13 results on '"Satoko Harada"'
Search Results
2. Prevalence and characteristics of human parechovirus and enterovirus infection in febrile infants
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Mayumi Hara, Tomoko Ogawa, Hiromichi Hamada, Atsushi Ogura, Jun-ichi Takanashi, Satoko Harada, Mai Koizumi, Shoko Hirose, Masakatsu Taira, Haruna Nishijima, Kentaro Sano, and Kenta Sugiura
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Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Fever ,030106 microbiology ,Parechovirus ,medicine.disease_cause ,Virus ,Feces ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Epidemiology ,Enterovirus Infections ,Prevalence ,medicine ,Asian country ,Humans ,Prospective Studies ,030212 general & internal medicine ,Cerebrospinal Fluid ,Enterovirus ,Picornaviridae Infections ,Leukopenia ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Human parechovirus ,Infant, Newborn ,Infant ,Abnormal CSF findings ,Pediatrics, Perinatology and Child Health ,Pharynx ,Female ,medicine.symptom ,business ,Breast feeding - Abstract
Background Human parechovirus (HPeV) and human non-polio enterovirus (EV) are important causes of fever without sources (FWS) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HPeV and EV infections in febrile young infants in Japan. Methods During February 2010 – August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid (CSF) samples from 56 infants (
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- 2018
3. Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus
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Hiroki Fujieda, Naoki Takahashi, Noriyasu Kato, Satoko Harada, Mitsuhiro Makino, Masao Sakairi, Tokuyuki Yamashita, Masakazu Kogami, and Miyazawa Toshiyuki
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0301 basic medicine ,Male ,medicine.medical_specialty ,Pyrrolidines ,Allosteric regulation ,Enzyme Activators ,Type 2 diabetes ,Thiophenes ,Hypoglycemia ,01 natural sciences ,03 medical and health sciences ,Internal medicine ,Drug Discovery ,Glucokinase ,medicine ,Glucose homeostasis ,Animals ,Humans ,Hypoglycemic Agents ,Pancreas ,Pharmacology ,chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Type 2 Diabetes Mellitus ,General Medicine ,Glucose Tolerance Test ,medicine.disease ,0104 chemical sciences ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,Enzyme ,Endocrinology ,chemistry ,Diabetes Mellitus, Type 2 ,Liver - Abstract
Glucokinase (GK) is an enzyme that plays an important role as a glucose sensor while maintaining whole body glucose homeostasis. Allosteric activators of GK (GKAs) have the potential to treat type 2 diabetes mellitus. To identify novel GKAs, a series of compounds based on a thiophenyl-pyrrolidine scaffold were designed and synthesized. In this series, compound 38 was found to inhibit glucose excursion in an oral glucose tolerance test (OGTT) in mice. Optimization of 38 using a zwitterion approach led to the identification of the novel GKA 59. GKA 59 exhibited potent blood glucose control in the OGTT test as well as a favorable safety profile. Owing to low pancreatic distribution, compound 59 primarily activates GK in the liver. This characteristic could overcome limitations of other GKAs, such as hypoglycemia, increased plasma triglycerides, and loss of efficacy.
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- 2018
4. Photoinduced electron-transfer reactions and magnetic field effects on the decay rates of a photogenerated biradical from zinc porphyrin–viologen linked compounds in an ionic liquid
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Hironobu Tahara, Hiroaki Yonemura, Satoko Harada, Sunao Yamada, and Akio Nakashima
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General Physics and Astronomy ,Viologen ,Photochemistry ,Photoinduced electron transfer ,chemistry.chemical_compound ,Benzonitrile ,Reaction rate constant ,chemistry ,Excited state ,Ionic liquid ,medicine ,Singlet state ,Physical and Theoretical Chemistry ,Methylene ,medicine.drug - Abstract
Fluorescence and transient absorption spectra of zinc-porphyrin (ZnP)–viologen linked compounds with various methylene groups indicate that intramolecular electron-transfer from the singlet or triplet excited state of ZnP to viologen occurred and a biradical was generated in the ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate) at various temperatures (283–343 K). The decay rate constants of the biradical decreased in 0–0.2∼0.5 T and became constant in 0.2∼0.5–1 T. Unique effects of temperature and methylene chain length on electron-transfer and magnetic field effects were observed and are probably due to the properties of the ionic liquid as compared with benzonitrile.
