diagnostic markers, Body mass index, Genètica, 030217 neurology & neurosurgery, 0301 basic medicine, Linkage disequilibrium, GIANT, Medizin, Obesity/genetics, Overweight, Medical and Health Sciences, Oral and gastrointestinal, Anorexia Nervosa/genetics, 2.1 Biological and endogenous factors, Psychiatry, 2. Zero hunger, Allele, Eating disorder, Single Nucleotide, Biological Sciences, Polymorphism, Single Nucleotide/genetics, Price Foundation Collaborative Group, Stroke, psychiatric disorders, Gene Frequency/genetics, medicine.symptom, Databases, Internal medicine, Body Weight/genetics, medicine, Journal Article, Linkage Disequilibrium/genetics, ddc:610, Metabolic and endocrine, Nutrition, 030304 developmental biology, GCAN, business.industry, Risk Factor, Human Genome, Psychology and Cognitive Sciences, Bulimia nervosa, business
Abstract: The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values
Published: 2017

8. Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

Author: Sandborn, Wj, Feagan, Bg, Rutgeerts, P, Hanauer, S, Colombel, Jf, Sands, Be, Lukas, M, Fedorak, Rn, Lee, S, Bressler, B, Fox, I, Rosario, M, Sankoh, S, Xu, J, Stephens, K, Milch, C, Parikh, A, Bampton P, GEMINI 2 Study G. r. o. u. p., Borody, T, Chung, A, Debinski, H, Florin, T, Hetzel, D, Jakobovits, S, Lawrance, I, Leong, R, Macrae, F, Mitchell, B, Moore, G, Pavli, P, Samuel, D, Weltman, M, Haas, T, Reinisch, W, Vogel, W, Baert, F, De Maeyer, M, De Vos, M, Dewit, O, D'Haens, G, Louis, E, Muls, V, Van Assche, G, Krastev, Z, Nikolovska, D, Petrov, P, Petrov, A, Stoinov, S, Tchernev, K, Vasileva, G, Aumais, G, Axler, J, Bailey, R, Bernstein, C, Bitton, A, Bourdages, R, Cohen, A, Devroede, G, Dhalla, S, Feagan, B, Fedorak, R, Green, D, Greenberg, G, Jones, J, Larkai, E, Macintosh, D, Panaccione, R, Ponich, T, Singh, R, Sy, R, Wiesinger, H, Albin, A, Douda, L, Horny, I, Stehlik, J, Stuksa, J, Volfova, M, Vyhnalek, P, Zadorova, Z, Andersen, V, Bendtsen, F, Fallingborg, J, Rannem, T, Maelt, A, Margus, B, Salupere, R, Allez, M, Des Varennes SB, Desreumaux, P, Dupas, Jl, Grimaud, Jc, Hebuterne, X, Lerebours, E, Picon, L, Zerbib, F, Aldinger, V, Baumgart, D, Buening, C, Dollinger, M, Hoffmann, P, Howaldt, S, Klaus, J, Konturek, Jw, Krummenerl, T, Malfertheiner, P, Schmidt, W, Schreiber, S, Seidler, U, Stallmach, A, Stremmel, W, Zeitz, M, Mantzaris, G, Triantafyllou, K, Ng, C, Bene, L, Fazekas, I, Fejes, R, Gall, J, Horvat, G, Hunyady, B, Salamon, A, Toth, T, Tulassay, Z, Varga, E, Varga, M, Varga Szabo, L, Vincze, A, Oddsson, E, Örvar, K, Ahuja, V, Amarapurkar, D, Chandra, A, Koshy, A, Krishna, P, Ramakrishna, K, Reddy, N, Thorat, V, Patchett, S, Ryan, B, Ben Horin, S, Fishman, S, Lavy, A, Rachmilewitz, D, Ardizzone, S, Corazziari, E, Danese, S, Fries, Walter, Gasbarrini, A, Kohn, A, Sturniolo, Gc, Danilans, A, George, Am, Hilmi, In, Engels, Lg, Ponsioen, Cy, van der Woude CJ, Gearry, R, Haines, M, Schultz, M, Wallace, I, Wyeth, J, Florholmen, J, Jahnsen, J, Lygren, I, Röseth, A, Ciecko Michalska, I, Gonciarz, M, Horynski, M, Huk, J, Jamrozik Kruk, Z, Janke, A, Klupinska, G, Marecik, J, Paradowski, L, Rudzinski, J, Rydzewska, G, Han, Ds, Hong, Sp, Kim, Hj, Kim, Js, Kim, Ko, Kim, Yh, Yang, Sk, Gheorghe, Ls, Voiosu, Rm, Alexeeva, O, Baranovsky, A, Bunkova, E, Burnevich, E, Dolgikh, O, Grinevich, V, Lakhin, A, Tarabar, D, Ling, Kl, Bunganic, I, Cernok, S, Gregus, M, Coetzer, T, Grundling, H, Moola, Sa, Wright, Jp, Ziady, C, Bermejo, F, Calvet, X, Herrerias, Jm, Perez Calle JL, Perez Gisbert, J, Hertervig, E, Karlen, P, Michetti, P, Rogler, G, Seibold, F, Wu, Dc, Atug, O, Kurdas, Oo, Datsenko, O, Dorofyeyev, A, Dudar, L, Golovchenko, O, Klyarits'Ka, I, Skrypnyk, I, Hawthorne, Ab, Middleton, S, Abreu, M, Bala, N, Becker, S, Behm, B, Braun, R, Bukhari, M, Chen, S, Coates, A, Dar, S, Dassopoulos, T, De Villiers, W, Desautels, S, Desta, T, Dimitroff, J, Dryden, G, Duvall, A, Farraye, F, Fein, S, Liu, Bf, Gatof, D, Geenen, D, Ginsburg, P, Glombicki, A, Glover, S, Gordon, G, Grisolano, S, Hanson, J, Hardi, R, Hoffman, B, Isaacs, K, Kim, C, Koval, G, Lashner, B, Lawitz, E, Leman, B, Levine, J, Loftus, E, Mahadevan, U, Mannon, P, Marcet, J, Matsuyama, R, Matusow, G, Mccabe, R, Mirkin, K, Murphy, M, Mushahwar, A, Mutlu, E, Nagrani, M, Nguyen, D, Nichols, M, Nieves Ramirez, A, Oubre, B, Pace, S, Pandak, W, Perera, L, Quadri, A, Quallich, L, Rajapakse, R, Randall, C, Regueiro, M, Safdi, A, Sandborn, W, Sands, B, Saubermann, L, Scherl, E, Schwartz, D, Sedghi, S, Shafran, I, Shepard, R, Siegel, C, Stein, L, Tatum, H, Triebling, A, Vasudeva, R, Winston, B, Wolf, D, Younes, Z, Jewell, D, Mahon, J, Rothstein, R, Snydman, D, Massaro, J, Clifford, D, Berger, J, Major, E, Provenzale, J, Lev, M., GEMINI 2 Study Group, Bampton, P., Borody, T., Chung, A., Debinski, H., Florin, T., Hetzel, D., Jakobovits, S., Lawrance, I., Leong, R., Macrae, F., Mitchell, B., Moore, G., Pavli, P., Samuel, D., Weltman, M., Haas, T., Reinisch, W., Vogel, W., Baert, F., De Maeyer, M., De Vos, M., Dewit, O., D'Haens, G., Louis, E., Muls, V., Van Assche, G., Krastev, Z., Nikolovska, D., Petrov, P., Petrov, A., Stoinov, S., Tchernev, K., Vasileva, G., Aumais, G., Axler, J., Bailey, R., Bernstein, C., Bitton, A., Bourdages, R., Bressler, B., Cohen, A., Devroede, G., Dhalla, S., Feagan, B., Fedorak, R., Green, D., Greenberg, G., Jones, J., Larkai, E., MacIntosh, D., Panaccione, R., Ponich, T., Singh, R., Sy, R., Wiesinger, H., Albin, A., Douda, L., Horny, I., Lukas, M., Stehlik, J., Stuksa, J., Volfova, M., Vyhnalek, P., Zadorova, Z., Andersen, V., Bendtsen, F., Fallingborg, J., Rannem, T., Maelt, A., Margus, B., Salupere, R., Allez, M., Des Varennes SB., Desreumaux, P., Dupas, JL., Grimaud, JC., Hebuterne, X., Lerebours, E., Picon, L., Zerbib, F., Aldinger, V., Baumgart, D., Buening, C., Dollinger, M., Hoffmann, P., Howaldt, S., Klaus, J., Konturek, JW., Krummenerl, T., Malfertheiner, P., Schmidt, W., Schreiber, S., Seidler, U., Stallmach, A., Stremmel, W., Zeitz, M., Mantzaris, G., Triantafyllou, K., Ng, C., Bene, L., Fazekas, I., Fejes, R., Gall, J., Horvat, G., Hunyady, B., Salamon, A., Toth, T., Tulassay, Z., Varga, E., Varga, M., Varga-Szabo, L., Vincze, A., Oddsson, E., Örvar, K., Ahuja, V., Amarapurkar, D., Chandra, A., Koshy, A., Krishna, P., Ramakrishna, K., Reddy, N., Thorat, V., Patchett, S., Ryan, B., Ben Horin, S., Fishman, S., Lavy, A., Rachmilewitz, D., Ardizzone, S., Corazziari, E., Danese, S., Fries, W., Gasbarrini, A., Kohn, A., Sturniolo, GC., Danilans, A., George, AM., Hilmi, IN., Engels, LG., Ponsioen, CY., van der Woude CJ., Gearry, R., Haines, M., Schultz, M., Wallace, I., Wyeth, J., Florholmen, J., Jahnsen, J., Lygren, I., Röseth, A., Ciecko-Michalska, I., Gonciarz, M., Horynski, M., Huk, J., Jamrozik-Kruk, Z., Janke, A., Klupinska, G., Marecik, J., Paradowski, L., Rudzinski, J., Rydzewska, G., Han, DS., Hong, SP., Kim, HJ., Kim, JS., Kim, KO., Kim, YH., Yang, SK., Gheorghe, LS., Voiosu, RM., Alexeeva, O., Baranovsky, A., Bunkova, E., Burnevich, E., Dolgikh, O., Grinevich, V., Lakhin, A., Tarabar, D., Ling, KL., Bunganic, I., Cernok, S., Gregus, M., Coetzer, T., Grundling, H., Moola, SA., Wright, JP., Ziady, C., Bermejo, F., Calvet, X., Herrerias, JM., Perez Calle JL., Perez Gisbert, J., Hertervig, E., Karlen, P., Michetti, P., Rogler, G., Seibold, F., Wu, DC., Atug, O., Kurdas, OO., Datsenko, O., Dorofyeyev, A., Dudar, L., Golovchenko, O., Klyarits'ka, I., Skrypnyk, I., Hawthorne, AB., Middleton, S., Abreu, M., Bala, N., Becker, S., Behm, B., Braun, R., Bukhari, M., Chen, S., Coates, A., Dar, S., Dassopoulos, T., De Villiers, W., Desautels, S., Desta, T., Dimitroff, J., Dryden, G., Duvall, A., Farraye, F., Fein, S., Liu, BF., Gatof, D., Geenen, D., Ginsburg, P., Glombicki, A., Glover, S., Gordon, G., Grisolano, S., Hanauer, S., Hanson, J., Hardi, R., Hoffman, B., Isaacs, K., Kim, C., Koval, G., Lashner, B., Lawitz, E., Lee, S., Leman, B., Levine, J., Loftus, E., Mahadevan, U., Mannon, P., Marcet, J., Matsuyama, R., Matusow, G., McCabe, R., Mirkin, K., Murphy, M., Mushahwar, A., Mutlu, E., Nagrani, M., Nguyen, D., Nichols, M., Nieves Ramirez, A., Oubre, B., Pace, S., Pandak, W., Perera, L., Quadri, A., Quallich, L., Rajapakse, R., Randall, C., Regueiro, M., Safdi, A., Sandborn, W., Sands, B., Saubermann, L., Scherl, E., Schwartz, D., Sedghi, S., Shafran, I., Shepard, R., Siegel, C., Stein, L., Tatum, H., Triebling, A., Vasudeva, R., Winston, B., Wolf, D., Younes, Z., Feagan, BG., Colombel, JF., Rutgeerts, P., Sandborn, WJ., Sands, BE., Jewell, D., Mahon, J., Rothstein, R., Snydman, D., Massaro, J., Clifford, D., Berger, J., Major, E., Provenzale, J., Lev, M., and Medical Microbiology & Infectious Diseases
Subjects: Adult, Male, Integrins, medicine.medical_specialty, HUMAN POLYOMAVIRUSES, JC, Antibodies/blood, Antibodies, Monoclonal, Humanized/adverse effects, Antibodies, Monoclonal, Humanized/immunology, Crohn Disease/drug therapy, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Glucocorticoids/therapeutic use, Humans, Immunosuppressive Agents/therapeutic use, Induction Chemotherapy, Infusions, Intravenous/adverse effects, Integrins/antagonists & inhibitors, Integrins/immunology, Maintenance Chemotherapy, Middle Aged, PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY, Antibodies, Monoclonal, Humanized, Placebo, Gastroenterology, Inflammatory bowel disease, Antibodies, Vedolizumab, CERTOLIZUMAB PEGOL, Natalizumab, Crohn Disease, Maintenance therapy, HUMANIZED ANTIBODY, Internal medicine, Ustekinumab, medicine, Certolizumab pegol, Infusions, Intravenous, Glucocorticoids, NATALIZUMAB, business.industry, Induction chemotherapy, General Medicine, medicine.disease, PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY, RELAPSING MULTIPLE-SCLEROSIS, INFLAMMATORY-BOWEL-DISEASE, HUMAN POLYOMAVIRUSES, HUMANIZED ANTIBODY, CERTOLIZUMAB PEGOL, ULCERATIVE-COLITIS, RANDOMIZED-TRIAL, NATALIZUMAB, JC, RANDOMIZED-TRIAL, digestive system diseases, Surgery, ULCERATIVE-COLITIS, RELAPSING MULTIPLE-SCLEROSIS, business, Immunosuppressive Agents, INFLAMMATORY-BOWEL-DISEASE, medicine.drug
Abstract: BACKGROUND: The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is unknown. METHODS: In an integrated study with separate induction and maintenance trials, we assessed intravenous vedolizumab therapy (300 mg) in adults with active Crohn's disease. In the induction trial, 368 patients were randomly assigned to receive vedolizumab or placebo at weeks 0 and 2 (cohort 1), and 747 patients received open-label vedolizumab at weeks 0 and 2 (cohort 2); disease status was assessed at week 6. In the maintenance trial, 461 patients who had had a response to vedolizumab were randomly assigned to receive placebo or vedolizumab every 8 or 4 weeks until week 52. RESULTS: At week 6, a total of 14.5% of the patients in cohort 1 who received vedolizumab and 6.8% who received placebo were in clinical remission (i.e., had a score on the Crohn's Disease Activity Index [CDAI] of ≤150, with scores ranging from 0 to approximately 600 and higher scores indicating greater disease activity) (P=0.02); a total of 31.4% and 25.7% of the patients, respectively, had a CDAI-100 response (≥100-point decrease in the CDAI score) (P=0.23). Among patients in cohorts 1 and 2 who had a response to induction therapy, 39.0% and 36.4% of those assigned to vedolizumab every 8 weeks and every 4 weeks, respectively, were in clinical remission at week 52, as compared with 21.6% assigned to placebo (P
Published: 2013

