42 results on '"Sarah Buchanan"'
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2. Filmic memory texts: Seeing America’s archeological turn from salvage to conservation in Spadework for History
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Sarah Buchanan
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Cultural Studies ,Social Psychology ,Experimental and Cognitive Psychology - Abstract
Over two decades in mid-century America, the professional approach to sites endangered by post-war construction and development projects was to excavate and “save the data” from certain loss. Archeologists led such salvage efforts from 1945 to 1970, first meeting the increased demand for their labor and skills. Then, in seeing the permanence of destruction, they shifted by extending their concept of safe preservation into the future: an early conservationist archeology. One broad impact of the River Basin Surveys was in memorializing tribal histories and relationships to the land environment by the recovery of large swaths of biological, ecological, palynological, and geological data from excavations coordinated from branch offices in Nebraska, Oregon, California, Washington, D.C., and Texas. With funding from the National Science Foundation, Texas professor E. Mott Davis created a meticulous record of such archeological practices through a film series which captures that shift from the perspective of one of its practitioners. Spadework for History (1964), subtitled “Salvaging American History,” seeks to document the country’s anthropological archeology through a pioneering academic collaboration between film and archeology. Weighing scholarship on the production of archives—including an awakening to power in their production of history—this article considers the power of film in creating a memory text. In retelling Davis’s contribution, evidence from the films’ reception and memory studies perspectives together expand the temporal framework available to support further audiovisual collection-based analyses of professional work.
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- 2022
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3. Informative Storytelling with Provenance Research Sources
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Sarah Buchanan and Jane E. Bartley
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Provenance has underpinned archival practice in America across the past century, guiding archivists in the arrangement, description, and accessioning of new and legacy collections. Provenance research is a necessary step taken to secure pending donations and title information, and ultimately tell the story of the object’s journey to the current possessor. Across four domains of key interest in the “Developing Extensible Methods for Provenance Research” project, we examine source-specific methods that are most useful to practitioners, and communicate them in an open educational resource (OER) meant to broaden access and awareness of provenance research among administrators and students engaging with collections. Our poster will demonstrate how archival workers seek and then combine information laboriously gathered from photographs, legal documents, and handwritten materials among other resources in creative, inventive, and engaging ways that invite visitors into stories that the objects – if only they are displayed – can tell about our shared pasts and futures. Such information sources can serve a multitude of stakeholder goals, e.g. employing datapoints about transfers and handoffs to encourage object-based learning, transparency, and accountability.
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- 2022
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4. Undergraduate Learning and Research with Provenance Information
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Sarah Buchanan
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Objects in multiple formats can comprise both the subjects and the approach making up “material culture”: a mode of investigating and understanding culture. Some colleges and universities steward millions of objects in academic galleries, libraries, archives, and museums (GLAM institutions). Convergence among such information professionals has led to recent offerings of an undergraduate honors seminar around campus material culture which is the focus of analysis in this paper. Students in that setting interrogated and applied the concept of provenance in reflecting on their object-based interactions. We analyze three categories of provenance lessons from the students to inform future teaching: (1) an object’s origins and pathways, (2) what provenance is and helps people do, and (3) new storytelling contributions.
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- 2022
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5. Management of Malignant Bowel Obstruction: An Innovative Proactive Outpatient Nurse-Led Model of Care for Patients With Advanced Gynecologic Cancer
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Nazlin Jivraj, Yeh Chen Lee, Lisa Tinker, Valerie Bowering, Sarah E. Ferguson, Jennifer Croke, Katherine Karakasis, Tanya Chawla, Jenny Lau, Pamela Ng, Preeti Dhar, Eran Shlomovitz, Sarah Buchanan, Neesha Dhani, Amit M. Oza, Terri Stuart-McEwan, and Stephanie Lheureux
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Neoplasms ,Outpatients ,Palliative Care ,Quality of Life ,Humans ,Female ,Nurse's Role ,General Nursing ,Intestinal Obstruction - Abstract
Malignant bowel obstruction (MBO) in patients with advanced gynecologic cancer (GyCa) can negatively impact clinical outcomes and quality of life. Oncology nurses can support these patients with adequate tools/processes.Patients with GyCa with/at risk of MBO endure frequent emergency or hospital admissions, impacting patient care.Optimizing oncology nurses' role to improve care for patients with GyCa with/at risk of MBO, the gynecology oncology interprofessional team collaborated to develop a proactive outpatient nurse-led MBO model of care (MOC).The MBO MOC involves a risk-based algorithm engaging interdisciplinary care, utilizing standardized tools, risk-based assessment, management, and education for patients and nurses. The MOC has improved patient-reported confidence level of bowel self-management and decreased hospitalization. Following education, nurses demonstrated increased knowledge in MBO management.An outpatient nurse-led MBO MOC can improve patient care and may be extended to other cancer centers, fostering collaboration and best practice.
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- 2022
6. Envisioning networked provenance data storytelling with American cuneiform collections
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Sarah Buchanan
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Library and Information Sciences - Abstract
Cuneiform tablets remain founding cornerstones of two hundred plus collections in American academic institutions, having been acquired a century or more ago under dynamic ethical norms and global networks. To foster data sharing, this contribution incorporates empirical data from interactive ArcGIS and reusable OpenContext maps to encourage tandem dialogues about using the inscribed works and learning their collecting histories. Such provenance research aids, on their own, initiate the narration of objects’ journeys over time while cultivating the digital inclusion of expert local knowledge relevant to an object biography. The paper annotates several approaches institutions are or might consider using to expand upon current provenance information in ways that encourage visitors’ critical thinking and learning about global journeys, travel archives, and such dispositions as virtual reunification, reconstructions, or restitution made possible by the provenance research.