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- 2012
5. Collaborative work on evaluation of ovarian toxicity 15) Two- or four-week repeated-dose studies and fertility study of bromocriptine in female rats
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Zhu Jiuxin, Satoko Harada, Yoshiaki Tagawa, Toshihiko Kumazawa, Hiromi Nishitani, Tsukasa Ishiguro, Takashi Tanaharu, Yukiko Inoue, Ikuo Hayasaka, and Atsushi Nakajima
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Male ,Societies, Scientific ,medicine.medical_specialty ,Longevity ,Fertility Study ,Estrous Cycle ,Ovary ,Toxicology ,Public-Private Sector Partnerships ,Drug Administration Schedule ,Bromocriptine Mesylate ,Antiparkinson Agents ,Rats, Sprague-Dawley ,Japan ,Corpus Luteum ,Pregnancy ,Proliferating Cell Nuclear Antigen ,Internal medicine ,Toxicity Tests ,medicine ,Animals ,Ovarian Diseases ,Adverse effect ,Bromocriptine ,Estrous cycle ,business.industry ,Organ Size ,Rats ,Fertility ,medicine.anatomical_structure ,Endocrinology ,Pituitary Gland ,Toxicity ,Gestation ,Female ,business ,Infertility, Female ,medicine.drug - Abstract
The main focus of this study is to determine the optimal administration period concerning toxic effects on ovarian morphological changes in a repeated-dose toxicity study. To assess morphological and functional changes induced in the ovary by bromocriptine, the compound was administered to female rats at dose levels of 0, 0.08, 0.4 and 2 mg/kg for the 2- or 4-week repeated-dose toxicity study, and for the female fertility study from 2 weeks prior to mating to day 7 of gestation. In the 2-week repeated-dose toxicity study, increase of ovarian weights was observed at 2 mg/kg. In the 4-week repeated-dose toxicity study, ovarian weights were increased at 0.4 and 2 mg/kg. The number of corpora luteum was increased in the 0.4 and 2 mg/kg groups of the 2- and 4-week repeated-dose toxicity studies by histopathological examination of the ovaries. Bromocriptine did not affect estrous cyclicity in 2- and 4-week repeated dosing. In the female fertility study, although animals in any groups mated successfully, no females in 0.4 and 2 mg/kg groups were pregnant. There were no adverse effects on reproductive performance in the 0.08 mg/kg group. Based on these findings, the histopathological changes in the ovary are considered important parameters for evaluation of drugs including ovarian damage. We conclude that a 2-week administration period is sufficient to detect ovarian toxicity of bromocriptine in a repeated-dose toxicity study.
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- 2009
6. Perospirone, a Novel Antipsychotic Drug, Inhibits Marble-Burying Behavior via 5-HT1A Receptor in Mice: Implications for Obsessive-Compulsive Disorder
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Kenichi Mishima, Katsunori Iwasaki, Nobuaki Egashira, Michihiro Fujiwara, Ryoko Okuno, Ryoji Nishimura, Michihiko Matsushita, and Satoko Harada
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Male ,Agonist ,Obsessive-Compulsive Disorder ,Indoles ,medicine.drug_class ,Atypical antipsychotic ,Isoindoles ,Motor Activity ,Pharmacology ,Piperazines ,Marble burying ,Mice ,medicine ,Haloperidol ,Animals ,8-Hydroxy-2-(di-n-propylamino)tetralin ,Mice, Inbred ICR ,Risperidone ,Behavior, Animal ,Dose-Response Relationship, Drug ,Chemistry ,lcsh:RM1-950 ,Antagonist ,Perospirone ,Serotonin Receptor Agonists ,Disease Models, Animal ,Thiazoles ,lcsh:Therapeutics. Pharmacology ,Receptor, Serotonin, 5-HT1A ,Molecular Medicine ,5-HT1A receptor ,Serotonin Antagonists ,Antipsychotic Agents ,medicine.drug - Abstract
