Author: "Schoket B" / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

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Author: David Phillips, Schoket B, Hewer A, and Pl, Grover
Subjects: Smoking, Carcinogens, Leukocytes, Humans, Psoriasis, Bronchi, Polycyclic Compounds, DNA, Occupations, Lung, Epithelium, Tars
Published: 1990

Author: Marie Pedersen, Ma, Mendez, Schoket B, Rw, Godschalk, Espinosa A, Landström A, Cm, Villanueva, Df, Merlo, Fthenou E, Gracia-Lavedan E, Fj, Schooten, Hoek G, Brunborg G, Hm, Meltzer, Alexander J, Jk, Nielsen, Sunyer J, Wright J, Kovács K, and de Hoogh K

Author: David Phillips, Schoket B, Hewer A, and Pl, Grover
Subjects: Mice, Carcinogens, Animals, Humans, Polycyclic Compounds, DNA, Cells, Cultured, Skin
Abstract: 32P-Postlabelling analysis has been used to detect the formation in vivo of DNA adducts by components of complex mixtures of polycyclic aromatic hydrocarbons (PAHs) in coal-tar, creosote, bitumen, juniper tar, used engine oils and fuel exhaust condensates. The presence of DNA adducts derived from these agents has been investigated in mouse skin, in human skin explants maintained in short-term organ culture and in human skin in vivo, and the formation of many different PAH-DNA adducts was observed. Similar levels and patterns of adducts were found in DNA from human skin to those in mouse skin, which is known to be susceptible to the carcinogenic activity of PAH mixtures, thus demonstrating the potential hazard to man of epidermal contact with these materials.

Author: Garte, S., Gaspari, L., Alexandrie, A. -K, Rannug, A., Ingelman-Sundberg, M., Persson, I., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Boffetta, P., Breskvar, K., Dolzan, V., Brockmoller, J., Cascorbi, I., Clapper, M. L., Dresler, C. M., Coutelle, C., Daly, A., Dell’omo, M., Fryer, A., Strange, R. C., Haugen, A., Ryberg, D., Hein, D. W., Hildesheim, A., Hirvonen, A., Hsieh, L. -L, Kalina, I., Salagovic, J., Daehee Kang, Kihara, M., Noda, K., Kiyohara, C., Kremers, P., Roelandt, L., Lazarus, P., Le Marchand, L., Lechner, M. C., Lieshout, E. M. M., Peters, W. H. M., London, S., Manni, J. J., Maugard, C. M., Morita, S., Nazar-Stewart, V., Oda, Y., Parl, F. F., Pastorelli, R., Rebbeck, T., Risch, A., Romkes, M., Schoket, B., Seidegard, J., Shields, P. G., Sim, E., Sinnet, D., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M. C., and Taioli, E.

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