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- 2022
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7. Indigenous Languages and the Promise of Archives. AdriannaLink, AbigailShelton, and PatrickSpero, eds. Lincoln: University of Nebraska Press, 2021. 517+xviii pp. ISBN 978‐1‐4962‐2433‐0
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Sarah Buchanan
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Anthropology ,Museology - Published
- 2022
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8. The psychosocial needs of patients who have chronic kidney disease without kidney replacement therapy: a thematic synthesis of seven qualitative studies
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Sarah Buchanan and Christina Seery
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Renal Replacement Therapy ,Nephrology ,Renal Dialysis ,Humans ,Renal Insufficiency, Chronic ,Qualitative Research - Abstract
Background Limited quantitative data suggests that patients who have chronic kidney disease without kidney replacement therapy (CKD without KRT) may present with psychosocial needs just as patients who have acute kidney injury and are treated by dialysis (AKI stage 3D) do. This systematic review aims to synthesise qualitative research on patients’ experiences of CKD without KRT to provide further insight into patients’ experience of the healthcare they receive and simultaneously, their psychosocial needs, to inform the development of appropriate psychological interventions. Methods The review followed ENTREQ guidelines. PubMed/MEDLINE, PsycINFO, EMBASE and CINAHL were searched in July and August 2021. Qualitative studies in English on the experiences of CKD without KRT care were included in the review. Thematic synthesis was conducted on the findings of the included studies. Results The search identified 231 articles for screening. Eight studies met the inclusion criteria, and one was excluded at the quality assessment stage. The final seven articles [n = 130 patients] were analysed. Five themes on psychosocial needs were developed: addressing patients’ CKD-related educational needs, supporting the patient’s relationships, honouring the patient’s need for control, adjusting to change, and recognising fear of disease and treatment. Discussion This review highlights the range of psychosocial needs of patients who have CKD without KRT. There are numerous intervention options that clinicians may develop that could benefit patients and address multiple needs, such as group educational programmes. Graphical abstract
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- 2022
9. Evaluating the Effect of Parent-Child Interactive Groups in a School-Based Parent Training Program: Parenting Behavior, Parenting Stress and Sense of Competence
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Sarah, Buchanan-Pascall, Glenn A, Melvin, Michael S, Gordon, and Kylie M, Gray
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The Exploring Together program is a group-based parent training program that comprises separate parent, child, and teacher components, and a combined parent-child interactive component. A cluster-randomized trial design was used to compare the Exploring Together program with (Exploring Together; ET) and without (Exploring Together-Adapted; ET-Adapted) the parent-child interactive component. One hundred and thirty-six parents and their children (aged 5-10 years) with externalizing and/or internalizing problems participated in the trial, recruited from primary schools. There was a significant reduction in negative parenting behavior across both treatment groups (ET and ET-Adapted) but no significant improvement in positive parenting behaviors. Parenting self-efficacy improved significantly across both treatment groups however there was no significant change in parenting satisfaction or parenting stress. There was no consistent evidence of superiority of one version of the Exploring Together program over the other. Further investigation regarding treatment dosage and mastery of parenting skills associated with the program is warranted.
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- 2021
10. Recordkeeping Cultures (2nd ed.). By Gillian Oliver and Fiorella Foscarini
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Sarah Buchanan
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Library and Information Sciences ,Education - Published
- 2022
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11. Optimizing the Care of Malignant Bowel Obstruction in Patients With Advanced Gynecologic Cancer
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Johane P. Allard, Yeh Chen Lee, Sunu Cyriac, Eran Shlomovitz, Sarah Buchanan, Catherine A. O’Brien, Tanya P. Chawla, Lisa Tinker, Jenny Lau, Terri Stuart-McEwan, Nazlin Jivraj, Jennifer Croke, Kashish Nathwani, Pamela Ng, Katherine Karakasis, Valerie Bowering, Amit M. Oza, Sarah E. Ferguson, Lisa Wang, Neesha C. Dhani, and Stephanie Lheureux
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Adult ,Canada ,medicine.medical_specialty ,Genital Neoplasms, Female ,MEDLINE ,ORIGINAL CONTRIBUTIONS ,03 medical and health sciences ,0302 clinical medicine ,Gynecologic cancer ,medicine ,Humans ,Intestinal obstruction surgery ,In patient ,Focus on Quality ,030212 general & internal medicine ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Ovarian Neoplasms ,Oncology (nursing) ,business.industry ,Health Policy ,General surgery ,Palliative Care ,Middle Aged ,medicine.disease ,Hospitalization ,Bowel obstruction ,Oncology ,030220 oncology & carcinogenesis ,Genital neoplasm ,Female ,Neoplasm staging ,Complication ,business ,Intestinal Obstruction - Abstract
PURPOSE: Malignant bowel obstruction (MBO) is a common and distressing complication in women with advanced gynecologic cancer. A pilot, interprofessional MBO program was launched in 2016 at a large Canadian tertiary cancer center to integrate these patients’ complex care needs across multiple disciplines and support women with MBO. METHOD: Retrospective analysis to evaluate the outcomes of women with advanced gynecologic cancer who were admitted to hospital because of MBO, before (2014 to 2016: baseline group) and after (2016 to 2018) implementation of the MBO program. RESULTS: Of the 169 women evaluated, 106 and 63 were in the baseline group and MBO program group, respectively. Most had ovarian cancer (n = 124; 73%) and had small-bowel obstruction (n = 131; 78%). There was a significantly shorter cumulative hospital length of stay (LOSsum) within the first 60 days of MBO diagnosis in the MBO program group compared with the baseline group (13 v 22 days, respectively; adjusted P = .006). The median overall survival for women treated in the MBO program was also significantly longer compared with the baseline group (243 v 99 days, respectively; adjusted P = .002). Using the interprofessional MBO care platform, a greater proportion of patients received palliative chemotherapy (83% v 56%) and less surgery (11% v 21%) in the MBO program group than in the baseline group, respectively. A subgroup of women (n = 11) received total parenteral nutrition for longer than 6 months. CONCLUSION: Implementation of a comprehensive, interprofessional MBO program significantly affects patient care and may improve outcomes. Unique to this MBO program is an integrated outpatient model of care and education that empowers patients to recognize MBO symptoms for early intervention.