Perospirone is a novel atypical antipsychotic drug with dopamine (DA) D2- and serotonin (5-hydroxytryptamine, 5-HT) 5-HT2A-receptor antagonist, and 5-HT1A-receptor agonist properties. In the present study, we examined the effect of perospirone on marble-burying behavior, which has been considered an animal model of obsessive-compulsive disorder (OCD), compared with the effects of other antipsychotics such as haloperidol and risperidone. Perospirone at a dose of 10 mg/kg (p.o.) inhibited marble-burying behavior without affecting the locomotor activity in mice. On the other hand, haloperidol (0.1 mg/kg, i.p.) and risperidone (1 mg/kg, p.o.) showed significant suppression of locomotor activity at the dose that inhibited marble-burying behavior. Furthermore, the inhibition of marble-burying behavior by perospirone was antagonized by WAY100135 (10 mg/kg, i.p.), a selective 5-HT1A-receptor antagonist. WAY100135 at the same dose also antagonized the inhibition of marble-burying behavior by 8-OH-DPAT (3 mg/kg, i.p.), a selective 5-HT1A-receptor agonist. These findings suggest that perospirone may exhibit anti-OCD activity in clinical use and that 5-HT1A-receptor agonistic activity may be involved in the inhibition of marble-burying behavior by perospirone. Keywords:: marble-burying behavior, perospirone, antipsychotic drug, 5-HT1A receptor, obsessive-compulsive disorder
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- 2005
7. Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one
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Daisuke Kataoka, Nobuhide Watanabe, Toshiyuki Miyazawa, Megumi Inoue, Masafumi Torii, Masakazu Kogami, Mitsuhiro Makino, Masao Sakairi, Ryuji Okamoto, Satoko Harada, and Naoki Takahashi
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Male ,Agonist ,medicine.drug_class ,Stereochemistry ,Cell Line ,Receptors, G-Protein-Coupled ,Mice ,Piperidines ,Drug Discovery ,medicine ,Animals ,Humans ,Inverse agonist ,Rats, Wistar ,Glucagon-like peptide 1 receptor ,G protein-coupled receptor ,Gastric emptying ,Chemistry ,General Chemistry ,General Medicine ,Glucose Tolerance Test ,Rats ,Mice, Inbred C57BL ,GPR119 ,Indenes ,Biochemistry ,Glucagon receptor family ,Isopropyl - Abstract
6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.
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- 2012
8. Synthesis and SAR studies of bicyclic amine series GPR119 agonists
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Hiroki Fujieda, Ryuji Okamoto, Satoko Harada, Mitsuhiro Makino, Naoki Takahashi, Masakazu Kogami, Nobuhide Watanabe, Okabe Morio, Daisuke Kataoka, Hiroyo Kataoka, Masao Sakairi, Megumi Inoue, Masafumi Torii, and Miyazawa Toshiyuki
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Blood Glucose ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Plasma protein binding ,Biochemistry ,Receptors, G-Protein-Coupled ,chemistry.chemical_compound ,Bridged Bicyclo Compounds ,Mice ,Structure-Activity Relationship ,Drug Discovery ,Structure–activity relationship ,Animals ,Humans ,Hypoglycemic Agents ,Gpr119 agonist ,Amines ,Receptor ,Molecular Biology ,Bicyclic molecule ,Organic Chemistry ,Glucose Tolerance Test ,Mice, Inbred C57BL ,GPR119 ,Pyrimidines ,chemistry ,Indans ,Molecular Medicine ,Amine gas treating ,Derivative (chemistry) ,Protein Binding - Abstract
We disclosed a novel series of G-protein coupled receptor 119 (GPR119) agonists based on a bicyclic amine scaffold. Through the optimization of hit compound 1, we discovered that the basic nitrogen atom of bicyclic amine played an important role in GPR119 agonist activity expression and that an indanone in various bicyclic rings was suitable in this series of compounds. The indanone derivative 2 showed the effect of plasma glucose control in oGTT and scGTT in the rodent model.
