11 results on '"Scaioli E."'
Search Results
2. Can fecal calprotectin better stratify Crohn's disease activity index?
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Scaioli, E., Cardamone, C., Scagliarini, M., Zagari, R. M., Bazzoli, F., andrea belluzzi, Scaioli, Eleonora, Cardamone, Carla, Scagliarini, Michele, Rocco Maurizio Zagari, Bazzoli, Franco, and Belluzza, Andrea
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Crohn’s disease ,fluids and secretions ,Crohn’s disease activity index ,Original Article ,inflammatory bowel diseases ,digestive system diseases ,fecal calprotectin - Abstract
Background. Crohn’s disease (CD) activity index (CDAI) is still widely used for monitoring clinical activity in CD patients, but is of little value as indicator of persistent inflammation in symptomless patients. Fecal calprotectin levels ≥150 μg/g are strongly indicative of endoscopically and/or histologically active disease. Our aim was to study, in a large cohort of CD patients, the relationship between CDAI and fecal calprotectin levels. Methods. CDAI and fecal calprotectin levels were evaluated in consecutive patients from a CD outpatient clinic. Results. We enrolled 193 CD patients, of whom 38% with CDAI 120, we found a high diagnostic accuracy of 72%, with 88% specificity and 50% sensitivity (positive predictive value: 76%, negative predictive value: 71%) to identify a calprotectin value ≥150 μg/g. Conclusion. CDAI scores between 100 and 150 display an acceptable ability to quantify the risk of persistent inflammation as expressed by the high calprotectin level.
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- 2014
3. Extrahepatic cholangiocarcinoma: Clinical features
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Festi, D., Scaioli, E., ANTONIO COLECCHIA, Brandi G, Ercolani G, Festi D, Scaioli E, and Colecchia A
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hilar cholangiocarcinoma, risk factors, clinical presentation, symptoms and associated diseases ,clinical presentation ,risk factors ,hilar cholangiocarcinoma ,symptoms and associated diseases - Abstract
Extrahepatic cholangiocarcinomas (E-CCAs), are hepatobiliary cancers with features of cholangiocyte differentiations, originating from extrahepatic biliary tree at the bifurcation of the hepatic ducts and also in the distal duct. E-CCAs represent the most common type of cholangiocarcinomas (CCAs) and are characterized by poor overall survival. The principal risk factors for E-CCAs are strictly related to geographic location. Jaundice is the most common physical sign at disease presentation. Other common more non-specific symptoms include hepatomegaly, right upper qudrant mass, weight loss, vomiting, nausea, diarrhoea, malaise and fatigue. Unlike intrahepatic CCA, an incidental asymptomatic presentation occurs in a small percentage of cases. This chapter evaluates the principal clinical features of E-CCAs, briefly discussing its specific risk factors.
4. Aortic thrombosis recurrence in a Crohn’s disease patient
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Giovanni Marasco, Scaioli, E., Zagari, R. M., and Belluzzi, A.
5. A rare case of giant pseudopolyp and colitis cystica profunda coexistence in an ulcerative colitis patient
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Cecinato, P., Scaioli, E., Leonardi, F., Liverani, E., Cardamone, C., Rosati, G., Balbi, T., and andrea belluzzi
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lcsh:Diseases of the digestive system. Gastroenterology ,lcsh:RC799-869
6. Pomegranate juice to reduce fecal calprotectin levels in inflammatory bowel disease patients with a high risk of clinical relapse: Study protocol for a randomized controlled trial
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Luigi Ricciardiello, Francesca Danesi, Pedro Mena, Daniele Del Rio, Eleonora Scaioli, Enrica Rotondo, Andrea Belluzzi, Eleonora Derlindati, Scaioli E., Belluzzi A., Ricciardiello L., Del Rio D., Rotondo E., Mena P., Derlindati E., and Danesi F.