9. Exon-disrupting deletions ofNRXN1in idiopathic generalized epilepsy

Author: Møller, R.S., Weber, Y.G., Klitten, L.L., Trucks, H., Muhle, H., Kunz, W.S., Mefford, H.C., Franke, A., Kautza, M., Wolf, P., Dennig, D., Schreiber, S., Rückert, I.M., Wichmann, H.E., Ernst, J.P., Schurmann, C., Grabe, H.J., Tommerup, N., Stephani, U., Lerche, H., Hjalgrim, H., Helbig, I., Sander, T., Zimprich, F., Mörzinger, M., Feucht, M., Suls, A., Weckhuysen, S., Claes, L., Deprez, L., Smets, K., Van Dyck, T., Deconinck, T., De Jonghe, P., Velizarova, R., Dimova, P., Radionova, M., Tournev, I., Kancheva, D., Kaneva, R., Jordanova, A., Kjelgaard, D.B., Lehesjoki, A.E., Siren, A., Baulac, S., Leguern, E., Von Spiczak, S., Ostertag, P., Leber, M., Leu, C., Toliat, M.R., Nürnberg, P., Hempelmann, A., Rüschendorf, F., Elger, C.E., Kleefuß Lie, A.A., Surges, R., Gaus, V., Janz, D., Schmitz, B., Klein, K.M., Reif, P.S., Oertel, W.H., Hamer, H.M., Rosenow, F., Becker, F., Marini, C., Guerrini, R., Mei, D., Norci, V., Zara, F., Striano, P., Robbiano, A., Pezzella, M., Bianchi, A., Gambardella, A., Tinuper, P., La Neve, A., Capovilla, G., Vigliano, P., Crichiutti, G., Vanadia, F., Vignoli, A., Coppola, A., Striano, S., Giallonardo, M.T., Franceschetti, S., Belcastro, V., Benna, P., Coppola, G., De Palo, A., Ferlazzo, E., Vecchi, M., Martinelli, V., Bisulli, F., Beccaria, F., Del Giudice, E., Mancardi, M., Stranci, G., Scabar, A., Gobbi, G., Giordano, I., Koeleman, B.P.C., De Kovel, C., Lindhout, D., De Haan, G.J., Ozbeck, U., Bebek, N., Baykan, B., Ozdemir, O., Ugur, S., Kocasoy Orhan, E., Yücesan, E., Cine, N., Gokyigit, A., Gurses, C., Gul, G., Yapici, Z., Ozkara, C., Caglayan, H., Yalcin, O., Yalcin, D., Turkdogan, D., Dizdarer, G., Agan, K., R. S. Møller, Y. G. Weber, L. L. Klitten, H. Truck, H. Muhle, W. S. Kunz, H. C. Mefford, A. Franke, M. Kautza, P. Wolf, D. Dennig, S. Schreiber, I. Rückert, H. Wichmann, J. P. Ernst, C. Schurmann, H. J. Grabe, N. Tommerup, U. Stephani, H. Lerche, H. Hjalgrim, I. Helbig, T. Sander, P. Tinuper, F. Bisulli, EPICURE Consortium, Suls, Arvid, Weckhuysen, Sarah, Claes, Godelieve, Deprez, Liesbet, Smets, Katrien, Van Dyck, Tine, Deconinck, Tine, De Jonghe, Peter, Jordanova, Albena, Møller, R, Weber, Yg, Klitten, Ll, Trucks, H, Muhle, H, Kunz, W, Mefford, Hc, Franke, A, Kautza, M, Wolf, P, Dennig, D, Schreiber, S, Rückert, Im, Wichmann, He, Ernst, Jp, Schurmann, C, Grabe, Hj, Tommerup, N, Stephani, U, Lerche, H, Hjalgrim, H, Helbig, I, Sander, T, Epicure, Consortium, DEL GIUDICE, Ennio, Coppola, Antonietta, and YÜCESAN, EMRAH
Subjects: Male, Idiopathic generalized epilepsy, Neuronal, Idiopathic Generalized Epilepsy, 1q21, 1 Microdeletion, Two-hit Hypothesis, Nrxn1, Neuropsychological Tests, Immunoglobulin E, Cell Adhesion Molecules, Neuronal/genetics, Adult, Age of Onset, Anticonvulsant, Exon, 1q21.1 microdeletion, Exons/genetics, Odds Ratio, Nerve Tissue Proteins/genetics, Copy-number variation, Valproic Acid/therapeutic use, Age of Onset, Neural Cell Adhesion Molecules, genetics, DNA Copy Number Variations, Electroencephalography, Epilepsy, Genetics, biology, Triazines, Anticonvulsants/therapeutic use, Electroencephalography, genetics, Family, Female, Fructose, Exons, Middle Aged, Settore MED/39 - Neuropsichiatria Infantile, Pedigree, therapeutic use, Valproic Acid, Neurology, Settore MED/26 - Neurologia, Anticonvulsants, Epilepsy, Generalized, Female, Adult, Case-Control Studies, Cell Adhesion Molecules, Neuronal, DNA Copy Number Variations, Family, Fructose, Gene Deletion, Genotype, Humans, Infant, Microarray Analysis, Nerve Tissue Proteins, Valproic Acid, analogs /&/ derivatives/therapeutic use, Gene Deletion, Genotype, Humans, Infant, Male, Microarray Analysis, Middle Aged, Nerve Tissue Protein, therapeutic use, Case-Control Studies, Cell Adhesion Molecule, drug therapy/genetics/psychology, Exon, genetics, Neuropsychological Tests, Odds Ratio, Pedigree, Triazine, Lamotrigine, NRXN1, Topiramate, Epilepsy, Generalized/drug therapy, medicine, Allele, Biology, Gene, Generalized, Point mutation, Calcium-Binding Proteins, Odds ratio, medicine.disease, Triazines/therapeutic use, Settore MED/03 - Genetica Medica, therapeutic use, biology.protein, Fructose/analogs & derivatives, Human medicine, Neurology (clinical), Two-hit hypothesis
Abstract: Summary Purpose Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs). Methods We screened for deletions involving the NRXN1 gene in 1,569 patients with IGE and 6,201 controls using high-density oligonucleotide microarrays. Key Findings We identified exon-disrupting deletions of NRXN1 in 5 of 1,569 patients with IGE and 2 of 6,201 control individuals (p = 0.0049; odds ratio (OR) 9.91, 95% confidence interval (CI) 1.92–51.12). A complex familial segregation pattern in the IGE families was observed, suggesting that heterozygous NRXN1 deletions are susceptibility variants. Intriguingly, we identified a second large copy number variant in three of five index patients, supporting an involvement of heterogeneous susceptibility alleles in the etiology of IGE. Significance We conclude that exon-disrupting deletions of NRXN1 represent a genetic risk factor in the genetically complex predisposition of common IGE syndromes.
Published: 2013

10. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Author: Ehret, Georg B., Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sober, Siim, Parsa, Afshin, Luan, Jian'an, Arora, Pankaj, Dehghan, Abbas, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Fox, Ervin R., Kumari, Meena, Go, Min Jin, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D. G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Tayo, Bamidele, Seielstad, Mark, Sim, Xueling, Hoang Nguyen, Khanh-Dung, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G. P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S. P. M., Adeyemo, Adebowale, Palmas, Walter, Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Kardia, Sharon L., Morrison, Alanna C., Hernandez, Dena, Najjar, Samer, McArdle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N. M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Dreisbach, Albert W., Li, Yali, Hunter Young, J., Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthias, Pattaro, Cristian, Bolton, Judith A Hoffman, Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johannes, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inês, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Sun, Yan V., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Markus, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., Artigas, Maria Soler, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Doumatey, Ayo, Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margus, Kinra, Sanjay, Prabhakaran, Dorairaj, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., Corsi, Anna Maria, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thomas, Wichmann, H. -Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, James, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Christopher J., Schwartz, Stephen M., Arfan Ikram, M., Longstreth Jr. , W. T., Mosley, Thomas H., Seshadri, Sudha, Shrine, Nick R. G., Wain, Louise V., Morken, Mario A., Swift, Amy J., Laitinen, Jaana, Prokopenko, Inga, Zitting, Paavo, Cooper, Jackie A., Humphries, Steve E., Danesh, John, Rasheed, Asif, Goel, Anuj, Hamsten, Anders, Watkins, Hugh, Bakker, Stephan J. L., van Gilst, Wiek H., Janipalli, Charles S., Radha Mani, K., Yajnik, Chittaranjan S., Hofman, Albert, Mattace-Raso, Francesco U. S., Oostra, Ben A., Demirkan, Ayse, Isaacs, Aaron, Rivadeneira, Fernando, Lakatta, Edward G., Orru, Marco, Scuteri, Angelo, Ala-Korpela, Mika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Soininen, Pasi, Tukiainen, Taru, Würtz, Peter, Twee-HeeOng, Rick, Dörr, Marcus, Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Spector, Tim D., Zhai, Guangju, Meschia, James F., Nalls, Michael A., Sharma, Pankaj, Terzic, Janos, Kranthi Kumar, M. V., Denniff, Matthew, Zukowska-Szczechowska, Ewa, Wagenknecht, Lynne E., Fowkes, F. Gerald R., Charchar, Fadi J., Schwarz, Peter E. H., Hayward, Caroline, Guo, Xiuqing, Rotimi, Charles, Bots, Michiel L., Brand, Eva, Samani, Nilesh J., Polasek, Ozren, Talmud, Philippa J., Nyberg, Fredrik, Kuh, Diana, Laan, Maris, Hveem, Kristian, Palmer, Lyle J., van der Schouw, Yvonne T., Casas, Juan P., Mohlke, Karen L., Vineis, Paolo, Raitakari, Olli, Ganesh, Santhi K., Wong, Tien Y., Shyong Tai, E., Cooper, Richard S., Laakso, Markku, Rao, Dabeeru C., Harris, Tamara B., Morris, Richard W., Dominiczak, Anna F., Kivimaki, Mika, Marmot, Michael G., Miki, Tetsuro, Saleheen, Danish, Chandak, Giriraj R., Coresh, Josef, Navis, Gerjan, Salomaa, Veikko, Han, Bok-Ghee, Zhu, Xiaofeng, Kooner, Jaspal S., Melander, Olle, Ridker, Paul M., Bandinelli, Stefania, Gyllensten, Ulf B., Wright, Alan F., Wilson, James F., Ferrucci, Luigi, Farrall, Martin, Tuomilehto, Jaakko, Pramstaller, Peter P., Elosua, Roberto, Soranzo, Nicole, Sijbrands, Eric J. G., Altshuler, David, Loos, Ruth J. F., Shuldiner, Alan R., Gieger, Christian, Meneton, Pierre, Uitterlinden, Andre G., Wareham, Nicholas J., Gudnason, Vilmundur, Rotter, Jerome I., Rettig, Rainer, Uda, Manuela, Strachan, David P., Witteman, Jacqueline C. M., Hartikainen, Anna-Liisa, Beckmann, Jacques S., Boerwinkle, Eric, Vasan, Ramachandran S., Boehnke, Michael, Larson, Martin G., Järvelin, Marjo-Riitta, Psaty, Bruce M., Abecasis, Gonçalo R., Chakravarti, Aravinda, Elliott, Paul, van Duijn, Cornelia M., Newton-Cheh, Christopher, Levy, Daniel, Caulfield, Mark J., Johnson, Toby, Tang H, Knowles J, Hlatky M, Fortmann S, Assimes TL, Quertermous T, Go A, Iribarren C, Absher D, Risch N, Meyers R, Sidney S, Ziegler A, Schillert A, Bickel C, Sinning C, Rupprecht HJ, Lackner K, Wild P, Schnabel R, Blankenberg S, Zeller T, Münzel T, Perret C, Cambien F, Tiret L, Nicaud V, Proust C, Dehghan A, Hofman A, Uitterlinden A, van Duijn C, Levy D, Whitteman J, Cupples LA, Demissie-Banjaw S, Ramachandran V, Smith A, Gudnason V, Boerwinkle E, Folsom A, Morrison A, Psaty BM, Chen IY, Rotter JI, Bis J, Volcik K, Rice K, Taylor KD, Marciante K, Smith N, Glazer N, Heckbert S, Harris T, Lumley T, Kong A, Thorleifsson G, Thorgeirsson G, Holm H, Gulcher JR, Stefansson K, Andersen K, Gretarsdottir S, Thorsteinsdottir U, Preuss M, Schreiber S, Meitinger T, König IR, Lieb W, Hengstenberg C, Schunkert H, Erdmann J, Fisher M, Grosshennig A, Medack A, Stark K, Linsel-Nitschke P, Bruse P, Aherrahrou Z, Peters A, Loley C, Willenborg C, Nahrstedt J, Freyer J, Gulde S, Doering A, Meisinger C, Wichmann HE, Klopp N, Illig T, Meinitzer A, Tomaschitz A, Halperin E, Dobnig H, Scharnagl H, Kleber M, Laaksonen R, Pilz S, Grammer TB, Stojakovic T, Renner W, März W, Böhm BO, Winkelmann BR, Winkler K, Hoffmann M, O'Donnell CJ, Voight BF, Altshuler D, Siscovick DS, Musunuru K, Peltonen L, Barbalic M, Melander O, Elosua R, Kathiresan S, Schwartz SM, Salomaa V, Guiducci C, Burtt N, Gabriel SB, Stewart AF, Wells GA, Chen L, Jarinova O, Roberts R, McPherson R, Dandona S, Pichard AD, Rader DJ, Devaney J, Lindsay JM, Kent KM, Qu L, Satler L, Burnett MS, Li M, Reilly MP, Wilensky R, Waksman R, Epstein S, Mattha W, Knouf CW, Waterworth DM, Hakonarson HH, Walker M, Mooser V, Hall AS, Balmforth AJ, Wright BJ, Nelson C, Thompson JR, Samani NJ, Braund PS, Ball SG, Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Rosamond WD, Rivadeneira F, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Wang YA, Stricker B, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Heckbert SR, Fox ER, Uitterlinden AG, Willerson JT, van Duijn CM, Witteman JC, Vasan RS, Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson A, Teumer A, Paré G, Atkinson EJ, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Struchalin M, Cavalieri M, Singleton A, Giallauria, Francesco, Metter J, de Boer J, Siscovick D, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turne ST, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS, Vasan R, Felix SB, Watzinger N, Larson MG, Homuth G, Aragam J, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Deckers JW, Stritzke J, Lackner KJ, Ingelsson E, Kullo I, Haerting J, Stricker BH, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Arnett D, Blettner M, Friedrich N, Benjamin EJ, Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic T, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Munroe PB, Nordfors L, Penninx BW, Perucha E, Pouta A, Roderick PJ, Ruokonen A, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Abecasis GR, Lightstone L, Scott J, Navis G, Elliot P, Kooner JS., AII - Amsterdam institute for Infection and Immunity, Nephrology, Epidemiologie, RS: CARIM School for Cardiovascular Diseases, Epidemiology, Medical Microbiology & Infectious Diseases, Radiology & Nuclear Medicine, Cardiology, Internal Medicine, Clinical Genetics, Erasmus MC other, Obstetrics & Gynecology, International Consortium for Blood Pressure Genome-Wide Association Studies, CARDIoGRAM consortium, CKDGen Consortium, KidneyGen Consortium, EchoGen consortium, CHARGE-HF consortium, Zhao, Jing Hua [0000-0003-4930-3582], Luan, Jian'an [0000-0003-3137-6337], Barroso, Ines [0000-0001-5800-4520], Khaw, Kay-Tee [0000-0002-8802-2903], Danesh, John [0000-0003-1158-6791], Soranzo, Nicole [0000-0003-1095-3852], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Center for Complex Disease Genomics, Johns Hopkins University School of Medicine, Clinical Pharmacology and The Genome Centre, Queen Mary University of London (QMUL), Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Center for Human Genetic Research, Massachusetts General Hospital [Boston], Program in Medical and Population Genetics, Harvard University-Massachusetts Institute of Technology (MIT), Ehret, Georg B., Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sober, Siim, Parsa, Afshin, Luan, Jian'An, Arora, Pankaj, Dehghan, Abba, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Fox, Ervin R., Kumari, Meena, Go, Min Jin, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D. G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Tayo, Bamidele, Seielstad, Mark, Sim, Xueling, Hoang Nguyen, Khanh-Dung, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G. P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S. P. M., Adeyemo, Adebowale, Palmas, Walter, Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Kardia, Sharon L., Morrison, Alanna C., Hernandez, Dena, Najjar, Samer, Mcardle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N. M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Dreisbach, Albert W., Li, Yali, Hunter Young, J., Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthia, Pattaro, Cristian, Bolton, Judith A Hoffman, Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johanne, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inê, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Sun, Yan V., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Marku, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., Artigas, Maria Soler, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Doumatey, Ayo, Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margu, Kinra, Sanjay, Prabhakaran, Dorairaj, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., Corsi, Anna Maria, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, Mckenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thoma, Wichmann, H. -Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, Jame, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Christopher J., Schwartz, Stephen M., Arfan Ikram, M., Longstreth Jr., W. 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H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink-Veltmaat, Lj, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliot, P, and Kooner, Js.
Subjects: novel loci, Kidney Disease, Polymorphism, Single Nucleotide/*genetics, [SDV]Life Sciences [q-bio], left ventricular wall thickness, LOCI, Genome-wide association study, Blood Pressure, Disease, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery disease, 0302 clinical medicine, RELEVANCE, Africa/ethnology, Cardiovascular Disease, genetics, Kidney Diseases/genetics, Stroke, genome wide association study, POPULATION, ta118, Blood pressure, hypertension, stroke, coronary artery disease, ddc:616, 0303 health sciences, education.field_of_study, Asia/ethnology, Multidisciplinary, Coronary Artery Disease/genetics, COMMON VARIANTS, Genetic Predisposition to Disease/*genetics, 3. Good health, Europe, Cardiovascular Diseases, Hypertension, Cardiology, Kidney Diseases, HEALTH, Human, medicine.medical_specialty, Asia, Population, Renal function, Polymorphism, Single Nucleotide, Europe/ethnology, Article, CLONING, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Stroke/genetics, Internal medicine, medicine, Humans, Cardiovascular Diseases/*genetics, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, education, METAANALYSIS, 030304 developmental biology, RECEPTOR, genes, blood pressure, cardiovascular disease risk, medicine.disease, Africa, Blood Pressure/*genetics/physiology, Hypertension/genetics, Kidney disease, Genome-Wide Association Study
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. ispartof: Nature vol:478 issue:7367 pages:103-109 ispartof: location:England status: published
Published: 2011

