7 results on '"Sarah E. Canetta"'
Search Results
2. Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period
- Author
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Sarah E. Canetta, Emma S. Holt, Laura J. Benoit, Eric Teboul, Gabriella M. Sahyoun, R. Todd Ogden, Alexander Z. Harris, and Christoph Kellendonk
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biology ,Interneuron ,General Immunology and Microbiology ,Period (gene) ,General Neuroscience ,Sensory system ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,medicine.anatomical_structure ,biology.protein ,medicine ,Sensory cortex ,Adolescent development ,Prefrontal cortex ,Neuroscience ,Parvalbumin ,Function (biology) - Abstract
SummaryIn their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable sensitive periods exist for non-sensory cortices, such as the prefrontal cortex, in which alterations in activity determine adult circuit function and behavior is still an active area of research. Here, we demonstrate that inhibition of prefrontal parvalbumin-expressing interneurons during the juvenile and adolescent period, results in persistent impairments in adult prefrontal circuit connectivity, in vivo network function and behavioral flexibility that can be reversed by targeted activation of parvalbumin interneurons in adulthood. In contrast, transient suppression of parvalbumin interneuron activity in adulthood produces no lasting effects. These findings identify an activity-dependent sensitive period for prefrontal circuit maturation and highlight how abnormal parvalbumin interneuron activity during development alters adult prefrontal circuit function and cognitive behavior.
- Published
- 2022
3. Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine
- Author
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Elizabeth A. Pekarskaya, Jonathan A. Javitch, Mark S. Ansorge, Jay A. Gingrich, Emma S Holt, and Sarah E. Canetta
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medicine.medical_specialty ,Mice, 129 Strain ,Thiazepines ,Science ,Serotonin reuptake inhibitor ,Anxiety ,Antidepressive Agents, Tricyclic ,Pharmacology ,Serotonergic ,Article ,Open field ,Fluoxetine ,Internal medicine ,Monoaminergic ,Avoidance Learning ,medicine ,Animals ,Tianeptine ,Multidisciplinary ,Behavior, Animal ,Disease model ,Depression ,business.industry ,Brain ,Feeding Behavior ,Mice, Inbred C57BL ,Endocrinology ,Monoamine neurotransmitter ,Animals, Newborn ,In utero ,Medicine ,Antidepressive Agents, Second-Generation ,medicine.symptom ,business ,Open Field Test ,Selective Serotonin Reuptake Inhibitors ,medicine.drug - Abstract
Depression and anxiety are two of the most common mental health disorders, often sharing symptoms and administrations. Most pharmacological agents available to treat these disorders target monoamine systems. Currently, finding the most effective treatment for an individual is a process of trial and error. Therefore, to better understand how disease etiology may predict treatment response, we studied mice exposed developmentally to the selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX). These mice show the murine equivalent of anxiety- and depression-like symptoms in adulthood and here we report that these mice are also behaviorally resistant to the antidepressant-like effects of adult SSRI administration. We investigated whether tianeptine (TIA), which exerts its therapeutic effects through the mu-opioid receptor (MOR) instead of directly targeting monoaminergic systems, would be more effective in this model.We injected C57BL/6J (C57) pups with either FLX (10 mg/kg, i.p) or vehicle from postnatal (PN) day 2 to 11, a period in which mouse brain development parallels that of the third trimester of a human pregnancy. Prior work established that adult 129SvEv (129) mice exposed to FLX in this time period (PN-FLX) showed increased avoidant and decreased hedonic behaviors, which correspond to anxiety- and depressive-like symptoms in humans, respectively. We performed baseline testing in adulthood in C57 PN-FLX animals and confirmed a similar avoidant phenotype to that reported in 129 PN-FLX mice. We then treated these animals with chronic FLX (18 mg/kg in the drinking water) and evaluated effects on two tasks that measure avoidant behavior – the open field and novelty suppressed feeding (NSF) tasks. This administration failed to improve, and even exacerbated, avoidance symptoms in PN-FLX mice. The same animals then underwent chronic administration with TIA (30 mg/kg, 2x/day, i.p.) as an alternative treatment strategy. TIA administration decreased avoidance behavior as measured in the open field and NSF. Overall, this demonstrates that TIA may be a promising alternative treatment to typical antidepressants, especially in patients whose serotonergic system has been altered.
