1. Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis
- Author
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Mueller, Stefanie H, Färber, Anna, Sühs, Kurt-Wolfram, Lempert, Thomas, Winter, Benjamin, Schluh, Giesela, Gass, Achim, Hagenah, Ulrich, Hausler, Martin Georg, König, Schiffner, C., Tauber, Simone, Ayzenbeig, Ilya, Ringelstein, Marius, Ingo, Kleiter, Hellwig, Kerstin, Krogias, Christos, Heneka, Michael, Widmann, Guido, Witt, Juri-Alexander, Niehusmann, Pitt, Wagner, Jan, Schoch, Susanne, Becker, Albert, Kellinghaus, Christoph, Helmstaedter, Christoph, Elger, Christian, Kehrer, Stefanie, Langenfurth, Anika, Spruth, Eike, Priller, Josef, Paul, Friedemann, Harms, Lutz, Finke, Carsten, Wöpking, Sigrid, Bien, Christian G, Schneider, Auke, Seitz, Rüdiger, Goebels, Norbert, Aktas, Orhan, Huttner, Hagen, Gemer, Stefan, Staykov, Dimitre, van Elst, Ludger Tebartz, Endres, Dominique, Kraft, Andrea, Stich, Oliver, Rauer, Sebastian, Baumgartner, Annette, Neubauer, Bemd, Hofmann, Regina, Schirotzek, Ingo, Döppner, Thorsten, von Podewils, Felix, Süße, M., Dressel, Alexander, Zettl, Uwe K, Kaufmann, Max, Fleischer, Sabine, Heesen, Christoph, Stellmann, Jan-Patrick, Friese, Manuel, Ufer, Frederike, Trebst, Corinna, Stangel, Martin, Schönenberger, Silvia, Ehrlich, Sven, Wildemann, Brigitte, Jarius, Sven, Bösel, Julian, Roepke, Luise, Brämer, Dirk, Strubl, Julia, Kunze, Albrecht, Geis, Christian, Günther, Albrecht, Grote, Susann, Handreka, Robert, Maker, Michael, Dohmen, Christian, Stoppe, Muriel, Bergh, Florian Then, Ettrich, Barbara, Schilling, Ruth, Koertvelyessy, Peter, Bittner, Daniel, Spreer, Annette, Methner, Axel, Rostásy, Kevin, Pledl, Hans-Wemer, Hoyer, Carolin, Anlonso, Angelika, Szabo, Kristina, Held, Valentin, Tackenberg, B., Meuth, Sven, Philipp, Konstanze, Golombeck, Stefanie, Posevitz-Fejfar, Anita, Then Bergh, Florian, Wuerdemann, Till, Dik, Andre, Strippel, Christine, Möning, Constanze, Wiendl, Heinz, Melzer, Nico, Weissert, Robert, Fuchs, Komelius, Retzlaff, Nele, Schroeder, Herr, Prüss, Harald, Faiss, Jürgen H, Zettl, Uwe, Fousse, Mathias, Ragoschke-Schumm, Andreas, van Baalen, Andreas, Stumer, Klarissa, Berg, Daniela, Peuser, Anna, Nissen, Gunnar, Schmütz, Isa, Leypoldt, Frank, Lieb, Wolfgang, Bartsch, Thorsten, Falk, Kim Christin, Hummel, Katja, Moser, Andreas, Wandinger, Klaus Peter, Becker, Felicitas, Krumbholz, Markus, Bischof, Felix, Ihle, Jennifer, Dürr, Marc, Franke, Andre, Tumani, Hayrettin, Lewerenz, Jan, Doppler, Kathrin, Sommer, Claudia, Kuhlenbäumer, Gregor, Wandinger, Klaus-Peter, Encephalitis, German Network for Research on Autoimmune, Krämer, Markus, Lyss, Birgit, Schreiber, Stephan, Faiss, J., Wallenfelsova, Eva, Othman, Jalal, Sinnecker, Tim, Riedlinger, Arne, Fonseca, Patricia, Kern, Peter, Bogarin, Yuri, Hoffmann, Anna, Schwabe, Julia, Golombeck, Kristin S, Seidel, Gunter, Herwig, Antje, Rostasy, Kevin, Stolze, Henning, Körber, Rüdiger, Wiese, Lars, Schulze-Amberger, Jörg, Heide, Wolfgang, Geis, Tobias, Kümpfel, Tania, Blaes, Franz, Köhler, Wolfgang, Dogan, Muejgan, Bien, Christian, Kramme, Corinna, Grofß, Martin, Thomsen, Jens, Pulkowski, Ulrich, Hoepner, Robert, Thaler, Franziska, Schindler, Kaspar, Lippert, Julian, Marziniak, Martin, Ewering, Carina, Reimann, Gemot, Juranek, Aleksandra, Kanitz, Rolf-Dieter, Obrocki, Jost, Pfefferkorn, Thomas, Schimrigk, Sebastian, Elisak, Martin, Urbanek, Christian, Schön, Frauke, Schabet, Martin, Melville, Jutta, Finke, Alexander, Henningsen, Henning, Hansen, Hans-Christian, Küpper, Philipp, Berning, Sascha, Nagel, Michael, Hofstadt, Ulrich, Trendelenburg, George, Heider, Steffen, Linsa, Andreas, Muth, Carolin, Borggräfe, Ingo, Blaschek, Astrid, Laurent, Sarah, Havla, Joachim, Menge, Til, Bieniek, Rolf, Hoffmann, Frank, Philipsen, Alexandra, Gorsler, Anna, Pomschlegel, Sebastian, and Tesch, Manfred
- Subjects
Adult ,Male ,Adolescent ,genetics [Protein Serine-Threonine Kinases] ,Hashimoto Disease ,Protein Serine-Threonine Kinases ,LGI1 protein, human ,genetics [Protein-Serine-Threonine Kinases] ,Polymorphism, Single Nucleotide ,Receptors, N-Methyl-D-Aspartate ,Young Adult ,Doublecortin-Like Kinases ,immunology [Receptors, N-Methyl-D-Aspartate] ,genetics [Hashimoto Disease] ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,immunology [Encephalitis] ,genetics [Genetic Predisposition to Disease] ,Aged ,Autoantibodies ,metabolism [Hashimoto Disease] ,Intracellular Signaling Peptides and Proteins ,Proteins ,genetics [Encephalitis] ,DCLK2 protein, human ,Middle Aged ,Protein-Serine-Threonine Kinases ,genetics [Proteins] ,immunology [Proteins] ,immunology [Hashimoto Disease] ,genetics [Polymorphism, Single Nucleotide] ,metabolism [Encephalitis] ,Encephalitis ,metabolism [Autoantibodies] ,Female ,Genome-Wide Association Study - Abstract
We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10
- Published
- 2017