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- 2019
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12. Evaluating the Role of Parent-Child Interactive Groups in a Parent Training Program for Children with Externalizing and/or Internalizing Behavior Problems
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Sarah Buchanan-Pascall, Glenn A. Melvin, Kylie Megan Gray, and Michael Gordon
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Family studies ,Social Psychology ,Randomized controlled trial ,law ,education ,Developmental and Educational Psychology ,Parent training ,Psychology ,Mental health ,Education ,law.invention ,Clinical psychology - Abstract
SYNOPSISObjective: This study evaluated the role of parent-child interactive groups in a group-based parent training program for children with externalizing and/or internalizing behavior problems; ...
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- 2019
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13. Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape
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Sarah Buchanan, Paul G. Shiels, Natália A. Borges, Ludmila F M F Cardozo, Denise Mafra, Hannah Craven, Milena B. Stockler-Pinto, Marta Esgalhado, Bengt Lindholm, and Peter Stenvinkel
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0301 basic medicine ,Aging ,Nutritional Status ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,Biology ,Bioinformatics ,Epigenesis, Genetic ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Gene expression ,medicine ,Humans ,Microbiome ,Epigenetics ,Renal Insufficiency, Chronic ,Gene ,Nutrition and Dietetics ,DNA Methylation ,medicine.disease ,Phenotype ,030104 developmental biology ,Gene Expression Regulation ,chemistry ,DNA methylation ,DNA ,Kidney disease - Abstract
Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Although few studies have actually reported alterations of DNA methylation via methyl donor nutrient intake, emerging evidence indicates that nutritional modification of the microbiome can affect one-carbon metabolism and the capacity to methylate the genome in CKD. In this review, we discuss the nutritional modifications that may affect one-carbon metabolism and the possible impact of methyl donor nutrients on the microbiome, CKD, and its phenotype.
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- 2019
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14. There Is No Substitute for Effective Education About Biosimilars
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Angela Sandell, Sarah Buchanan, Laura Wingate, Megan McNicol, Ross M Maltz, Sandra C. Kim, and David T. Rubin
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Risk analysis (engineering) ,business.industry ,Gastroenterology ,Medicine ,Biosimilar ,business - Published
- 2021
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15. Endangered but not too late : the state of digital news preservation
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Kara Van Malssen, Dorothy Carner, Bernard Reilly, Neil Mara, Sandy Schiefer, Kerri Willette, Edward McCain, Sarah Buchanan, and Joe Askins
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History ,business.industry ,Digital preservation ,Midnight ,Section (typography) ,Electronic publishing ,State (computer science) ,Business model ,business ,Computer security ,computer.software_genre ,computer - Abstract
"What we found in this research is that news organizations are saving digital news content to at least a limited extent, one that often depends on the kind of technologies where news content resides, their purpose, and other key factors. We found that the degree to which your existing content is accessible and useful depends not only on the technologies used, but also on your policies, if any, about what is saved. Other factors that affect access to content include the workflows used to assemble and store content, the metadata that’s saved with your content--or missing depending on how it is managed--whether or not you have staff dedicated to preservation work, and how well content translates when you undergo a transition from one technology platform to another, an inevitable fact of life in today’s publishing industry. News organizations that use either an archive or digital asset management (DAM) system of some kind have the most control of the content used to post, publish, broadcast or stream the news. They are also in the best position to find and access past content, understand its origins and licensing rights, reuse it for new products, tap it for newsroom research, publish it in related content links, and take full advantage of the long-tail phenomenon by reselling to the public or research community. ..."--Findings summar
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- 2021
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16. ‘They call teachers by their first names!’
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Sarah Buchanan, Abigail Luna, Kelli McLaughlin, Michael Kamen, Abigail Earle, Alys Mendus, and Adaire Kamen
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- 2020
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17. Klotho, Aging, and the Failing Kidney
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Emilie Combet, Sarah Buchanan, Peter Stenvinkel, and Paul G. Shiels
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0301 basic medicine ,kidney ,senotherapeutic ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Review ,Gut flora ,urologic and male genital diseases ,Fibroblast growth factor ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Klotho ,03 medical and health sciences ,Endocrinology ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Humans ,Renal Insufficiency, Chronic ,Fibroblast ,Receptor ,Klotho Proteins ,Glucuronidase ,phosphate ,Kidney ,lcsh:RC648-665 ,biology ,business.industry ,aging ,medicine.disease ,biology.organism_classification ,female genital diseases and pregnancy complications ,Pathophysiology ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,030104 developmental biology ,medicine.anatomical_structure ,business ,Signal Transduction ,Kidney disease - Abstract
Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. The α-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism. Phosphate toxicity is a hallmark of mammalian aging and correlates with diminution of Klotho levels with increasing age. As such, modulation of Klotho activity is an attractive target for therapeutic intervention in the diseasome of aging; in particular for chronic kidney disease (CKD), where Klotho has been implicated directly in the pathophysiology. A range of senotherapeutic strategies have been developed to directly or indirectly influence Klotho expression, with varying degrees of success. These include administration of exogenous Klotho, synthetic and natural Klotho agonists and indirect approaches, via modulation of the foodome and the gut microbiota. All these approaches have significant potential to mitigate loss of physiological function and resilience accompanying old age and to improve outcomes within the diseasome of aging.