11. Supplementary Material for: Genetic Variants of the Copy Number Polymorphic β-Defensin Locus Are Associated with Sporadic Prostate Cancer

Author: Huse, K., Taudien, S., Groth, M., Rosenstiel, P., Szafranski, K., Hiller, M., Hampe, J., Junker, K., Schubert, J., Schreiber, S., Birkenmeier, G., Krawczak, M., and Platzer, M.
Abstract: Background/Aims: Prostate cancer represents the cancer with the highest worldwide prevalence in men. Chromosome 8p23 has shown suggestive genetic linkage to early-onset familial prostate cancer and is frequently deleted in cancer cells of the urogenital tract. Within this locus some β-defensin genes (among them DEFB4, DEFB103, DEFB104) are localized, which are arranged in a gene cluster shown to exhibit an extensive copy number variation in the population. This structural variation considerably hampers genetic studies. In a new approach considering both sequence as well as copy number variations we aimed to compare the defensin locus at 8p23 in prostate cancer patients and controls. Methods: We apply PCR/cloning-based haplotyping and high-throughput copy number determination methods which allow assessment of both individual haplotypes and gene copy numbers not accessible to conventional SNP-based genotyping. Results: We demonstrate association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts. Moreover, we show that high copy numbers (>9) of the defensin gene cluster are significantly underrepresented in both patient samples. Conclusions: Our findings imply a role of the antibacterial defensins in prostate cancerogenesis qualifying distinct gene variants and copy numbers as potential tumor markers.
Published: 2017
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12. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Author: Okada, Y, Sim, X, Go, Mj, Wu, Jy, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, Sc, Wong, Ty, Liu, J, Young, Tl, Aung, T, Seielstad, M, Teo, Yy, Kim, Yj, Lee, Jy, Han, Bg, Kang, D, Chen, Ch, Tsai, Fj, Chang, Lc, Fann, Sj, Mei, H, Rao, Dc, Hixson, Je, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, Jc, Zhang, W, Kooner, Js, Kidneygen, Consortium, Ckdgen, Consortium, Albrecht, E, Gugc, Consortium, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Yt, Cho, Ys, Tai, Es, Tanaka, T., Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, Js, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Smith, Gd, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, van der Heide JJ, Hepkema, Bg, Hernandez Fuentes, M, Hypponen, E, Johnson, T, de Jong PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Melander, O, Munroe, Pb, Nordfors, L, Parsa, A, Peltonen, L, Penninx, Bw, Perucha, E, Pouta, A, Prokopenko, I, Roderick, Pj, Ruokonen, A, Samani, Nj, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Shuldiner, Ar, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Tanaka, T, Ubink Veltmaat LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Mooser, V, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliott, P, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Glazer, Nl, Gao, X, Yang, Q, Smith, Av, O'Connell, Jr, Li, M, Schmidt, H, Isaacs, A, Ketkar, S, Hwang, Sj, Johnson, Ad, Dehghan, A, Teumer, A, Paré, G, Atkinson, Ej, Zeller, T, Lohman, K, Cornelis, Mc, Probst Hensch NM, Kronenberg, F, Tönjes, A, 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D.P., Wass, M.N., Ahmadi, K.R., Bakker, S.J., Beckmann, J., Bilo, H.J., Bochud, M., Brown, M.J., Caulfield, M.J., Connell, J.M., Cook, H.T., Cotlarciuc, I., Smith, G.D., de Silva, R., Deng, G., Devuyst, O., Dikkeschei, L.D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N.G., Gansevoort, R.T., Han, X., Hedblad, B., van der Heide, J.J., Hepkema, B.G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P.E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R.J., Luan, J., Luttropp, K., Maréchal, C., Melander, O., Munroe, P.B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B.W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P.J., Ruokonen, A., Samani, N.J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M.A., Shuldiner, A.R., Sjögren, M., Smit, J.H., Snieder, H., Soranzo, N., Spector, T.D., Stenvinkel, P., Sternberg, M.J., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L.J., Uda, 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Jer-Yuarn, Gu, Dongfeng, Takeuchi, Fumihiko, Takahashi, Atsushi, Maeda, Shiro, Tsunoda, Tatsuhiko, Chen, Peng, Lim, Su-Chi, Wong, Tien-Yin, Liu, Jianjun, Young, Terri L., Aung, Tin, Seielstad, Mark, Teo, Yik-Ying, Kim, Young Jin, Lee, Jong-Young, Han, Bok-Ghee, Kang, Daehee, Chen, Chien-Hsiun, Tsai, Fuu-Jen, Chang, Li-Ching, Cathy Fann, S. -J. C., Mei, Hao, Rao, Dabeeru C., Hixson, James E., Chen, Shufeng, Katsuya, Tomohiro, Isono, Masato, Ogihara, Toshio, Chambers, John C., Zhang, Weihua, Kooner, Jaspal S., Albrecht, Eva, Yamamoto, Kazuhiko, Kubo, Michiaki, Nakamura, Yusuke, Kamatani, Naoyuki, Kato, Norihiro, He, Jiang, Chen, Yuan-Tsong, Cho, Yoon Shin, Tai, E-Shyong, Tanaka, Toshihiro, de Silva, R Deng G, Hernandez-Fuentes, M, Ubink-Veltmaat, Lj, Probst-Hensch, Nm, Giallauria, Francesco, Pirastu, N, D'Adamo, P, Gasparini, P, and Bouatia-Naji, N
Subjects: Asian Continental Ancestry Group, kidney, Population, Renal function, Genome-wide association study, Biology, Kidney, Polymorphism, Single Nucleotide, Article, Blood Urea Nitrogen, Cohort Studies, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Asian People, loci, Asian, medicine, Humans, genetics, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, education, meta-analysis, Genome-Wide Association Study, Genetic association, Genetics, Creatinine, education.field_of_study, ta3121, medicine.disease, Uric Acid, Asian Continental Ancestry Group/genetics, Creatinine/blood, Glomerular Filtration Rate/genetics, Kidney/physiology, Renal Insufficiency, Chronic/genetics, Uric Acid/blood, medicine.anatomical_structure, chemistry, Genetic epidemiology, Cohort Studie, Human, Kidney disease, Glomerular Filtration Rate
Abstract: Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Published: 2012

13. Correction: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Author: Gormley, P, Anttila, V, Winsvold, BS, Palta, P, Esko, T, Pers, TH, Farh, KH, Cuenca-Leon, E, Muona, M, Furlotte, NA, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, GM, Kallela, M, Freilinger, TM, Ran, C, Gordon, SG, Stam, AH, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, HHH, Lehtimäki, T, Sarin, AP, Wedenoja, J, Hinds, DA, Buring, JE, Schürks, M, Ridker, PM, Gudlaug Hrafnsdottir, M, Stefansson, H, Ring, SM, Hottenga, JJ, Penninx, BWJH, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Heath, AC, Madden, PAF, Martin, NG, Montgomery, GW, Kurki, MI, Kals, M, Mägi, R, Pärn, K, Hämäläinen, E, Huang, H, Byrnes, AE, Franke, L, Huang, J, Stergiakouli, E, Lee, PH, Sandor, C, Webber, C, Cader, Z, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, JG, Salomaa, V, Heikkilä, K, Loehrer, E, Uitterlinden, AG, Hofman, A, Van Duijn, CM, Cherkas, L, Pedersen, LM, Stubhaug, A, Nielsen, CS, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, AL, Francke Christensen, A, Folkmann Hansen, T, Werge, T, Kaprio, J, Aromaa, AJ, Raitakari, O, Arfan Ikram, M, Spector, T, Järvelin, MR, Metspalu, A, Kubisch, C, Strachan, DP, Ferrari, MD, Belin, AC, Dichgans, M, Wessman, M, Van den Maagdenberg, AMJM, Zwart, JA, Boomsma, DI, and Davey Smith, G
Subjects: ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, 06 Biological Sciences, 11 Medical and Health Sciences, Developmental Biology
Abstract: In the version of this article initially published online, the affiliations for Bertram Muller-Myhsok and Patricia Pozo-Rosich were incorrect or incomplete. These errors have been corrected for the print, PDF and HTML versions of this article.
Published: 2016