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Male ,Crohn’s disease ,Time Factors ,Anti-Inflammatory Agents ,Medicine (miscellaneous) ,Systemic inflammation ,Gastroenterology ,Inflammatory bowel disease ,Pomegranate ,law.invention ,Feces ,Study Protocol ,0302 clinical medicine ,Fecal calprotectin ,Randomized controlled trial ,law ,Recurrence ,Risk Factors ,Ellagitannins ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Randomized Controlled Trials as Topic ,Aged, 80 and over ,lcsh:R5-920 ,Crohn's disease ,Ellagitannin ,Remission Induction ,Middle Aged ,Ulcerative colitis ,Hydrolyzable Tannins ,Fruit and Vegetable Juices ,Treatment Outcome ,Italy ,Female ,medicine.symptom ,Inflammation Mediators ,lcsh:Medicine (General) ,Adult ,medicine.medical_specialty ,Adolescent ,IBD ,Down-Regulation ,Placebo ,Risk Assessment ,03 medical and health sciences ,Young Adult ,Double-Blind Method ,Internal medicine ,Pomegranate juice ,Humans ,Punica granatum L ,Aged ,Inflammation ,business.industry ,Surrogate endpoint ,medicine.disease ,Inflammatory Bowel Diseases ,Calprotectin ,business ,Leukocyte L1 Antigen Complex ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Background Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent episodes of intestinal inflammation and is thought to be related to an autoimmune reaction to genetic and environmental factors. Although evidence indicates that a polyphenolic-rich diet plays an important role in modulating aspects of chronic inflammation, few studies have focused on the effect of ellagitannin (ET)-rich food consumption on long-term remission maintenance in IBD patients with a high risk of clinical relapse. Therefore, we hypothesize that supplementation with a pomegranate juice, a naturally rich source of ETs, could significantly modulate the markers of mucosal and systemic inflammation relative to a control group receiving a placebo. Methods/design This double-blind, randomized controlled trial includes patients with IBD involving the colorectum who have been in stable therapy for at least the three previous months and have a high risk of clinical relapse. Participants are randomly allocated to one of two groups: active supplementation (125 mL of cv. Wonderful pomegranate juice) or placebo (125 mL) taken twice daily for 12 weeks. The primary outcome is changes in the fecal neutrophil-derived protein calprotectin, a surrogate marker of mucosal improvement, between the two groups from baseline to 12 weeks later. The secondary outcomes include transcriptomic changes in peripheral blood mononuclear cells and intestinal biopsies and changes in circulating inflammatory markers and trimethylamine-N-oxide levels. Pomegranate ET-derived metabolites are identified and quantified in plasma and urine samples. Discussion The results will provide information on the possible reduction of fecal calprotectin levels following the consumption of pomegranate juice. The findings will also show the in vivo metabolism of pomegranate ETs. Finally, the effect of 12-week pomegranate juice consumption on local and systemic inflammatory markers will be elucidated, which will likely provide additional insights into the maintenance of remission in IBD patients. Trial registration ClinicalTrials.gov, NCT03000101. Registered on 21 December 2016. Electronic supplementary material The online version of this article (10.1186/s13063-019-3321-8) contains supplementary material, which is available to authorized users.
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- 2018
7. Review article: the diagnosis of non-alcoholic fatty liver disease - availability and accuracy of non-invasive methods
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Daniele Mandolesi, Eleonora Scaioli, G. Bonato, Davide Festi, L. Marzi, Antonio Colecchia, A. Di Biase, G. Marchesini-Reggiani, L. Montrone, Ramona Schiumerini, Festi D, Schiumerini R., Marzi L., Di Biase A.R., Mandolesi D., Montrone L., Scaioli E., Bonato G., Marchesini Reggiani G., and ColecchiaA.