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- 2020
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18. Identifying Differing Intracellular Cargo Release Mechanisms by Monitoring
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Panagiota, Markopoulou, Nikolaos, Panagiotou, Aurelia, Li, Rocio, Bueno-Perez, David, Madden, Sarah, Buchanan, David, Fairen-Jimenez, Paul G, Shiels, and Ross S, Forgan
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real-time cell analysis ,drug delivery ,anticancer ,metal-organic frameworks ,nanomedicine ,in vitro ,doxorubicin ,Article - Abstract
Summary Metal-organic frameworks (MOFs) have been proposed as biocompatible candidates for the targeted intracellular delivery of chemotherapeutic payloads, but the site of drug loading and subsequent effect on intracellular release is often overlooked. Here, we analyze doxorubicin delivery to cancer cells by MIL-101(Cr) and UiO-66 in real time. Having experimentally and computationally verified that doxorubicin is pore loaded in MIL-101(Cr) and surface loaded on UiO-66, different time-dependent cytotoxicity profiles are observed by real-time cell analysis and confocal microscopy. The attenuated release of aggregated doxorubicin from the surface of Dox@UiO-66 results in a 12 to 16 h induction of cytotoxicity, while rapid release of pore-dispersed doxorubicin from Dox@MIL-101(Cr) leads to significantly higher intranuclear localization and rapid cell death. In verifying real-time cell analysis as a versatile tool to assess biocompatibility and drug delivery, we show that the localization of drugs in (or on) MOF nanoparticles controls delivery profiles and is key to understanding in vitro modes of action., Graphical Abstract, Highlights Comprehensive analysis confirms in vitro biocompatibility of UiO-66 and MIL-101(Cr) Real-time observation of doxorubicin delivery from MOFs and subsequent cytotoxicity Location of drug within MOF nanoparticles greatly affects release mechanisms Tunable anticancer cytotoxicity profiles are possible by modifying drug location, Markopoulou et al. demonstrate that real-time cell analysis can be used to assess biocompatibility and drug delivery from MOFs. Different time-dependent cytotoxicity profiles occur when drugs are pore loaded versus surface loaded, making tunable drug release possible.
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- 2020
19. Systematic Review and Meta-analysis of Parent Group Interventions for Primary School Children Aged 4–12 Years with Externalizing and/or Internalizing Problems
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Michael Gordon, Sarah Buchanan-Pascall, Glenn A. Melvin, and Kylie Megan Gray
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Male ,Parents ,050103 clinical psychology ,medicine.medical_specialty ,medicine.medical_treatment ,education ,Psychological intervention ,Child Behavior Disorders ,law.invention ,Group psychotherapy ,Randomized controlled trial ,Behavior Therapy ,law ,Intervention (counseling) ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Child ,Psychiatry ,Defense Mechanisms ,Problem Behavior ,Schools ,05 social sciences ,Moderation ,Psychiatry and Mental health ,Treatment Outcome ,Child, Preschool ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Parent training ,Anxiety ,Female ,medicine.symptom ,Psychology ,050104 developmental & child psychology ,Clinical psychology - Abstract
This systematic review and meta-analysis evaluates the efficacy of parent training group interventions to treat child externalizing and/or internalizing problems. A search identified 21 randomized controlled trials of parent group interventions aimed at ameliorating child externalizing and/or internalizing problems in children aged 4-12 years. Random effects meta-analyses yielded significant pooled treatment effect size (g) estimates for child externalizing (g = -0.38) and internalizing problems (g = -0.18). Child anxiety symptoms or internalizing problems evident in children with externalizing behavior problems did not change significantly following intervention. Study quality was a statistically significant moderator of treatment response for child externalizing problems, however hours of planned parent group treatment and treatment recipient were not. Findings support the use of parent group interventions as an effective treatment for reducing externalizing problems in children aged 4-12 years. Whilst statistically significant, programs had a limited impact on internalizing symptoms, indicating a need for further investigation.
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- 2017
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20. Outil de sensibilisation des proches à la conduite automobile des aînés
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Sarah Buchanan, Ariane Vigeant, Mylène Arseneault-Legault, Rachel Boily, Jean-François Carosella, and Mélanie Levasseur
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Male ,Gerontology ,Automobile Driving ,030506 rehabilitation ,Health (social science) ,Future studies ,Poison control ,Suicide prevention ,Occupational safety and health ,03 medical and health sciences ,Surveys and Questionnaires ,Intervention (counseling) ,0502 economics and business ,Injury prevention ,Openness to experience ,Humans ,Medicine ,Family ,Aged ,Community and Home Care ,050210 logistics & transportation ,business.industry ,05 social sciences ,Human factors and ergonomics ,Middle Aged ,Ethnology ,Female ,Safety ,Geriatrics and Gerontology ,0305 other medical science ,business - Abstract
This study aimed to explore the impact of an awareness tool for relatives of older drivers (OSCARPA) on i) their interest, openness and knowledge, ii) changes of abilities required for safe driving, and iii) utilization of compensatory strategies. A pre-experimental design with pretest (T0) and post-test (T1) eight to ten weeks after the intervention was realized with 45 relatives in contact with an older driver of 65 years old or older and who was driving at least once a week. Overall, the results demonstrated that OSCARPA increased i) interest, openness and knowledge of relatives (p
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- 2017
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21. Evaluation of the CAMHS and Schools Early Action (CASEA) Exploring Together Early Primary School Program
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SARAH BUCHANAN-PASCALL
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education ,Developmental and Educational Psychology - Abstract
This thesis comprises an evaluation of a group-based parent training program for primary school aged children with behavioural and/or emotional problems. The study compares the relative effectiveness of two versions of Monash Health’s adapted Exploring Together program, with and without the parent-child interactive component, in terms of the impact on child behaviour, parenting behaviour, parenting stress and sense of competence. This thesis contributes to a deeper understanding of the effectiveness of group-based parent training programs for treatment of child behaviour problems in primary school settings, as well as highlighting areas requiring further clinical and research attention.