14. A genome-wide association study of anorexia nervosa

Author: Boraska, V., Franklin, C. S., Floyd, J. A. B., Thornton, L. M., Huckins, L. M., Southam, L., Rayner, N. W., Tachmazidou, I., Klump, K. L., Treasure, J., Lewis, C. M., Schmidt, U., Tozzi, F., Kiezebrink, K., Hebebrand, J., Gorwood, P., Adan, R. A. H., Kas, M. J. H., Favaro, Angela, Santonastaso, Paolo, Fernández Aranda, F., Gratacos, M., Rybakowski, F., Dmitrzak Weglarz, M., Kaprio, J., Keski Rahkonen, A., Raevuori, A., Van Furth, E. F., Slof Op 't Landt, M. C. T., Hudson, J. I., Reichborn Kjennerud, T., Knudsen, G. P. S., Monteleone, P., Kaplan, A. S., Karwautz, A., Hakonarson, H., Berrettini, W. H., Guo, Y., Li, D., Schork, N. J., Komaki, G., Ando, T., Inoko, H., Esko, T., Fischer, K., Männik, K., Metspalu, A., Baker, J. H., Cone, R. D., Dackor, J., Desocio, J. E., Hilliard, C. E., O'Toole, J. K., Pantel, J., Szatkiewicz, J. P., Taico, C., Zerwas, S., Trace, S. E., Davis, O. S. 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E., Dina, C., Sladek, R., Gambaro, G., Soranzo, N., Julia, A., Marsal, S., Rabionet, R., Gaborieau, V., Dick, D. M., Palotie, A., Ripatti, S., Widén, E., Andreassen, O. A., Espeseth, T., Lundervold, A., Reinvang, I., Steen, V. M., Le Hellard, S., Mattingsdal, M., Ntalla, I., Bencko, V., Foretova, L., Janout, V., Navratilova, M., Gallinger, S., Pinto, D., Scherer, S. W., Aschauer, H., Carlberg, L., Schosser, A., Alfredsson, L., Ding, B., Klareskog, L., Padyukov, L., Courtet, P., Guillaume, S., Jaussent, I., Finan, C., Kalsi, G., Roberts, M., Logan, D. W., Peltonen, L., Ritchie, G. R. S., Barrett, J. C., Anderson, Carl A., Barrett, Jeffrey C., Floyd, James A. B., Franklin, Christopher S., Ralph, Mcginnis, Nicole, Soranzo, Eleftheria, Zeggini, Jennifer, Sambrook, Jonathan, Stephens, Ouwehand, Willem H., Mcardle, Wendy L., Ring, Susan M., Strachan, David P., Graeme, Alexander, Bulik, Cynthia M., Collier, David A., Conlon, Peter J., Anna, Dominiczak, Audrey, Duncanson, Adrian, Hill, Cordelia, Langford, Graham, Lord, Maxwell, Alexander P., Linda, Morgan, Leena, Peltonen, Sandford, Richard N., Neil, Sheerin, Vannberg, Fredrik O., Hannah, Blackburn, Wei Min Chen, Sarah, Edkins, Mathew, Gillman, Emma, Gray, Hunt, Sarah E., Suna Onengut Gumuscu, Simon, Potter, Rich, Stephen S., Douglas, Simpkin, Pamela, Whittaker, Estivill, X., Hinney, A., Sullivan, P. F., Collier, D. A., Zeggini, E., Bulik, C. M., Boraska, V., Franklin, Christopher S., Floyd, James A. B., Thornton, L. M., Huckins, L. M., Southam, L., Rayner, N. W., Tachmazidou, I., Klump, K. L., Treasure, J., Lewis, C. M., Schmidt, U., Tozzi, F., Kiezebrink, K., Hebebrand, J., Gorwood, P., Adan, R. A. H., Kas, M. J. H., Favaro, A., Santonastaso, P., Fernández-Aranda, F., Gratacos, M., Rybakowski, F., Dmitrzak-Weglarz, M., Kaprio, J., Keski-Rahkonen, A., Raevuori, A., Van Furth, E. F., Slof-Op 't Landt, M. C. T., Hudson, J. I., Reichborn-Kjennerud, T., Knudsen, G. P. S., Monteleone, P., Kaplan, A. S., Karwautz, A., Hakonarson, H., Berrettini, W. H., Guo, Y., Li, D., Schork, N. J., Komaki, G., Ando, T., Inoko, H., Esko, T., Fischer, K., Männik, K., Metspalu, A., Baker, J. H., Cone, R. D., Dackor, J., Desocio, J. E., Hilliard, C. E., O'Toole, J. K., Pantel, J., Szatkiewicz, J. P., Taico, C., Zerwas, S., Trace, S. E., Davis, O. S. P., Helder, S., Bühren, K., Burghardt, R., De Zwaan, M., Egberts, K., Ehrlich, S., Herpertz-Dahlmann, B., Herzog, W., Imgart, H., Scherag, A., Scherag, S., Zipfel, S., Boni, C., Ramoz, N., Versini, A., Brandys, M. K., Danner, U. N., De Kovel, C., Hendriks, J., Koeleman, B. P. C., Ophoff, R. A., Strengman, E., Van Elburg, A. A., Bruson, A., Clementi, M., Degortes, D., Forzan, M., Tenconi, E., Docampo, E., Escaramís, G., Jiménez-Murcia, S., Lissowska, J., Rajewski, A., Szeszenia-Dabrowska, N., Slopien, A., Hauser, J., Karhunen, L., Meulenbelt, I., Slagboom, P. E., Tortorella, A., Maj, M., Dedoussis, G., Dikeos, D., Gonidakis, F., Tziouvas, K., Tsitsika, A., Papezova, H., Slachtova, L., Martaskova, D., Kennedy, J. L., Levitan, R. D., Yilmaz, Z., Huemer, J., Koubek, D., Merl, E., Wagner, G., Lichtenstein, P., Breen, G., Cohen-Woods, S., Farmer, A., Mcguffin, P., Cichon, S., Giegling, I., Herms, S., Rujescu, D., Schreiber, S., Wichmann, H. -E., Dina, C., Sladek, R., Gambaro, G., Soranzo, Nicole, Julia, A., Marsal, S., Rabionet, R., Gaborieau, V., Dick, D. M., Palotie, A., Ripatti, S., Widén, E., Andreassen, O. A., Espeseth, T., Lundervold, A., Reinvang, I., Steen, V. M., Le Hellard, S., Mattingsdal, M., Ntalla, I., Bencko, V., Foretova, L., Janout, V., Navratilova, M., Gallinger, S., Pinto, D., Scherer, S. W., Aschauer, H., Carlberg, L., Schosser, A., Alfredsson, L., Ding, B., Klareskog, L., Padyukov, L., Courtet, P., Guillaume, S., Jaussent, I., Finan, C., Kalsi, G., Roberts, M., Logan, D. W., Peltonen, Leena, Ritchie, G. R. S., Barrett, Jeffrey C., Anderson, Carl A., Mcginnis, Ralph, Zeggini, Eleftheria, Sambrook, Jennifer, Stephens, Jonathan, Ouwehand, Willem H., Mcardle, Wendy L., Ring, Susan M., Strachan, David P., Alexander, Graeme, Bulik, C. M., Collier, David A., Conlon, Peter J., Dominiczak, Anna, Duncanson, Audrey, Hill, Adrian, Langford, Cordelia, Lord, Graham, Maxwell, Alexander P., Morgan, Linda, Sandford, Richard N., Sheerin, Neil, Vannberg, Fredrik O., Blackburn, Hannah, Chen, Wei-Min, Edkins, Sarah, Gillman, Mathew, Gray, Emma, Hunt, Sarah E., Onengut-Gumuscu, Suna, Potter, Simon, Rich, Stephen S., Simpkin, Dougla, Whittaker, Pamela, Estivill, X., Hinney, A., Sullivan, P. F., Martaskova D., Wellcome Trust Case Control Consortium 3, Anderson, CA., Barrett, JC., Floyd, JA., Franklin, CS., McGinnis, R., Soranzo, N., Zeggini, E., Sambrook, J., Stephens, J., Ouwehand, WH., McArdle, WL., Ring, SM., Strachan, DP., Alexander, G., Bulik, CM., Collier, DA., Conlon, PJ., Dominiczak, A., Duncanson, A., Hill, A., Langford, C., Lord, G., Maxwell, AP., Morgan, L., Peltonen, L., Sandford, RN., Sheerin, N., Vannberg, FO., Blackburn, H., Chen, WM., Edkins, S., Gillman, M., Gray, E., Hunt, SE., Onengut-Gumuscu, S., Potter, S., Rich, SS., Simpkin, D., and Whittaker, P.
Subjects: Male, Candidate gene, Anorexia Nervosa, Medizin, Genome-wide association study, anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic, Japan, Settore MED/14 - NEFROLOGIA, Guanine Nucleotide Exchange Factors, genome wide association study, Nuclear Protein, Genetics, Calcineurin, Eating disorder, Anorèxia nerviosa, Nuclear Proteins, Genomics, Cullin Proteins, 3. Good health, Anorexia, VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714, Anorexia nervosa (differential diagnoses), Psychiatry and Mental Health, Female, Case-Control Studie, Human, Asian Continental Ancestry Group, European Continental Ancestry Group, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, White People, Cellular and Molecular Neuroscience, Asian People, Meta-Analysis as Topic, Genetic linkage, Humans, Genotyping, Molecular Biology, anorexia nervosa, body mass index, eating disorders, genome wide association study, GWAS, metabolic, Cullin Protein, Case-control study, Anorexia nervosa, VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714, Guanine Nucleotide Exchange Factor, Genòmica, Case-Control Studies, Carrier Protein, Carrier Proteins, Body mass index, Genome-Wide Association Study
Abstract: Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P = 3.01 x 10(-7)) in SOX2OT and rs17030795 (P = 5.84 x 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P = 5.76 x 10(-6)) between CUL3 and FAM124B and rs1886797 (P = 8.05 x 10(-6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P= 4x10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
Published: 2014

15. A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease

Author: Dotan, I., Rachmilewitz, D., Schreiber, S., Eliakim, R., Woude, C.J. van der, Kornbluth, A., Buchman, A.L., Bar-Meir, S., Bokemeyer, B., Goldin, E., Maaser, C., Mahadevan, U., Seidler, U., Hoffman, J.C., Homoky, D., Plasse, T., Powers, B., Rutgeerts, P., Hommes, D., Semapimod-CD04 CD05 Investigators, and Gastroenterology & Hepatology
Subjects: Adult, Male, medicine.medical_specialty, Placebo, Severity of Illness Index, Gastroenterology, Inflammatory bowel disease, Drug Administration Schedule, law.invention, Young Adult, chemistry.chemical_compound, Crohn Disease, Double-Blind Method, Gastrointestinal Agents, Randomized controlled trial, law, Internal medicine, Severity of illness, Humans, Medicine, Outpatient clinic, Dosing, Infusions, Intravenous, Semapimod, Crohn's disease, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Hydrazones, Middle Aged, medicine.disease, Surgery, C-Reactive Protein, Treatment Outcome, chemistry, tumor-necrosis-factor inflammatory-bowel-disease monoclonal-antibody ca2 tetravalent guanylhydrazone factor-alpha map kinases suppression inhibition lymphoma infliximab, Female, business, Immunosuppressive Agents
Abstract: Objective Semapimod, a small molecule known to inhibit proinflammatory cytokine activity, was studied to determine the optimal dose necessary to achieve a response in patients with moderate to severe Crohn's disease (CD). Methods A randomised, double-blind, placebo-controlled trial (CD04) was carried out followed by an open-label extension study (CD05). The trial was conducted in international multicentre outpatient clinics and included patients with moderate to severe CD (Crohn's Disease Activity Index (CDAI) 250-400). Placebo was administered for 3 days; 60 mg semapimod intravenously for 1 day with placebo for 2 days; or 60 mg semapimod intravenously for 3 days. Participants who completed CD04 could participate in the open-label extension study, CD05, to receive up to five additional semapimod HCl 60 mg daily doses three times every 6-8 weeks. The main outcome measures were CDAI, Inflammatory Bowel Disease Questionnaire (IBDQ), Crohn's Disease Endoscopic Inflammation Score (CDEIS) and serum C-reactive protein (CRP) concentration. Results 152 patients were randomised in CD04. Responses for 1 and 3 day regimens were similar to placebo for CDAI (p=0.82), IBDQ (p=0.85), CDEIS (p=0.57) and CRP (p=0.40). The only noteworthy treatment-related safety finding was infusion reaction (phlebitis): 7.3, 34.8 and 62.7% for the placebo and 1 and 3 day semapimod treatment groups, respectively (p= 360 mg was associated with decreased CDAI in a limited number of patients.
Published: 2010

16. Ist die Colitis ulcerosa eine Autoimmunerkrankung?

Author: Schreiber S and Raedler A
Subjects: business.industry, Medicine, General Medicine, business
Published: 2009

17. Genetic Association of DLG5 R30Q with Familial and Sporadic Inflammatory Bowel Disease in Men

Author: Lin, Z., Poritz, L., Franke, A., Li, T.Y., Ruether, A., Byrnes, K.A., Wang, Y., Gebhard, A.W., MacNeill, C., Thomas, N.J., Wu, R., Schreiber, S., and Koltun, W.A.
Subjects: lcsh:R5-920, Biochemistry (medical), Clinical Biochemistry, Genetics, General Medicine, lcsh:Medicine (General), digestive system, Molecular Biology, digestive system diseases
Abstract: Background: The association of DLG5 R30Q with IBD has been replicated in several populations, but is not statistically significant in others. We studied the incidence of DLG5 alleles in a population of IBD patients from Pennsylvania.Methods: DLG5 R30Q (rs1248696) and G1066G (rs1248634) were analyzed with PCR-based RFLP methods in a total of 521 subjects, that included 105 individuals with IBD and 139 without IBD from a familial IBD registry, 107 with sporadic IBD, and 170 unrelated healthy controls. R30Q was further analyzed with SNPlex™ Genotyping System in 473 samples.Results: RFLP genotyping data showed that, DLG5 R30Q was significantly associated with IBD overall (p=0.006), and separately with CD (p=0.009) and UC (p=0.024). The association of R30Q with IBD was entirely due to a male-associated effect (male vs femalep=0.015 vs 0.241 (IBD),p=0.024 vs 0.190 (CD), andp=0.019 vs 0.575 (UC)). The frequency of the A allele carriage was elevated in both affected and unaffected members in the familial IBD cohort compared to healthy controls (p=0.037). In the family pedigrees, we observed differences in the expression of IBD in individuals carrying the A allele between families.Conclusions: In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry. This association of the R30Q variant with IBD was male-specific.
Published: 2009

18. Erratum: Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy (Epilepsia (2013) 54 (256-264) DOI:10.1111/epi.12517)

Author: Møller, R. S., Weber, Y. G., Klitten, L. L., Trucks, H., Muhle, H., Kunz, W. S., Mefford, H. C., Franke, A., Kautza, M., Wolf, P., Dennig, D., Schreiber, S., Rückert, I. -M., Wichmann, H. -E., Ernst, J. P., Schurmann, C., Grabe, H. J., Tommerup, N., Stephani, U., Lerche, H., Hjalgrim, H., Helbig, I., Sander, T., Zimprich, F., Mörzinger, M., Feucht, M., Suls, A., Weckhuysen, S., Claes, L., Deprez, L., Smets, K., Van Dyck, T., Deconinck, T., De Jonghe, P., Velizarova, R., Dimova, P., Radionova, M., Tournev, I., Kancheva, D., Kaneva, R., Jordanova, A., Kjelgaard, D. B., Lehesjoki, A. -E., Siren, A., Baulac, S., Leguern, E., Von Spiczak, S., Ostertag, P., Leber, M., Leu, C., Toliat, M. R., Nürnberg, P., Hempelmann, A., Rüschendorf, F., Elger, C. E., Kleefuß-Lie, A. A., Surges, R., Gaus, V., Janz, D., Schmitz, B., Klein, K. M., Reif, P. S., Oertel, W. H., Hamer, H. M., Rosenow, F., Becker, F., Marini, C., Guerrini, R., Mei, D., Norci, V., Zara, F., Striano, P., Robbiano, A., Pezzella, M., Bianchi, A., Gambardella, A., Tinuper, P., La Neve, A., Capovilla, G., Vigliano, P., Crichiutti, G., Vanadia, F., Vignoli, A., Coppola, A., Striano, S., Giallonardo, M. T., Franceschetti, S., Belcastro, V., Benna, P., Coppola, G., De Palo, A., Ferlazzo, E., Vecchi, M., Martinelli, V., Bisulli, F., Beccaria, F., Del Giudice, E., Mancardi, M., Stranci, G., Scabar, A., Gobbi, G., Giordano, I., Koeleman, B. P. C., De Kovel, C., Lindhout, D., De Haan, G. -J., Ozbeck, U., Bebek, N., Baykan, B., Ozdemir, O., Ugur, S., Kocasoy-Orhan, E., Yücesan, E., Cine, N., Gokyigit, A., Gurses, C., Gul, G., Yapici, Z., Ozkara, C., Caglayan, H., Yalcin, O., Yalcin, D., Turkdogan, D., Dizdarer, G., Agan, K., Møller, R. S., Weber, Y. G., Klitten, L. L., Trucks, H., Muhle, H., Kunz, W. S., Mefford, H. C., Franke, A., Kautza, M., Wolf, P., Dennig, D., Schreiber, S., Rückert, I. -M., Wichmann, H. -E., Ernst, J. P., Schurmann, C., Grabe, H. J., Tommerup, N., Stephani, U., Lerche, H., Hjalgrim, H., Helbig, I., Sander, T., Zimprich, F., Mörzinger, M., Feucht, M., Suls, A., Weckhuysen, S., Claes, L., Deprez, L., Smets, K., Van Dyck, T., Deconinck, T., De Jonghe, P., Velizarova, R., Dimova, P., Radionova, M., Tournev, I., Kancheva, D., Kaneva, R., Jordanova, A., Kjelgaard, D. B., Lehesjoki, A. -E., Siren, A., Baulac, S., Leguern, E., Von Spiczak, S., Ostertag, P., Leber, M., Leu, C., Toliat, M. R., Nürnberg, P., Hempelmann, A., Rüschendorf, F., Elger, C. E., Kleefuß-Lie, A. A., Surges, R., Gaus, V., Janz, D., Schmitz, B., Klein, K. M., Reif, P. S., Oertel, W. H., Hamer, H. M., Rosenow, F., Becker, F., Marini, C., Guerrini, R., Mei, D., Norci, V., Zara, F., Striano, P., Robbiano, A., Pezzella, M., Bianchi, A., Gambardella, A., Tinuper, P., La Neve, A., Capovilla, G., Vigliano, P., Crichiutti, G., Vanadia, F., Vignoli, A., Coppola, A., Striano, S., Giallonardo, M. T., Franceschetti, S., Belcastro, V., Benna, P., Coppola, G., De Palo, A., Ferlazzo, E., Vecchi, M., Martinelli, V., Bisulli, F., Beccaria, F., Del Giudice, E., Mancardi, M., Stranci, G., Scabar, A., Gobbi, G., Giordano, I., Koeleman, B. P. C., De Kovel, C., Lindhout, D., De Haan, G. -J., Ozbeck, U., Bebek, N., Baykan, B., Ozdemir, O., Ugur, S., Kocasoy-Orhan, E., Yücesan, E., Cine, N., Gokyigit, A., Gurses, C., Gul, G., Yapici, Z., Ozkara, C., Caglayan, H., Yalcin, O., Yalcin, D., Turkdogan, D., Dizdarer, G., and Agan, K.
Published: 2013