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- 2012
9. Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder
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Ryoko Okuno, Nobuaki Egashira, Kenichi Mishima, Satoko Harada, Ryoji Nishimura, Michihiko Matsushita, Ryozo Oishi, Katsunori Iwasaki, and Michihiro Fujiwara
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Male ,Obsessive-Compulsive Disorder ,Reflex, Startle ,Glutamic Acid ,AMPA receptor ,Pharmacology ,Motor Activity ,Receptors, N-Methyl-D-Aspartate ,Marble burying ,chemistry.chemical_compound ,Mice ,Memantine ,Quinoxalines ,medicine ,Amantadine ,Animals ,Prepulse inhibition ,Mice, Inbred ICR ,Riluzole ,Behavior, Animal ,Dizocilpine ,chemistry ,Acoustic Stimulation ,Receptors, Glutamate ,NMDA receptor ,NBQX ,Dizocilpine Maleate ,Excitatory Amino Acid Antagonists ,medicine.drug - Abstract
Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive–compulsive disorder (OCD). We examined the effects of glutamate-related drugs on marble-burying behavior, which is an animal model of OCD. The uncompetitive N-methyl- d -aspartate (NMDA) antagonists memantine (10 mg/kg, i.p.) and amantadine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity in mice. Similarly, the uncompetitive NMDA receptor antagonist 5R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine hydrogen maleate (MK-801, 0.3 mg/kg, i.p.) inhibited marble-burying behavior. However, MK-801 at the same dose markedly increased locomotor activity. By contrast, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide (NBQX) and the glutamate release inhibitor riluzole showed no effect on marble-burying behavior and significant suppression of locomotor activity. MK-801 (0.3 mg/kg, i.p.) and memantine (10 mg/kg, i.p.) significantly disrupted prepulse inhibition as an operational measure of sensorimotor gating. By contrast, amantadine (30 mg/kg, i.p.) did not affect prepulse inhibition. These findings suggest that amantadine could be a useful drug for the treatment of OCD.
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- 2007
10. Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine
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Katsunori Iwasaki, Ryoko Okuno, Satoko Harada, Ryoji Nishimura, Nobuaki Egashira, Kenichi Mishima, Kensuke Orito, Michihiro Fujiwara, and Michihiko Matsushita
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Male ,Obsessive-Compulsive Disorder ,medicine.drug_class ,Serotonin reuptake inhibitor ,Morpholines ,Sigma receptor ,Fluvoxamine ,Pharmacology ,Piperazines ,Marble burying ,Mice ,Phenazocine ,medicine ,Animals ,Receptors, sigma ,BD-1047 ,Mice, Inbred ICR ,Psychotropic Drugs ,Behavior, Animal ,Dose-Response Relationship, Drug ,Chemistry ,Antagonist ,Brain ,Receptor antagonist ,Ethylenediamines ,Paroxetine ,Butyrates ,Disease Models, Animal ,Selective Serotonin Reuptake Inhibitors ,medicine.drug ,Tropanes - Abstract
In the present study, we examined the involvement of the sigma1 receptor in the inhibitory effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, compared with that of paroxetine, on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Sigma1 receptor agonists (+)-SKF 10047 and PRE-084 significantly inhibited marble-burying behavior. Sigma receptor antagonist BD 1047 and selective sigma1 receptor antagonist BD 1063 significantly attenuated the inhibition of marble-burying behavior by fluvoxamine. In contrast, selective sigma2 receptor antagonist SM-21 failed to affect the inhibition of marble-burying behavior by fluvoxamine. On the other hand, BD 1047 and BD 1063 had no effect on the inhibition of marble-burying behavior by paroxetine. These observations show that activation of the sigma1 receptor is a necessary component in the inhibitory effect of fluvoxamine on marble-burying behavior, and that the mechanism of its action is clearly different from that of paroxetine.