- Published
- 2021
4. Elevated Maternal C-Reactive Protein and Increased Risk of Schizophrenia in a National Birth Cohort
- Author
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Christoph Kellendonk, Alan Brown, Andre Sourander, Sarah E. Canetta, Jaana Leiviska, Susanna Hinkka-Yli-Salomäki, Ian W. McKeague, and Heljä-Marja Surcel
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Adult ,Male ,medicine.medical_specialty ,Offspring ,Physiology ,Pregnancy Proteins ,Risk Assessment ,Article ,Cohort Studies ,Pregnancy ,Risk Factors ,Confidence Intervals ,Odds Ratio ,medicine ,Humans ,Psychiatry ,Finland ,Biological Specimen Banks ,Inflammation ,Psychopathology ,biology ,business.industry ,C-reactive protein ,Case-control study ,Odds ratio ,medicine.disease ,ta3124 ,Psychiatry and Mental health ,C-Reactive Protein ,Schizophrenia ,Case-Control Studies ,Prenatal Exposure Delayed Effects ,biology.protein ,Female ,Risk assessment ,business ,Cohort study - Abstract
The objective of the present study was to investigate an association between early gestational C-reactive protein, an established inflammatory biomarker, prospectively assayed in maternal sera, and schizophrenia in a large, national birth cohort with an extensive serum biobank.A nested case-control design from the Finnish Prenatal Study of Schizophrenia cohort was utilized. A total of 777 schizophrenia cases (schizophrenia, N=630; schizoaffective disorder, N=147) with maternal sera available for C-reactive protein testing were identified and matched to 777 control subjects in the analysis. Maternal C-reactive protein levels were assessed using a latex immunoassay from archived maternal serum specimens.Increasing maternal C-reactive protein levels, classified as a continuous variable, were significantly associated with schizophrenia in offspring (adjusted odds ratio=1.31, 95% confidence interval=1.10-1.56). This finding remained significant after adjusting for potential confounders, including maternal and parental history of psychiatric disorders, twin/singleton birth, urbanicity, province of birth, and maternal socioeconomic status.This finding provides the most robust evidence to date that maternal inflammation may play a significant role in schizophrenia, with possible implications for identifying preventive strategies and pathogenic mechanisms in schizophrenia and other neurodevelopmental disorders.
- Published
- 2014
5. Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring
- Author
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Yuanyuan Bao, Christoph Kellendonk, Catherine Schaefer, John Cruz, Francis A. Ennis, Masanori Terajima, Ling Shen, Mary Dawn T. Co, Sarah E. Canetta, and Alan Brown
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Adult ,Male ,Psychosis ,Pregnancy ,Bipolar Disorder ,business.industry ,Case-control study ,Middle Aged ,medicine.disease ,Adult offspring ,Serology ,Psychiatry and Mental health ,Schizophrenia ,Risk Factors ,Case-Control Studies ,Prenatal Exposure Delayed Effects ,Immunology ,Influenza, Human ,Medicine ,Humans ,Female ,Bipolar disorder ,Risk factor ,business - Abstract
The authors examined whether serologically confirmed maternal exposure to influenza was associated with an increased risk of bipolar disorder in the offspring and with subtypes of bipolar disorder, with and without psychotic features.The study used a nested case-control design in the Child Health and Development Study birth cohort. In all, 85 individuals with bipolar disorder were identified following extensive ascertainment and diagnostic assessment and matched to 170 comparison subjects in the analysis. Serological documentation of maternal exposure to influenza was determined using the hemagglutination inhibition assay.No association was observed between serologically documented maternal exposure to influenza and bipolar disorder in offspring. However, maternal serological influenza exposure was related to a significant fivefold greater risk of bipolar disorder with psychotic features.The results suggest that maternal influenza exposure may increase the risk for offspring to develop bipolar disorder with psychotic features. Taken together with earlier associations between prenatal influenza exposure and schizophrenia, these results may suggest that prenatal influenza is a risk factor for psychosis rather than for a specific psychotic disorder diagnosis.
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- 2014
6. PRENATAL INFECTION, MATERNAL IMMUNE ACTIVATION, AND RISK FOR SCHIZOPHRENIA
- Author
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Alan S. Brown and Sarah E. Canetta
- Subjects
medicine.medical_specialty ,Pregnancy ,Neurology ,business.industry ,Offspring ,General Neuroscience ,medicine.disease ,Affect (psychology) ,Article ,Schizophrenia ,Immunology ,Epidemiology ,Medicine ,Gestation ,business ,Immune activation - Abstract
A body of epidemiological literature has suggested an association between prenatal infection, subsequent maternal immune activation (MIA), and later risk of schizophrenia. These epidemiological studies have inspired preclinical research using rodent and primate models of prenatal infection and MIA. The findings from these preclinical studies indicate that severe infection and immune activation during pregnancy can negatively impact offspring brain development and impair adult behavior. This review aims to summarize the major epidemiological and preclinical findings addressing the connection between prenatal infection and immune activation and later risk of developing schizophrenia, as well as the more limited literature addressing the mechanisms by which this gestational insult might affect offspring neurodevelopment. Finally, directions for future research will be discussed.
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- 2013
7. SEROLOGICALLY DOCUMENTED MATERNAL INFLUENZA AND BIPOLAR DISORDER IN ADULT OFFSPRING
- Author
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Ling Shen, Yuanyuan Bao, Sarah E. Canetta, Masanori Terajima, John Cruz, Mary Dawn T. Co, Catherine Schaefer, Francis A. Ennis, Christoph Kellendonk, and Alan Brown
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Psychiatry and Mental health ,business.industry ,Immunology ,medicine ,Bipolar disorder ,medicine.disease ,Adult offspring ,business ,Biological Psychiatry - Published
- 2014
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