19. Experimental characterization and numerical simulations of the electron source at PITZ

Author: Abrahamyan, K., Bähr, J., Petrossyan, B., Pose, D., Richter, D., Schreiber, S., Staykov, L., Stephan, F., Ovsyannikov, D., Berz, M., Makino, K., Carneiro, J. P., Flöttmann, K., Han, J. H., v. Hartrott, M., Krasilnikov, M., Lipka, D., Miltchev, V., and Oppelt, A.
Subjects: Free electron model, Physics, Nuclear and High Energy Physics, business.industry, DESY, Electron, Laser, law.invention, Transverse plane, Optics, law, Cathode ray, Physics::Accelerator Physics, ddc:530, Thermal emittance, business, Instrumentation, Beam (structure)
Abstract: The Photo Injector Test facility at DESY Zeuthen (PITZ) works on the optimization of electron sources for Free Electron Lasers (FELs). The main motivation and challenge of PITZ is the production of electron beams with high charge and small normalized transverse emittance. Recent results of electron beam studies at PITZ are presented in this paper. The experimental characterization of the electron source is discussed together with beam dynamics simulations.
Published: 2006

20. Report on Gun Conditioning Activities at PITZ in 2013

Author: Otevrel, M., Boonpornprasert, P., Good, J.D., Gross, M., Isaev, I., Kalantaryan, D., Khojoyan, M., Kourkafas, G., Krasilnikov, M., Malyutin, D., Melkumyan, D., Rublack, T., Stephan, F., Vashchenko, G., Brinker, F., Floettmann, K., Lederer, S., Marchetti, B., Schreiber, S., Rimjaem, S., Pathak, G., Richter, D., Asova, G., Nozdrin, M.A., and Ivanisenko, Ye.
Subjects: Large scale facilities for research with photons neutrons and ions
Abstract: Recently three RF guns were prepared at the Photo Injector Test Facility at DESY, location Zeuthen PITZ for their subsequent operation at FLASH and the European XFEL. The gun 3.1 is a previous cavity design and is currently installed and operated at FLASH, the other two guns 4.3 and 4.4 were of the current cavity design and are dedicated to serve for the start up of the European XFEL photo injector. All three cavities had been dry ice cleaned prior their conditioning and hence showed low dark current levels. The lowest dark current level as low as 60 amp; 956;A at 65MV m field amplitude has been observed for the gun 3.1. This paper reports in details about the conditioning process of the most recent gun 4.4. It informs about experience gained at PITZ during establishing of the RF conditioning procedure and provides a comparison with the other gun cavities in terms of the dark currents. It also summarizes the major setup upgrades, which have affected the conditioning processes of the cavities
Published: 2014

21. Precision electroweak measurements on the Z resonance RID C-6238-2011 RID G-1279-2010 RID H-5578-2011 RID E-5642-2011 RID D-5260-2011 RID B-5372-2009 RID A-4297-2011 RID A-6508-2010 RID C-3725-2011 RID C-8369-2011 RID D-2463-2009 RID E-4473-2011 RID C-2983-2009 RID C-4549-2008 RID C-5719-2008 RID A-5333-2010 RID A-4009-2011 RID B-2993-2011 RID E-8846-2011 RID A-5598-2009 RID A-2675-2009

Author: Schael S, Barate R, Bruneliere R, Buskulic D, De Bonis I, Decamp D, Ghez P, Goy C, Jezequel S, Lees JP, Lucotte A, Martin F, Merle E, Minard MN, Nief JY, Odier P, Pietrzyk B, Trocme B, Bravo S, Casado MP, Chmeissani M, Comas P, Crespo JM, Fernandez E, Fernandez Bosman M, Garrido L, Grauges E, Juste A, Martinez M, Merino G, Miquel R, Mir LM, Orteu S, Pacheco A, Park IC, Perlas J, Riu I, Ruiz H, Sanchez F, Colaleo A, Creanza D, De Filippis N, de Palma M, Iaselli G, Maggi G, Maggi M, Nuzzo S, Ranieri A, Raso G, Ruggieri F, Selvaggi G, Silvestris L, Tempesta P, Tricomi A, Zito G, Huang X, Lin J, Ouyang Q, Wang T, Xie Y, Xu R, Xue S, Zhang J, Zhang L, Zhao W, Abbaneo D, Bazarko A, Becker U, Boix G, Bird F, Blucher E, Bonvicini B, Bright Thomas P, Barklow T, Buchmuller O, Cattaneo M, Cerutti F, Ciulli V, Clerbaux B, Drevermann H, Forty RW, Frank M, Greening TC, Hagelberg R, Halley AW, Gianotti F, Girone M, Hansen JB, Harvey J, Jacobsen R, Hutchcroft DE, Janot R, Jost B, Knobloch J, 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Hoffman, K, Holl, B, Homer, Rj, Honma, Ak, Horvath, D, Hossain, Kr, Howard, R, Howarth, Cp, Huntemeyer, P, Hughes Jones, Re, Humbert, R, Igo Kemenes, P, Ihssen, H, Imrie, Dc, Ingram, M, Ishii, K, Jacob, Fr, Janissen, Ac, Jawahery, A, Jeffreys, Pw, Jeremie, H, Jimack, M, Jobes, M, Joly, T, Jones, Cr, Jones, G, Jones, M, Jost, U, Jovanovic, P, Jui, C, Joly, A, Junk, Tr, Kanaya, N, Kanzaki, J, Karapetian, G, Karlen, D, Kartvelishvili, V, Kawagoe, K, Kawamoto, T, Keeler, Rk, Kellogg, Rg, Kennedy, Bw, Kim, Dh, King, Bj, Kirk, J, Klein, K, Kleinwort, C, Klem, De, Klier, A, Kluth, S, Kobayashi, T, Kobel, M, Kopke, L, Koetke, D, Kokott, Tp, Komamiya, S, Kormos, L, Kowalewski, R, Kramer, T, Kral, Jf, Kress, T, Kreutzmann, H, Krieger, P, von Krogh, J, Kroll, J, Krop, D, Kruger, K, Kuhl, T, Kupper, M, Kuwano, M, Kyberd, P, Lafferty, Gd, Lafoux, H, Lahmann, R, Lai, Wp, Lamarche, F, Landsman, H, Lanske, D, Larson, Wj, Lauber, J, Lautenschlager, Sr, Lawson, I, Layter, Jg, Lazic, D, Le Du, P, Leblanc, P, Lee, Am, Lefebvre, E, Lehto, Mh, Leins, A, Lellouch, D, Lennert, P, Leroy, C, Lessard, L, Letts, J, Levegrun, S, Levinson, L, Lewis, C, Liebisch, R, Lillich, J, Littlewood, C, Lloyd, Aw, Lloyd, Sl, Loebinger, Fk, Long, Gd, Lorah, Jm, Lorazo, B, Losty, Mj, Lou, Xc, Lu, J, Ludwig, A, Ludwig, J, Luig, A, Macchiolo, A, Macpherson, A, Mader, W, Mattig, P, Malik, A, Mannelli, M, Marcellini, S, Marchant, Te, Maringer, G, Markus, C, Martin, A, Martinez, G, Masetti, G, Mashimo, T, Matthews, W, Maur, U, Mcdonald, Wj, Mcgowan, Rf, Mckenna, J, Mckigney, Ea, Mcmahon, Tj, Mcnab, Ai, Mcnutt, J, Mcpherson, Ac, Mcpherson, Ra, Meijers, F, Mendez Lorenzo, P, Menges, W, Menke, S, Menszner, D, Merritt, F, Mes, H, Meyer, J, Meyer, N, Michelini, A, Middleton, Rp, Mihara, S, Mikenberg, G, Mildenberger, J, Miller, Dj, Milstene, C, Mir, R, Moed, S, Mohr, W, Moisan, C, Montanari, A, Mori, T, Morii, M, Moss, Mw, Mouthuy, T, Muller, U, Murphy, Pg, Mutter, A, Nagai, K, Nakamura, I, Nanjo, H, Neal, Ha, Nellen, B, Nguyen, Hh, Nijjhar, B, Nisius, R, Nozaki, M, Oakham, Fg, Odorici, F, Ogg, M, Ogren, Ho, Oh, A, Oh, H, Okpara, A, Oldershaw, Nj, Omori, T, O'Neale, Sw, O'Neill, Bp, Oram, Cj, Oreglia, Mj, Orito, S, Pahl, C, Palinkas, J, Palmonari, F, Pansart, Jp, Panzer Steindel, B, Paschievici, P, Pasztor, G, Pater, Jr, Patrick, Gn, Pawley, Sj, Paz Jaoshvili, N, Pearce, Mj, Petzold, S, Pfeifenschneider, P, Pfister, P, Pilcher, Je, Pinfold, J, Pitman, D, Plane, De, Poffenberger, P, Poli, B, Polok, J, Pooth, O, Posthaus, A, Pouladdej, A, del Poz, La, Prebys, E, Pritchard, Tw, Przybycien, M, Przysiezniak, H, Quadt, A, Rabbertz, K, Raith, B, Redmond, Mw, Rees, Dl, Rembser, C, Renkel, P, Richards, Ge, Rick, H, Rigby, D, Robins, Sa, Robinson, D, Rodning, N, Rollnik, A, Roney, Jm, Rooke, A, Ros, E, Rosati, S, Roscoe, K, Rossberg, S, Rossi, Am, Rosvick, M, Routenburg, P, Rozen, Y, Runge, K, Runolfsson, O, Ruppel, U, Rust, Dr, Rylko, R, Sachs, K, Saeki, T, Sahr, O, Sanghera, S, Sarkisyan, Ekg, Sasaki, M, Sbarra, C, Schaile, Ad, Schaile, O, Schappert, W, Scharf, F, Scharff Hansen, P, Schenk, P, Schieck, J, von der Schmitt, H, Schmitt, S, Schorner Sadenius, T, Schreiber, S, Schroder, M, Schutz, P, Schultz Coulon, Hc, Schulz, M, Schumacher, M, Schwarz, J, Schwick, C, Schwiening, J, Scott, Wg, Settles, M, Seuster, R, Shears, Tg, Shen, Bc, Shepherd Themistocleous, Ch, Sherwood, P, Shypit, R, Simon, A, Singh, P, Siroli, Gp, Sittler, A, Skillman, A, Skuja, A, Smith, Am, Smith, Tj, Snow, Ga, Sobie, R, Soldner Rembold, S, Spagnolo, S, Spano, F, Springer, Rw, Sproston, M, Stahl, A, Starks, M, Steiert, M, Stephens, K, Steuerer, J, Stier, He, Stockhausen, B, Stoll, K, Strohmer, R, Strom, D, Strumia, F, Stumpf, L, Surrow, B, Szymanski, P, Tafirout, R, Takeda, H, Takeshita, T, Talbot, Sd, Tanaka, S, Taras, P, Tarem, S, Tasevsky, M, Taylor, Rj, Tecchio, M, Tesch, N, Teuscher, R, Thackray, Nj, Thiergen, M, Thomson, Ma, von Torne, E, Torrence, E, Towers, S, Toya, D, Trocsanyi, Z, Tran, P, Trefzger, T, Tresilian, Nj, Trigger, I, Tscheulin, M, Tsukamoto, T, Tsur, E, Turcot, A, Tumer Watson, Mf, Tysarczyk Niemeyer, G, Ueda, I, Ujvari, B, Utzat, P, Vachon, B, Van den Plas, D, Van Kooten, R, Vandalen, Gj, Vannerem, P, Vasseur, G, Vertesi, R, Verzocchi, M, Vikas, P, Vincter, M, Virtue, Cj, Vokurka, Eh, Vollmer, Cf, Voss, H, Vossebeld, J, Wackerle, F, Wagner, A, Wagner, Dl, Wahl, C, Walker, Jp, Waller, D, Ward, Cp, Ward, Dr, Watkins, Pm, Watson, At, Watson, Nk, Weber, P, Weisz, S, Wels, P, Wengler, T, Wermes, N, Wetterling, D, Weymann, M, Whalley, Ma, White, J, Wilkens, B, Wilson, Ja, Wilson, Gw, Wingerter, I, Winterer, Vh, Wood, Nc, Wotton, S, Wyatt, Tr, Yaari, R, Yamashita, S, Yang, Y, Yeaman, A, Yekutieli, G, Yurko, M, Zacek, V, Zacharov, I, Zer Zion, D, Zeuner, W, Zivkovic, L, Zorn, Gt, Abe, K, Abe, T, Abt, I, Adam, I, Agnew, G, Akagi, T, Akimoto, H, Allen, Nj, Ash, Ww, Aston, D, Bacchetta, N, Baird, Kg, Baltay, C, Band, Hr, Barakat, Mb, Baranko, Gj, Bardon, O, Barklow, Tl, Bashindzhagian, Gl, Bauer, Jm, Bazarko, Ao, Bean, A, Bellodi, G, Ben David, R, Benvenuti, Ac, Berger, R, Bienz, T, Bilei, Gm, Bisello, D, Blaylock, G, Bogart, J, Bolen, B, Bolton, T, Bower, Gr, Brau, Je, Breidenbach, M, Bugg, Wm, Burke, D, Burnett, Th, Burrows, Pn, Busza, W, Calcaterra, A, Caldwell, Do, Camanzi, B, Carpinelli, M, Cassell, R, Castaldi, R, Castro, A, Cavalli Sforza, M, Chadwick, Gb, Chou, A, Church, E, Claus, R, Cohn, Ho, Coller, Ja, Convery, Mr, Cook, V, Cotton, R, Cowan, Rf, Coyle, Pa, Coyne, Dg, Crawford, G, D'Oliveira, A, Damerell, Cj, Daoudi, M, Dasu, S, de Groot, N, de Sangro, R, De Simone, P, De Simone, S, Dervan, Pj, Dima, M, Dong, Dn, Doser, M, Du, Pyc, Dubois, R, Eisenstein, Bi, Elia, R, Erdos, E, Erofeeva, I, Eschenburg, V, Fahey, S, Falciai, D, Fan, C, Fernandez, Jp, Fero, Mj, Flood, K, Frey, R, Friedman, Ji, Furuno, K, Garwin, El, Gillman, T, Gladding, G, Hallewell, Gd, Hart, El, Hasegawa, Y, Hasuko, K, Hedges, S, Hertzbach, S, Hitlin, Dg, Honma, A, Huber, J, Huffer, Me, Hughes, Ew, Huynh, X, Hwang, H, Iwasaki, M, Iwasaki, Y, Izen, Jm, Jackson, Dj, Jacques, P, Jaros, Ja, Jiang, Zy, Johnson, A, Johnson, Jr, Johnson, Ra, Junk, T, Kajikawa, R, Kalelkar, M, Kamyshkov, Ya, Kang, Hj, Karliner, I, Kawahara, H, Kelsey, Mh, Kendall, Hw, Kim, Yd, King, M, King, R, Kofler, R, Krishna, Nm, Kwon, Y, Labs, Jf, Kroeger, R, Langston, M, Lath, A, Lauber, Ja, Leith, Dwg, Lia, V, Lin, C, Liu, Mx, Loreti, M, Lu, A, Lynch, Hl, Ma, J, Mancinelli, G, Manly, S, Mantovani, G, Markiewicz, Tw, Maruyama, T, Masuda, H, Mazzucato, H, Mcgowan, Jf, Mckemey, Ak, Meadows, Bt, Messner, R, Mockett, Pm, Moffeit, Kc, Moore, Tb, Mours, B, Muller, D, Mueller, G, Murzin, V, Nagamine, T, Narita, S, Nauenberg, U, Neal, H, Nesom, G, Nussbaum, M, Ohnishi, Y, Oishi, N, Onoprienko, D, Osborne, L, Panvini, R, Park, Ch, Park, H, Pavel, Tj, Peruzzi, I, Pescara, L, Piccolo, M, Piemontese, L, Pieroni, E, Pitts, Kt, Plano, Rj, Prepost, R, Prescott, Cy, Punkar, G, Quigley, J, Ratcliff, Bn, Reeves, K, Reeves, Tw, Reidy, J, Reinertsen, Pl, Rensing, Pe, Rochester, L, Rothberg, Je, Rowson, Pc, Russell, Jj, Saxton, Oh, Schalk, T, Schindler, Rh, Schneekloth, U, Schumm, Ba, Seiden, A, Sen, S, Serbo, Vv, Shaevitz, Mh, Shank, Jt, Shapiro, G, Sherden, Dj, Shmakov, Kd, Simopoulos, C, Sinev, Nb, Smith, Sr, Smy, Mb, Snyder, Ja, Sokoloff, Md, Staengle, H, Starner, P, Steiner, H, Steiner, R, Strauss, Mg, Su, D, Suekane, F, Sugiyama, A, Suzuki, A, Suzuki, S, Swartz, M, Szumilo, A, Takahashi, T, Taylor, Fe, Thaler, Jj, Thom, J, Trandafir, Ai, Turk, Jd, Usher, T, Va'Vra, J, Vella, E, Venuti, Jp, Verdier, R, Wagner, Sr, Waite, Ap, Walston, S, Wang, J, Watts, Sj, Weidemann, Aw, Weiss, Er, Whitaker, J, White, Sl, Wickens, Fj, Williams, Da, Williams, Dc, Williams, Sh, Willocq, S, Wilson, Rj, Wisniewski, Wj, Wittlin, Jl, Woods, M, Word, Gb, Wright, Tr, Wyss, J, Yamamoto, Rk, Yang, Xq, Yashima, J, Yellin, Sj, Young, Cc, Yuta, H, Zapalac, G, Zdarko, Rw, Zeitlin, C, and Zhou, J.
Published: 2006

22. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis

Author: Beaudoin, Melissa, Goyette, Philippe, Goel, Gautam, Louis, E., Mansfield, J. C., Mathew, C. G., McGovern, D. P., Mitrovic, M., Montgomery, G. W., Mowat, C., Newman, W., Palmieri, O., Panés, J., Lagace, Caroline, Parkes, M., Phillips, A., Ponsioen, C. Y., Potocnik, U., Prescott, N. J., Proctor, D. D., Radford-Smith, G. L., Regueiro, M., Rioux, J. D., Roberts, R., Annese, Vito, Rotter, J. I., Rutgeerts, P., Sanderson, J., Sans, M., Satsangi, J., Schreiber, S., Schumm, P., Seibold, F., Sharma, Y., Silverberg, M. S., Bitton, Alain, Simms, L. A., Steinhart, A., Targan, S. R., Taylor, K. D., Torkvist, L., Vermeire, S., Halfvarson, J., Verspaget, H. W., De Vos, M., Walters, T., Begun, Jakob, Wang, K., Weersma, R. K., Whiteman, D., Wijmenga, C., Brant, Steven R., Bresso, Francesca, Cho, Judy H., Duerr, Richard H., Halfvarson, Jonas, Boucher, Gabrielle, McGovern, Dermot P. B., Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L., Sharma, Yashoda, Silverberg, Mark S., Weersma, Rinse K., Quebec IBD Genetics Consortium, NIDDK IBD Genetics Consortium, International IBD Genetics Consortium (IIBDGC), Lo, Ken Sin, D'Amato, Mauro, Vermeire, Severine, Franke, Andre, Lettre, Guillaume, Xavier, Ramnik J., Daly, Mark J., Rioux, John D., Aumais, G., Bernard, E. J., Bitton, A., Rivas, Manuel A., Cohen, A., Deslandres, C., Lahaie, R., Paré, P., Brant, S. R., Cho, J. H., Duerr, R. H., Stevens, Christine, Ahmad, T., Anderson, C. A., Annese, V., Baldassano, R. N., Balschun, T., Barclay, M., Barrett, J. C., Bayless, T. M., Bis, J. C., Alikashani, Azadeh, Brand, S., Bumpstead, S., Buning, C., Colombel, J. F., Cottone, M., D'Amato, M., D'Inca, R., Ladouceur, Martin, Daly, M. J., Denson, T., Dubinsky, M., Edwards, C., Ellinghaus, D., Florin, T., Franchimont, D., Franke, A., Gearry, R., Ellinghaus, David, Georges, M., Glas, J., Van Gossum, A., Griffiths, A. M., Guthery, S. L., Hakonarson, H., Haritunians, T., Hugot, J. P., de Jong, D. J., Jostins, L., Torkvist, Leif, Kugathasan, S., Kullak-Ublick, G., Latiano, A., Laukens, D., Lawrance, I., Lee, J., Lees, C. W., Lemann, M., Levine, A., Libioulle, C., and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
Subjects: Cancer Research, Génétique clinique, LIVER, Genome-wide association study, Inflammatory bowel disease, 0302 clinical medicine, Crohn Disease, GENETIC-VARIANTS, Medicine and Health Sciences, Ethnicity, UBIQUITIN LIGASES, Genetics(clinical), Genetics (clinical), Genetics, 0303 health sciences, Ecology, High-Throughput Nucleotide Sequencing, CROHN-DISEASE, CROHNS-DISEASE, 3. Good health, 030220 oncology & carcinogenesis, Medical genetics, Biologie, Research Article, EXPRESSION, medicine.medical_specialty, Canada, lcsh:QH426-470, SUSCEPTIBILITY LOCI, Evolution, Ubiquitin-Protein Ligases, Ethnic Groups, Evolution des espèces, Biology, Molecular gastro-enterology and hepatology Pathogenesis and modulation of inflammation [IGMD 2], Polymorphism, Single Nucleotide, 03 medical and health sciences, Behavior and Systematics, medicine, Humans, Genetic Predisposition to Disease, Ligase activity, MODULATION, Allele, GENOME-WIDE ASSOCIATION, Molecular Biology, Genotyping, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Genetic association, Ecologie, Biologie moléculaire, Receptors, Interleukin, medicine.disease, NUCLEAR FACTOR 4-ALPHA, Genetic architecture, Cancérologie, CARD Signaling Adaptor Proteins, lcsh:Genetics, CELLS, Colitis, Ulcerative, INTESTINAL EPITHELIAL-CELLS, Genome-Wide Association Study, INFLAMMATORY-BOWEL-DISEASE
Abstract: Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries have already had a tremendous impact on our understanding of the genetic architecture of these diseases and have directed functional studies that have revealed some of the biological functions that are important to IBD (e.g. autophagy). Nonetheless, these loci can only explain a small proportion of disease variance (~14% in CD and 7.5% in UC), suggesting that not only are additional loci to be found but that the known loci may contain high effect rare risk variants that have gone undetected by GWAS. To test this, we have used a targeted sequencing approach in 200 UC cases and 150 healthy controls (HC), all of French Canadian descent, to study 55 genes in regions associated with UC. We performed follow-up genotyping of 42 rare non-synonymous variants in independent case-control cohorts (totaling 14,435 UC cases and 20,204 HC). Our results confirmed significant association to rare non-synonymous coding variants in both IL23R and CARD9, previously identified from sequencing of CD loci, as well as identified a novel association in RNF186. With the exception of CARD9 (OR = 0.39), the rare non-synonymous variants identified were of moderate effect (OR = 1.49 for RNF186 and OR = 0.79 for IL23R). RNF186 encodes a protein with a RING domain having predicted E3 ubiquitin-protein ligase activity and two transmembrane domains. Importantly, the disease-coding variant is located in the ubiquitin ligase domain. Finally, our results suggest that rare variants in genes identified by genome-wide association in UC are unlikely to contribute significantly to the overall variance for the disease. Rather, these are expected to help focus functional studies of the corresponding disease loci. © 2013 Beaudoin et al., 0, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2013

23. A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1

Author: Hofmann, S, Fischer, A, Till, A, Müller-Quernheim, J, Häsler, R, Franke, A, Gäde, K. I, Schaarschmidt, H, Rosenstiel, P, Nebel, A, Schürmann, M, Nothnagel, M, Schreiber, S, Günther, A, Dubaniewicz, A, Pabst, S, Bumbacea, D, Prasse, A, Grubanovic, A, Rottoli, P, Bargagli, E, Bresser, P, Poletti, V, Luisetti, M, Vucinic, V, and Videnovic-Ivanov, J
Subjects: Pulmonary and Respiratory Medicine, Genetics, Linkage disequilibrium, Sarcoidosis, Chromosome Mapping, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Disease, Biology, Polymorphism, Single Nucleotide, Hedgehog signaling pathway, Linkage Disequilibrium, rab GTP-Binding Proteins, Gene chip analysis, Humans, Chromosomes, Human, Pair 6, Genetic Predisposition to Disease, Gene, Genome-Wide Association Study
Abstract: Sarcoidosis is a complex systemic inflammatory disease of unknown aetiology that is influenced by a variety of genetic and environmental factors. To identify further susceptibility loci for sarcoidosis, a genome-wide association study (GWAS) was conducted in 381 patients and 392 control individuals based on Affymetrix 100k GeneChip data. The top 25 single-nucleotide polymorphisms (SNPs) were selected for validation in an independent study panel (1,582 patients versus 1,783 controls). Variant rs10484410 on chromosome 6p12.1 was significantly associated, with a Bonferroni-corrected p-value of 2.90 × 10⁻² in the validation sample and a nominal p-value of 2.64 × 10⁻⁴ in the GWAS. Extensive fine mapping of the novel locus narrowed down the signal to a region comprising the genes BAG2, C6orf65, KIAA1586, ZNF451 and RAB23. Verification of the sarcoidosis-associated nonsynonymous SNP rs1040461 in a further independent case-control sample and quantitative mRNA expression studies point to the RAB23 gene as the most likely risk factor. RAB23 is proposed to be involved in antibacterial defence processes and regulation of the sonic hedgehog signalling pathway. The identified association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component that may open up new perspectives in the pathophysiology of sarcoidosis.
Published: 2011

24. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Author: Schunkert, H, König, Ir, Kathiresan, S, Reilly, Mp, Assimes, Tl, Holm, H, Preuss, M, Stewart, Af, Barbalic, M, Gieger, C, Absher, D, Aherrahrou, Z, Allayee, H, Altshuler, D, Anand, Ss, Andersen, K, Anderson, Jl, Ardissino, D, Ball, Sg, Balmforth, Aj, Barnes, Ta, Becker, Dm, Becker, Lc, Berger, K, Bis, Jc, Boekholdt, Sm, Boerwinkle, E, Braund, Ps, Brown, Mj, Burnett, Ms, Buysschaert, I, Cardiogenics, Carlquist, Jf, Chen, L, Cichon, S, Codd, V, Davies, Rw, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, Jm, Diemert, P, Do, R, Doering, A, Eifert, S, Mokhtari, Ne, Ellis, Sg, Elosua, R, Engert, Jc, Epstein, Se, de Faire, U, Fischer, M, Folsom, Ar, Freyer, J, Gigante, B, Girelli, Domenico, Gretarsdottir, S, Gudnason, V, Gulcher, Jr, Halperin, E, Hammond, N, Hazen, Sl, Hofman, A, Horne, Bd, Illig, T, Iribarren, C, Jones, Gt, Jukema, Jw, Kaiser, Ma, Kaplan, Lm, Kastelein, Jj, Khaw, Kt, Knowles, Jw, Kolovou, G, Kong, A, Laaksonen, R, Lambrechts, D, Leander, K, Lettre, G, Li, M, Lieb, W, Loley, C, Lotery, Aj, Mannucci, Pm, Maouche, S, Martinelli, Nicola, Mckeown, Pp, Meisinger, C, Meitinger, T, Melander, O, Merlini, Pa, Mooser, V, Morgan, T, Mühleisen, Tw, Muhlestein, Jb, Münzel, T, Musunuru, K, Nahrstaedt, J, Nelson, Cp, Nöthen, Mm, Olivieri, Oliviero, Patel, Rs, Patterson, Cc, Peters, A, Peyvandi, F, Qu, L, Quyyumi, Aa, Rader, Dj, Rallidis, Ls, Rice, C, Rosendaal, Fr, Rubin, D, Salomaa, V, Sampietro, Ml, Sandhu, Ms, Schadt, E, Schäfer, A, Schillert, A, Schreiber, S, Schrezenmeir, J, Schwartz, Sm, Siscovick, Ds, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, Tb, Snoep, Jd, Soranzo, N, Spertus, Ja, Stark, K, Stirrups, K, Stoll, M, Tang, Wh, Tennstedt, S, Thorgeirsson, G, Thorleifsson, G, Tomaszewski, M, Uitterlinden, Ag, van Rij AM, Voight, Bf, Wareham, Nj, Wells, Ga, Wichmann, He, Wild, Ps, Willenborg, C, Witteman, Jc, Wright, Bj, Ye, S, Zeller, T, Ziegler, A, Cambien, F, Goodall, Ah, Cupples, La, Quertermous, T, März, W, Hengstenberg, C, Blankenberg, S, Ouwehand, Wh, Hall, As, Deloukas, P, Thompson, Jr, Stefansson, K, Roberts, R, Thorsteinsdottir, U, O'Donnell, Cj, Mcpherson, R, Erdmann, J, the CARDIoGRAM Consortium, Samani, N. J., Epidemiology, Internal Medicine, ACS - Amsterdam Cardiovascular Sciences, Cardiology, and Vascular Medicine
Subjects: Adult, Male, Multifunction cardiogram, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Coronary Artery Disease, Biology, Polymorphism, Single Nucleotide, Genetic determinism, artery disease, Article, Coronary artery disease, Gene Frequency, SDG 3 - Good Health and Well-being, Risk Factors, Genetics, medicine, Humans, Genetic Predisposition to Disease, cardiovascular diseases, Allele, Genotyping, Allele frequency, coronary, Alleles, Genetics (clinical), Aged, Genetic association, business.industry, Case-control study, Middle Aged, medicine.disease, coronary artery disease, Large-scale association analysis, Case-Control Studies, Female, Cardiology and Cardiovascular Medicine, business, Genome-Wide Association Study
Abstract: 1. The CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011;43:333–338. ### Study Hypothesis Recently, genome-wide association studies (GWAS) have identified several common variants that are associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). The authors state that the current loci discovered in CAD and MI GWAS explain only a small fraction of the heritability of this complex disease. The authors hypothesized that a larger study would provide more power to discover common variants with modest effect sizes. Therefore, they formed the Coronary ARtery DIsease Genome-wide Replication And Meta-analysis (CARDIoGRAM) consortium, which consisted of data from 14 GWAS of CAD and MI.1 ### How Was the Hypothesis Tested? The authors performed a meta-analysis of 14 GWAS of CAD comprising 22 233 cases and 64 762 control subjects, all of European ancestry. CAD was defined angiographically in a subset (n=7364) and by history in the entire sample. Presence of MI ranged from 48.1% to 100% of each cohort. After the meta-analysis, they genotyped the lead single-nucleotide polymorphisms (SNPs) within the most promising (defined a priori as P 90% power to detect effect sizes observed in the GWAS meta-analysis. Finally, to understand potential mechanisms and intermediate pathways by which novel loci may mediate risk, the authors interrogated 3 genome-wide studies that also assessed gene expression in multiple tissues, using human cell lines, a genome-wide map of allelic expression imbalance, and other human disease traits. ### Principal Findings The analysis of approximately 135 000 individuals more than doubled the number of loci with CAD association, yielding 13 previously unidentified loci and confirming at …
Published: 2011

25. Genome-wide linkage analysis for longevity in European nonagenarian siblings: Genetics of Healthy Ageing Study (GEHA)

Author: Beekman, M., Slagboom, P. E., Blanche, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Christiansen, L., Schreiber, S., De Craen, A. J. M., Kirkwood, T. B. L., Rea, I. M., Poulain, M., Robine, J. M., Valensin, S., Stazi, M. A., Passarino, G., Deiana, L., Gonos, S., Tornwall, O., Helmer, Q., Martella, Francesca, and Westendorp, R. G. J.
Published: 2011

26. Extraintestinale Manifestationen

Author: Schreiber S
Subjects: German, medicine.medical_specialty, business.industry, Gastroenterology, language, medicine, Intensive care medicine, business, language.human_language
Published: 2001

27. Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk (vol 105, pg 395, 2010)

Author: Festen, EAM, Stokkers, PCF, van Diemen, CC, van Bodegraven, AA, Boezen, HM, Crusius, BJA, Hommes, DW, van der Woude, C.J., Balschun, T, Verspaget, HW, Schreiber, S, de Jong, DJ, Franke, A, Dijkstra, G, Wijmenga, C, Weersma, RK, and Gastroenterology & Hepatology
Published: 2010

28. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

Author: Anttila, V., Stefansson, H., Kallela, M., Todt, U., Terwindt, G.M., Calafato, M.S., Nyholt, D.R., Dimas, A.S., Freilinger, T., Muller-Myhsok, B., Artto, V., Inouye, M., Alakurtti, K., Kaunisto, M.A., Hamalainen, E., Vries, B. de, Stam, A.H., Weller, C.M., Heinze, A., Heinze-Kuhn, K., Goebel, I., Borck, G., Gobel, H., Steinberg, S., Wolf, C., Bjornsson, A., Gudmundsson, G., Kirchmann, M., Hauge, A., Werge, T., Schoenen, J., Eriksson, J.G., Hagen, K., Stovner, L., Wichmann, E., Meitinger, T., Alexander, M., Moebus, S., Schreiber, S., Aulchenko, Y.S., Breteler, M.M.B., Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Tikka-Kleemola, P., Lucae, S., Tozzi, F., Muglia, P., Barrett, J., Kaprio, J., Farkkila, M., Peltonen, L., Stefansson, K., Zwart, J.A., Ferrari, M.D., Olesen, J., Daly, M., Wessman, M., Maagdenberg, A.M.J.M. van den, Dichgans, M., Kubisch, C., Dermitzakis, E.T., Frants, R.R., Palotie, A., Vepsalainen, Int Headache Genetics Consortium, Epidemiology, and Internal Medicine
Subjects: Oncology, Glutamate Carboxypeptidase II, Male, medicine.medical_specialty, Genotype, Migraine Disorders, Quantitative Trait Loci, Medizin, Genome-wide association study, Biology, familial hemiplegic migraine lymphoblastoid cell-lines gene-expression episodic ataxia spreading depression confers risk mutation type-2 involvement mechanisms, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genetics, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Lymphocytes, Familial hemiplegic migraine, Cells, Cultured, 030304 developmental biology, Episodic ataxia, 0303 health sciences, Genome, Human, Calcium-Binding Proteins, Membrane Proteins, RNA-Binding Proteins, MTDH, Odds ratio, medicine.disease, 3. Good health, Minor allele frequency, Migraine, Case-Control Studies, Immunology, Antigens, Surface, Female, Cell Adhesion Molecules, 030217 neurology & neurosurgery, Chromosomes, Human, Pair 8, Genome-Wide Association Study, Microsatellite Repeats
Abstract: Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10(-)(9), odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(-)(1)(1) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 x 10(-)(5), permuted threshold for genome-wide significance 7.7 x 10(-)(5). To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.
Published: 2010

29. Measurement of the τ topological branching ratios at LEP

Author: Acton, P D, Alexander, Gideon, Allison, J, Allport, P P, Anderson, K J, Arcelli, S, Astbury, Alan, Axen, D A, Azuelos, Georges, Bahan, G A, Baines, J T M, Ball, A H, Banks, J, Barker, G J, Barlow, R J, Barnett, S, Batley, J Richard, Beaudoin, G, Beck, A, Becker, J, Behnke, T, Bell, K W, Bella, G, Berlich, P, Bethke, Siegfried, Biebel, O, Binder, U, Bloodworth, Ian J, Bock, P, Boden, B, Bosch, H M, Bougerolle, S, Breuker, Horst, Brown, R M, Brun, R, Buijs, A, Burckhart, Helfried J, Capiluppi, P, Carnegie, R K, Carter, A A, Carter, J R, Chang, C Y, Charlton, D G, Clarke, P E L, Cohen, I, Collins, W J, Conboy, J E, Cooper, M, Couch, M, Coupland, M, Cuffiani, M, Dado, S, Dallavalle, G M, De Jong, S, del Pozo, L A, Deninno, M M, Dieckmann, A, Dittmar, Michael, Dixit, M S, do Couto e Silva, E, Duboscq, J E, Duchovni, E, Duckeck, G, Duerdoth, I P, Dumas, D J P, Elcombe, P A, Estabrooks, P G, Etzion, E, Evans, H G, Fabbri, Franco Luigi, Fincke-Keeler, Margret, Fischer, H M, Fong, D G, Fukunaga, C, Gaidot, A, Ganel, O, Gary, J W, Gascon, J, McGowan, R F, Geddes, N I, Geich-Gimbel, C, Gensler, S W, Gentit, F X, Giacomelli, G, Gibson, V, Gibson, W R, Gillies, James D, Goldberg, J, Goodrick, M J, Gorn, W, Grandi, C, Grant, F C, Hagemann, J, Hanson, G G, Hansroul, M, Hargrove, C K, Harrison, P F, Hart, J, Hattersley, P M, Hauschild, M, Hawkes, C M, Heflin, E, Hemingway, Richard J, Heuer, R D, Hill, J C, Hillier, S J, Hinshaw, D A, Hobbs, J D, Hobson, P R, Hochman, D, Homer, R James, Honma, A K, Hou, S R, Howarth, C P, Hughes-Jones, R E, Humbert, R, Igo-Kemenes, P, Ihssen, H, Imrie, D C, Janissen, L, Jawahery, A, Jeffreys, P W, Jeremie, H, Jimack, Martin Paul, Jobes, M, Jones, R W L, Jovanovic, P, Karlen, D A, Kawagoe, K, Kawamoto, T, Keeler, Richard K, Kellogg, R G, Kennedy, B W, Klem, D E, Kobayashi, T, Kokott, T P, Komamiya, S, Köpke, L, Kral, F, Kowalewski, R V, Von Krogh, J, Kroll, J, Kuwano, M, Kyberd, P, Lafferty, G D, Lamarche, F, Layter, J G, Le Dû, P, Leblanc, P, Lee, A M, Lehto, M H, Lellouch, Daniel, Lennert, P, Leroy, C, Letts, J, Levegrün, S, Levinson, L, Lloyd, S L, Loebinger, F K, Lorah, J M, Lorazo, B, Losty, Michael J, Lou, X C, Ludwig, J, Mannelli, M, Marcellini, S, Maringer, G, Martin, A J, Martin, J P, Mashimo, T, Mättig, P, Maur, U, McKenna, J A, McMahon, T J, McNutt, J R, Meijers, F, Menszner, D, Merritt, F S, Mes, H, Michelini, Aldo, Middleton, R P, Mikenberg, G, Mildenberger, J L, Miller, D J, Milstene, C, Mir, R, Mohr, W, Moisan, C, Montanari, A, Mori, T, Mouthuy, T, Nellen, B, Nguyen, H H, O'Neale, S W, Oakham, F G, Odorici, F, Ogg, M, Ögren, H O, Oh, J H, Oram, C J, Oreglia, M J, Orito, S, Pansart, J P, Panzer-Steindel, B, Paschievici, P, Patrick, G N, Paz-Jaoshvili, N, Pfister, P, Pilcher, J E, Pitman, D, Plane, D E, Poffenberger, P R, Poli, B, Pouladdej, A, Prebys, E J, Pritchard, T W, Przysiezniak, H, Quast, G, Redmond, M W, Rees, D L, Richards, G E, Riles, K, Robins, S A, Robinson, D, Rollnik, A, Roney, J M, Ros, E, Rossberg, S, Rossi, A M, Rosvick, M, Routenburg, P, Runge, K, Runólfsson, O, Rust, D R, Sanghera, S, Sasaki, M, Sbarra, C, Schaile, A D, Schaile, O, Schappert, W, Scharff-Hansen, P, Schenk, P, von der Schmitt, H, Schreiber, S, Schwick, C, Schwiening, J, Scott, W G, Settles, M, Shen, B C, Sherwood, P, Shypit, R L, Simon, A, Singh, P, Siroli, G P, Skuja, A, Smith, A M, Smith, T J, Snow, G A, Sobie, Randall J, Springer, R W, Sproston, M, Stephens, K, Steuerer, J, Ströhmer, R, Strom, D, Takeda, H, Takeshita, T, Taras, P, Tarem, S, Teixeira-Dias, P, Tesch, N, Thackray, N J, Tranströmer, G, Tresilian, N J, Tsukamoto, T, Turner, M F, Tysarczyk-Niemeyer, G, Van den Plas, D, Van Kooten, R, VanDalen, G J, Vasseur, G, Virtue, C J, Wagner, A, Wagner, D L, Wahl, C, Walker, J P, Ward, C P, Ward, D R, Watkins, P M, Watson, A T, Watson, N K, Weber, M, Weber, P, Weisz, S, Wells, P S, Wermes, N, Whalley, M A, Wilson, G W, Wilson, J A, Winterer, V H, Wlodek, T, Wotton, S A, Wyatt, T R, Yaari, R, Yekutieli, G, Yurko, M, Zeuner, W, and Zorn, G T
Subjects: Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Branching fraction, Electron–positron annihilation, Particle Data Group, Branching (polymer chemistry), lcsh:Physics, lcsh:QC1-999, Particle Physics - Experiment, Charged particle, Lepton
Abstract: The inclusive branching ratios of the τ lepton to one, three and five charged particle final states are measured from data collected with the OPAL detector at LEP. The data sample consists of 12707e + e − → τ + τ − candidate events and has an estimated background of 1.9%. The branching ratios are obtained from a simultaneous fit to the data which gives B 1 = 84.48 ± 0.27 (stat) ±0.23 (sys)%, B 3 = 15.26±0.26±0.22% and B 5 = 0.26±0.06±0.05% respectively where B 1 + B 3 + B 5 is constrained to equal one. The inclusive one-prong branching ratio is found to be significantly lower than the 1990 Particle Data Group world average while the branching ratio to three charged particles is correspondingly higher. The five-prong branching ratio is in agreement with the world average measurement.
Published: 1992

30. Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

Author: Es, M.A. van, Veldink, J.H., Saris, C.G.J., Blauw, H.M., Vught, P.W. van, Birve, A., Lemmens, R., Schelhaas, H.J., Groen, E.J., Huisman, M.H., Kooi, A.J. van der, Visser, M. de, Dahlberg, C., Estrada, K., Rivadeneira, F., Hofman, A., Zwarts, M.J., Doormaal, P.T. van, Rujescu, D., Strengman, E., Giegling, I., Muglia, P., Tomik, B., Slowik, A., Uitterlinden, A.G., Hendrich, C., Waibel, S., Meyer, T., Ludolph, A.C., Glass, J.D., Purcell, S., Cichon, S., Nothen, Markus, Wichmann, H.E., Schreiber, S., Vermeulen, S., Kiemeney, L.A.L.M., Wokke, J.H.J., Cronin, S., McLaughlin, R.L., Hardiman, O., Fumoto, K., Pasterkamp, R.J., Meininger, V., Melki, J., Leigh, P.N., Shaw, C.E., Landers, J.E., Al-Chalabi, A., Brown Jr., R.H., Robberecht, W., Andersen, P.M., Ophoff, R.A., and Berg, L.H. van den
Abstract: We conducted a genome-wide association study among 2,323 individuals with sporadic amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and evaluated all SNPs with P < 1.0 x 10(-4) in a second, independent cohort of 2,532 affected individuals and 5,940 controls. Analysis of the genome-wide data revealed genome-wide significance for one SNP, rs12608932, with P = 1.30 x 10(-9). This SNP showed robust replication in the second cohort (P = 1.86 x 10(-6)), and a combined analysis over the two stages yielded P = 2.53 x 10(-14). The rs12608932 SNP is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate at neuromuscular synapses. Follow-up of additional SNPs showed genome-wide significance for two further SNPs (rs2814707, with P = 7.45 x 10(-9), and rs3849942, with P = 1.01 x 10(-8)) in the combined analysis of both stages. These SNPs are located at chromosome 9p21.2, in a linkage region for familial ALS with frontotemporal dementia found previously in several large pedigrees.
Published: 2009