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Liver Cirrhosis ,medicine.medical_specialty ,Biopsy ,MEDLINE ,diagnostic approach route ,Severity of Illness Index ,Gastroenterology ,acoustic radiation force impulse imaging ,computer assisted tomography ,contrast enhancement ,lipid accumulation product ,magnetic resonance elastography ,nuclear magnetic resonance imaging ,Non-alcoholic Fatty Liver Disease ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Acoustic radiation force impulse imaging ,Hepatology ,medicine.diagnostic_test ,business.industry ,Fatty liver ,Reproducibility of Results ,medicine.disease ,Review article ,Magnetic resonance elastography ,Fatty Liver ,Liver biopsy ,Elasticity Imaging Techniques ,Steatohepatitis ,Transient elastography ,business - Abstract
Summary Background Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of clinical conditions, actually representing an emerging disease of great clinical interest. Currently, its diagnosis requires liver biopsy, an invasive procedure not free from potential complications. However, several non-invasive diagnostic strategies have been proposed as potential diagnostic alternatives, each with different sensitivities and accuracies. Aim To review non-invasive diagnostic parameters and tools for NAFLD diagnosis and to formulate a diagnostic and prognostic algorithm for a better classification of patients. Methods A literature search was carried out on MEDLINE, EMBASE, Web of Science and Scopus for articles and abstracts in English. The search terms used included ‘NAFLD’, ‘non invasive method and NAFLD’, ‘transient elastography’ and ‘liver fibrosis’. The articles cited were selected based on their relevancy to the objective of the review. Results Ultrasonography still represents the first-line diagnostic tool for simple liver steatosis; its sensitivity could be enhanced by the complex biochemical score SteatoTest. Serum cytokeratin-18 is a promising and accurate non-invasive parameter (AUROCs: 0.83; 0.91) for the diagnosis of non-alcoholic steatohepatitis (NASH). The staging of liver fibrosis still represents the most important prognostic problem: the most accurate estimating methods are FibroMeter, FIB-4, NAFLD fibrosis score (AUROCs: 0.94; 0.86; 0.82) and transient elastography (AUROC: 0.84–1.00). Conclusions Different non-invasive parameters are available for the accurate diagnosis and prognostic stratification of non-alcoholic fatty liver disease which, if employed in a sequential algorithm, may lead to a reduced use of invasive methods, i.e. liver biopsy.
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- 2012
8. Development and application of a simple and powerful tool for nutrition and lifestyle education for the Italian general population by general practitioners and family paediatricians
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M. Letizia Petroni, Eleonora Scaioli, Sergio Coccheri, Susy Pini, Claudio Maffeis, Antonio Colecchia, Davide Festi, Festi D., Colecchia A., Pini S., Scaioli E., Maffeis C., Coccheri S., and Petroni M.L.
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lifestyle ,obesity ,medicine.medical_specialty ,Food intake ,food intake ,Endocrinology, Diabetes and Metabolism ,Nutrition Education ,Population ,children ,adults ,Medicine ,education ,education.field_of_study ,Nutrition and Dietetics ,business.industry ,Nationwide database ,health survey ,nutrition ,Press release ,Family medicine ,Global Positioning System ,Family doctors ,Epidemiological Monitoring ,business ,Food Science - Abstract
The role of general practitioners (GPs) and family paediatricians (FPs) in nutrition education and counselling for the general population is crucial. However, time constraints, insufficient knowledge and lack of suitable educational instruments have so far prevented family doctors from having an active role in this respect. In this paper the project “Osservatorio Nutrizionale Grana Padano (ON-GP)”, launched in 2005, an innovative and powerful tool for nutritional education and epidemiological monitoring by GPs and FPs, is described. GPs and FPs agreed to participate on a voluntary basis and were from all Italian regions. So far, since 2005, over 17,250 subjects (6306 children and 10,944 adults) have been surveyed by 346 GPs and 207 paediatricians. In addition to the possibility of free use of the software for clinical and educational purposes, GPs and FPs are also invited to take part in epidemiological research in order to build a nationwide database. The results of the survey are disseminated on an annual basis to family doctors and as a press release to the media, together with messages of nutrition education targeted to the general population. The success of the project so far — beyond all expectations — has prompted the planning of further improvements.