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- 2006
11. Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
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Katsunori Iwasaki, Gozoh Tsujimoto, Satoko Harada, Tomomi Matsuda, Emi Koushi, Nobuaki Egashira, Yukio Takano, Kenichi Mishima, Michihiro Fujiwara, and Akito Tanoue
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Male ,medicine.medical_specialty ,Vasopressin ,Receptors, Vasopressin ,Neuropeptide ,Anxiety ,Statistics, Nonparametric ,Behavioral Neuroscience ,Mice ,Internal medicine ,medicine ,Animals ,Social Behavior ,Phencyclidine ,Mice, Knockout ,medicine.disease ,Social relation ,Mice, Inbred C57BL ,Endocrinology ,Schizophrenia ,Knockout mouse ,Exploratory Behavior ,Autism ,medicine.symptom ,Psychology ,Neuroscience ,medicine.drug - Abstract
The arginine vasopressin (AVP) system plays an important role in social behavior. Autism, with its hallmark disturbances in social behavior, has been associated with the V1a receptor (V1aR) gene. Furthermore, impairments of social function are often observed in symptoms of schizophrenia. Subchronic phencyclidine (PCP) produces behaviors relating to certain aspects of schizophrenic symptoms such as impairing social interaction in animals and it reduces the density of V1aR binding sites in several brain regions. Here, we report that V1aR knockout (KO) mice exhibited impairment of social behavior in a social interaction test, and showed reduced anxiety-related behavior in elevated plus-maze and marble-burying behavior tests. Given the current findings, the V1aR may be involved in the regulation of social interaction, and V1aR KO mice could be used as an animal model of psychiatric disorders associated with social behavior deficits, such as autism and schizophrenia.
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- 2006
12. Magnetic Field Effects on Photoelectrochemical Reactions of Porphyrin–Viologen Linked Compounds in an Ionic Liquid
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Sunao Yamada, Hiroaki Yonemura, Satoko Harada, and Hironobu Tahara
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Tetrafluoroborate ,Physics and Astronomy (miscellaneous) ,General Engineering ,General Physics and Astronomy ,Viologen ,Photochemistry ,Porphyrin ,Magnetic field ,chemistry.chemical_compound ,Crystallography ,chemistry ,Electrode ,Ionic liquid ,medicine ,Methylene ,Visible spectrum ,medicine.drug - Abstract
Magnetic field effects (MFEs) on photoelectrochemical reactions of three porphyrin–viologen linked compounds with various methylene groups [ZnP(n)V (n=4,6,8)] were examined in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) as an ionic liquid using a two-electrode cell. Stable anodic photocurrents are produced by irradiating ZnP(n)V (n=4,6,8) in [BMIM][BF4] with visible light, and the MFEs on photocurrents were clearly observed in ZnP(n)V (n=4,6,8). The MFEs on photocurrents increase with magnetic field for lower magnetic fields (B ≤200 mT) and are constant for higher magnetic fields (B > 200 mT). The magnitude of the MFEs in ZnP(n)V (n=6,8) are larger than that in ZnP(4)V. The MFEs can be explained by radical pair mechanism. The magnitude of the MFEs is larger than those in electrodes modified with ZnP(n)V (n=4,6,8) as Langmuir–Blodgett films. The results are most likely attributable to the properties of [BMIM][BF4] and the mechanism of photoelectrochemical reaction.
- Published
- 2011
13. Magnetic Field Effects on Photoelectrochemical Reactions of a Porphyrin-Viologen Linked Compound in an Ionic Liquid
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Hironobu Tahara, Sunao Yamada, Satoko Harada, and Hiroaki Yonemura
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Photocurrent ,Viologen ,General Chemistry ,Condensed Matter Physics ,Photochemistry ,Porphyrin ,Magnetic field ,chemistry.chemical_compound ,chemistry ,Ionic liquid ,Electrode ,medicine ,General Materials Science ,Methylene ,Visible spectrum ,medicine.drug - Abstract
Magnetic field effects (MFEs) on photoelectrochemical reaction of a porphyrin-viologen linked compound with six methylene group (ZnP(n)V(n = 6)) were examined in an ionic liquid ([BMIM][BF4 ]) using two-electrode cell. A stable anodic photocurrent is produced by irradiating ZnP(6)V in [BMIM][BF4 ] with visible light, and the photocurrent clearly increased in the presence of a magnetic field. The MFEs are explained by radical pair mechanism. The magnitude of the MFEs is larger than those in electrodes modified with ZnP(n)V(n = 4,6,8) as Langmuir-Blodgett films. The results are most likely ascribed to the properties of [BMIM][BF 4 ].
- Published
- 2011
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