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- 2020
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22. Nrf2 in early vascular ageing: Calcification, senescence and therapy
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Julia Steinmetz, Sarah Buchanan, Shno Alsalhi, Karolina Kublickiene, Paul G. Shiels, Sam Hobson, Samsul Arefin, and Peter Stenvinkel
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0301 basic medicine ,Senescence ,Aging ,NF-E2-Related Factor 2 ,Clinical Biochemistry ,Inflammation ,Context (language use) ,medicine.disease_cause ,environment and public health ,Biochemistry ,Cardiovascular System ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Humans ,Vascular Calcification ,Transcription factor ,Cellular Senescence ,chemistry.chemical_classification ,Reactive oxygen species ,business.industry ,Biochemistry (medical) ,General Medicine ,respiratory system ,medicine.disease ,030104 developmental biology ,chemistry ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Cancer research ,medicine.symptom ,Carcinogenesis ,business ,Oxidative stress ,Calcification ,Signal Transduction - Abstract
Under normal physiological conditions, free radical generation and antioxidant defences are balanced, and reactive oxygen species (ROS) usually act as secondary messengers in a plethora of biological processes. However, when this balance is impaired, oxidative stress develops due to imbalanced redox homeostasis resulting in cellular damage. Oxidative stress is now recognized as a trigger of cellular senescence, which is associated with multiple chronic 'burden of lifestyle' diseases, including atherosclerosis, type-2 diabetes, chronic kidney disease and vascular calcification; all of which possess signs of early vascular ageing.\ud \ud Nuclear factor erythroid 2-related factor 2 (Nrf2), termed the master regulator of antioxidant responses, is a transcription factor found to be frequently dysregulated in conditions characterized by oxidative stress and inflammation. Recent evidence suggests that activation of Nrf2 may be beneficial in protecting against vascular senescence and calcification. Both natural and synthetic Nrf2 agonists have been introduced as promising drug classes in different phases of clinical trials. However, overexpression of the Nrf2 pathway has also been linked to tumorigenesis, which highlights the requirement for further understanding of pathways involving Nrf2 activity, especially in the context of cellular senescence and vascular calcification.\ud \ud Therefore, comprehensive translational pre-clinical and clinical studies addressing the targeting capabilities of Nrf2 agonists are urgently required. The present review discusses the impact of Nrf2 in senescence and calcification in early vascular ageing, with focus on the potential clinical implications of Nrf2 agonists and non-pharmacological Nrf2 therapeutics.
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- 2019
23. Allostatic load and ageing: linking the microbiome and nutrition with age-related health
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Paul G. Shiels, Colin Selman, Sarah Buchanan, and Peter Stenvinkel
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Gerontology ,Exposome ,Aging ,media_common.quotation_subject ,Nutritional Status ,Disease ,030204 cardiovascular system & hematology ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Microbiome ,Life Style ,030304 developmental biology ,media_common ,Inflammation ,0303 health sciences ,business.industry ,Allostasis ,Epigenome ,Allostatic load ,Diet ,Gastrointestinal Microbiome ,Ageing ,Psychological resilience ,business - Abstract
Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature of age-related morbidities, which also appear to share common underpinning features, including low-grade persistent inflammation, phosphate toxicity, diminished Nrf2 activity, a depleted metabolic capability, depressed mitochondrial biogenesis and a low diversity gut microbiome. Social, psychological, lifestyle and nutritional risk factors can all influence the trajectory of age-related health, as part of an individual's exposome, which reflects the interplay between the genome and the environment. This is manifest as allostatic (over)load reflecting the burden of lifestyle/disease at both a physiological and molecular level. In particular, age-related genomic methylation levels and inflammatory status reflect exposome differences. These features may be mediated by changes in microbial diversity. This can drive the generation of pro-inflammatory factors, such as TMAO, implicated in the ‘diseasome’ of ageing. Additionally, it can be influenced by the ‘foodome’, via nutritional differences affecting the availability of methyl donors required for maintenance of the epigenome and by the provision of nutritionally derived Nrf2 agonists. Both these factors influence age-related physiological resilience and health. This offers novel insights into possible interventions to improve health span, including a rage of emerging senotherapies and simple modifications of the nutritional and environmental exposome. In essence, the emerging strategy is to treat ageing processes common to the diseasome of ageing itself and thus preempt the development or progression of a range of age-related morbidities.
- Published
- 2019
24. The development, delivery and evaluation of a year-long skills and formulation training programme in a community residential rehabilitation setting
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Sarah Buchanan and Rosanne Shocolinsky-Dwyer
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Clinical Psychology - Abstract
The psychologist’s role in rehabilitation settings includes supporting both team formulation and training (e.g. New Ways of Working, 2007). This article summarises our attempts to embed formulation within a year-long training programme in a community rehabilitation setting.
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- 2016
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25. Guiding Principles of Practice
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Maren Willins, Sarah Buchanan, and Ashley Ratliff
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Engineering ,Guiding Principles ,business.industry ,Engineering ethics ,business - Published
- 2018
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26. The Role of Cannabis in the Management of Inflammatory Bowel Disease: A Review of Clinical, Scientific, and Regulatory Information
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Nada Zmeter, David T. Rubin, Laura Wingate, Arun Swaminath, Adam S. Cheifetz, Jami Kinnucan, Sarah Buchanan, Eric P Berlin, and Edward J. Hoffenberg
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0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Medical Marijuana ,Inflammatory bowel disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,White paper ,medicine ,Immunology and Allergy ,Humans ,Intensive care medicine ,Crohn's disease ,Government ,biology ,business.industry ,Gastroenterology ,Disease Management ,medicine.disease ,biology.organism_classification ,Inflammatory Bowel Diseases ,Prognosis ,030104 developmental biology ,Government Regulation ,Biomarker (medicine) ,030211 gastroenterology & hepatology ,Cannabis ,Cannabinoid ,Leading Off ,business - Abstract
There is significant interest among patients and providers in using cannabis (marijuana) and its derivatives to treat a number of chronic illnesses, including inflammatory bowel disease. Despite the Schedule I classification of cannabis by the federal government, state governments have sought ways to make cannabis available for specific medical conditions, and some states have legalized cannabis outright. This white paper summarizes the preclinical data, clinical data, safety data, and the regulatory landscape as they apply to medical cannabis use in inflammatory bowel disease. Animal models of cannabinoid chemistry and physiology give evidence of anti-inflammatory, antidiarrheal, and nociceptive-limiting properties. Human studies have found benefit in controlling symptoms and improving quality of life, but no studies have established true disease modification given the absent improvement in biomarker profiles or endoscopic healing. Finally, this review describes the legal, regulatory, and practical hurdles to studying the risks and benefits of medical cannabis in the United States. 10.1093/ibd/izy319_video1 izy319.video1 5852852028001
- Published
- 2018
27. CSTutor
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Sarah Buchanan and Joseph J. LaViola
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AVL tree ,General Computer Science ,Computer science ,Whiteboard ,Programming language ,Interface (Java) ,Linked list ,computer.software_genre ,Data structure ,Sketch ,Education ,Visualization ,Binary search tree ,computer - Abstract
We present CSTutor, a sketch-based interface designed to help students understand data structures, specifically Linked Lists, Binary Search Trees, AVL Trees, and Heaps. CSTutor creates an environment that seamlessly combines a user’s sketched diagram and code. In each of these data structure modes, the user can naturally sketch a data structure on the canvas just as they would on a white board. CSTutor analyzes the user’s diagrams in real time, and automatically generates code in a separate code view to reflect any changes the user has made. Additionally, the code can also be edited and any new code changes will animate the data structure drawn on the canvas. The connection between the data structure drawn on the canvas and the code implementation is intended to bridge the gap between the conceptual diagram of a data structure and the actual implementation. We also present the results of two semester-long studies using CSTutor in a CS1 course. The results indicate that students preferred CSTutor and were more engaged using it than a standard whiteboard lecture; however, results were mixed in quiz and exam performance.