31. A direct measurement of theZ 0 invisible width by single photon counting

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Beaudoin, G., Beck, A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Hinshaw, D. A., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, L., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Leroy, C., Lessard, L., Levegrun, S., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Moisan, C., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W.J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Prebys, E., Pritchard, T. W., Prsysiezniak, H., Quast, G., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Taras, P., Thackray, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanKooten, R., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Particle physics, Photon, Physics and Astronomy (miscellaneous), Calorimeter (particle physics), Branching fraction, Elementary particle, Resonance (particle physics), Photon counting, Standard Model, Nuclear physics, High Energy Physics::Experiment, Neutrino, Engineering (miscellaneous), Particle Physics - Experiment
Abstract: 著者人数: 289名, 資料番号: SA1003498000
Published: 1991

32. Intermittency in hadronic decays of the Z0

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Ashton, P., Astbury, A., Axen, D., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Beaudoin, G., Beck, A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Bougerolle, S., Brabson, B. B., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Cooper, M., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., DeJong, S., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D. J. P., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fincke-Keeler, M., Fischer, H. M., Fong, D. G., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Gross, E., Hagedorn, H., Hagemann, J., Hanson, G. G., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Hinshaw, D. A., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, L., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., von, Krogh J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Leroy, C., Lessard, L., Levegrun, S., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Lou, X. C., Ludwig, J., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Moisan, C., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Neale, S. W., O'Neill, B. P., Oakham, F. G., Odorici, F., Ogg, M., Ogren, H. O., Oh, H., Oram, C. J., Oreglia, M. J., Orito, S., Pansart, J. P., Paschievici, P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poffenberger, P., Poli, B., Pouladdej, A., Prebys, E., Pritchard, T. W., Przysiezniak, H., Quast, G., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Rust, D. R., Sanghera, S., Sasaki, M., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schenk, P., von, der Schmitt H., Schreiber, S., Schwarz, J., Settles, M., Shen, B. C., Sherwood, P., Shypit, R., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Sobie, R., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Stroehmer, R., Strom, D., Takeda, H., Takeshita, T., Taras, P., Tarem, S., Thackray, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanKooten, R., VanDalen, G. J., Vasseur, G., Virtue, C. J., Wagner, A., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P. S., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zacharov, I., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Quantum chromodynamics, Nuclear and High Energy Physics, Particle physics, Electron–positron annihilation, High Energy Physics::Phenomenology, Hadron, Multiplicity (mathematics), law.invention, Nuclear physics, law, Intermittency, High Energy Physics::Experiment, Rapidity, Parton shower, Particle Physics - Experiment, Factorial moment
Abstract: 著者人数: 299名, 資料番号: SA1003501000
Published: 1991

33. A study of angular correlations in 4-jet final states of hadronicZ 0 decays

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., G.M.Dallavalle, P.Debu, Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., McPherson, A. C., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Ward, C. P., Ward, D. R., Waterhouse, J., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wuensch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Quantum chromodynamics, Particle physics, Annihilation, Physics and Astronomy (miscellaneous), Logarithm, High Energy Physics::Lattice, High Energy Physics::Phenomenology, Hadron, Observable, Gluon, High Energy Physics::Experiment, Gauge theory, Abelian group, Engineering (miscellaneous), Particle Physics - Experiment
Abstract: 著者人数: 280名, 資料番号: SA1003491000
Published: 1991

34. Measurement of the cross sections of the reactions e+e− → γγ and e+e− → γγγ at LEP

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Beaudoin, G., Beck, A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., DeJong, S., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Hinshaw, D. A., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, L., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Leroy, C., Lessard, L., Levegrun, S., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Moisan, C., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Prebys, E., Pritchard, T. W., Prsysiezniak, H., Quast, G., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Taras, P., Thackray, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanKooten, R., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Angular distribution, Branching fraction, Electron–positron annihilation, Cutoff, Propagator, Electron
Abstract: 著者人数: 290名, 資料番号: SA1003499000
Published: 1991

35. Search for the minimal standard model Higgs boson in e+e− collisions at LEP

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Beck, A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, L., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Prebys, E., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Taras, P., Thackray, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wunsch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, Electron–positron annihilation, High Energy Physics::Phenomenology, Higgs boson, Mass spectrum, High Energy Physics::Experiment, Particle Physics - Experiment, Standard Model
Abstract: 著者人数: 284名, 資料番号: SA1003496000
Published: 1991

36. Search for pair produced stable singly charged heavy particles in Z0 decays

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Beck, A., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Janissen, L., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Mildenberger, J., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Prebys, E., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Thackray, N. J., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Walker, J. P., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wunsch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Range (particle radiation), Branching fraction, Fermion, Resonance (particle physics), Charged particle, law.invention, Nuclear physics, Pair production, law, High Energy Physics::Experiment, Collider, Particle Physics - Experiment, Lepton
Abstract: 著者人数: 284名, 資料番号: SA1003494000
Published: 1990

37. A direct search for neutralino production at LEP

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Clarke, P. E. L., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., G.M.Dallavalle, P.Debu, Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Harrus, I., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Humbert, R., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lehto, M. H., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McNutt, J. R., McPherson, A. C., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Singh, P., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Vasseur, G., Virtue, C. J., von, der Schmitt H., von, Krogh J., Wagner, A., Wahl, C., Ward, C. P., Ward, D. R., Waterhouse, J., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wells, P., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wuensch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Nuclear physics, Nuclear and High Energy Physics, Range (particle radiation), Particle physics, Annihilation, Branching fraction, Electron–positron annihilation, Neutralino, Direct search, Particle Physics - Experiment, Visible energy
Abstract: 著者人数: 280名, 資料番号: SA1003489000
Published: 1990

38. Evidence for final state photons in multihadronic decays of the Z0

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., Debu, P., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gaidot, A., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grosse-Wiesmann, P., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., von, Krogh J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Lasota, M. M. B., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Lupu, N., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McPherson, A. C., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Pansart, J. P., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S. A., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., von, der Schmitt H., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Spreadbury, E. J., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Vasseur, G., Virtue, C. J., Wagner, A., Wahl, C., Ward, C. P., Ward, D. R., Waterhouse, J., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wuensch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Quark, Physics, Coupling constant, Nuclear and High Energy Physics, Particle physics, Photon, High Energy Physics::Phenomenology, Electroweak interaction, Hadron, Detector, Radiation, Nuclear physics, Yield (chemistry), High Energy Physics::Experiment, Particle Physics - Experiment
Abstract: 著者人数: 277名, 資料番号: SA1003485000
Published: 1990

39. A search for technipions and charged Higgs bosons at LEP

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Dallavalle, G. M., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Ganel, O., Gary, J. W., Gascon, J., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grosse-Wiesmann, P., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., von, Krogh J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Lasota, M. M. B., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Lupu, N., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McPherson, A. C., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., von, der Schmitt H., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Spreadbury, E. J., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Virtue, C. J., Wagner, A., Wahl, C., Ward, C. P., Ward, D. R., Waterhouse, J., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wuensch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., and Yoshida, Tetsuya
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Annihilation, Branching fraction, Electron–positron annihilation, Scalar (physics), Lower limit, Nuclear physics, Angular distribution, Higgs boson, High Energy Physics::Experiment, Particle Physics - Experiment, Boson
Abstract: 著者人数: 273名, 資料番号: SA1003482000
Published: 1990

40. A combined analysis of the hadronic and leptonic decays of the Z0

Author: The, OPAL Collaboration, Akrawy, M. Z., Alexander, G., Allison, J., Allport, P. P., Anderson, K. J., Armitage, J. C., Arnison, G. T. J., Ashton, P., Azuelos, G., Baines, J. T. M., Ball, A. H., Banks, J., Barker, G. J., Barlow, R. J., Batley, J. R., Becker, J., Behnke, T., Bell, K. W., Bella, G., Bethke, S., Biebel, O., Binder, U., Bloodworth, I. J., Bock, P., Breuker, H., Brown, R. M., Brun, R., Buijs, A., Burckhart, H. J., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrin, J. T. M., Cohen, I., Collins, W. J., Conboy, J. E., Couch, M., Coupland, M., Cuffani, M., Dado, S., Deninno, M. M., Dieckmann, A., Dittmar, M., Dixit, M. S., Duchovni, E., Duerdoth, I. P., Dumas, D., El, Mamouni H., Elcombe, P. A., Estabrooks, P. G., Etzion, E., Fabbri, F., Farthouat, P., Fischer, H. M., Fong, D. G., French, M. T., Fukunaga, C., Gandois, B., Ganel, O., Gary, J. W., Geddes, N. I., Gee, C. N. P., Geich-Gimbel, C., Gensler, S. W., Gentit, F. X., Giacomelli, G., Gibson, V., Gibson, W. R., Gillies, J. D., Goldberg, J., Goodrick, M. J., Gorn, W., Granite, D., Gross, E., Grosse-Wiesmann, P., Grunhaus, J., Hagedorn, H., Hagemann, J., Hansroul, M., Hargrove, C. K., Hart, J., Hattersley, P. M., Hauschild, M., Hawkes, C. M., Heflin, E., Hemingway, R. J., Heuer, R. D., Hill, J. C., Hillier, S. J., Ho, C., Hobbs, J. D., Hobson, P. R., Hochman, D., Holl, B., Homer, R. J., Hou, S. R., Howarth, C. P., Hughes-Jones, R. E., Igo-Kemenes, P., Ihssen, H., Imrie, D. C., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Jobes, M., Jones, R. W. L., Jovanovic, P., Karlen, D., Kawagoe, K., Kawamoto, T., Kellogg, R. G., Kennedy, B. W., Kleinwort, C., Klem, D. E., Knop, G., Kobayashi, T., Kokott, T. P., Kopke, L., Kowalewski, R., Kreutzmann, H., von, Krogh J., Kroll, J., Kuwano, M., Kyberd, P., Lafferty, G. D., Lamarche, F., Larson, W. J., Lasota, M. M. B., Layter, J. G., Le, Du P., Leblanc, P., Lee, A. M., Lellouch, D., Lennert, P., Lessard, L., Levinson, L., Lloyd, S. L., Loebinger, F. K., Lorah, J. M., Lorazo, B., Losty, M. J., Ludwig, J., Lupu, N., Ma, J., Macbeth, A. A., Mannelli, M., Marcellini, S., Maringer, G., Martin, A. J., Martin, J. P., Mashimo, T., Mattig, P., Maur, U., McMahon, T. J., McPherson, A. C., Meijers, F., Menszner, D., Merritt, F. S., Mes, H., Michelini, A., Middleton, R. P., Mikenberg, G., Miller, D. J., Milstene, C., Minowa, M., Mohr, W., Montanari, A., Mori, T., Moss, M. W., Muller, A., Murphy, P. G., Murray, W. J., Nellen, B., Nguyen, H. H., Nozaki, M., O'Dowd, A. J. P., O'Neale, S. W., O'Neill, B., Oakham, F. G., Odorici, F., Ogg, M., Oh, H., Oreglia, M. J., Orito, S., Patrick, G. N., Pawley, S. J., Pfister, P., Pilcher, J. E., Pinfold, J. L., Plane, D. E., Poli, B., Pouladdej, A., Pritchard, T. W., Quast, G., Raab, J., Redmond, M. W., Rees, D. L., Regimbald, M., Riles, K., Roach, C. M., Robins, S., Rollnik, A., Roney, J. M., Rossberg, S., Rossi, A. M., Routenburg, P., Runge, K., Runolfsson, O., Sanghera, S., Sansum, R. A., Sasaki, M., Saunders, B. J., Schaile, A. D., Schaile, O., Schappert, W., Scharff-Hansen, P., von, der Schmitt H., Schreiber, S., Schwarz, J., Shapira, A., Shen, B. C., Sherwood, P., Simon, A., Siroli, G. P., Skuja, A., Smith, A. M., Smith, T. J., Snow, G. A., Spreadbury, E. J., Springer, R. W., Sproston, M., Stephens, K., Stier, H. E., Strohmer, R., Strom, D., Takeda, H., Takeshita, T., Tsukamoto, T., Turner, M. F., Tysarczyk-Niemeyer, G., Van, den plas D., VanDalen, G. J., Virtue, C. J., Wagner, A., Wahl, C., Ward, C. P., Ward, D. R., Waterhouse, J., Watkins, P. M., Watson, A. T., Watson, N. K., Weber, M., Weisz, S., Wermes, N., Weymann, M., Wilson, G. W., Wilson, J. A., Wingerter, I., Winterer, V-H., Wood, N. C., Wotton, S., Wuensch, B., Wyatt, T. R., Yaari, R., Yang, Y., Yekutieli, G., Zeuner, W., Zorn, G. T., Zylberajch, S., and Yoshida, Tetsuya
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Partial width, Muon, Electron–positron annihilation, High Energy Physics::Phenomenology, Hadron, Electron, Nuclear physics, High Energy Physics::Experiment, Nuclear Experiment, Beam energy, Particle Physics - Experiment, Lepton, Boson
Abstract: 著者人数: 274名, 資料番号: SA1003480000
Published: 1990

41. Omnidirectional Tracking and Recognition of Persons in Planar Views

Author: Schreiber, S., Störmer, A., and Rigoll, G.
Subjects: ddc
Published: 2007

42. High QE photocathodes performance during operation at FLASH / PITZ photoinjectors

Author: Monaco, L., Michelato, P., Pagani, C., Sertore, D., Bähr, J. W., Han, J. H., Krasilnikov, M., Lederer, S., Schreiber, S., and Stephan, F.
Subjects: Physics, Flash (photography), business.industry, Optoelectronics, Quantum efficiency, DESY, Laser beam quality, business, Preparation procedures, Photocathode, Beam (structure), Electron gun
Abstract: Since 1998, the DESY photoinjectors at FLASH and PITZ routinely use high quantum efficiency (QE) photocathodes produced at LASA (INFN-Milano). To further understand the photocathode behavior during beam operation, photocathode QE measurements have been performed at different operating conditions in both photoinjectors. The analysis of these measurements will be used to improve the photocathode preparation procedures and deepen our understanding of the photocathode properties. An important goal is to further increase their lifetime and to preserve a high beam quality during the operation in the RF gun of the photoinjector.
Published: 2007