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- 2009
9. Letter: FibroTest for staging fibrosis in non-alcoholic fatty liver disease - authors' reply
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Eleonora Scaioli, Ramona Schiumerini, Antonio Colecchia, Davide Festi, Festi D, Schiumerini R, Scaioli E, and Colecchia A
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medicine.medical_specialty ,Liver fibrosis ,Disease ,LIVER FIBROSIS ,Gastroenterology ,Fibrosis ,Internal medicine ,Diagnostic equipment ,diagnostic equipment ,nonalcoholic fatty liver ,Medicine ,Humans ,Pharmacology (medical) ,DIAGNOSTIC ACCURACY ,receiver operating characteristic ,Hepatology ,Receiver operating characteristic ,business.industry ,FibroTest ,Fatty liver ,Non alcoholic ,medicine.disease ,Fatty Liver ,business - Abstract
No abstract available
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- 2013
10. Gut microbiota and its pathophysiology in disease paradigms
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Antonio Colecchia, Eleonora Scaioli, Birtolo C, L. Marzi, Di Biase Ar, L. Montrone, Ramona Schiumerini, Davide Festi, Festi D, Schiumerini R, Birtolo C, Marzi L, Montrone L, Scaioli E, Di Biase AR, and Colecchia A.
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Flora ,Digestive System Diseases ,Gut flora ,Cell Transformation ,Inflammatory bowel disease ,digestive system ,Digestive System Disease ,Immune system ,Intestinal mucosa ,medicine ,Humans ,Barrier function ,Irritable bowel syndrome ,Neoplastic ,biology ,business.industry ,digestive, oral, and skin physiology ,Gastroenterology ,HUMANS ,General Medicine ,medicine.disease ,biology.organism_classification ,Host-Pathogen Interaction ,Gastrointestinal Tract ,Cell Transformation, Neoplastic ,Host-Pathogen Interactions ,Immune System ,Metagenome ,Immunology ,business ,Dysbiosis - Abstract
The gut flora carries out important functions for human health, although most of them are still unknown, and an alteration of any of them, due to a condition of dysbiosis, can lead to relevant pathological implications. Commensal bacteria in the gut are essential for the preservation of the integrity of the mucosal barrier function and an alteration in the anatomic functional integrity of this barrier has been implicated in the pathophysiologic process of different diseases. The gut microflora plays a role in modulating the intestinal immune system; in fact, it is essential for the maturation of gut-associated lymphatic tissue, the secretion of IgA and the production of antimicrobial peptides. The enteric flora represents a potent bioreactor which controls several metabolic functions, even if most of them are still unknown. The main metabolic functions are represented by the fermentation of indigestible food substances into simple sugars, absorbable nutrients, and short-chain fatty acids. Furthermore, the gut microbiota exerts important trophic and developmental functions on the intestinal mucosa. This overview focuses briefly on the physiological role of the gut microbiota in maintaining a healthy state and the potential role played by disturbances of both the function and composition of the gut microbiota in determining important pathological conditions, such as irritable bowel syndrome, inflammatory bowel disease, metabolic syndrome, obesity, and cancer.
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- 2011
11. Coeliac disease and autoimmune hepatitis: Gluten-free diet can influence liver disease outcome
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Eleonora Scaioli, Antonio Colecchia, Anna Rita Di Biase, Davide Festi, Colecchia A, Di Biase AR, Scaioli E, and Festi D
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medicine.medical_specialty ,Hepatology ,CELIAC DISEASE ,business.industry ,Anti-Inflammatory Agents ,Gastroenterology ,Autoimmune hepatitis ,Adrenal Cortex Hormone ,medicine.disease ,Combined Modality Therapy ,Coeliac disease ,Anti-Inflammatory Agent ,autoimmune Hepatitis ,Liver disease ,Adrenal Cortex Hormones ,Internal medicine ,medicine ,Gluten free ,business - Abstract
no abstract available
- Published
- 2011
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