- Published
- 2014
- Full Text
- View/download PDF
28. Implementation of malignant bowel obstruction multidisciplinary case conferences (MCCs) to improve clinical decision making in malignant bowel obstruction (MBO) in gynecologic oncology
- Author
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Sarah Buchanan, Catherine O'Brien, Amit M. Oza, Luisa Bonilla, Neesha C. Dhani, Gita Bhat, Ainhoa Madariaga, Yeh Chen Lee, Katherine Karakasis, Sarah E. Ferguson, Muralidharan Chllamma, Jenny Lau, Stephanie Lheureux, Susan Mulumba, Eran Shlomovitz, Nazlin Jivraj, Tanya Chawla, and Preeti Dhar
- Subjects
Bowel obstruction ,Cancer Research ,medicine.medical_specialty ,Oncology ,Clinical decision making ,Multidisciplinary approach ,business.industry ,General surgery ,Medicine ,Gynecologic oncology ,business ,medicine.disease ,Gynecological cancer - Abstract
e18322 Background: Though patients (pts) with gynecological cancer are at higher risk of MBO, clinical management is not well defined. We implemented a coordinated team approach to evaluate MBO at Princess Margaret Cancer Centre. The Princess Margaret Cancer Centre inter-professional MBO management program includes nurse led ambulatory symptom management, inpatient treatment algorithm, patient directed bowel management education & MCCs. This study evaluates the utility of MBO MCC on clinical decision making in gynecologic oncology. Methods: Monthly MBO MCCs are conducted to discuss complex clinical management issues. A clinical summary is presented prior to the discussion with each case incorporating radiology review followed by interdisciplinary discussion. In this study, the initial management plan was compared to post-MCC consensus. A change in plan was defined as a consensus plan different from the pre-MCC plan or no definite plan prior to MCC. Barriers to implementation of the consensus were analyzed. Results: From December 2016 to November 2018, 90 pts were discussed in 22 MCCs. Of these, 60 had high grade serous ovarian carcinoma (67%) & 64 had small bowel obstruction (71%). Discussion in MCCs lead to a change in management plan in 49 cases(54%). These changes included recommendations for palliative surgery (25%) or radiation (10%), interventional radiology (23%), pharmacologic management alone (14%), imaging studies (4%) & total parenteral nutrition (TPN) (4%). Chemotherapy continuation, break or regimen changes were recommended in 20%. MCC consensus plan could not be implemented in 11 cases (23%). The barriers were refusal of surgery (8%), interventional radiology procedures (2%), TPN (4%) by patients, functional decline (6%) & inability to create a colostomy due to dense adhesions (2%). During MCC referrals to the dietitian & palliative care team were planned for 16 (18%) & 22 (24%) pts respectively. Conclusions: Interdisciplinary MBO MCCs have a significant impact on decision making in complex MBO cases. Radiology review & group discussion facilitates greater clarity in formulation of a management plan.
- Published
- 2019
- Full Text
- View/download PDF
29. Legislative Advocacy
- Author
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Sarah Buchanan
- Published
- 2017
- Full Text
- View/download PDF
30. Visualization of Classical Architecture from Literature: Cultural Motifs and the Case of Alexander’s Monument
- Author
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Sarah Buchanan
- Subjects
Information visualization ,business.industry ,Computer science ,Human–computer interaction ,General Arts and Humanities ,Classical architecture ,business ,Visualization - Published
- 2010
- Full Text
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31. Defining Social Work within Holistic Public Defense: Challenges and Implications for Practice
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Sarah Buchanan and Roger M. Nooe
- Subjects
Social Work ,Sociology and Political Science ,Social work ,business.industry ,05 social sciences ,Environmental resource management ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,Holistic Health ,Public relations ,Tennessee ,Lawyers ,Component (UML) ,Forensic social work ,050501 criminology ,Humans ,0501 psychology and cognitive sciences ,Sociology ,Public defender ,business.job_title ,business ,050104 developmental & child psychology ,0505 law ,Forecasting - Abstract
Social work has a history of forensic practice, but social work as an integral component of the holistic model of public defense is new and is creating a demand for better definition of roles and services. The intent of this article is to contribute to and encourage dialogue surrounding social work practice within the holistic public defense model. A brief overview of the indigent criminal defense system and its emerging models of defense practice is provided. Models of practice established by the Knox County Public Defender's Community Law Office are offered. Challenges, implications, and future directions are discussed.
- Published
- 2015
32. The Influence of Multi-Touch Interaction on Procedural Training
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Joseph J. LaViola, Jared N. Bott, and Sarah Buchanan
- Subjects
Procedural training ,Computer science ,Human–computer interaction ,Significant difference ,Multi-touch ,Transfer of learning ,Procedural knowledge ,Sensorimotor skills ,Task (project management) ,Test (assessment) - Abstract
This paper explores the use of multi-touch interaction in a 3D training environment as a way to enhance learning of sensorimotor skills as well as procedural knowledge. We present a between subjects experiment with 36 participants distributed into 3 groups that use multi-touch interaction, interaction with the physical apparatus, and a control group using basic mouse-based interaction. A post-training test carried out 3 days later evaluated performance in conducting the real world task from memory. Results show that the multi-touch interaction and the real world groups had significantly better performance scores than the mouse interaction group, with no significant difference between multi-touch and real world groups. Our results demonstrate that multi-touch interaction trained participants on the task as well as training on the actual equipment, indicating multi-touch interaction is a potential replacement for the physical apparatus when doing procedural training.
