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One hundred and twenty-seven eyes from 66 Mycobacterium leprae inoculated armadillos were studied histologically and some ultrastructurally. Inflammatory reactions were found in the following extraocular tissues: the eyelid, including the orbicularis muscle and the third eyelid, extraocular muscles, tear gland and Harder's gland. The early and slight changes of the intraocular tissues, small amounts of lymphocytes, plasma cells and macrophage infiltrations were confined to the area around the anterior angle specifically within the trabeculae and the adjacent ciliary body, the root of the iris and the limbus region of the cornea. But in the cases with severe lesions the whole uvea was densely infiltrated with large, foamy macrophages intermingled with small amounts of lymphocytes, plasma cells and frequently, neutrophils. No specific necrosis of the granulomas was seen. No explanation for the neutrophil infiltrations was given. The lesions in the cornea were significantly less severe than those in the uvea. Retinal lesions comprised of macrophage infiltrations were all obvious extensions of the adjacent uvea lesions. Acid-fast bacilla (AFB) were found within all tissues. The infection of the intraocular tissues in the armadillo eyes seemed to be mainly, if not solely, haematogenous.

Von 1970 bis 1974 wurde bei 73 Patienten die Diagnose einer primar biliaren Lebererkrankung gestellt und histologisch sowie durch den Nachweis von Antikorpern gegen Mitochondrienproteine bestatigt. Bei einem Vergleich der Falle aus den Jahren 1950 bis 1961 und 1970 bis 1974 mit der Haufigkeit anderer chronischer entzundlicher Lebererkrankungen ergab sich, das die Zahl der bereits kompletten primar biliaren Zirrhosen in beiden Zeitabschnitten gleichblieb, wahrend sich primar biliare Erkrankungen mit der Erfassung von Vorstadien erheblich hauften. In Kassel entfielen auf einen Patienten mit chronischer nicht eitriger destruierender Cholangitis bzw. kompletter primar biliarer Zirrhose acht Falle von chronisch aggressiver Hepatitis und 15 von Leberzirrhosen unterschiedlicher Atiologie, in Gottingen betrug das Verhaltnis 1 : 5 bzw. 1 : 6. Unter Einbeziehung von Fruhfallen aufgrund besserer histologischer und immunologischer Diagnostik sind demnach primar biliare Erkrankungen keineswegs mehr selten. Verlaufskontrollen sind notwendig, um die einmal gestellte Diagnose kritisch zu uberprufen. Primary biliary liver disease was diagnosed and verified by histology and demonstration of antibodies against mitochondrial proteins in 73 patients between 1970 and 1974. Comparing cases between 1950 and 1961 and between 1970 and 1974 with the frequency of other chronic inflammatory liver diseases it was found that figures for advanced primary biliary cirrhosis remained unchanged during both periods whereas early stages of primary biliary disease were detected far more frequently in the latter period. One case with chronic non-suppurative destructive cholangitis or complete primary biliary cirrhosis was outnumbered by 8 cases of chronic aggressive hepatitis and 15 of liver cirrhosis of various aetiologies in Kassel. The relations in Gottingen were 1 : 5 and 1 : 6, respectively. Primary biliary diseases are no longer rare.