- Published
- 2015
- Full Text
- View/download PDF
33. Novel malignant bowel obstruction (MBO) management program for women with advanced gynecological cancer
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Yeh Chen Lee, Johane P. Allard, Terri Stuart-McEwan, Sarah E. Ferguson, Catherine A. O’Brien, Pamela Savage, Preeti Dhar, Jenny Lau, Amit M. Oza, Lisa Tinker, Stephane Laframboise, Sarah Buchanan, Pamela Ng, Stephanie Lheureux, Marcus O. Butler, Neesha C. Dhani, Tanya Chawla, Eran Shlomovitz, Nazlin Jivraj, and Jennifer Croke
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Palliative care ,Symptom management ,business.industry ,medicine.disease ,Gynecological cancer ,Bowel obstruction ,03 medical and health sciences ,0302 clinical medicine ,Parenteral nutrition ,Quality of life (healthcare) ,030502 gerontology ,030220 oncology & carcinogenesis ,Internal medicine ,Family medicine ,Ambulatory ,Cancer centre ,medicine ,0305 other medical science ,business - Abstract
158 Background: Malignant bowel obstruction (MBO) is a common and challenging clinical predicament in women with advanced gynecological cancers. However, there is a lack of evidence-based guidelines or innovative approaches to improve patient care and quality of life. We implemented an inter-professional MBO management program incorporating a nurse-led ambulatory symptom management algorithm and multidisciplinary care conferences (MCC) as hallmarks of this program. Methods: Princess Margaret Cancer Centre has piloted an inter-professional MBO management program that supports women with advanced gynecological cancers who are at risk of/have developed MBO. The MBO team includes oncologists (medical, surgical, gynecologic and radiation), palliative care physicians, diagnostic and interventional radiologists, home parenteral nutrition physicians, specialized oncology nurses, dietitians, pharmacists and social workers. Complex MBO cases are discussed at regular MCC to derive treatment consensus. A symptom-driven MBO management algorithm has been devised and all patients are educated with a personalized bowel symptom management and dietary plan. For outpatient care, patients with MBO are proactively monitored by our specialized oncology nurses via phone or an eHealth bowel application to facilitate communication of symptoms and early intervention. Access to community services and home palliative care services are utilized to support care at home. All patients are enrolled into a prospective database to assess care impact and quality. Results: A total of 145 patients have been followed through the MBO management program over 12 months. At time of data cutoff, 14 had MBO (3 inpatients and 11 outpatients) and 22 were deemed at risk of MBO. Majority patients are managed as an outpatient and avoided unnecessary emergency department episodes. Detailed methodology and data analyses will be presented. Conclusions: A successful novel MBO program incorporating inter-professional care model and nurse-led ambulatory symptom management algorithm optimizes patient care in this vulnerable population and foster collaboration in implementing best practice clinical processes.
- Published
- 2017
- Full Text
- View/download PDF
34. Risk-stratified multidisciplinary ambulatory management of malignant bowel obstruction (MAMBO) program for women with advanced gynecological cancer
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Eran Shlomovitz, Johane P. Allard, Nazlin Jivraj, Toral Patel, Jennifer Croke, Lisa Tinker, Katherine Karakasis, Jenny Lau, Alexandra M. Easson, Stephane Laframboise, Yeh Chen Lee, Pamela Ng, Terri Stuart-McEwan, Pamela Savage, Sarah Buchanan, Catherine O'Brien, Amit M. Oza, Tanya Chawla, and Stephanie Lheureux
- Subjects
Cancer Research ,medicine.medical_specialty ,Poor prognosis ,business.industry ,General surgery ,Gynecologic oncology ,medicine.disease ,Gynecological cancer ,Bowel obstruction ,Oncology ,Quality of life ,Multidisciplinary approach ,Ambulatory ,Medicine ,business - Abstract
e18024 Background: Malignant bowel obstruction (MBO) in gynecologic oncology patients is associated with poor prognosis, debilitating symptoms and compromises quality of life. Management of MBO poses a clinical challenge with prolonged hospitalization. Evidence based guidelines for surgical intervention, use of chemotherapy, total parenteral nutrition or best supportive care in this patient population is lacking. Surgical correction may improve survival in selected patients. Retrospective analysis to assess impact of MBO show variable range of MBO-related admissions up to 60 days, and is associated with significant morbidity. Methods: A risk stratified MAMBO program for gynecologic patients has been implemented at Princess Margaret Cancer Centre to define a systematic approach for MBO management and build multidisciplinary consensus for personalized treatment of our patients. The program is novel and includes a nurse-led ambulatory management algorithm with an eHealth application designed to monitor bowel symptoms. A symptom-driven classification system has been devised to objectively define risk using a MBO management algorithm. Complex MBO cases are discussed in designated MBO rounds for consensus treatment recommendation. All patients with MBO are enrolled into a prospective database. Patients undergoing surgical procedures for MBO are consented for opportunistic tissue collection for translational research. MBO patient education materials have been developed to improve awareness and encourage proactive bowel symptom management. Results: Seventy nine patients have been followed through this risk stratified MAMBO program for ambulatory care over 6 months. The MBO program integrates diet, laxatives/stool softeners and drug therapy. Designated MBO rounds are now established for complex case discussion. A prospective MBO database will evaluate treatment and patient-reported outcomes. Conclusions: Risk stratified model of care for multidisciplinary MBO program facilitates decision-making between disciplines and optimize patient care in a vulnerable population with support for ambulatory care.
- Published
- 2017
- Full Text
- View/download PDF
35. Multimodal Input for Perceptual User Interfaces
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Corey Pittman, Joseph J. LaViola, and Sarah Buchanan
- Subjects
Facial expression ,Computer science ,Human–computer interaction ,Eye tracking ,Perceptual user interfaces ,Multimodal interaction ,Gesture - Published
- 2014
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- View/download PDF
36. Designing the Research Commons: Classical Models for School Libraries
- Author
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Sarah Buchanan
- Abstract
School libraries and media centers today are embracing the idea of the "learning commons," an approach to learning which makes use of the facility's physical openness and group meeting places to facilitate current shifts towards computer-based resource sharing and collaborative student projects. How can libraries yet to make this transition reverse a prior, mid-twentieth-century architectural bent toward segmentation of school library resources from the surrounding institution, and implement a more inclusive school library design?
- Published
- 2001
- Full Text
- View/download PDF
37. A practical framework for constructing structured drawings
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Salman Cheema, Joseph J. LaViola, Sumit Gulwani, and Sarah Buchanan
- Subjects
Engineering drawing ,Line segment ,Computer science ,Programming by example ,Technical drawing ,business.industry ,Computer graphics (images) ,Inference ,Natural (music) ,User interface ,business ,Sketch ,Gesture - Abstract
We describe a novel theoretical framework for modeling structured drawings which contain one or more patterns of repetition in their constituent elements. We then present PatternSketch, a sketch-based drawing tool built using our framework to allow quick construction of structured drawings. PatternSketch can recognize and beautify drawings containing line segments, polylines, arcs, and circles. Users can employ a series of gestures to identify repetitive elements and create new elements based on automatically inferred patterns. PatternSketch leverages the programming-by-example (PBE) paradigm, enabling it to infer non-trivial patterns from a few examples. We show that PatternSketch, with its sketch-based user interface and a unique pattern inference algorithm, enables efficient and natural construction of structured drawings.
- Published
- 2014
- Full Text
- View/download PDF
38. Translating Freedom Between Cultures and Ideologies: A Comparative Analysis of the Translation of Keywords in Galatians
- Author
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Sarah Buchanan
- Subjects
Literature ,Bible translations ,business.industry ,media_common.quotation_subject ,Pragmatics ,language.human_language ,Key (music) ,German ,New Testament ,Political science ,language ,Translation studies ,Ideology ,business ,media_common - Abstract
This paper presents a comparative analysis of Bible translations in German, French, Spanish and English targeted towards a range of cross-confessional audiences. It focuses on the key word translation of concepts such as freedom and slavery. It examines the translator’s choices and the pragmatic implications of these decisions for readers of translations of the Bible. The case study centres on the concepts of freedom and slavery in Paul’s letter to the Galatians with an intercultural corpus of 16 translations. Authorised and widely accepted translations in English, German, French and Spanish such as the Lutherbibel (1984) and Reina Valera (1989) are compared with new competing translations, such as the New Living Translation (Tyndale House Publishers, Carol Stream, 2007), The Message (Peterson, The Message: the new testament in contemporary English. NavPress, Colorado Springs, 2005), and Die Volxbibel (2005). This study draws from the fields of Pragmatics, Translation Studies and Theology, to provide a unique cross-cultural examination of Galatians, and of sacred translation. It is found that the choices of the translator of sacred texts are not merely linguistic choices, but rather they are often rooted in various ideological and theological positions.
- Published
- 2014
- Full Text
- View/download PDF
39. Towards user-defined multi-touch gestures for 3D objects
- Author
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William Holderness, Joseph J. LaViola, Sarah Buchanan, and Bourke Floyd
- Subjects
Focus (computing) ,InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.,HCI) ,business.industry ,Computer science ,Multi-touch ,User defined ,Gesture recognition ,Natural (music) ,Computer vision ,Artificial intelligence ,business ,Set (psychology) ,Mobile device ,Gesture - Abstract
Although multi-touch interaction in 2D has become widespread on mobile devices, intuitive ways to interact with 3D objects has not been thoroughly explored. We present a study on natural and guided multi-touch interaction with 3D objects on a 2D multi-touch display. Specifically, we focus on interactions with 3D objects that have either rotational, tightening, or switching components on mechanisms that might be found in mechanical operation or training simulations. The results of our study led to the following contributions: a classification procedure for determining the category and nature of a gesture, an initial user-defined gesture set for multi-touch gestures applied to 3D objects, and user preferences with regards to metaphorical versus physical gestures.
- Published
- 2013
- Full Text
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40. Environmental Impacts, Products and Technology
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Anita Atwal, Marcus Sivell‐Muller, Anthony Slater, Sarah Buchanan, and Sue Vernon
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Occupational therapy ,Engineering ,medicine.medical_specialty ,business.industry ,Environmental health ,medicine ,business ,Environmental planning - Published
- 2013
- Full Text
- View/download PDF
41. CSTutor
- Author
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Sarah Buchanan, Joseph J. LaViola, and Brandon Ochs
- Subjects
Human–computer interaction ,Computer science ,Interface (Java) ,Programming language ,Code (cryptography) ,computer.software_genre ,Data structure ,computer ,Sketch ,Visualization - Abstract
We present CSTutor, a sketch-based interface designed to help students understand data structures. It currently supports Linked Lists, Binary Search Trees, AVL Trees, and Heaps, and creates an environment in which a user's sketched diagram and code are combined seamlessly. In each of the data structure modes, the user can naturally sketch a data structure on the canvas just as they would on the white board. CSTutor analyzes the user's diagrams in real time, and automatically generates code in a separate code view to reflect any changes the user has made. Additionally, the code can also be edited and any new code changes animate the data structure drawn on the canvas. The connection between the data structure drawn on the canvas and the code implementation is intended to bridge the gap between the conceptual diagram of a data structure and the actual implementation. We also present the results of a perceived usefulness survey. The results of the study indicate that the majority of students would find CSTutor helpful for learning data structures.
- Published
- 2012
- Full Text
- View/download PDF
42. Review section
- Author
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Sarah Buchanan
- Subjects
Development - Published
- 1992
- Full Text
- View/download PDF
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